Journal of Materials Chemistry A
·
2021
·Vol. 10
·期 6
·2907-2916
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IF 12.732
Qiyu Wang,Xiangqun Xu,Bo Hong,Maohui Bai,Jie Li,Zhian Zhang,Yanqing Lai
Quasi-solid-state lithium metal batteries hold great potential for use in next generation energy systems due to their high energy capacity and safety. However, these systems still suffer from incompatible interphases and limited cycling performance due to Li dendrite growth. Considering this, nonpolar triallyl cyanurate with a ring-centred –CN coupled structure with pentaerythritol tetraacrylate as a cross-linking agents was applied in the in situ synthesis of gel polymer electrolyte (GPE). The GPE displays high ionic conductivity (7.93 mS cm−1) at room temperature and high stability towards a Li metal anode. Furthermore, the micro-electric field created by triallyl cyanurate (TAC) after polymerization provides uniform adsorption sites for Li+ flow and induces even distribution, which ensures a long cycling life (700 cycles) with a capacity retention of 80.6% for a LiFePO4|GPE|Li battery at 1C. The design of the polymer skeleton provides new insights into solid-state battery optimization different from the intrinsic properties of the electrolyte. This polymeric electrolyte also allows for new opportunities to practically manufacture lithium metal batteries.
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International Journal of Nanomedicine
·
2013
·
IF 3.463
Yijun Wu,Jing Yao,Jianping Zhou,Fatima Zohra Dahmani
For nearly a decade, thermoresponsive ophthalmic in situ gels have been recognized as an interesting and promising ocular topical delivery vehicle for lipophilic drugs. In this study, a series of thermosensitive copolymers, hyaluronic acid-g-poly(N-isopropylacrylamide) (HA-g-PNIPAAm), was synthesized, by coupling carboxylic end-capped PNIPAAm to aminated hyaluronic acid through amide bond linkages, and was used as a potential carrier for the topical ocular administration of cyclosporine A (CyA). The lower critical solution temperature of HA-g-PNIPAAm59 in aqueous solutions was measured as 32.7°C, which was not significantly affected by the polymer concentration. Moreover, HA-g-PNIPAAm59 microgels showed a high drug loading efficiency (73.92%) and a controlled release profile that are necessary for biomedical application. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) observations showed that HA-g-PNIPAAm microgels were spherical in shape with homogeneous size. Based on the result of the eye irritation test, the HA-g-PNIPAAm microgels formulation was shown to be safe and nonirritant for rabbit eyes. In addition, HA-g-PNIPAAm microgels achieved significantly higher CyA concentration levels in rabbit corneas (1455.8 ng/g of tissue) than both castor oil formulation and commercial CyA eye drops. Therefore, these newly described thermoresponsive HA-g-PNIPAAm microgels demonstrated attractive properties to serve as pharmaceutical delivery vehicles for a variety of ophthalmic applications.
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JOURNAL OF NEUROSCIENCE
·
2024
·
IF 4.4
Jing Chen,Yuan Gao,Shu-Ting Bao,Ying-Di Wang,Tao Jia,Cui Yin,Cheng Xiao,Chunyi Zhou
The comorbidity of chronic pain and depression poses tremendous challenges for the treatment of either one because they exacerbate each other with unknown mechanisms. As the posterior insular cortex (PIC) integrates multiple somatosensory and emotional information and is implicated in either chronic pain or depression, we hypothesize that the PIC and its projections may contribute to the pathophysiology of comorbid chronic pain and depression. We show that PIC neurons were readily activated by mechanical, thermal, aversive, and stressful and appetitive stimulation in naïve and neuropathic pain male mice subjected to spared nerve injury (SNI). Optogenetic activation of PIC neurons induced hyperalgesia and conditioned place aversion in naïve mice, whereas inhibition of these neurons led to analgesia, conditioned place preference (CPP), and antidepressant effect in both naïve and SNI mice. Combining neuronal tracing, optogenetics, and electrophysiological techniques, we found that the monosynaptic glutamatergic projections from the PIC to the basolateral amygdala (BLA) and the ventromedial nucleus in the thalamus (VM) mimicked PIC neurons in pain modulation in naïve mice; in SNI mice, both projections were enhanced accompanied by hyperactivity of PIC, BLA and VM neurons, and inhibition of these projections led to analgesia, CPP, and antidepressant-like effect. The present study suggests that potentiation of the PIC-BLA and PIC-VM projections may be important pathophysiological bases for hyperalgesia and depression-like behavior in neuropathic pain, and reversing the potentiation may be a promising therapeutic strategy for comorbid chronic pain and depression.Significance Statement Treatment of chronic pain is quite challenging because of the involvement of central sensitization and emotional disorders. It is keenly demanding to search for brain circuits commonly or separately contributing to hyperalgesia and emotional dysfunction in chronic pain. The PIC is involved in both pain and emotional processing. But, the relationship between the malfunction in the PIC and the comorbidity of chronic pain and depression has not been elucidated. Here, we demonstrate that in chronic pain, PIC neurons became hyperactive, and their projections to the BLA and the VM of the thalamus were augmented; these alterations may confer hyperalgesia and depression-like behaviors in chronic pain. Therefore, these pathways may be potential therapeutic targets for comorbid chronic pain and depression.
