ChemistrySelect
·
2025
·Vol. 10
·期 37
·e02789
·
IF 2
Li Zhong,Yuxin Duan,Meiying Wang,Xiao Xu,Minghuan Qian,Xu Jia
The polymers of N , N -diethylacrylamide (DEA) exhibit temperature-dependent sensitivity attributable to the presence of both hydrophilic and hydrophobic groups. However, their lower critical solution temperature (LCST) is only 25 °C, a limitation that restricts their practical applications. Previous studies have shown that the incorporation of cationic monomers for copolymerization can enhance the LCST of polymers. In this study, dimethyldiallylammonium chloride (DMDAAC) and DEA were selected for copolymerization to obtain a series of thermosensitive water-soluble polymers, poly(DMDAAC- co -DEA). Structure and properties were characterized using FT-IR, 1 H NMR, TG-DSC, and surface tension test. Combined with the critical phase transition mechanism, it was determined that the hydrophilicity of the polymer underwent a gradual increase in proportion with the increase of DMDAAC blocks in polymers, and the LCST exhibited an increase of up to 36.8 °C. The relationship between polymer structure and demulsification performance was also explored, as represented by the application of O/W emulsion. The experimental findings demonstrated that all poly(DMDAAC- co -DEA) products exhibited effective demulsification performance. The demulsification rate of the polymers with 30%, 50%, and 70% of DMDAAC could reach 97.03%, 98.20%, and 98.40% respectively, which shows great potential for the petroleum demulsification application. Graphical Water-soluble polymer Poly(DMDAAC- co -DEA) are synthesized using a three-step heating method. A comprehensive investigation is conducted into the relationship between its LCST and copolymerization ratio, resulting in the elucidation of the underlying mechanism. Furthermore, the demulsifying properties of the copolymer are investigated.
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IEEE ELECTRON DEVICE LETTERS
·
2020
·Vol. 42
·期 2
·176-179
·
IF 4.221
Junjie Wang,Yanan Ding,Zhen Wang,Qi Tang,Qian Chen,Guoxia Liu,Fukai Shan
In this report, In2O3 nanofiber networks (NFNs) were prepared by electrospinning and the field-effect transistors (FETs) based on In2O3 NFNs were fabricated. The effects of plasma treatment on the electrical performance of the FETs based on In2O3 NFNs were investigated. It is found that the oxygen vacancy in In2O3 NFNs can be tuned by the plasma treatment and the electrical performance of the FETs can be tuned accordingly. In this work, X-ray photoelectron spectroscopy was employed to investigate the chemical stoichiometry in In2O3 nanofibers with respect to plasma treatment conditions. The electrical performances of the FETs based on In2O3 NFNs treated by various plasma treatment conditions were systematically studied. It is found that, compared to those without O2 plasma treatment, the FET based on In2O3 NFNs treated by O2 plasma at 120 W for 5 min exhibits high electrical performance, including the variation of threshold voltage from -22.34 to 7.81 V and current on/off ratio from ~103 to ~107 and a μFE of 1.51 cm2/Vs. This result demonstrates that moderate plasma treatment can be adopted to improve the electrical performance of the FETs based on metal oxide NFNs.
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CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Peng Liu,Qiang Ru,Peiming Zheng,Zhenglu Shi,Yang Liu,Chiquan Su,Xianhua Hou,Shichen Su,Francis Chi-Chung Ling
Currently, there are three primary obstacles to the development of high-performance supercapacitors: low electron conductivity of the electrode materials used, their poor ion-transport efficiency, and the unstable structure. Herein, to overcome these obstacles, one-dimensional Zn 2 GeO 4 (ZGO) rods were grown within a carbon nanotube (CNT) framework using a simple one-step hydrothermal strategy for use as a supercapacitor electrode material. The crosslinked ZGO/CNT-O hybrid exhibits a large contact surface area with respect to electrolytes, contains abundant electrochemical active sites, and has short ion-diffusion paths. Further, the flexible CNTs act as superior connective bridges, promoting electron transmission and resulting in a stable structure. The ZGO/CNT-O hybrid showed a specific capacitance of 164.25 F/g at a current density of 1 A/g. It also displayed superior cycling durability, exhibiting a specific capacity of 120 F/g at a current density of 10 A/g, even after 200,000 cycles. A simple crosslinking strategy and prolonged cycle durability are demonstrated, which endow ZGO/CNT-O with potential for use in supercapacitor electrodes.
