JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Haohao Zhang,Mingyuan Pang,Min Yang,Zhen Kong,Jiajia Ye,Wensi Li,Yen Leng Pak,Juan An,Koulong Wu,Jibin Song
Chemotherapy, as a primary cancer treatment modality, faces limitations in efficacy and patient tolerance due to non-specific cytotoxicity, drug resistance, and adverse effects. This study develops a multifunctional nanoplatform (DOX-FA-CS-BiO 1 . 5 ) for NIR-Ⅱ photoacoustic imaging-guided visualized synergistic photothermal-chemotherapy, aiming to achieve enhanced therapeutic outcomes. The BiO 1 . 5 component ensures superior photothermal conversion efficiency and photoacoustic imaging performance, while the synergistic platform's high drug loading capacity and pH-responsive controlled release profile significantly improve tumor cell eradication rates. The chitosan-folic acid dual coating enhances biocompatibility and tumor-targeting specificity. Through synergistic effects, this nanoplatform demonstrates superior antitumor efficacy, offering a novel paradigm for constructing integrated platforms for imaging-guided visualized cancer theranostics.
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DOI
高影响因子
BIOMATERIALS
·
2025
·
IF 12.9
Xianshe Meng,Jianwen Song,Huawen Meng,Chenzhong Liao,Zequn Yin,Ke Gong,Deling Kong,Ji Qi,Yajun Duan
Arterial restenosis is a critical risk factor for life-threatening cardiovascular diseases. Precise intervention and real-time monitoring are extremely important but remain major clinical challenges. Here, we present an advanced theranostic nanoagent that integrates hypoxia-responsive second near-infrared (NIR-II) fluorescence imaging with hypoxia-activatable anti-proliferative therapy for real-time diagnostics and precision treatment. This nanoplatform is constructed by co-encapsulating a novel N -oxide-based molecular probe and a hypoxia-activatable prodrug tirapazamine (TPZ) into osteopontin (OPN)-targeted liposomes. Under hypoxic conditions, the N -oxide probe undergoes conversion to its amine derivative, altering the intramolecular charge transfer properties and triggering turn-on NIR-II fluorescence signal. This property enables high-sensitivity, real-time monitoring of restenosis lesions in vivo. The nanoplatform exhibits dual hypoxia-responsive functionality: TPZ is selectively activated in hypoxic vascular lesions to inhibit vascular smooth muscle cell proliferation, and sustained OPN-mediated targeting promotes vascular repair. In guidewire-induced restenosis models, this system achieves simultaneous real-time monitoring of lesion progression via NIR-II imaging and significantly reduce restenosis while enhancing re-endothelialization. This study offers a promising strategy for developing high-performance theranostic nanoplatforms, enabling precise detection and improved treatment of restenosis-related diseases.
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DOI
PubMed
高影响因子
Journal of the American Chemical Society
·
2020
·
IF 14.612
Xianju Zhang,Xianxin Wu,Xiaoyu Liu,Gaoyu Chen,Yongkai Wang,Jianchun Bao,Xiangxing Xu,Xinfeng Liu,Qi Zhang,Kehan Yu,Wei Wei,Jingjing Liu,Jun Xu,Hua Jiang,Peng Wang,Xun Wang
Perovskite and chalcogenide quantum dots (QDs) are important nano semiconductors. It has been a challenge to synthesize heterostructural QDs combining perovskite and chalcogenide with tailorable photoelectronic properties. In this report, heterostructural CsPbX3-PbS (X = Cl, Br, I) QDs were successfully synthesized via a room temperature in situ transformation route. The CsPbX3-PbS QDs show a tunable dual emission feature with the visible and near-infrared (NIR) photoluminescence (PL) corresponding to CsPbX3 and PbS, respectively. Typically, the formation and evolution of the heterostructural CsPbBr3–PbS QDs with reaction time was investigated. Femtosecond transient absorption spectroscopy (TAS) was applied to illuminate the exciton dynamics in CsPbBr3–PbS QDs. The mild synthetic method and TAS proved perovskite to PbS energy transfer may pave the way toward highly efficient QD photovoltaic and optoelectronic devices.
