RSC Advances
·
2011
·Vol. 1
·期 2
·282-289
·
IF 0
Xueying Qiu,Yuhong Yang,Liping Wang,Shanling Lu,Zhengzhong Shao,Xin Chen
Time-evolved gelation behavior of a chitosan-β-glycerophosphate (CS/β-GP) system was elucidated from rheological investigation, NMR analysis, fluorescence measurement, and morphology observation. Urea and isobutanol were selected to assess the interactions between the two components during the gelation process of the CS/β-GP system. Urea was found to be detrimental to the gelation process by both disrupting hydrogen bonding and retarding the formation of hydrophobic domains. On the contrary, the addition of isobutanol accelerated the sol–gel transition by strengthening the hydrophobic interactions. These results reveal that both hydrogen bonding and hydrophobic interactions within chitosan or between chitosan and β-glycerophosphate molecules are the main reasons for gel formation. The results also indicate that firstly the formation of hydrogen bonds makes the hydrophobic sites more accessible, and then the synergistic hydrogen bonding and hydrophobic interactions lead to the final formation of CS/β-GP gel network. This work demonstrates the possibility of tuning the gelling ability as well as the mechanical properties of CS/β-GP hydrogels. Thus, it gives the opportunities to optimize the performance of this promising natural thermosensitive material for practical applications in the future.
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CRYSTENGCOMM
·
2024
·
IF 2.6
yufei Song,Xiaojie Guo,Wenxiang Mu,Xutang Tao,Zeliang Gao
β-Ga2O3 is an ultra-wide bandgap semiconductor with immense potential applications in high voltage, electronic devices, and deep-ultraviolet optoelectronic devices, etc. However, to date, the growth of bulk β-Ga2O3 crystals has predominantly utilized melt methods, which are heavily dependent on specific growth vessels. In this work, bulk crystal β-Ga2O3 with a size of 7 × 13 × 4 mm3 is grown using TeO2-Li2CO3 as flux by a top-seeded solution growth (TSSG) method for the first time. It is noteworthy that the saturation point of β-Ga2O3 in the flux has been reduced to 1023 K, significantly lower than its melting point of 2073 K. The resulting β-Ga2O3 crystal exhibits well-formed faces, predominantly the (010), (100), (01(-)1), and (11(-)1(-)) forms, which closely align with the ideal morphological predictions made by the Bravais-Friedel and Donnay-Harker methods.The full-width at half maximum (FWHM) of the rocking curves for the (010) oriented plane is determined to be 140.4″. This work provides a potential β-Ga2O3 crystal growth method with a little platinum loss at a low temperature.
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Cell Death & Disease
·
2024
·Vol. 15
·期 8
·1-10
·
IF 8.1
Zhu Chen,Weng Qingyu,Gao Shenwei,Li Fei,Li Zhouyang,Wu Yinfang,Wu Yanping,Li Miao,Zhao Yun,Han Yinling,Lu Weina,Qin Zhongnan,Yu Fangyi,Lou Jiafei,Ying Songmin,Shen Huahao,Chen Zhihua,Li Wen
Eosinophils, traditionally associated with allergic phenomena, play a pivotal role in inflammatory responses. Despite accumulating evidence suggesting their pro-inflammatory function upon activation, the underlying mechanisms governing eosinophil activation remain incompletely characterized. In this study, we investigate the local activation of pulmonary and colon eosinophils within the inflammatory microenvironment. Leveraging transcriptional sequencing, we identify TGF-β as a putative regulator of eosinophil activation, leading to the secretion of granule proteins, including peroxidase. Genetic deletion of TGF-β receptors on eosinophils resulted in the inhibition of peroxidase synthesis, affirming the significance of TGF-β signaling in eosinophil activation. Using models of HDM-induced asthma and DSS-induced colitis, we demonstrate the indispensability of TGF-β-driven eosinophil activation in both disease contexts. Notably, while TGF-β signaling did not significantly influence asthmatic inflammation, its knockout conferred protection against experimental colitis. This study delineates a distinct pattern of eosinophil activation within inflammatory responses, highlighting the pivotal role of TGF-β signaling in regulating eosinophil behavior. These findings deepen our comprehension of eosinophil-related pathophysiology and may pave the way for targeted therapeutic approaches in allergic and inflammatory diseases.