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PHYTOMEDICINE
·
2026
·
IF 11.3
Tingwen Zhang,Ruihong Zou,Zheng Chen,Yawei Li,Xin Sun,Xialin Sun
Background Overuse of acetaminophen (APAP) can induce acute liver injury (ALI), and its mechanism is closely related to ferroptosis. 4′-O-β-D-glucosyl-5-O-methylvisamminol (5-O) is a natural coumarin glycoside with anti-inflammatory and antioxidant activities, but whether it can alleviate liver injury through intervention in ferroptosis and multi-dimensional mechanisms remains unclear. Purpose To explore whether 5-O can alleviate APAP-induced ALI through multiple mechanisms such as inhibiting ferroptosis, regulating inflammation, promoting lipid metabolism, and reshaping the intestinal microbiota . Methods Through in vitro and in vivo experiments, combined with CCK-8, Western blot, whole transcriptome sequencing, 16S rRNA sequencing, FMT and other techniques and methods, the mechanism of 5-O was evaluated from multiple levels such as cells, tissues, metabolism and flora. Results 5-O downregulated Tfrc/Slc39a14 in cells to reduce iron intake and upregulated Slc7a11/GPX4 to enhance antioxidant capacity. It reduced serum ALT/AST, alleviated liver tissue pathological damage, inhibited the expression of chemokines and inflammatory factors, and activated the PPARα-Fabp1/Me1 axis to promote lipid metabolism. Whole transcriptome analysis revealed that 5-O intervention was associated with upregulation of miR-30e-3p and downregulation of Tfrc, suggesting a potential role in modulating iron metabolism. Concurrently, the analysis indicated that 5-O treatment was linked to inhibition of the ferroptosis pathway and activation of the PPAR pathway. In addition, 5-O reshaped the intestinal microbiota, inhibited pro-inflammatory bacterial genera, and promoted the colonization of the probiotic Lactobacillus . Conclusion This study systematically clarified that the hepatoprotective effect of 5-O against APAP-induced liver injury is associated with a multi-dimensional network involving "ferroptosis-inflammation-metabolism-flora". The innovation lies in systematically elucidating the multi-faceted actions of a natural product, which may involve regulating ferroptosis through miR-30e-3p associated changes, cross-organ metabolic reprogramming, and microecological modulation. This work provides a candidate drug with multi-dimensional synergistic potential for the prevention and treatment of liver injury.
