POLYMERS FOR ADVANCED TECHNOLOGIES
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2026
·Vol. 37
·期 7
·e70685
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IF 3.8
Yi-zhen Sun,Shuai-nan Zhang,Xu-zhao Li
In this study, polyethylene glycol dimethacrylate-ethylene glycol dimethacrylate-4-vinylbenzyl chloride (PEGMA-EGDMA-VBC, PEV) nanospheres were synthesized using PEGMA, EGDMA, and VBC as copolymerizable monomers, with polyvinylpyrrolidone (PVP) as a dispersant. Subsequently, using sodium diethyldithiocarbamate trihydrate (NaDDC) as the iniferter and employing Iniferter radical polymerization technology with an LED lamp as the UV light source, a novel myricetin surface molecularly imprinted polymer (MYr-MIPs) was successfully prepared. The results showed that the material has a maximum equilibrium adsorption capacity of 45.26 mg g −1 and an imprinting factor (IF) of 4.15. It exhibits excellent selectivity for myricetin, with capacity loss < 16% after five adsorption–desorption cycles, demonstrating good reusability. Characterization by TEM, SEM, FT-IR, BET, EDS, DLS, and TGA confirmed the feasibility of this experimental method, laying the foundation for convenient, rapid, and efficient enrichment of myricetin in complex systems at low concentrations.
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DENTAL MATERIALS
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2026
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IF 6.3
Tianjia Huang,Huan Chen,Shuwei Qiao,Boyu Sun,Shuyao Zheng,Haiya Liao,Zuosen Shi,Song Zhu
A multifunctional Myr@ZIF-8 nanoplatform was developed for dentin bonding. • Myr@ZIF-8 exhibited pH-responsive release of myricetin and Zn²⁺. • Myr@ZIF-8 enhanced antibiofilm activity against Streptococcus mutans . • Myr@ZIF-8 stabilized dentin collagen and suppressed MMP activity. • The modified adhesive significantly improved dentin bonding durability. Objectives This study aimed to develop a myricetin-loaded ZIF-8 (Myr@ZIF-8)-modified universal adhesive with antibacterial, collagen-stabilizing, and matrix metalloproteinase (MMP)-inhibitory properties to improve bonding durability. Methods Myr@ZIF-8 nanoparticles were synthesized and characterized. Myr loading efficiency, drug loading, and pH-responsive release were evaluated. Myr@ZIF-8 was incorporated into a universal adhesive at 2.5–10 wt%, and the optimal concentration was selected according to degree of conversion, dentin wettability, and antibiofilm activity. Dentin collagen stability, MMP-mediated gelatinolytic activity, microtensile bond strength (μTBS), interfacial nanoleakage, interfacial mechanical properties, and in vitro cytocompatibility were evaluated. Short-term systemic toxicity was preliminarily assessed by oral gavage of cured adhesive extracts. Molecular docking was performed to investigate potential interactions between myricetin and collagen, MMP-2, and MMP-9. Results Myr@ZIF-8 exhibited a Myr loading efficiency of 50.72%, drug loading of 50.36%, and pH-responsive release. The adhesive containing 5 wt% Myr@ZIF-8 showed the best overall performance, including enhanced antibiofilm activity, improved collagen stability, and reduced MMP-mediated gelatinolytic activity. Incorporation of 5 wt% Myr@ZIF-8 increased immediate μTBS from 22.79 MPa to 32.07 MPa and aged μTBS after 10,000 thermocycles from 13.91 MPa to 27.99 MPa. Molecular docking predicted potential interactions between myricetin and collagen, MMP-2, and MMP-9. The modified adhesive showed acceptable in vitro cytocompatibility, with no obvious short-term systemic toxicity after oral gavage of cured adhesive extracts. Significance These findings demonstrate that Myr@ZIF-8 functions as a multifunctional bioactive nanoplatform and represents a promising strategy for improving bonding durability. Download: Download high-res image (189KB) Download: Download full-size image Schematic diagram of the experimental process.
