CHEMICAL PAPERS
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2022
·Vol. 76
·期 5
·2703-2719
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IF 2.146
Sun Ke Wei,Wang Fang,Ma Ting Mei,Zeng Han
Core–shell structure nano-composite made up of Ag nano-wire and metal organic framework material (MOF) was proposed to accommodate Hemoglobin (Hb) molecules. Influences of mutual interactions between Hb and components of core–shell nano-complex on direct electrochemistry and electro-catalytic efficiency on H 2 O 2 reduction of nano-composite with Hb attachment is the main objective of this exploration in this submission. The microscopy, spectrometry and electro-chemical techniques were used to achieve such goal in this paper. The experimental results revealed that the abutting ligation between Hb and Ag nano-wire would lead to the prominent alteration in configuration of heme site in Hemoglobin molecule. However such combination would not increase the active energy of substrate electro-reduction seriously. The quasi-reversible redox process with one proton and single electron participation for Hb-based electrode should be imputed to a typical thin-film confining pattern with normalized rate constant of heterogeneous electron shuttle at 6.6 × 10 –2 s −1 . Mass transferring step of electro-active species in nano-complex with Hb detention (normalized rate at 1.2 × 10 –4 s −1 ) should be regarded as the key factor in restraining the efficiency of enzyme-induced catalysis. Graphical abstract
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Yu-Yang Wei,Shao-Hua Wu,Qi-Meng Wang,Jian-Jun Sun
A novel split-type and signal-on photoelectrochemical (PEC) biosensor was proposed based on double-strand specific nuclease (DSN)-assisted recycling amplification coupled with photodeposited Ag enhanced BiVO 4 photoanode for sensitive detection of microRNA (miRNA)− 155. In the presence of target miRNA, the capture DNA (cDNA) modified with silver nanocube（AgNC）would hybridize with the miRNA, then DSN-assisted cycle amplification was triggered, leading to the release of AgNCs. The released AgNCs were acidolyzed and photodeposited on the BiVO 4 electrode. Compared with the BiVO 4 electrode, an enhanced photocurrent could be achieved at this obtained BiVO 4 /Ag electrode. And the morphology change from worm-like nanoparticles to nanosheets after Ag photodeposition was observed for the first time. This PEC signal enhancement was mainly contributed to the synergistic action of localized surface plasmon resonance (LSPR) effect of Ag, Schottky junction formed between BiVO 4 and Ag, and the formation of BiVO 4 nanosheets with larger specific surface area. The PEC signal enhancement was positively related to the miRNA-155 concentration, so this method could be used to sensitively and selectively detect miRNA-155. A limit of detection of 8 aM could be achieved. This strategy does not require layer-by-layer modification of the electrode, so it is easy to operate, and owns good stability.
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Journal of Materials Chemistry B
·
2020
·Vol. 9
·期 9
·2200-2211
·
IF 5.344
Qing Sun,Mengting Duan,Wei Fan,Bing Fan
Enterococcus faecalis is the main cause of refractory root canal infections in human teeth. The control of root canal infection is one of the conditions necessary for the successful treatment of refractory root canal infections. In the present study, nano-scale silver–zinc–calcium–silica particles loaded with different ratios of silver–zinc were successfully prepared (Ag0.5Zn3-MCSNs and Ag0.5Zn10-MCSNs). The release profiles, antibacterial activity against E. faecalis, infiltration depth into dentinal tubules, biocompatibility and effects on dentin microhardness in vitro were investigated. In addition, the antimicrobial effects of the particles against Enterococcus faecalis reinfection were evaluated in vivo in the teeth of beagle dogs. Ag, Zn, Ca and Si were released from Ag–Zn-MCSNs, and the atomic ratio of silver and zinc released can reach the optimal value of 1 : 12 (Ag0.5Zn10-MCSNs). The particles also showed good biocompatibility and antibacterial activity against Enterococcus faecalis and did not reduce the hardness of dentin. The nanoparticles could be driven into the dentinal tubules of dentin slices by ultrasonic activation. In the root canals of beagle dogs, both Ag0.5Zn3-MCSNs and Ag0.5Zn10-MCSNs demonstrated strong preventive effects against E. faecalis infection. The Ag–Zn–Ca–Si mesoporous nanoparticles may develop into a new effective root canal disinfectant or root canal sealer.