研究领域:
材料科学
·
光电子学
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2016
·
IF 3.782
Xuefei Zhou,Xiaohong He,Shiliang Wei,Kun Jia,Xiaobo Liu
A novel cyano-terminated zinc phthalocyanine (ZnPc-CN) exhibiting visible near infrared (vis-NIR) emitting around 690 nm in N,N -dimethylformamide (DMF) solvent has been synthesized. Furthermore, the peripheral cyano groups of newly synthesized zinc phthalocyanine were hydrolyzed in strong basic solution, leading to water soluble carboxylated zinc phthalocyanine (ZnPc-COOH) with completely quenched fluorescence in aqueous solution. Interestingly, we found that the NIR fluorescence of aqueous ZnPc-COOH was dramatically recovered in the presence of gold nanorods (Au NR), which was due to the alternation of ZnPc-COOH molecules self-assembling via electrostatic interaction between cetyltrimethylammonium bromide (CTAB) on the surface of Au NR and peripheral carboxyl of ZnPc-COOH. In addition, ZnPc-COOH/Au NR conjugates demonstrated an improved singlet oxygen generation, which could be served as potential bioimaging probe and photosensitizer for photodynamic therapy.
研究领域:
生物医学工程
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材料科学
·
化学
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DOI
高影响因子
DYES AND PIGMENTS
·
2018
·
IF 3.767
Weifen Niu,Zhiwen Wei,Juan Jia,Shaomin Shuang,Chuan Dong,Keming Yun
A novel ratiometric emission NIR-fluorescence probe N , N -dimethyl-4-((1E, 3E)-4-(3,3-dimethyl-3H-indol-2-yl)buta-1,3-dienyl)benzenamine, namely, DIDBA, is facilely synthesized on the basis of ethylene bridging of indole derivatives and 4-(dimethylamino) cinnamaldehyde. The probe exhibits a remarkable NIR ratiometric fluorescence emission ( F 618nm / F 697nm ) characteristic with p K a 4.5, and the linear response over the pH range of 3.5–5.2. DIDBA also displays favorable features include large Stokes shift of 200 nm under acidic conditions, high sensitivity, good selectivity, fine photostability and reversibility . The probe has low cytotoxicity and excellent cell membrane permeability, and is applied successfully to visualize intracellular pH fluctuations in live cells without influence of autofluorescence and native cellular species in biological systems.
研究领域:
生物化学
·
细胞生物学
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医学影像学
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DOI
高影响因子
Laser & Photonics Reviews
·
2023
·Vol. 18
·期 1
·2300732
·
IF 11
Zhuowei Li,Ge Zhu,Shanshan Li,Wen Xu,Qingfeng Bian,Yan Cong,Ming He,Xixian Luo,Shuangyu Xin,Bin Dong
The burgeoning phosphor-converted near-infrared light-emitting diodes (pc-NIR LEDs) have important applications in special illumination and spectroscopy analysis. However, the development of efficient NIR-emitting phosphors with high performance is still a challenge. In this work, a chemical unit co-substitution strategy is proposed to realize the excitation transition regulation and successfully achieve high-performance NIR luminescence in Ca 3- y Na y Mg 1- y Sb 2- x Al 2+ y O 12 : x Cr 3+ (0 ≤ x ≤ 0.05, 0 ≤ y ≤ 1) garnet-type solid solution phosphors. Through the excitation transition modulation from the 4 A 2 ground state to the 4 T 1 ( 4 P) and 4 T 1 ( 4 F) excitation state, the excitation intensity at the blue light region is largely enhanced by 25.6 times. Moreover, the NIR-emitting efficiency and thermal stability are improved, with the optimal luminescence internal quantum efficiency of 90.6% and thermal stability of 97%@423 K, without any flux-assisted sintering or reduction atmosphere protection. The structure regulation induced small Stokes shift, weak electron-phonon coupling effect, and decreased non-radiative transition are responsible for the excellent NIR-emitting performance. Finally, the NIR pc-LED is fabricated with photoelectric efficiencies of 18.7%@100 mA and NIR output powers of 63 mW@100 mA, presenting potential applications in nondestructive internal defect detection, veins imaging, and night vision surveillance.