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FOOD CHEMISTRY
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2023
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IF 8.8
Jingjing Chen,Peipei Li,Yixiu Han,Yuchen Li,Yingxiang Du
Highly photoluminescent N -doped carbon quantum dots ( N -CDs) which the quantum yield reached 63% were prepared through hydrothermal treatment. The obtained N -CDs displayed a uniform distribution of particle size, superior stability in high-salt conditions, and excellent sensitivity. A green fluorescence probe based on N -CDs was constructed for ultrasensitive determination of myricetin in vine tea on account of the static quenching. The N -CDs presented excellent linear fluorescence response in the concentration range of 0.2–40 μM and 56–112 μM and with a low detection limit of 56 nM. Additionally, the practicability of the probe was verified in spiked vine tea sample, and the satisfactory recoveries of myricetin varied from 98.8% to 101.2%, with relative standard deviations in the range of 1.52%-3.48%. It is the first time to employ N -CDs without any material modification as a fluorescence sensor to detect myricetin, which is a promising approach to expand the path for myricetin screening.
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ELECTROCHIMICA ACTA
·
2019
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IF 5.383
Jianzhi Huang,Lishi Wang
In this work, we first discover the new bifunctional abilities of wood for highly selective electrocatalytic CO 2 reduction to formate and highly sensitive electroanalytical detection of myricetin and cadmium (II). The highly developed microchannels in wood ensure most effective reactant and electrolyte transport, great facilitating the electrode reaction . The activated wood electrode displays excellent electrocatalytic CO 2 reduction activity, attained the highest formate Faradaic Efficiency (FE) of 70.8% at −1.8 V with high current density of 53.8 mA cm −2 in aqueous solution, and displayed at least 24 h CO 2 electrolysis durability. Furthermore, the wood is also first utilized as new electrode matrix for electroanalytical detection of drug (myricetin is as an example) and heavy metal ion (cadmium (II) is as an example). Compared with traditional glassy carbon electrode (GCE) and its derived modified electrodes , the wood electrode exhibits a wide linear detection range (0.01–50 μmol dm −3 ) and a low detection limit (0.002 μmol dm −3 , S/N = 3) for myricetin , and displays a wide linear detection range (0.1–20 μg l −1 ) and a low detection limit (0.05 μg L −1 , S/N = 3) for cadmium (II). These remarkable bifunctional performances of low cost wood electrode show great potential for large-scale using in CO 2 electroreduction and electroanalytical detection.
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Bioactive Materials
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2025
·
IF 20.3
Lei Zhang,Kailai Liu,Jiachen Zhou,Yuchen Zhang,Jinpeng Wen,Jiangchuan He,Yunhe Zheng,Li Yang,Ke Wang,Jun Tian
Cutaneous fungal infections, particularly those caused by Candida albicans , pose significant clinical challenges due to high recurrence rates and rising antifungal resistance. Conventional therapies, including azoles and polyenes, are limited by toxicity, resistance, and cost. This study addresses these limitations by developing a multifunctional hydrogel integrating lauric acid (LA)-a natural antifungal anionic surfactant-with the antioxidant plant polyphenol myricetin (Myr). The synergistic combination of LA and Myr disrupts fungal membrane integrity through lipid bilayer destabilization. To enhance therapeutic delivery, myricetin laurate ester was encapsulated in DSPE-PEG2000 micelles and embedded into a hydrogel matrix formed by crosslinking oxidized chondroitin sulfate and hydrazide-functionalized PEG. The resulting hydrogel demonstrated potent antifungal activity against C. albicans by disrupting cell membranes and alleviating oxidative stress in infected wounds. In vitro assays confirmed minimal cytotoxicity to mammalian cells, while in vivo studies in ICR mice showed accelerated healing of C. albicans -infected skin lesions. The hydrogel's sustained release profile and biocompatibility highlight its potential as a dual-action therapeutic platform, combining antifungal efficacy with antioxidant wound repair. This innovative strategy offers a promising solution to overcome drug resistance, reduce toxicity, and improve outcomes in managing cutaneous candidiasis and related dermatomycoses.