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高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Chang Liu,Xinrui You,Dingkun Lu,Guoyue Shi,Jingjing Deng,Tianshu Zhou
Nowadays, the environmental risk factors for Alzheimer’s disease (AD) have received widespread attention. Two major amyloid-β peptide (Aβ) variants, Aβ42 and Aβ40, play a pivotal role in the etiology of AD and the concentration ratio of which (i.e., Aβ42%) has been suggested to be the superior biomarker for AD. In this study, an “aggregation-based colorimetric sensor array” for the simultaneous identification and detection of Aβ40 and Aβ42 with structural similarity was established based on gelsolin-modified silver nanotriangles (Ag NTs) and silver nanorods (Ag NRs). Different aggregation behaviors of gelsolin-modified Ag NTs and Ag NRs in the presence of Aβ42 and Aβ40 resulted in different color and spectral changes, which could be quantitatively analyzed in terms of unique spectral patterns by principal component analysis. With the colorimetric sensor array employed here, the fluctuation of Aβ42% in different brain regions of rats exposed to Cd2+ could be directly monitored. The downward trend of Aβ42% accompanied by variations of other biochemical indicators suggested that subchronic Cd2+ exposure possibly triggered the onset of AD through the intervention of lipid peroxidation pathway. Furthermore, in vivo monitoring the downtrend of Aβ42% in cerebrospinal fluid (CSF) could also be realized, which offers a great opportunity for early diagnosis and treatment of AD that may be induced by environmental factors with CSF Aβ42% as a reliable indicator.
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JOM
·
2022
·Vol. 75
·期 5
·1515-1529
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IF 2.597
Ge Yang,Liu Zhihong,Yu Zhiqian,Wang Huanwen,Lu Xingwu,Zhang Leru,Xia Longgong
The present study focused on the Cu-Pb system and investigating the distribution behaviors of various minor elements through the equilibration-quenching-EPMA analysis experimental technique. Obtained results showed that: (1) An intermetallic compound consisting mainly of Cu-Pb-Se-Te formed below 956°C. (2) As, Sb and Sn had similar distribution behaviors, which mainly entered the solid Cu phase at the temperature range of 500–900°C, but became concentrated in the liquid alloy phase at temperature range of 900–1060°C, and their distribution ratios increased along with increasing temperature. (3) Bi was mainly found in the liquid alloy phase, and its distribution ratio ranged from 6.8 to 836.5 at the experimental conditions. (4) Se and Te formed an intermetallic alloy phase under 900°C, and they enriched in the liquid alloy phase between 960°C and 1060°C. (5) Au was mainly found in the solid Cu phase at the temperature range of 500–900°C, and its distribution ratio was about 1.5 at 900–1060°C. The distribution ratio of Ag decreased from 8.7 to 2.3 when increasing the temperature from 500°C to 1060°C. Distribution behavior of As, Sb, Bi and Sn is consistent with their interfacial enthalpies with Cu and Pb.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Houwen Hu,Zewei Chen,Changxing Wang,Linfan Wang,Xu Wang,Yue Shi,Da Chen
Since the last decade, water pollution by silver ions (Ag + ) has been a serious potential threat to environmental protection and an enormous research effort has been put into the detection and removal of environmental Ag + . Here, we report a novel fluorescent cellulose polyacrylamide-hydrogel (FCPH) modified by boron/nitrogen doped carbon dots (BN-CDs) for sensitive visual detection and efficient extraction of Ag + . In addition, the introduction of BN-CDs in the cross-linking process promotes the formation of 3D network structures with more ionic adsorption sites in FCPH. On the one hand, the FCPH exhibits an excellent sensing performance in the range of 0–300 μM with a limit detection of 51 nM. On the other hand, the adsorption experiments confirm that the FCPH exhibits an excellent Ag + extraction performance of over 251.4 mg‧g −1 , and the adsorption results accord well with the pseudo-second-order model and the Langmuir model. Detailed mechanism characterizations reveal that the excellent adsorption capacity of FCPH is caused by the redox reaction and formation of metal complexes between the surface functional groups of BN-CDs and Ag + in FCPH. Hence, this work fabricates a bifunctional hydrogel and provides a convenient “two birds with one stone” strategy for the visual sensing and extraction of Ag + .