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COLLOID AND POLYMER SCIENCE
·
2025
·
IF 2.3
Liu Yinyin,Wang Lei,Liu Guiru,Jin Hongtao,Lai Xiaojuan,Li Haibin,Chen Jiali
X-β-cyclodextrin (β-CD), a vinyl-functionalized monomer, was successfully synthesized through the chemical modification of β-CD. Subsequently, X-β-CD was co-polymerized with acrylic acid, acrylamide, and 2-acrylamido-2-methylpropane sulfonic acid via free radical copolymerization to produce a novel hydrophobic inclusion polymer—X-β-HPAM. The structure of X-β-HPAM was characterized using Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and scanning electron microscopy. Furthermore, its aqueous rheological properties were analyzed through rheometry. The results revealed that at shearing temperatures of 120 °C and 150 °C and a shear rate of 170 s −1 , the viscosity of a 0.4% X-β-HPAM aqueous solution gradually increased beyond a shear time of 1200 s, indicating the thickening effect of the X-β-CD monomer on the solution at elevated temperatures. Following shearing for 2 h, the residual viscosity stabilized at 62.24 mPa·s, after undergoing a shearing process for a duration of 2 h, the viscosity of a X-β-HPAM salt solution, with a mass fraction of 0.4% and dissolved in a 5% NaCl aqueous solution at a temperature of 150℃, remains consistently stable at the value of 60.04 mPa·s, demonstrating the excellent salt, temperature, and shear resistance of X-β-HPAM. Thus, β-CD-modified polyacrylamide enhances the thermal resistance and shear resistance of fracturing fluids, thereby improving recovery efficiency. Graphical abstract
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Molecular Catalysis
·
2025
·
IF 4.9
Bing He,Chen Huang,Liya Zhou,Guanhua Liu,Ying He,Li Ma,Lihui Wang,Yanjun Jiang,Yunting Liu
The synthesis of enantiopure β-nitroalcohols is of great meaningful, but remains highly challenging especially for commercial applications. Herein, we developed a continuous-flow chemoenzymatic system for the enantioselective synthesis of chiral β-nitroalcohols by combing metal-catalyzed non-enantioselective Henry reaction and enzymatic enantioselective kinetic resolution (KR) reaction. A Lewis acidic metal catalyst (Co(II)@DON) for Henry reaction was prepared by immobilizing cobalt ions on dendrimeric organosilica nanoparticle (DON), which exhibited high activity and reusability for production of racemic β-nitroalcohols. A biocatalyst (BCL@DON) for KR reaction with high activity and high enantioselectivity was prepared by immobilizing the lipase from Burkholderia cepacia (BCL) on DON. The integration of these two catalysts in continuous-flow systems produced enantiopure chiral β-nitroalcohols in 37-49% yields and 99% ee, and achieved a 26-fold improvement in space-time yield (STY) compared to the batch system.
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BIORESOURCE TECHNOLOGY
·
2025
·
IF 9
Jingwen Zhang,Binge Zhang,Feiyu Duan,Zehui Xuan,Tong Sun,Lili Lu
β-Galactosidases are important enzymatic tools for glycosylation, but their properties vary greatly with the source. Here, ten putative β-galactosidase genes, designated as bga 1 to bga 10, encoding proteins Bga1 to Bga10, were mined from an environmental metagenomic dataset comprising 119,152 sequences. Five of the encoded enzyme proteins exhibited less than 80% sequence similarity to known enzymes, but displayed conserved catalytic sites in their predicted three-dimensional models. After heterologous expression and characterization, two recombinant enzymes showed specific hydrolysis activity toward o -nitrophenyl-β- d -galactopyranoside. One of them, Bga4R, exhibited remarkable activity at pH 7.4 and 50℃, with excellent alkaline stability. Notably, Bga4R tolerated a wide range of acceptors for transglycosylation. It catalyzed galactosyl transfer to various monosaccharides and sugar alcohols, and enabling the synthesis of diverse glycosylated derivatives. This study identifies a novel GH 1 β-galactosidase as a powerful tool for glycosylation engineering, with promising potential for synthesizing galactosides valuable to food and pharmaceutical industries.