研究领域:
材料科学
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光学工程
·
固体化学
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发光材料
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半导体器件
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DOI
高影响因子
JOURNAL OF RARE EARTHS
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2026
·
IF 7.2
Yu Zha,Fangxue Chen,Fanju Meng,Xiancheng Ning,Tianyu Guo,Danxia Liu,Jin Han,Yugeng Wen,Jianbei Qiu
Transition metal ion-activated phosphors are promising candidates for broadband near-infrared (NIR) spectroscopy applications. However, achieving high external quantum efficiency (EQE) and good thermal stability in low-dimensional halide perovskites has presented challenge. Herein, a design strategy based on cerium doping has been developed for realizing high-efficiency broadband NIR tetravalent molybdenum (Mo 4+ ) luminescence to overcome multivalent Mo-related lattice defects and self-absorption. Particularly, Ce 4+ , Mo 4+ -codoped Cs 2 TeCl 6 shows broadband NIR emissions ranging from 800–1300 nm with a full width at half-maximum of 186 nm, high EQE > 50% and good thermal stability (85%@150 °C). Experimental and theoretical studies verify the synergistic effects of breakdown of site symmetry, reduction of lattice defects and relaxation of the spin-selection rule of Mo 4+ . Moreover, gas sensing of toxic toluene with low detection limit and high sensitivity is presented due to strong molecular interaction-induced luminescence quenching. These findings provide new opportunities for broadband NIR spectroscopy applications.
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DOI
高影响因子
Small
·
2026
·
IF 11.8
Xinyue Kou,Juan Yue,Yingge Cong,Ruoqian Gao,Wenfei Dong,Li Li
Boron-doped aggregation-induced emission (AIE) nanomaterials (B@AIE NPs) were successfully synthesized via a facile one-pot solvothermal method for dual-modality fluorescence (FL) and magnetic resonance (MR) imaging. The as-prepared B@AIE NPs exhibited a uniform core–shell structure, excellent dispersibility, and strong NIR-II fluorescence emission at 984 nm upon aggregation, attributed to restricted intramolecular motion. Moreover, the boron doping conferred remarkable T 1 -weighted MR contrast capability, with a high longitudinal relaxivity (r 1 ) of 6.12 m m − 1 s − 1 . In vitro studies demonstrated excellent biocompatibility and efficient cellular uptake, with preferential localization in lysosomes. In vivo experiments in HeLa tumor-bearing mice revealed effective tumor accumulation via the enhanced permeability and retention (EPR) effect, enabling high-contrast NIR-II fluorescence and MR imaging. These results highlight the great potential of B@AIE NPs as a promising metal-free nanoprobe for precise tumor diagnosis through FL/MR dual-modal imaging.
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DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2026
·
IF 5.9
Xiang Wang,Ruo-Bing Han,Xin Ding,Lan Xiao,Yuan-Wen Luo,Xiao-Huan Huang,Yan-Jun Hu
Drug-resistant bacterial biofilm infections severely impede wound healing. Here, we report a nanozyme-integrated hydrogel (HEA@OAH) that combines high-entropy alloy nanozymes with an injectable self-healing hydrogel cross-linked by dynamic Schiff base bonds for treating methicillin-resistant Staphylococcus aureus (MRSA) biofilm-infected wounds. Under NIR irradiation, HEA@OAH exerts photothermal therapy to disrupt biofilms and photothermally enhances dual enzyme-mimicking activities: peroxidase-like activity generates bactericidal ·OH from H2O2, while glutathione peroxidase-like activity scavenges excess H2O2, to protect tissue. Theoretical calculations reveal the synergistic effects of multimetallic sites. In vitro, the reduction rate of the MRSA biofilm reached 84.5%. In vivo, it effectively eliminates biofilms, alleviates inflammation, and promotes near-scarless wound healing. This study provides a synergistic therapeutic strategy for next-generation intelligent wound dressings.
