MICROCHIMICA ACTA
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2019
·Vol. 186
·期 6
·1-10
·
IF 5.479
Li Zhuanying,Cui Zhimeng,Tang Yiwei,Liu Xiuying,Zhang Xuemei,Liu Bingxiang,Wang Xianghong,Draz Mohamed Shehata,Gao Xue
The authors describe a microparticle-based system for the detection of the fluoroquinolone antibiotic ciprofloxacin. The method is using the tris(dibenzoylmethane)(1,10-phenanthroline)europium(III) luminophore in polystyrene microparticles along with a molecularly imprinted polymer (MIP) for ciprofloxacin. If ciprofloxacin is captured by the MIP, it quenches the fluorescence of the luminophores. Fluorescence drops linearly in the 0.5–100 μg L −1 ciprofloxacin concentration range, and the detection limit is 92 ng L −1 . The method was applied to the analysis of fish samples to assess the analytical performance of the probe. Recoveries ranged from 85.4 to 86.6%, and relative standard deviations between 2.1 and 3.9% (for n = 5).
Schematic presentation of a microparticle-based probe using the tris(dibenzoylmethane)(1,10-phenanthroline)europium(III) luminophore in polystyrene particles along with a molecularly imprinted polymer for ciprofloxacin. After removal of template, carboxylic groups left in the probe can bind to ciprofloxacin through hydrogen bonds.
研究领域:
分析化学
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药物分析
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PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2019
·
IF 4.175
Li Wang,Hanlun Yang,Lijuan Xu,Canwei Peng,Yonghai Song
A novel Cu–Co-zeolite imidazole framework (Cu–Co-ZIF)-derived CuCo 2 O 4 @carbon nanocomposites supported on three-dimensional porous carbon (3D-KSC) were prepared to develop molecularly imprinted electrochemical sensors for sensing dopamine (DA). Firstly, polyhedral Cu–Co-ZIF was synthesized at room temperature and uniformly arrayed on 3D-KSC, and then the CuCo 2 O 4 @carbon nanostructure was obtained by high-temperature carbonization under nitrogen atmosphere. Finally, the molecularly imprinted polymer (MIPs) DA-imprinted chitosan was covered by potentiostatic electrodeposition to obtain the MIPs/CuCo 2 O 4 @carbon/3D-KSC integrated electrode. The results showed 15 μm-sized polyhedral Cu–Co-ZIF crystals were transformed into smaller irregular porous CuCo 2 O 4 @carbon nanocomposites with rough surface by calcination . Here, the produced 5 nm-sized CuCo 2 O 4 crystals were uniformly embedded into the N-doped porous carbon frameworks. Various experimental conditions including the amount of Cu–Co-ZIF grew on 3D-KSC, calcination temperature, electrodepositing time of MIPs, the eluted time of template molecule and the pH of electrolyte were explored. The as-prepared MIPs/CuCo 2 O 4 @carbon/3D-KSC integrated electrode exhibited excellent anti-interference ability and good stability. The sensitivity for DA detection was 720.8 μA mM −1 cm −2 , the detection range was 0.51 μM–1.95 mM, and the detection limit was 0.16 μM.
研究领域:
材料科学
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分析化学
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生物医学工程
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高影响因子
ANALYTICA CHIMICA ACTA
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2019
·
IF 5.256
Yu-Zhen Zhang,Bei Qin,Bo Zhang,Jin-Ge Ma,Ya-Qi Hu,Lu Han,Mao-Fang He,Chun-Ye Liu
Specific recognition of caffeic acid (CA) from Taraxacum mon-golicum Hand.-Mazz. was successfully performed using a new pH responsive magnetic molecularly imprinted polymers (pH-MMIPs) by simple surface molecular imprinting polymerization. The pH-MMIPs were prepared on the surface of the Fe 3 O 4 @SiO 2 @MPS particles using CA as a template, 2-(dimethylamino) ethyl methacrylate (DMA) as the pH responsive functional monomer , 4-vinylpyridine (4-VP) as an assisting functional monomer, ethylene glycol dimethyl acrylate (EGDMA) as cross-linker, 2,2′-azobisisobutyronitrile (AIBN) as initiator and methanol-H 2 O (1:1, v/v) as the porogen . The resultant polymers were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), vibrating sample magnetometry (VSM) and x-ray diffraction (XRD). The adsorption experiments revealed that the pH-MMIPs performed high adsorption ability (11.5 mg g −1 ) by changing solution pH. Successful selective adsorption of CA was achieved with distribution coefficient of 0.12 and 0.21 towards ferulic acid and chlorogenic acid . Furthermore, pH-MMIPs were employed as adsorbents for extraction and enrichment of CA from Taraxacum mon-golicum Hand.-Mazz. extract. The recoveries of CA in the Taraxacum mon-golicum Hand.-Mazz. ranged from 90.47% to 98.97%. The results proved that the polymers have the potential to provide a selective recognition of CA in complex samples by simple pH regulation.