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BIOTECHNOLOGY LETTERS
·
2013
·Vol. 35
·期 8
·1323-1330
·
IF 1.853
Guan Liye,Di Bin,Su Mengxiang,Qian Jie
The aminopropyl-functionalized ethane-bridged bifunctional periodic mesoporous organosilicas (APEPMOs) were synthesized by the co-condensation of 1,2-bis (triethoxysilyl) ethane and 3-aminopropyltriethoxysilane in the presence of cationic surfactants octadecyltrimethylammonium chloride in basic medium. The pores of the APEPMOs were expanded with N , N -dimethyldecylamine and the pore-expanded materials were utilized as supports for β - glucosidase immobilization. A high enzyme loading of 120 mg per g support was achieved in 18 h, and 95.5 % of enzymatic activity was retained. β-Glucosidases were strongly immobilized on APEPMOs with only 5 % desorption in the washing step with buffer solution. The immobilized enzyme had 75 % activity after 20 batch reactions and had improved thermal stability, relative to the free enzyme. These results demonstrate that APEPMOs would be promising supports for β-glucosidases immobilization.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Qiaochun Chen,Zening Zhang,Weiqi Qiu,Qian Zhou,Mingfu Wang
The inhibitory mechanisms of flavonoids suppressing the formation of foodborne β-carboline heterocyclic amines, Harman and Norharman, remain unclear. In this study, structure–activity and correlation analyses linked the distinct inhibitory effects of spice-containing flavonoids on β-carboline formation (13.36–86.98%) to their phenolic hydroxyl groups and antioxidant capacity. The pronounced decrease in free radicals and reduced consumption of tetrahydro-β-carbolines (THβCs) in flavonoid-containing model systems indicated a radical scavenging mechanism that prevented the oxidation of THβC into β-carbolines. Concurrently, the significant reductions in formaldehyde, acetaldehyde, and THβCs levels revealed an additional pathway that flavonoids captured aldehydes to form adducts, thus diminishing THβC formation. Two major adducts, tryptophan–formaldehyde–flavonoid and flavonoid–formaldehyde–flavonoid, were identified by UPLC-MS/MS analysis. These mechanisms were verified in soy sauce brine systems, though their inhibitory efficacy was weakened by preexisting THβCs and β-carbolines, and the limited aqueous solubility of hydrophobic flavonoids. This work deepens insight into flavonoid-mediated inhibition of β-carboline formation and underscores their prospective application in controlling foodborne toxicants.
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Small
·
2025
·
IF 12.1
Yunxiang Sun,Nicholas Andrikopoulos,Guofang Zhang,Yuying Liu,Xiufang Liang,Dongjie Li,Xiaoman Suo,Yue Wang,Yuhuan Li,Chuang Wang,Yang Li,Pu Chun Ke,Feng Ding
Senile plaques, comprised of nanosized aggregates of amyloid-β (Aβ) peptides in the brain, are a pathological hallmark of Alzheimer's disease (AD). On the other hand, regular physical exercise is known to significantly reduce the risk of developing AD. Here, it is reported on the transformation and toxicity mitigation of Aβ amyloid aggregation by a spontaneous “corona” of β-endorphin, a major peptide hormone released upon exercise to suppress post-exercise pain. Given that both Aβ and β-endorphin co-localize extracellularly in the brain, it is postulated that β-endorphin may mitigate the toxicity of Aβ aggregation via direct molecular interactions, thereby contributing to an exercise-mediated reduction of AD risk. Combining biophysical characterizations in vitro with atomistic discrete molecular dynamics simulations in silico, a strong interaction is shown between β-endorphin and Aβ, where β-endorphins are located at the periphery to render a corona of their hetero-complexes with Aβ. Cell viability, immunofluorescence and western blotting assays further revealed that the corona shielded cellular exposure to Aβ aggregates and suppressed the toxicity of Aβ in vivo. This work offered a new molecular mechanism for the benefits of physical exercise, which may facilitate a rational design of future therapy and prevention strategies against AD and dementia.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2015
·
IF 5.337
Kelin Peng,Changzhong Chen,Wanli Pan,Wenmin Liu,Zhiqiang Wang,Lanlan Zhu
Four β-cyclodextrin/4,4′-diphenylmethane diisocyanate/polyethylene glycol (β-CD/MDI/PEG) crosslinking copolymers with different crosslinking density were prepared and characterized as novel polymeric solid–solid phase change materials (SSPCMs) for thermal energy storage . In the SSPCMs, PEG acts as the phase change functional chain and β-cyclodextrin (β-CD) acts as the molecular framework. The results from wide-angle X-ray diffraction (WAXD) and polarizing optical microscopy (POM) show that the synthesized SSPCMs have good crystallization properties and spherocrystal morphology with smaller size than that of PEG. According to the results of differential scanning calorimetry (DSC) and thermogravimetry (TG) curves, the SSPCMs possess high phase change enthalpies , good reusability , thermal reliability and stability. It is concluded that the crosslinking density of SSPCMs is a crucial factor significantly influenced the free movement and crystallization of PEG segments, and then affects phase transition properties of SSPCMs.
