INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2025
·
IF 5.2
Kaixin Feng,Zhongkun Zhang,Jingjing Zhang,Xiaohan Xia,Siyu Yao,Yufei Wang,Min Wu
Doxorubicin (DOX) is limited by its clinical toxicity as a breast cancer therapy. Traditional liposomal formulations improve the tumor delivery of DOX but suffer from inadequate controlled release and low encapsulation efficiency of DOX. To address these, we developed a photo-responsive liposomal formulation DTTPL by co-encapsulating DOX and TiO 2 nanostructures (TiO 2 ) within D-α-tocopheryl succinate (α-TOS)-PEG liposomes. DTTPL successfully facilitated the release of DOX through the light-sensitive catalysis mechanism of TiO 2 , exhibiting 4.6 times greater cytotoxicity against MCF-7 cells compared to free DOX. Transcriptional analysis revealed synergistic DOX/DTTPL dysregulation of key genes (Brca1, Bcl-2, Bax, Caspase-3), aligning with cytotoxicity. Eventually, light-triggered DOX/DTTPL formulation resulted in 70.09% of tumor growth inhibition (TGI) in mice with no significant organ toxicity. This photo-responsive nanoformulation enables efficient controlled release of DOX, offering an alternative strategy for small molecule delivery to treat triple negative breast cancer.
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DOI
PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2022
·Vol. 33
·期 7
·2313-2324
·
IF 3.348
Zhiyi Huang,Tingting Liao,Xiaochun Liu,Jianyu Wu,Zilun Tang,Guoyi Pan,Huameng Liu,Xiaofeng Lin,Wenjing Lin,Yong Li,Yuxin Gu,Guobin Yi
Thermoplastic elastomer ethylene/α-octene co-polymer (POE) is a special polymer material with both elasticity and thermoplasticity. However, the nonpolarity and low-tensile strength of POE limit its application in polar materials and high-strength materials fields. In this study, we synthesized a specific molecule with C═C bonds and N H bonds, which was introduced into POE to construct hydrogen bonding network, and the prepared modified POE is further blended with carboxyl terminated polystyrene nanospheres as toughening agent to prepare modified POE elastomer composites. Based on such dual toughening strategy containing chemical modification and physical toughening, the modified POE elastomer composites possess improved mechanical properties. The composites achieve a tensile strength of 21.4 MPa, elongation at break of 1268%, fracture energy of 109.6 MJ∙m −3 and exhibit improved thermal stability. Impressively, the tensile strength of reprocessed composites is restored to more than 90% of their original tensile strength even after four times of reprocessing steps, demonstrating excellent reusability.
研究领域:
材料科学
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高分子科学
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机械工程
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Jinmei Xu,Senqi Xu,Shangqing Tang,Luyao Wang,Kui Wan,Chuqiao Wang
The widespread use and release of 2,4,6-Trichlorophenol (TCP) poses a significant risk to water bodies and ecosystems. Designing efficient and stable catalysts for photocatalytic degradation of TCP remains a great challenge. In this paper, a Z-scheme α-MnO 2 /Bi 2 S 3 (Mn/Bi) composite enriched with oxygen (O Vs ) and sulfur (S Vs ) vacancies is designed for photocatalytic degradation of TCP. 60-Mn/Bi achieved 88 % degradation efficiency for 20 mg/L TCP solution. The reaction rate ( k ) of 60-Mn/Bi is 6.46 and 4.41 times higher than that of α-MnO 2 and Bi 2 S 3 , respectively. The catalyst exhibited high catalytic activity in a wide pH range and high resistance to anion. In addition, the cycling performance of 60-Mn/Bi is relatively stable, and the ion leaching rate is low. The Z-scheme mechanism is confirmed by characterization and DFT, which effectively retained the strong redox capacity. The abundant vacancy structure enhances the adsorption of TCP and promotes the migration of photogenerated carriers. In addition, the rod-shaped Bi 2 S 3 provides a carrier for α-MnO 2 nanoparticles, which effectively alleviates agglomeration and thus exposes more active sites. Three possible degradation pathways were explored by LC-MS and DFT. This study provides a facile method and guidance for the preparation of Z-scheme catalysts to improve photocatalytic degradation performance.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2017