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PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yifei Sun,Hang Su,Wei Xiong,Luhong Wen
Water is essential for maintaining human health and ecosystem stability, as it forms the foundation for biological processes. Monitoring pesticides in environmental water remains a critical area of research due to the significant importance of water quality. In this study, a lab-made thermal desorption split-type dielectric barrier discharge ionization source (TD-ST-DBDI) platform was developed, enabling the rapid and effective detection of surface water contaminants, such as amides, triazines, and carbamate pesticides, under environmental conditions without the need for complex pretreatment. Compared to conventional laboratory methods, this approach offered enhanced convenience and efficiency in analysis. Using the established quantitative method, we achieved limit of detections (LODs) ranging from 0.03 to 3 μg/L, limit of quantifications (LOQs) ranging from 0.10 to 10 μg/L, with relative standard deviations (RSDs) of less than 9 %, and linear correlation coefficients (R 2 ) of 0.99 for these pesticides. To track contamination trends over time, a multi-indicator risk assessment model incorporating various factors was developed to evaluate the potential ecological and human health risks of water pollution, revealing that pesticide pollution risks fluctuated over time. This finding provides new insights on monitoring large-scale surface water and exploring the impact of exposure to chemical pollutants on human health.
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Materials
·
2025
·Vol. 18
·期 8
·1786
·
IF 3.2
Xu Wang,Nan Wang,Kunpeng Liu,Meinan Yang,Ruiyong Zhang,Sikandar Khan,Jinhui Pang,Jizhou Duan,Baorong Hou,Wolfgang Sand
Marine biofouling causes significant economic losses, and conventional antifouling methods are often associated with environmental pollution. Hydrogen peroxide (H2O2), as a clean energy source, has gained increasing attention in recent years. Meanwhile, electrocatalytic 2e−oxygen reduction reaction (ORR) for H2O2production has received growing interest. However, the majority of current studies are conducted on acidic or alkaline electrolytes, and research on 2e−ORR in neutral NaCl solutions remains rare. Here, a bimetallic Zn-Cd zeolitic imidazolate framework (ZnCd-ZIF) is rationally designed to achieve chloride-resistant 2e−ORR catalysis under simulated seawater conditions (pH 7.5, 3.5% Cl−). Experimental results demonstrate that the ZnCd-ZIF catalyst exhibits an exceptional H2O2selectivity of 70% at 0.3 VRHE, surpassing monometallic Zn-ZIF (60%) and Cd-ZIF (50%). Notably, H2O2production reaches 120 mmol g−1in a Cl−-containing neutral electrolyte, exhibiting strong resistance to structural corrosion and Cl−poisoning. This work not only pioneers an effective strategy for designing ORR catalysts adapted to marine environments but also advances the practical implementation of seawater-based electrochemical H2O2synthesis.
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Applied Sciences-Basel
·
2025
·Vol. 15
·期 8
·4203
·
IF 2.5
Ping Yang,Chenhao Qiu,Na Zhang
Applying physical modification methods to raise the resistant starch content is a feasible strategy for developing foods with a low glycemic index (GI) and regulating postprandial hyperglycemia. Here, broken rice starch (C) was modified via ultrasound and quercetin complexation (US-Q). The structure, physicochemical properties, and in vitro digestibility of the US-Q product were subsequently determined. Scanning electron microscopy (SEM) images showed that the modification changed the starch granules’ morphology, forming a more compact and stable structure. Fourier transform infrared (FTIR) spectroscopy images revealed the interaction between the starch and quercetin. An X-ray diffraction (XRD) analysis demonstrated that the crystallinity of the US-Q was lower than that of the C, indicating that the combined modification with ultrasound and quercetin disrupted the long-range ordered structure of the starch and facilitated the formation of a short-range ordered structure from amylose. Size exclusion chromatography (SEC) images showed that both the molecular weight (from 72,080.96 kDa to 85,141.95 kDa) and amylose content (from 15.94% to 26.76%) increased significantly, while the branching degree and average degree of polymerization of amylopectin decreased, suggesting that the ultrasonic treatment processing method had a significant impact on the formation of the quercetin–starch complexes. In terms of in vitro digestion, the resistant starch content of the US-Q was significantly increased from 6.57% to 20.23%, whereas the hydrolysis rate was decreased from 92.6% to 78.35%, indicating that the presence of quercetin reduced the digestibility of the starch complexes by inhibiting the starch-hydrolyzing enzyme activity. Overall, this study improves the understanding of ultrasound and quercetin dual treatment of broken rice starch, providing a theoretical basis for the development of low-GI starch foods for industrial applications.