研究领域:
材料科学
·
高分子化学
·
热能存储
·
相变材料
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OPTICAL MATERIALS
·
2022
·
IF 3.754
Jingxin Ding,Huazhen Liao,Libin Pang,Deping Wang,Song Ye
Rare earth ions doped core-shell thermometers exhibit improved up-conversion emission behaviors, while the thermal sensitivity is not higher than the corresponding core-only structured luminescent thermometers via the thermal coupled levels based luminescence intensity ratio (LIR) technique. In this work, the core-only β-NaYF 4 : 16Yb 3+ , 4Er 3+ (C–4Er) up-conversion nanoparticles (UCNPs) and the sub 25 nm core-shell β-NaYF 4 : 16Yb 3+ , 4Er 3+ @0.5NaGdF 4 (CS–4Er@0.5Gd) and β-NaYF 4 : 16Yb 3+ , 4Er 3+ @1NaGdF 4 (CS–4Er@1Gd) UCNPs have been successfully synthesized by seed-mediated growth methods for temperature detection. The spectral study indicated that the up-conversion luminescence intensity of CS-4Er@0.5Gd and CS-4Er@1Gd was obviously enhanced compared withC-4Er. Luminescence intensity ratio originated from thermally coupled Stark sublevels (Stark-LIR) of Er 3+ ( 2 H 11/2 (1)(2), 4 S 3/2 (1)(2)(3)) of CS-4Er@0.5Gd and CS-4Er@1Gd has been firstly applied to calculated the relative thermal sensitivity (S R ) of core-shell UCNPs. As a result, S R of CS-4Er@1Gd is the largest among the considered UCNPs, and is increased from 10.95 × 10 −3 /K (LIR) to 17.80 × 10 −3 /K (Stark-LIR), indicating that with Stark-LIR techniques, the nano core-shell sensors behave a larger S R than core-only structured thermometers. This work may lead to an appropriate approach to improve the temperature sensitivity of core-shell thermometers for temperature sensing.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Hailin Wang,Leiwen Xiang,Zhuangwei Zhang,Guoqiang Li,Peng Li,Wentao Chen,Yu Fang,Xinyan Lin,Shufen Lin
Polyphenol-protein interactions are crucial for food processing, nutrition, and functional properties. This study investigates the interaction between rutin and β-casein (β-CAS) or β-lactoglobulin (β-LG) using multispectral analysis, molecular docking, and molecular dynamics (MD) simulations. Fluorescence spectroscopy reveals that rutin binds spontaneously (ΔG < 0) to β-CAS and β-LG, forming complexes with binding constants (Ka) at 298 K of 42.500 × 10 3 and 2.101 × 10 3 L·mol −1 , respectively, and at 308 K of 5.814 × 10 3 and 4.350 × 10 3 L·mol −1 . Multispectral analysis and microscopy reveal complex formation and changes in the proteins' secondary, crystalline, and microstructures. Molecular docking and MD simulations verify complex stability, showing heightened binding affinity between rutin and β-CAS. These results validate hydrophobic interactions and hydrogen bonding as the main forces between rutin and the two proteins. These findings offer insights for using milk proteins as rutin carriers and support potential food industry application.
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