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Xiaoyu Yang,Shunbi Xie,Weifen Wu,Jingwen Liu,Manjun Liao,Runzi Zhang,Yao Liu,Mengjun Wang,Yi He
In SERS analysis, SERS substrates often suffer from uneven “hot spot” distribution, poor stability, and susceptibility to oxidation and aggregation, which limit detection precision and accuracy. To overcome these aggregation, this study presents a novel core-shell Au@Ag@hydrogen-bonded organic framework twin cone (Au@Ag@HOF TCs) as efficient SERS substrate. The HOF shell effectively protects Au and Ag from oxidation, thereby enhancing the long-term stability of the SERS substrate. It also prevents signal inhomogeneity caused by noble metal nanoparticle agglomeration and captures target molecules at “hotspots” for maximum Raman enhancement. Leveraging these features, the proposed Au@Ag@HOF TCs enable sensitive detection of bisphenol A, F, and S in food, with detection limits of 1.8033 × 10 −9 M, 4.2170 × 10 −9 M, and 2.0815 × 10 −10 M, respectively. Furthermore, this substrate was successfully applied to analyze real samples, including canned soup, beverages, and milk, demonstrating its potential for the detection of bisphenol compounds in food.
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OPTICS EXPRESS
·
2019
·Vol. 27
·期 18
·25091-25106
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IF 3.561
Xu Gao,Hao Zhang,Xiangyu Fan,Chao Zhang,Chao Zhang,Yang Sun,Chundong Liu,Zhen Li,Shouzhen Jiang,Baoyuan Man,Cheng Yang,Cheng Yang
We report a structure to form a hybrid system in which a mesh is sandwiched between Au nanoparticles (AuNPs) and Ag nanoparticles (AgNPs). This self-assembly method uses smaller and denser AgNPs “hot spots” that are spin-coated on a AuNPs@GO mesh nanostructure formed by the reaction of GO@MoS2 and HAuCl4 to form AuNPs@GO mesh@AgNPs SERS substrates. Sub-40-nm mesh and 10-nm gaps ensure the landing sites and spacing of the AgNPs. Consequently, the design integrates the strong plasmonic effects of AgNPs and AuNPs with the biological compatibility of the GO mesh. Crystal violet (CV) as low as 10−15 M can be detected, which confirms the ultrahigh sensitivity of AuNPs@GO mesh@AgNPs. Furthermore, the reproducibility, stability, and finite-difference time-domain (FDTD) simulations confirm the value of this SERS substrate. This material can be used for label-free DNA detection, and the AuNPs@GO mesh@AgNPs substrate facilitated single-molecule DNA detection limits.
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高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Liu Jiannan,Xiao Wenxiang,Shao Liuwen,Chen Xinxin,Li Hua
As a critical index for heavy metal toxicity, the quantitative detection of silver ions (Ag + ) is essential for health assessment and environmental monitoring. A sensing platform based on composite gold nanoclusters with dual emissions located in the near-infrared (NIR) range has been constructed for highly sensitive Ag + quantification. Dual-emissive glutathione-functionalized gold nanoclusters (GSH-AuNCs) were first synthesized via a one-pot hydrothermal method. Then, the weak NIR emissions were effectively enhanced by introducing thiolated β-cyclodextrin to regulate the surface ligands of clusters and by ZIF-8 encapsulation to allow the spatial nanoconfinement effect. The GSH-AuNCs nanocomposite exhibited dual-channel emission peaked at 610 nm and 810 nm under 437 nm excitation. Compared with the native clusters, the fluorescent emissions were enhanced with total factors of 6.86-fold at 610 nm and 2.32-fold at 810 nm. The sensing nanocomposite can specifically complex with Ag + by the surface thiol groups and β-cyclodextrin cavities on clusters. The interaction between the fluorescent composite and Ag + changed the ligand-to-metal charge transfer (LMCT) of the clusters and caused fluorescence enhancement at 610 nm and quenching at 810 nm. This opposite variation trend in the fluorescence intensities gives the possibility of constructing a ratiometric fluorescent probe for Ag + detection. The dual-emission intensity ratio (F 610 /F 810 ) demonstrates a quantitative relationship with Ag + concentration (C Ag+ ). The sensing system possesses a linear response range of 0.02~5.00 μmol/L in pH 8.5 buffer, achieving a detection limit of 11.6 nmol/L (S/N = 3). Measurement results of real serum and water samples confirmed that the sensing platform had good accuracy and exceptional anti-interference capability for Ag + detection. Graphical Schematic synthesis of GSH-AuNCs, GSH-AuNCs@β-CD/ZIF-8 assembly, and the fluorescence sensing of Ag + .