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Oncotarget
·
2016
·
IF 5.008
Hui-Yun Zhang,Wen-Qian Xu,Yuan-yuan Zheng,Emmanuel Omari-Siaw,Yuan Zhu,Xia Cao,Shan-Shan Tong,Jiang-nan Yu,Xi-ming Xu
Cardiac glycosides could increase intracellular Ca 2+ ion by inhibiting the Na + /K + ATPase to induce apoptosis in many tumor cells. However, narrow therapeutic index, poor tumor selectivity and severe cardiovascular toxicity hinder their applications in cancer treatment. To improve the safety profile and tumor targetablility of cardiac glycosides, we designed octreotide conjugated periplocymarin, a cardiac glycoside isolated from Cortex periplocae . The conjugate showed higher cytotoxicity on MCF-7 cells and HepG2 tumor cells (SSTRs overexpression) but much less toxicity in L-02 normal cells. Tissue distribution studies of the conjugate using H 22 tumor model in mice showed higher accumulation in tumor and lower distribution in heart and liver than periplocymarin. Furthermore, in vivo anticancer effects of the conjugate on mice bearing H 22 cancer xenografts confirmed enhanced anti-tumor efficacy and decreased systemic toxicity. Altogether, octreotide-conjugated periplocymarin demonstrated tumor selectivity and may be useful as a targeting agent to improve the safety profile of cardiac glycosides for cancer therapy.
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ACS Nano
·
2023
·
IF 17.1
Tingting Wei,Yingke Ren,Yifan Wang,Li’e Mo,Zhaoqian Li,Hong Zhang,Linhua Hu,Guozhong Cao
The reversibility and cyclability of aqueous zinc-ion batteries (ZIBs) are largely determined by the stabilization of the Zn anode. Therefore, a stable anode/electrolyte interface capable of inhibiting dendrites and side reactions is crucial for high-performing ZIBs. In this study, we investigated the adsorption of 1,4-dioxane (DX) to promote the exposure of Zn (002) facets and prevent dendrite growth. DX appears to reside at the interface and suppress the detrimental side reactions. ZIBs with the addition of DX demonstrated a long-term cycling stability of 1000 h in harsh conditions of 10 mA cm–2 with an ultrahigh cumulative plated capacity of 5 Ah cm–2 and shows a good reversibility with an average Coulombic efficiency of 99.7%. The Zn//NH4V4O10 full battery with DX achieves a high specific capacity (202 mAh g–1 at 5 A g–1) and capacity retention (90.6% after 5000 cycles), much better than that of ZIBs with the pristine ZnSO4 electrolyte. By selectively adjusting the Zn2+ deposition rate on the crystal facets with adsorbed molecules, this work provides a promising modulation strategy at the molecular level for high-performing Zn anodes and can potentially be applied to other metal anodes suffering from instability and irreversibility.
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JOURNAL OF HAZARDOUS MATERIALS
·
2015
·
IF 4.529
Yao Wang,Wentao Zhu,Jing Qiu,Xinru Wang,Ping Zhang,Jin Yan,Zhiqiang Zhou
In the present study, the enantioselective metabolism, cytotoxicity of hexaconazole and its influence on tryptophan metabolism in rat hepatocytes in vitro were investigated. Following the exposure of primary rat hepatocytes to rac -hexaconazole, the concentrations of its enantiomers in the media were determined by chiral high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS). The half-lives ( t 1/2 ) of (+)-hexaconazole and (−)-hexaconazole were 5.17 h and 19.80 h, respectively, indicating that the metabolic process was enantioselective with (−)-hexaconazole enrichment. Using the MTT method, the EC 50 values of rac -hexaconazole, (+)-hexaconazole and (−)-hexaconazole after 12 h of exposure were determined to be 71.62, 62.71 and 67.94 μM, respectively. Tryptophan metabolism was monitored using metabolomics profiling techniques. Hexaconazole and its enantiomers caused the down-regulation of tryptophan levels and the up-regulation of kynurenine (KYN) levels, suggesting a role for hexaconazole in the activation of the KYN pathway and providing information for the mechanism of its toxicity.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2025
·
IF 8.4
Yifei Luo,Guohe Huang,Yongping Li,Jing Huang,Yao Yao,Peng Zhang,Zixin Zhang,Jian Shen,Jianan Yin,Xiujuan Chen,Yuwei Wu,Mengna Li,Kai Zhao,Sichen Gao,Chun Zhang