·
IF 6.216
Zheng Fang,Wei He,Tao Tu,Niuniu Lv,Chuanhong Qiu,Xin Li,Ning Zhu,Li Wan,Kai Guo
α-Fe 2 O 3 nanoparticles were prepared by using a continuous precipitation method with a valve assisted micromixer in the presence of iron (III) sulfate and ammonia water. The resulting nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM). Meanwhile, CaCO 3 nanoparticles were synthesized in a tube-in-tube flow reactor AF-2400. The acylation process catalyzed by modified lipophilic α-Fe 2 O 3 and CaCO 3 nanoparticles in the flow reactor were systematically investigated. Under the optimal conditions, a yield of 97.8% was obtained. Addition of CaCO 3 nanoparticles resulted in higher catalytic efficiency compared with pure modified α-Fe 2 O 3 nanoparticles. Moreover, this novel acylation also worked well for other substrates.
研究领域:
化学工程
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材料科学
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绿色化学
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DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
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2017
·
IF 2.084
Xiaowei Mu,Bihe Yuan,Ying Pan,Xiaming Feng,Lijin Duan,Ruowen Zong,Yuan Hu
A layer-by-layer (LBL) assembly coating composed of α-cobalt hydroxide (α-Co(OH) 2 ) and sodium alginate (SA) is deposited on flexible polyurethane (FPU) foam to reduce its flammability . Scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) are employed to prove the LBL assembly process. It is obvious from SEM results that a uniform and rough coating is deposited on FPU foam compared with that of untreated one. The peak intensity of methylene of SA in FITR spectra and typical (003) diffraction peak of α-Co(OH) 2 nanosheets at 11.0° in XRD patterns increases gradually with increment of bilayer number. Combustion behavior and toxicity suppression property of samples are characterized by cone calorimeter (under an irradiance of 35 kW m −2 ) and Thermogravimetry/Fourier transform infrared spectroscopy. The one and two bilayers (BL) coating on FPU foam can achieve excellent flame retardancy. Compared with untreated sample, the peak heat release rate of the coated FPU foam containing only one BL coating is reduced by 58.7%. The content of gaseous toxic substances during pyrolysis of FPU foam deposited with a single bilayer coating, such as CO and NCO-containing compounds, are reduced by 20.0% and 9.2%, respectively. Besides, the flame retardant mechanism of the coated FPU foam is also revealed.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Zhizhong Han,Min Luo,Li Chen,Jinghua Chen,Chunyan Li
In this work, a novel label free photoelectrochemical (PEC) immunosensor has been developed for the detection of α-fetoprotein (AFP). The immunosensor was based on Au-ZnO flower-rods (FRs) heterostructure, where Au nanoparticles (NPs) were firstly electrodeposited by cyclic voltammetry methods. Scanning electron microscopy (SEM), X-ray diffraction (XRD), Mott-Schottky plot (MS), UV–vis diffuse reflectance spectrum and fluorescence emission spectrum were used for the characterizations of Au-ZnO FRs. The results demonstrated that Au NPs not only obviously enhanced the visible light absorption of ZnO FRs due to surface plasmon resonance (SPR) but also improved the separation of photo-generated electron-hole pairs. Therefore, the photocurrent of Au-ZnO FRs was increased under simulated sunlight. The photocurrent was reduced after the specific antibody-antigen immune reaction. And the photocurrent decrement was linear with the logarithm of AFP antigen concentration in the range from 0.005 ng mL −1 to 50 ng mL −1 with a low detection limit of 0.56 pg mL −1 (S/N = 3). The PEC immunosensor also exhibited high anti-interference property and acceptable stability. This work would provide a promising photoelectrochemical strategy for the detection of other proteins in clinical diagnosis.