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jingxuan Zhao,Ying Xue,Yue Wu,Xiaonan Hao,Shulin Sun,Huiliang Zhang
This study presents an innovative approach to membrane fabrication by integrating electrospinning with surface modification techniques to develop a novel dual-layer protective membrane system. The key innovation lies in the incorporation of photothermally responsive nanocomposites, enabling multifunctional membrane performance. The primary layer is a PVDF-PNIPAAm thermoresponsive matrix synthesized by radical polymerization, integrated with BN@PDA-Ag nanosheets. This design combines Ag nanoparticles’ photothermal conversion and BN’s thermal conductivity to regulate pore size via PNIPAAm chain conformational changes induced by temperature. The secondary layer, comprising CS@CNT and PVDF, significantly enhances membrane hydrophilicity and antifouling properties through chitosan’s hydrophilic groups and chelating capabilities. The membrane demonstrates self-cleaning, adaptive filtration, antifouling and high flux, representing a significant advancement in smart membrane technology for water treatment applications.
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JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
·
2011
·Vol. 26
·期 6
·1191-1197
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IF 4.372
Jing-Min Liu,Xiu-Ping Yan
An ultrasensitive method for simultaneous determination of cytochrome c (cyt-c) and insulin was developed by combining aptamer-based bioassay and immunoassay, multielement-tagging and inductively coupled plasma mass spectrometry (ICP-MS). Aptamer-modified gold nanoparticles (apt-AuNPs) and antibody-modified silver nanoparticles (ab-AgNPs) were employed as specific element tags for cyt-c and insulin, respectively. The prepared surface-functionalized magnetic microparticles (MMPs) were used for efficient and fast magnetic separation. The bioassay conditions were carefully optimized, including the amount of MMPs, the concentration of AuNPs and AgNPs, and the reaction time. Under optimal conditions, the developed method gave a linear range of 0.1–20 nM for cyt-c and 0.2–40 nM for insulin, a detection limit (3s) of 1.5 fmol (30 pM in 50 μL) for cyt-c and 5.5 fmol (110 pM in 50 μL) for insulin. The precision (relative standard deviation) for six replicate determinations of cyt-c (0.6 nM) and insulin (2.0 nM) was 6.6%, and 6.0%, respectively. The present method exhibits good specificity with recoveries from 87% to 98% for spiked cyt-c and insulin in human serum samples. The methodology demonstrated here provides a new possibility for bioassays and clinical diagnoses, which has potential for simultaneous determination of two or more low-abundance biomarkers of interest via multi-element tags.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
·
IF 6.6
Haibin Liu,Yi Yuan,Qiuyue Wang,Hang Tian,Yingxue Wu,Haijie Li,Hongshuo Chen,Lei Wang,Bingrui Liu
Meat adulteration has become a significant concern due to its potential to diminish the nutritional value and trigger allergic reactions. To address the issue of fraudulent adulteration in beef ( Bos taurus ) products, a visual strategy is proposed for multiplex detection of chicken ( Gallus gallus ), duck ( Anas platyrhynchos ), and pork ( Sus scrofa ) components in beef. First, the DNA could be easily extracted from the meat samples using the microneedle within 1 min and used as recombinase polymerase amplification (RPA) template. Next, three primer pairs specific to chicken, duck, and pork DNA are designed with unique oligonucleotide tags and a spacerC9 to halt polymerase activity, enabling the RPA amplicons to possess a single-stranded DNA tail. These tail sequences precisely hybridize with nanoparticle-labeled detection probes and pre-immobilized capture probes on test lines, generating a colorimetric signal on the lateral flow strip (LFS). The enhanced LFS utilizes three distinct Au/Ag nanoparticles, including Au@Ag (yellow), gold nanoflowers (cyan), and gold nanospheres (magenta), each targeting chicken, duck, and pork DNA, respectively. The test output can be easily interpreted through a “magenta yellow cyan” color code. The sensitivity of the multicolor LFS is further improved by the incorporation of DNA-Au/Ag nanoaggregates. Four functional oligonucleotides with complementary sequences are combined to form DNA-Au/Ag nano aggregates, allowing for increased coupling of Au/Ag and enhancing detection sensitivity. Cross-reactivity tests with ten non-target species demonstrate the excellent specificity of the assay. The method can detect chicken, duck, or pork at levels as low as 0.1 g/kg in simulated adulterated beef samples. The entire process, including rapid DNA extraction (1 min), RPA reaction (15 min), and LFS detection (5 min), is completed within 21 min. This platform is user-friendly, eliminating extensive training and specialized equipment, making it ideal for rapid on-site detection of multiplex adulteration by personnel in various fields.
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危险品化学品经营许可证（带存储）