Ensuring the safe removal of fluoride from drinking water poses a significant challenge in numerous remote communities affected by fluoride contamination. Therefore, this study focuses on the in-situ growth of MOF—AlFu on ceramic filters (CFs), thereby synthesizing in-situ MOF-modified ceramic filters (IMCFs) for effective fluoride removal from drinking water in such communities. Initially, we conducted response surface optimization of the IMCF preparation process, followed by comprehensive characterization. Based on SEM, XRD, and FTIR analyses, it is confirmed that AlFu successfully grows on the surfaces and within the pores of CFs, forming layered structures that enhance the effective adsorption of fluoride on IMCFs. Besides, zeta potential and FTIR results indicated that electrostatic adsorption, ion exchange and hydrogen bonding are the primary mechanisms of fluoride adsorption on IMCFs, which is also confirmed by the adsorption kinetics. The results of adsorption isotherms show that the maximum adsorption of IMCFs is 9.51 mg/g. Within the pH range of 4–10, IMCFs reduced the fluoride concentration from 10 mg/L to below 1.2 mg/L. Furthermore, the IMCF retains over 75 % of its adsorption capacity after undergoing five use cycles, exhibiting remarkable durability during the multiple cycling filtration process. This study suggests that the developed IMCF can serve as a safe and effective defluoridation technology for purifying drinking water in remote communities.
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JOURNAL OF ASIA-PACIFIC ENTOMOLOGY
·
2025
·
IF 1.3
Yu Gao,Dong-Yang Liu,Quan Deng,Wen-Long Feng,Jia-Min Yu,Mao-Ye Li,Su Liu
Exposure to insecticides can cause abnormally high accumulation of reactive oxygen species (ROS) and oxidative stress in insects. Thioredoxin peroxidases (TPXs) play critical roles in protecting insects from insecticide-induced oxidative injury. The black cutworm, Agrotis ipsilon (Hufnagel) (Lepidoptera: Noctuidae), is an important agricultural pest. Lambda-cyhalothrin (LCT) is a pyrethroid insecticide used to control A. ipsilon . However, whether LCT causes oxidative stress and whether TPXs are involved in the antioxidant defense in A. ipsilon remain unknown. In this study, a TPX gene, AiTPX6 , was identified from A. ipsilon . AiTPX6 consists of five exons and four introns and encodes a protein of 227 amino acid residues. The AiTPX6 protein has characteristic features of TPXs, including the peroxidase active site motif PVCTTE with a conserved catalytic cysteine residue. Phylogenetic analysis revealed that AiTPX6 belongs to the “1-Cys” TPX group. The mRNA transcripts of AiTPX6 were most abundant in the larval midgut and at the fifth- and sixth-instar larval stages. Exposure to a sublethal concentration (LC 50 ) of LCT significantly increased the H 2 O 2 and malondialdehyde (MDA) concentrations and elevated the mRNA level of AiTPX6 , suggesting that LCT-induced oxidative stress activates AiTPX6 transcription. Recombinant AiTPX6 expressed in Escherichia coli displayed potent antioxidant activity, protecting the cells against oxidative stress. Knockdown of AiTPX6 via RNA interference (RNAi) significantly increased the mortality rate of A. ipsilon following LCT exposure. These findings revealed that AiTPX6 contributes to LCT tolerance via antioxidant defense and could therefore be used as a potential target for RNAi-based control of A. ipsilon .
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MATERIALS CHEMISTRY AND PHYSICS
·
2025
·
IF 4.7
Muhammad Umar Farooq,Rustem R. Zairov
A smart drug delivery system (DDs) based on PEGylated (polyethylene glycol) gold/zinc oxide (PEG-Au/ZnO) loaded with doxorubicin (DOX) and chlorine-e6 (Ce6) was successfully synthesized, characterized, and evaluated against breast malignancy. With and without laser exposure, the DOX-PEG-Au/ZnO–Ce6 nanoprobe bypassed the internal barriers and exhibited much higher synergistic therapeutic activity than Ce6 and DOX alone. The controlled release kinetics of DOX in combination with Ce6 could inhibit tumor growth and remarkably enhance the sensitivity of chemotherapy. Apart from the chemotherapeutic effect, the residual PEG-Au/ZnO could amplify the reactive oxygen species (ROS) generation through cascade reactions, which will benefit the release of free zinc ions in the lysosome of inflammatory cells. Taken together, the as-prepared DOX-PEG-Au/ZnO–Ce6 nanoprobe is expected to facilitate the management of chemo-photodynamic combination therapy as Trojan horses to eliminate cancer and improve the quality of life for the patient by reducing acute toxic side effects.
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