研究领域:
生物医学工程
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分析化学
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肿瘤学
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DOI
高影响因子
ChemistrySelect
·
2024
·Vol. 9
·期 45
·e202404657
·
IF 1.9
Chenyue Zhao,Heran Yang,Shuo Hu,Yaqian Liu,Dongping Cheng,Xiaoliang Xu
Graphical In the presence of CBrCl3 and ruthenium photocatalyst, the corresponding dione was obtained by visible light induced oxidation of α-hydroxyl ketone derivatives with the yield of 49%–95%. It has the advantages of medium to excellent yield, good functional group tolerance, and mild reaction conditions. A visible light-induced oxidation of α-hydroxy ketone derivatives is reported, which is carried out in the presence of CBrCl 3 and ruthenium photocatalyst, and the corresponding diketones are obtained in 49-95% yields. This reaction has the advantages of moderate to excellent yields, good functional group tolerance, and mild reaction condition. The free radical reaction process was confirmed by the addition of radical scavenger 2,2,6,6-tetramethylpiperidi-1-oxy (TEMPO). The fluorescence quenching experiment indicated that CBrCl 3 was participated in the oxidation quenching cycle.
研究领域:
有机化学
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光化学
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合成化学
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DOI
高影响因子
Frontiers in Plant Science
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2021
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IF 5.754
Liu Wenqian,Zhang Ruoyan,Xiang Chenggang,Zhang Ruiyun,Wang Qing,Wang Tao,Li Xiaojun,Lu Xiaohong,Gao Shunli,Liu Zixi,Liu Mengshuang,Gao Lihong,Zhang Wenna
Climate changes especially chilling stress affects cucurbit crops during winter seasonal production. Grafting to pumpkin rootstocks is widely used to improve the vigor of cucurbits, especially cucumber (Cucumis sativus L.) plants, in the face of chilling stress. In our study, multi-disciplinary aspect approaches were used to investigate growth changes of pumpkin under chilling stress. Firstly, the morphological and physiological characteristics of 14 pumpkin (Cucurbita moschata) varieties following different periods of chilling stress was analyzed by using physiological means. Mathematical results of principal component analysis (PCA) with chlorophyll-a, chlorophyll-b, carotenoid contents, chilling injury index and relative electrolyte permeability indicated that relative electrolyte permeability as the primary judgment index was best associated with the comparison of chilling tolerance in pumpkin rootstock varieties. Then, transcriptomic and DCMU (Diuron) application and chlorophyll fluorescence examination analysis of pumpkin leaves revealed that 390 Cucurbita moschata differentially expressed genes (CmoDEGs) that affect photosynthesis were upregulated in leaves. 127 CmoDEGs both in leaves and roots were enriched for genes involved in unsaturated fatty acid metabolism, suggesting that plasma membrane lipids are involved in chilling perception. The results of increased composition of unsaturated fatty acid in leaves and qRT-PCR analysis of relative mRNA abundance confirmed that α-linolenic acid biosynthesis was responding to pumpkin chilling tolerance. The integration of physiological, mathematical bioinformatical and biological analysis results contributes to our understanding of the molecular mechanisms underlying chilling tolerance and its improvement in cucumber grafted on pumpkin rootstocks. It provided an important theoretical basis and reference for further understanding on the impact of climate change on plant physiological changes.