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Sustainable Chemistry and Pharmacy
·
2026
·
IF 6.7
Zhenyu Wu,Zhiwei Ding,Yue Li,Shakeel Zeb,Weibai Bian,Yinhua Jiang,Yan Liu
The efficient capture of myricetin is often challenged by its instability in alkaline environments, which contradicts the alkaline conditions required for traditional boronate affinity materials. To address this, a dual-recognition molecularly imprinted polymer (DMIP) supported on HOF-101 was developed using a deep eutectic solvent (DES)-driven strategy. A dual DES system was employed to achieve synergistic recognition: ternary DES 1 acts as a functional monomer combining boronate affinity and hydrogen bonding, while binary DES 2 serves as a green solvent and porogen. Crucially, the ethylene glycol in DES 2 facilitates “teamed boronate affinity” via B–O coordination, significantly lowering the p K a of boronic acid groups. This mechanism enables efficient specific recognition at pH 6.0, effectively overcoming the limitation of decreased affinity under weakly acidic conditions. The optimized BA-DES/DMIPs exhibited rapid equilibrium (20 min), a high Langmuir maximum adsorption capacity (45.016 mg/g), and excellent stability over five cycles. Furthermore, the material demonstrated superior selectivity against structural analogs and achieved satisfactory recovery rates (99.80%–101.67%) in grape juice, confirming its potential for green and efficient separation in complex matrices.
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MICROCHEMICAL JOURNAL
·
2026
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IF 5.2
Hao Jiang,Yurou Zhang,Shiqi Guo,Pengcheng Zhao,Xinyi Li,Junjie Fei,Yixi Xie
MnFe₂O₄ was anchored on PPY-derived graphitized carbon nanotubes. • Graphitized carbon and MnFe₂O₄ exhibited synergistic electrocatalysis. • The sensor detected Myr over 0.005–5.0 μmol L −1 with 2.30 nmol L −1 LOD. • Excellent selectivity, reproducibility, and stability were achieved. • Successful determination of Myr in real samples was demonstrated. Accurate determination of myricetin (Myr) is essential due to its significant bioactivity and potential adverse effects at excessive intake. Herein, a MnFe 2 O 4 composite based electrochemical sensing platform was constructed to achieve highly sensitive Myr detection through synergistic electrocatalysis and enhanced interfacial electron transfer. The composite was synthesized via an in-situ growth followed by high-temperature pyrolysis, in which MnFe 2 O 4 nanoparticles were uniformly anchored onto polypyrrole nanotubes and subsequently converted into a conductive carbon framework. This transformation effectively improves electrical conductivity, suppresses aggregation, and enhances structural stability. The resulting hierarchical structure provides abundant active sites and facilitates rapid charge transport, leading to significantly enhanced electrochemical response toward Myr oxidation. Under optimized conditions, the sensor exhibited a wide linear range of 0.005–5 μmol L −1 and a low limit of detection (LOD) of 2.30 nmol L −1 . Additionally, the sensor demonstrated excellent reproducibility, stability, and anti-interference capability. Its practical applicability was confirmed by successful determination of Myr in real samples, with results consistent with those obtained by ultraviolet-visible (UV–Vis) spectroscopy. These findings provide an effective strategy for developing high-performance spinel ferrite‑carbon-based electrochemical sensors for bioactive compound analysis. Download: Download high-res image (130KB) Download: Download full-size image
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Fan Feng,Kun Zhang,Wenjing Zhang,Qingxia Zhang,Jiwei Li,Weichao Chen