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JOURNAL OF CATALYSIS
·
2022
·
IF 8.047
Adugna Boke Abdeta,Qinhan Wu,Dong-Hau Kuo,Ping Li,Hanya Zhang,Ting Huang,Jubin Zhang,Jinguo Lin,Xiaoyun Chen
The Mo-nonstoichiometry, oxygen vacancy, and S incorporation into Bi-Mo bimetallic oxide enhance the activity by creating defects that improve charge carrier separation efficiency and narrow bandgap energy. Oxygen vacancies synergistically attired nonstoichiometric and Mo-deficient and O-deficient Bi 2 Mo 3-x (S,O) 12-y oxysulfide (Mo-/O-deficient Bi 2 Mo 3 (S,O) 12 ) is found by a one-pot facile method to enhance the photocatalytic H 2 evolution and pollutant reduction via in-situ generated protons. The best Mo-/O-deficient Bi 2 Mo 3 (S,O) 12 catalyst with x = 0.75 and oxygen vacancy content of 27.6 % produced 480.87 µmol/h H 2 with 25 mg catalyst and achieved AQE of 14.26 % at λ = 420 nm, whereas reduced 88.9 % 4-NP and 91.6 % RhB by in-situ generated protons. Bi-non-stoichiometry leads to Mo 4+ and oxygen vacancy formation and creates active reaction sites of oxygen vacancy and active surface oxygen. These enhancements benefit photogenerated carrier separation efficiency and fast electron transfer and achieve Mo-/O-deficient Bi 2 Mo 3 (S,O) 12 with superb PHER. Therefore, non-stoichiometry and sulfur doping into Bi 2 Mo 3 O 12 bimetallic oxide is a promising approach for designing novel and synergistically defect-attired oxysulfide photocatalysts.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yanyan Sun,Xiaohua Song,Di Zhang,Dan Yang,Hanqing Jiang,Jun Qiu,Muzi Ge,Yi-Jun Wu
TOCP reduces COPII vesicles in the spinal cord and sciatic nerves of adult hens. • TOCP metabolite CBDP inhibits COPII-mediated ER-to-Golgi trafficking in Schwann cells. • TOCP/CBDP-induced COPII transport defects are involved in ER stress (ERS). • ERS inhibitor 4-PBA partially rescues COPII transport defects and neurotoxic injury. Tri- ortho -cresyl phosphate (TOCP) is an organophosphorus compounds (OP) known to induce delayed neurotoxicity, called OP-induced delayed neuropathy (OPIDN), which involves multiple pathological processes, including degeneration and demyelination of long axons within the spinal cord and peripheral nerves. In this study, we employed the Schwann cell line (sNF96.2 cells) and adult hen, the classical model animal for OPIDN study, to investigat e the mechanism of TOCP-induced myelin damage. The results showed that TOCP (750 mg/kg, p.o.) significantly reduced the number of COPII vesicles in the spinal cord and sciatic nerves of hens; on day 2 after the single exposure, the number of vesicles decreased to 27% and 38% of the control group, respectively, while 4-phenylbutyric acid (4-PBA, 150 mg/kg, i.p.), an inhibitor of endoplasmic reticulum (ER) stress restored them to 80% and 75% of the control group, respectively. In sNF96.2 cells, cresyl saligenin phosphate (CBDP), the active metabolite of TOCP, inhibited COPII vesicle transport from the ER to the Golgi apparatus, reducing the transport rate of ManII-SBP-mCherry from 76% to 38% and the relocation rate of GalNAc-T2-GFP in the Golgi apparatus from 91% to 26%. 4-PBA partially reversed the effects (restoring them to 62% and 72%, respectively). These results suggested that TOCP/CBDP impairs COPII vesicle transport at least partially by activating ER stress, and that impaired vesicle transport may be an important mechanism by which TOCP induces neuropathy. Download: Download high-res image (156KB) Download: Download full-size image
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STAR Protocols
·
2026
·Vol. 7
·期 3
·104713
·
IF 1.4
Jia Liu,Xugen Chen,Lebing Wang,Feng Zhou,Jiantao Zhang
Summary Here, we present a protocol for generating concentration-modulated water-in-oil-in-water (W/O/W) double-emulsion droplets (DEDs) to program DNA crystal morphology. We describe assembly of a dual-inner-phase glass capillary microfluidic device, flow-rate-controlled co-encapsulation, osmotic shrinkage, and image-based morphology analysis. This protocol validates encapsulation predictability using methylene blue and enables aspect-ratio control of 2T crystals and directional morphology regulation in 13-mer systems. For complete information on the generation and use of this protocol, please refer to Chen et al. 1
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Peng Gu,Yihe Fan,Jin Liu,Zhuang Cai,Jiannan Du,Yidong Song,Ying Dai,Guofeng Wang,Jinlong Zou