研究领域:
植物生理学
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分子生物学
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农学
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气候变化研究
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DOI
PubMed
高影响因子
Drug Design Development and Therapy
·
2022
·
IF 4.319
Huan Li,Bingtao Zhai,Jing Sun,Yu Fan,Junbo Zou,Jiangxue Cheng,Xiaofei Zhang,Yajun Shi,Dongyan Guo
Purpose Aralia taibaiensis, a medicinal food plant, and total saponins from its root bark extract inhibit α-glucosidase activity, which is associated with type 2 diabetes; however, the inhibitory mechanism is unknown. Furthermore, a green extraction technique superior to conventional hot reflux extraction (HRE) is needed for the rapid and easy extraction of A. taibaiensis total saponins (TSAT) to exploit and utilize this resource. Our aim was to develop a green extraction method for obtaining TSAT and to investigate the mechanism by which TSAT inhibits α-glucosidase.Materials and Methods In this study, the ultrasound-assisted extraction (UAE) process was optimized using a Box–Behnken design, and the extraction mechanism was investigated using scanning electron microscopy (SEM). High-performance liquid chromatography (HPLC) was used for qualitative and quantitative analyses of TSAT. In vitro glycosylation assays, enzyme kinetics, fluorescence spectroscopy measurements, atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FT-IR) and molecular docking techniques were used to investigate the mechanism by which the A. taibaiensis active ingredients inhibit α-glucosidase.Results The optimal parameters for the extraction yield were obtained as an ethanol concentration of 73%, ultrasound time of 34 min, ultrasound temperature of 61 °C and solid–liquid ratio of 16 g/mL, which were better than HRE. The SEM analysis showed that UAE effectively disrupted plant cells, thus increasing the TSAT yield. In vitro α-glucosidase inhibition experiments showed that both TSAT and its active ingredient, araloside A, inhibited α-glucosidase activity by binding to α-glucosidase, thereby changing the conformation and microenvironment of α-glucosidase to subsequently inhibit enzyme activity.Conclusion The optimal extraction conditions identified here established a basis for future scale-up of ultrasound extraction parameters with the potential for obtaining maximum yields. In vitro enzyme inhibition experiments investigated the mechanism of the TSAT interaction with α-glucosidase and further explored whether araloside A may be the main contributor to the good inhibition of α-glucosidase activity by TSAT.
研究领域:
药用植物学
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天然产物化学
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糖尿病研究
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Yu Tian,Xiaoru An,Xiaonan Du,Dalei Chang,Hong Li,Yue Hua,Xiuling Zhang,Jingsen Zhang,Lanbo Di
α-Co(OH) 2 has important applications in environmental, energy and catalysis applications. However, a complicated and harsh process is required for its production. Therefore, it is necessary to develop a rapid, facile, and green approach for the controllable synthesis of α-Co(OH) 2 . In this study, we successfully synthesized α-Co(OH) 2 supported on multiwalled carbon nanotubes (MWCNT) (α-Co(OH) 2 /MWCNT) by the plasma treatment of a mixture of cobalt nitrate and MWCNT in water without adding any other chemical reagents. The controllable synthesis of α-Co(OH) 2 was achieved only by adjusting the plasma conditions and support functionalization. The reduction of p -nitrophenol (4-NP) as a model using NaBH 4 was used to evaluate the performance of the obtained α-Co(OH) 2 /MWCNT catalysts. The results revealed that the sample prepared with 15 min of plasma treatment using H 2 /Ar as the working gas (α-Co(OH) 2 /MWCNT-15) had a good crystalline phase structure and showed excellent 4-NP reduction performance with a reaction rate constant as high as 1.97 min −1 . Structural characterization and electrochemical analyses of the different catalysts indicated that α-Co(OH) 2 /MWCNT-15 contains abundant defects, a large layer spacing, and abundant lattice sites for hydrogen adsorption, which are conducive to the adsorption of more active hydrogen species and 4-NP, and thus lead to significantly accelerated catalytic reduction of 4-NP.