Current nanofibrous membranes demonstrate unique advantages in encapsulating active substances for extending food freshness, but their practical applications are limited by safety concerns from high-voltage electric fields and complex facility requirements. To address these issues, we developed myricetin (Myr)-loaded thermoplastic polyurethane (TPU) nanofibrous membranes (TPU@Myr n ) via solution blow spinning (SBS). This technique enables direct deposition onto produce surfaces for in-situ packaging without electrical hazards. The resulting membranes exhibited smooth and uniform fiber morphology with excellent mechanical properties. The optimized formulation, TPU@Myr 7 (7% myricetin loading), demonstrated strong antioxidant activity with free radical scavenging rates exceeding 90%, and effective antibacterial activity against both Escherichia coli and Staphylococcus aureus (99.4% and 99.2% inhibition, respectively). Crucially, TPU@Myr 7 achieved sustained release of Myr over 4 days, significantly reducing strawberry spoilage during 10 days preservation. Meanwhile, the membrane exhibited good biocompatibility, and can be safely used for food contact. This work demonstrates the potential of myricetin-loaded nanofibers for in-situ fruit packaging, providing a flexible, safe, and scalable packaging solutions for post-harvest preservation applications.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2016
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IF 2.857
Rui Xue Guo,Xiong Fu,Jian Chen,Lin Zhou,Gu Chen
To improve the bioactivity and oral bioavailability of myricetin, a microemulsion formulation was successfully developed, which consisted of Cremophor RH40 (12%), Tween 80 (6%), Transcutol HP (9%), WL 1349 (18%), and distilled water (55%). With lower content of surfactants and higher stability after dilution and storage for 6 months, the optimized myricetin microemulsion (MYR-ME) could dramatically enhance the solubility of myricetin 1225 times that in water. MYR-ME significantly increased antiproliferative activity against human cancer cell HepG2 without influence on normal cell LO2. It also notably improved the cellular antioxidative activity of myricetin. Furthermore, the oral bioavailability of myricetin was remarkably enhanced by MYR-ME in Sprague–Dawley rats after oral administration, which was 14.43-fold that with myricetin suspension. Therefore, the MYR-ME developed here could be used as a potential carrier for myricetin with substantially enhanced bioactivities and bioavailability and might promote myricetin’s future utilization in functional foods and cosmetics.
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Food Bioscience
·
2024
·
IF 4.8
Zhi-Yuan Nie,Xue-Ying Li,Ying-Ying Chen,Yuan-Yuan Deng,Dan-Dan Kuang,Yu-Lin Sun,Huan-Huan Xiao,Qiang-Ming Li,Jian-Ping Luo,Xue-Qiang Zha
In this study, a novel self-assembled micelle (Myr-OSADS-CIn) based on OSA-debranched lotus root starch (OSADS) and cationic inulin (CIn) was successfully constructed to enhance the stability and bioavailability of myricetin (Myr). Firstly, lotus root starch and inulin were chemically modified. The results of Fourier transform infrared spectroscopy, X-ray diffraction, Nuclear magnetic resonance spectroscopy and Element analysis confirmed the successful synthesis of OSADS and CIn. When the optimal weight ratio of Myr/OSADS/CIn was 1:40:120, a stable Myr-OSADS-CIn composite micelle was successfully formed. The key characteristics of the micelle included a polydispersity index (PDI) of 0.321, a zeta-potential of +24.247 mV, and an encapsulation efficiency of 87.536%. Transmission electron microscopy analysis revealed unique core-shell structures within the Myr-OSADS-CIn micelle. The formation and stability of the composite micelle were primarily influenced by hydrogen bonds and electrostatic interactions. Notably, the Myr-OSADS-CIn micelle exhibited excellent biocompatibility, significant antioxidant activity and controlled release of Myr. Furthermore, in vivo bioavailability of Myr in the Myr-OSADS-CIn micelle was found to be 4.054 times higher compared to free Myr. In conclusion, the Myr-OSADS-CIn micelle shows promise as a delivery system for the effective use of Myr in the food industry.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
·
IF 5.895
Chen Wang,Yunlong Yan,Min Huang,Guangming Ma,Li Wang,Xin Xie,Wei Xue,Xiangyang Li