Size-controllable Cu 2 O nanocubes grow in-situ on AMXene via Oswald-ripening mechanism. • Cu 2 O induces MXene amorphization, generating edge-ligand unsaturated sites for HER. • The electron-rich Cu + boosts orbital hybridization for selective glycerol oxidation. • The catalyst requires only 1.31 V electrolyzer voltage with stability exceeding 150 h. Glycerol oxidation reaction (GOR) is a mild, sustainable pathway with great potential for producing high-value chemicals such as formic acid (FA). Integrating GOR with hydrogen evolution reaction (HER) circumvents the high energy barrier of anodic oxygen evolution in traditional water splitting. However, achieving selective C C bond cleavage in glycerol-to-FA conversion remains a major technical and scientific challenge. Here, via the Ostwald ripening mechanism, size-tunable cuprous oxide nanocubes are in-situ grown on amorphous MXene (Cu 2 O/AMXene), creating well-defined dual active sites with clear functional division: electron-rich Cu + for GOR and Ti sites for HER. The optimized Cu 2 O-0/AMXene (28 nm Cu 2 O) delivers a HER overpotential of 32 mV at 10 mA cm −2 , a GOR potential of 1.13 V at 10 mA cm −2 , and a full electrolyzer voltage of 1.31 V, while maintaining excellent catalytic efficiency after 150 h of continuous operation. Cu 2 O growth induces MXene amorphization, generating edge ligand-unsaturated Ti sites that enhance water dissociation for proton supply, while Ti 4+ promotes hydrogen spillover to transfer protons to Ti 3+ for efficient HER. Electron-rich Cu + forms asymmetric Ti-O-Cu interactions via electron donation from AMXene, enhancing orbital overlap with p orbitals of glycerol oxygen atoms for GOR. This electron-rich environment inhibits Cu + oxidation to Cu 2+ at high anodic potentials, stabilizing the active s - p hybrid configuration. This work also highlights the critical role of O-functional groups on AMXene and lattice O atoms in Cu 2 O for strengthening metal-support interactions. Download: Download high-res image (225KB) Download: Download full-size image
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MATERIALS LETTERS
·
2026
·
IF 2.6
Ziqi Xu,Yuanbang Zhao,Ruoyu Wang,Haitao Ma,Yunpeng Wang,Hanying Wang
Copper-based materials are attractive for non-enzymatic glucose sensing due to their high activity and low cost. However, conventional powder-based electrodes often suffer from high interfacial resistance and limited active sites. Herein, we develop a facile strategy combining electrodeposition and anodization to directly fabricate self-supporting porous Cu₂O electrodes on copper foil. This binder-free electrode exhibits outstanding electrocatalytic performance, achieving a sensitivity of 946.19 μA·mM −1 ·cm −2 and a detection limit of 1.01 μM. Notably, it shows an exceptionally wide three-stage linear range (0.02–5.71 mM), covering physiological glucose levels in tears, saliva, interstitial fluid, and blood. The sensor also demonstrates excellent anti-interference ability and reproducibility, offering a promising approach for practical glucose detection.
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Nanoscale
·
2026
·
IF 5.2
Tingting Cai,Shuangshuang Zhao,Qin Fang,Huixin Chen,Xiuli Jia,DONGXU YU
Vanadium (III) oxide (V2O3) has emerged as a promising cathode material for aqueous zinc-ion batteries owing to high theoretical capacity based on reversible two-electron redox chemistry. However, the cycling stability and reaction kinetics are highly sensitive to its microstructural characteristics, which remain insufficiently understood. Here, we report a facile and scalable synthesis of V2O3 via combining oil-bath reaction and controlled calcination process, enabling precise regulation of particle morphology and microstructure through calcination time. Systematic microstructural evolution is correlated with Zinc-ion storage behavior, revealing that optimized architectures effectively promote ion transport kinetics and structural stability. Coupled with a high-concentration water-in-salt electrolyte to suppress parasitic reactions, the optimized V2O3 cathode delivers a high specific capacity of 453.8 mA h g -1 at 0.05 A g -1 , exceptional rate capability with 180 mA h g -1 retained at 10 A g -1 , and prolonged cycling stability of 210 mAh g -1 after 1000 cycles at 1 A g -1 . This work elucidates the underlying structure-property relationship governed by microstructure but also provides valuable insights into the design of highperformance cathode materials for advanced energy storage systems.