研究领域:
材料科学
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环境科学
·
催化化学
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DOI
高影响因子
Chemical and Biological Technologies in Agriculture
·
2025
·Vol. 12
·期 1
·1-22
·
IF 5.2
Xia Lunbin,Chen Cunwu,Bi Shaoshuai,Zhang Yafei,Chen Naidong,Feng Jing
Background In recent years, the biological activities of polysaccharides derived from Chinese herbal medicones have garnered increasing attention. Polygonatum cyrtonema Hua, a widely used traditional Chinese medicinal herb, possesses significant healthcare value. However, the structure–activity relationship between polysaccharide structures and biological functions remains to be fully elucidated. Methods Crude Polygonatum cyrtonema Hua polysaccharides (PCHP) were extracted using hot water extraction followed by alcohol precipitation. The extract was subsequently purified through DEAE seplife FF chromatography, yielding two franctions: PCHP-1 and PCHP-2. Because of the highest content and the better solubility, PCHP-1 was further purified using Sephacryl S-400HR column chromatography to obtain a purified fraction designated as PCHP-1A. Subsequently, The structural characteristics of PCHP-1A were comprehensively analyzed through monosaccharide composition analysis, scanning electron microscopy (SEM), Fourier transform-infrared spectroscopy (FT-IR), methylation analysis, and nuclear magnetic resonance (NMR) spectroscopy. Additionally, the antioxidant and hypoglycemic activities of PCHP-1A were evaluated though in vitro experiments. Results Structural analysis revealed that PCHP-1A, with an average molecular weight of 2.90 × 10 4 Da, is comprised of fructose (Fru), glucose (Glc), galactose (Gal), mannose (Man), arabinose (Ara) and rhamnose (Rha). PCHP-1A exhibited a compact and curly spherical molecule conformation, and SEM analysis revealed its smooth, porous, clastic or lamellar microstructure. Comprehensive FT-IR, GC–MS, and 1D/2D NMR analyses indicated that the main chain of PCHP-1A consists of → 1)-β- d -Fru f -(2 → , → 1,6)-β- d -Fru f -(2 → , and → 6)-α- d -Glc p, with branch chains primarily composed of β- d -Fru f -(2 → linked at the O -6 position of → 1,6)-β- d -Fru f -(2 →. Biological activity assays demonstrated that at a concentration of 4.0 mg/mL, PCHP-1A exhibited a DPPH scavenging rate of 56.92 ± 1.42% and an inhibitory capacity against · OH radicals of 23.27 ± 1.80 U/mL. Furthermore, PCHP-1A showed significant hypoglycemic activity, with an IC 50 value of 5.15 ± 1.09 mg/mL. Conclusions This study successfully isolated and purified polysaccharide from Polygonatum cyrtonema Hua, elucidated its fundamental structure, and investigated its antioxidant and hypoglycemic activities. The findings provide a theoretical foundation for understanding the structure–activity relationship of the polysaccharide and suggest that Polygonatum cyrtonema Hua polysaccharide may be a natural potential antioxidant and hypoglycemic agent. Graphical
研究领域:
中药学
·
生物化学
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Xin Cheng,Yan Huang,Chao Yuan,Ke Dai,Hong Jiang,Jimei Ma
An ultrasensitive colorimetric method for α-glucosidase sensing based on iodine-mediated etching of gold nanorods (AuNRs) was developed. In this method, 2- O -α- d -glucopyranosyl- l -ascorbic acid (AA-2G) was used as an enzymatic substrate. The hydrolysate ascorbic acid in situ reduced KIO 3 to I 2 , which subsequently etched the AuNRs. A blue-shift of the localized surface plasmon resonance (LSPR) absorption of AuNRs was clearly observed by UV–vis spectroscopy and reflected with visual color changes. The shift showed a good linear relationship with the concentration of α-glucosidase during 2.5–45 U/L and a low α-glucosidase detection limit of 0.5 U/L was provided. This strategy was featured with low cost, simplicity, excellent sensitivity, high selectivity and successfully applied in the α-glucosidase inhibitor screening with Chinese Wolfberries as candidates.
研究领域:
生物化学
·
医学诊断
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药物筛选
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DOI
高影响因子
危险品化学品经营许可证（带存储）