Cucumber mosaic virus (CMV) 2b protein plays a key role in the process of CMV infecting plants and symptom formation and is a potential molecular target for the control of this important plant virus. The exploitation of antiviral compounds is one of the strategies with the highest input: output ratio in plant protection. In this study, the CMV 2b recombinant protein was cloned, purified, and identified as the target protein by mass spectrometry. Subsequently, we carried out preliminary functional screening of the LP series of myricetin derivatives designed and synthesized in our laboratory and commercial antiviral compounds by microscale thermophoresis (MST), which showed that LP compounds LP4, LP11, LP13, and LP20 interacted well with CMV 2b, with dissociation constant (Kd) values of 1.39, 0.88, 1.52, and 1.77 μM, respectively. Among the commercially available antiviral compounds, ningnanmycin (NNM) was the most active, with a Kd value of 4.09 μM. Then, the strongest binding force to CMV 2b was identified to be from LP11 by isothermal titration calorimetry (ITC) experiments, with a Kd of 1.19 μM. Among the commercial compounds, NNM had the strongest binding force with CMV 2b, with a Kd of 4.62 μM. Through the screening of commercial compounds and LP series compounds by MST and ITC, LP11, NNM (positive control), LP16 (negative control), and the blank control group were selected to test the in vivo impact of LP11 on CMV. Specifically, the screened compounds were sprayed onto CMV-inoculated Nicotiana benthamiana plants to determine their impact on the regulation of CMV pathogenic gene expression, symptoms, and virus titer. The results showed that LP11 had a strong ability to inhibit CMV infection of tobacco at the transcriptional and translational levels. By mutating the CMV 2b protein, the 15th amino acid leucine and the 18th amino acid methionine at the N-terminal region were shown to be potential sites for binding to compound LP11. This finding provided a theoretical basis for screening and developing anti-CMV agents.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Xin Wang,Wei Jia,Junyi Zhao
Direct visual monitoring of meat spoilage remains challenging due to limitations in dynamic tracking and precise classification. This study demonstrates that biogenic amine (BA) concentrations are positively correlated with spoilage levels, guiding the development of sensing systems requiring breakthroughs in dynamic inflection detection, gradient classification, and quantitative chromaticity-BA correlation models. Metabolomic analysis revealed that histamine (0.85–5.25 mg kg −1 ), cadaverine (3.10–14.97 mg kg −1 ), and tyramine (7.33–85.79 mg kg −1 ) accumulation synergistically interact with glutathione depletion, driven by histidine/arginine metabolism alterations during goat meat spoilage. Based on BAs variations, a dynamic biogenic amine index (BAI) model was established: BAI = -8.08 + 17.70e^(t/2.65), precisely identifying the spoilage inflection point at ≥3.25 days and enabling three-tier gradient classification of spoilage progression (16.28–103.81 mg kg −1 ). We developed a carnauba wax-carboxymethyl cellulose-polyvinyl alcohol-myricetin (CW-CPM) multifunctional film: i) Structural innovation: replicating peacock feather barbed textures and bamboo-like microstructures created multiscale rough surface, and coating CW induced superhydrophobic states (139.4° contact angle); ii) functional integration: UV-triggered reversible photochromism via myricetin regulation (465 nm-triggered yellow-green fluorescence, Commission Internationale de L'Eclairage (CIE) coordinates of (0.467, 0.524), switching to yellowish under natural lights), overcoming static anti-counterfeiting limitations; the film's B-values attenuation exponentially to BAI values, enabling in-situ spoilage visualization; iii) performance synergy: integrating high toughness, thermal stability, biodegradability, and preservation functions, forming an intelligent packaging system integrating spoilage mechanism analysis, dynamic monitoring, photo-responsive anti-counterfeiting, and active preservation for comprehensive solutions in food quality management.
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