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ACS Nano
·
2026
·
IF 17.3
Shanli Wang,Zejin Ju,Yingwu Wang,Zijie Liu,Xingzhe Wang,Hua Jiao,Minhua Cao,Yude Wang,Wenyan Yin,Yuliang Zhao
Nanozymes suffer from insufficient catalytic activity and sluggish electron transfer, while hypoxic tumor microenvironment (TME)-induced radioresistance and limited reactive oxygen species accumulation hinder radiotherapy efficacy. Existing nanozyme radiosensitizers often require high-dose radiotherapy or combined drugs to achieve only a modest efficacy. Herein, we report a Pt-anchored MoOx (MPP) nanozyme synthesized via a surface defect-ligand reduction strategy with Pt nanoclusters loading up to 34.39 ± 0.92 wt %. It features a gradient electron-transfer interface constructed by strong Pt–O–Mo interactions, which enables atomic-level integration of Pt0/Pt2+ nanoclusters with MoOx and the simultaneous introduction of oxygen vacancies and an interfacial electron pool. Density functional theory calculations confirm the interface upshifts MoOx’s d-band center, accelerates Mo → Pt electron transfer, and reduces the H2O2 dissociation barrier to 0.18 eV. Consequently, MPP achieves a catalase-like specific activity of 3884.53 U mg–1 (2-fold natural catalase, 7528-fold MnO2) and a turnover number (TON) of 25.7021 s–1. Additionally, MPP exhibits a quantitative factor for electron transfer efficiency of 1.75, exceeding reported nanozymes. In the acidic TME, MPP orchestrates a catalase/superoxide dismutase/oxidase cascade to relieve hypoxia and generate •O2–/1O2. Synergized with Pt’s high-Z effect, MPP amplifies the efficacy of 6 Gy with low-dose radiotherapy, achieving 75.24% tumor inhibition rate without inducing systemic toxicity. This gradient electron-transfer interface strategy provides a promising paradigm for high-efficacy, low-toxicity tumor-specific therapy.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Xiang Liu,Mutian Zhang,Wei Zheng,Junjiang Fan,Miaoxi Guo,Li Yang,ZhengMing Sun,Guobing Ying
Aqueous ammonium-ion batteries are promising for safety, low cost, and fast energy storage. However, the influence of electrode surface chemistry on NH4+ storage remains poorly understood. Two-dimensional Ti3C2Tx MXene, with metallic conductivity, tunable interlayer spacing, and abundant surface terminations, serves as an ideal platform to elucidate NH4+ storage mechanisms. Herein, the role of MXene surface termination in regulating NH4+ storage behavior is systematically investigated using density functional theory calculations and experimental validation. The calculations reveal that the -N terminations offer moderate NH4+ adsorption and high electronic conductivity for rapid charge transfer and ion transport, whereas the -O terminations exhibit stronger ion affinity and enhanced surface stability. Importantly, the mixed -N/-O terminations effectively balance adsorption strength and transition-state stabilization, resulting in the lowest NH4+ migration barrier among the modeled pathways. The calculations employ idealized vacuum-separated surfaces with isolated NH4+ and do not explicitly include solvation or electrolyte effects. Guided by these findings, a mixed -N/-O terminated Ti3C2Tx MXene is constructed via a urea-assisted hydrothermal strategy. The optimized NTC-20 electrode delivers 107 mAh g-1 at 1 A g-1, retains 67% capacity at 10 A g-1, and maintains 91% capacity after 10,000 cycles. Ex situ XRD, XPS, and FTIR analyses are consistent with reversible NH4+-associated changes in the local chemical environment and possible storage involving Ti-N···H-N and Ti-O···H-N interactions. Furthermore, the NTC-20//MnO2/CNTs full cell achieves an energy density of 26.7 Wh kg-1 at 1.3 kW kg-1. The results support a dominant role for mixed -N/-O terminations in regulating NH4+ adsorption and diffusion, providing insights into surface-termination engineering for high-performance AAIBs.
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