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DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Yibing Shi,Xiaoyi Zhu,Qingyuan Xu,Yanling Wu,Yishuo Sun,Xin Zhao,Yulong Liu,Wei Feng,Youhua Xie,Tianlei Ying,Zhenlin Yang
The oral administration of immunofluorophores has been limited by gastrointestinal degradation. To address this, a novel immunofluorophore (ICGM-B9-FCS), based on a single-domain antibody-dye targeting the CEACAM5 antigen, is coated with trifluoromethyl chitosan (5 mg kg −1 ) for NIR-II bioimaging of colorectal cancer and its distant metastases. ICGM-B9-FCS demonstrates unique advantages over existing intraoperative tumor-guidance bioagents, including resistance to liver metabolism, well-retained bioaffinity (EC 50 = 58.09 nmol L −1 ), enhanced relative quantum yield (up to 12 equivalents), significant redshifts in absorption (from 783 to 957 nm), effective oral delivery to colonic metastases, and in situ exploration of the capillary-lymphatic network transportation. These findings establish a regulatory pathway for modifying immunofluorophores as orally administered bioagents, offering innovative methods for preoperative diagnosis and intraoperative guidance in colorectal cancer.
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产品关联
DOI
PubMed
高影响因子
CHEMPHYSCHEM
·
2020
·Vol. 21
·期 5
·397-405
·
IF 3.144
Feiyu Zhao,Xue Luo,Lixiang Liu,Jianhang Lv,Xianping Fan,Xvsheng Qiao,Yang Xu,Lorenz Kienle,Xianghua Zhang,Guodong Qian
Graphical Improved responsivity : GeSe micro-sheets and micro-belts were synthesized by a chemical orientation growth method in 1-octadecene solvent and oleic acid solvent, respectively. The photodetectors based on single micro-belt showed a broadband spectral photoresponse with high responsivity (5562 A/W) and detectivity (3.01×10 12 Jones). It demonstrates significant application potential in the visible and NIR photodetection. GeSe micro-sheets and micro-belts have been synthesized by a facile one-pot wet chemical method in 1-octadecene solvent and oleic acid solvent, respectively. The adsorption of more oleic acid molecules on the (002) plane promoted growth along [010] direction of the GeSe micro-belts and limited carrier transport in this direction, resulting in higher carrier concentration and mobility of the GeSe micro-belts. The performance of the photodetectors based on the single GeSe micro-sheet and the single GeSe micro-belt was investigated under illumination at 532 nm, 980 nm and 1319 nm. Both, photodetectors based on a single GeSe micro-sheet and a single GeSe micro-belt, exhibit a high photoresponse, short response/recovery times, and long-term durability. Moreover, the photodetector based on a single GeSe micro-belt displays a broadband response with a high responsivity (5562 A/W at 532 nm, 1546 A/W at 980 nm) and detectivity (3.01×10 12 Jones at 532 nm, 8.38×10 11 Jones at 980 nm). These excellent characteristics render single GeSe micro-belts very interesting for use as highly efficient photodetectors, especially in the NIR region.
研究领域:
材料科学
·
光学工程
·
纳米技术
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DOI
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 10
·期 7
·2600-2607
·
IF 7.393
Chen Zhang,Kaige Wang,Xueyuan Guo,Yanli Tang
A light-triggered treatment strategy has been considered as a powerful therapeutic modality for sterilization due to its attractive properties including noninvasiveness, negligible drug resistance and minimized adverse side effects. Herein, a cationic water-soluble conjugated polymer PDTPBT based on a donor–acceptor (D–A) structure is designed and synthesized for photothermal antibacterial therapy under near-infrared light irradiation. The electron-rich dithieno-pyrrole and electron-deficient benzothiadiazole served as the electron donor and acceptor, respectively. Also, quaternary ammonium groups are modified on the side chain to enhance the water solubility of PDTPBT, promoting the effective combination of PDTPBT with bacteria. PDTPBT demonstrates a strong absorption in the near-infrared region, excellent photostability and a high photothermal conversion efficiency of up to 71.1%. High bacterial mortality rates are obtained upon 808 nm laser irradiation. Consequently, the new cationic conjugated polymer PDTPBT with excellent photothermal performance exhibited effective antibacterial ability, serving as a promising agent for light-triggered treatment.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
光疗
·
抗菌治疗
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DOI
高影响因子
危险品化学品经营许可证（带存储）