研究领域:
植物化学
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分析化学
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PubMed
高影响因子
ELECTROANALYSIS
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2012
·Vol. 24
·期 7
·1647-1654
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IF 2.872
Li Liu,Xuecai Tan,Xiaoxue Fang,Yuexin Sun,Fuhou Lei,Zaiyin Huang
A novel cross-linker (functional abietic-type acids) for preparing highly sensitive, molecularly imprinted sensors was proposed for quinine determination. A MIP film was created on a glassy carbon electrode for determination of quinine using free radical polymerization method. The modification procedure was characterized via electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The interaction between functional monomer and target molecule was observed by UV spectrometric methods. Under the optimal experimental conditions, the peak currents were proportional to the concentrations of quinine in the range from 8.0×10 −7 to 2.6×10 −4 M with a detection limit of 2.0×10 −8 M. Meanwhile the prepared sensor showed sensitive and selective binding sites for quinine. Determination of quinine in tonic water showed good recovery.
研究领域:
分析化学
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生物传感技术
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高影响因子
JOURNAL OF SEPARATION SCIENCE
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2012
·Vol. 36
·期 5
·898-906
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IF 2.733
Pierre Dramou,Deli Xiao,Hua He,Tiebing Liu,Wenyue Zou
The loading behavior of gatifloxacin (GTFX) in human urine and lake water on a novel magnetic molecularly imprinted polymer used as extraction sorbent with UV-Visible spectrometric analysis has been studied. The magnetic polymers had been prepared using GTFX as template molecule and Fe 3 O 4 as magnetic component. The polymer had been characterized by SEM, Fourier-transform infrared spectrometry, and appropriate magnet separator. Parameters affecting the extraction efficiency were evaluated in order to achieve optimal loading and reduce nonspecific interactions. Good linearity of the method had been obtained in the range between 0.25 and 15 μg mL −1 by UV-Vis spectrophotometry at 286 nm with spectral analysis from 240 to 400 nm. The method detection and quantification limits of GTFX in water were 0.075 and 0.25 μg mL −1 , respectively. This study showed good selectivity and loading efficiency (α > 2) of the polymers. The loading behavior of GTFX in the samples spiked on polymers had been obtained and each other with recovery higher than 91% with RSD% between 2.5 and 3.3. No pretreatment of samples were needed and no interference of compounds in urine and lake water were observed during adsorption.
研究领域:
分析化学
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环境科学
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药理学
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PubMed
高影响因子
Analytical Methods
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2015
·Vol. 7
·期 11
·4786-4792
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IF 1.821
Xuecai Tan,Jiawen Wu,Qi Hu,Xiaoyu Li,Pengfei Li,Huicheng Yu,Xiaoyan Li,Fuhou Lei
Graphene and a novel cross-linker (ethylene glycol maleic rosinate acrylate) for preparing highly sensitive, molecularly imprinted sensors were proposed for phoxim determination. A molecularly imprinted polymer (MIP) film was created on a graphene-modified electrode for the determination of phoxim using a free radical polymerization method. The electrochemical properties of the MIP and non-molecularly imprinted polymer (NIP) sensors were investigated via cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). The surface morphology of the imprinted film was characterized by scanning electron microscopy (SEM). Under the optimal experimental conditions, the peak currents were proportional to the concentrations of phoxim in the range of 8.0 × 10−7 to 1.4 × 10−4 mol L−1 with a detection limit of 2.0 × 10−8 mol L−1 (S/N = 3). The imprinted electrochemical sensor was employed to determine phoxim in cucumber samples with recovery ranging from 98.06% to 101.13%. An adsorption model for the imprinted sensor was investigated, and the measured imprinting factor β of the sensor was found to be 7.23, with the binding rate constant k being 14.2247 s. The developed electrochemical sensor based on the graphene modified electrode and the molecularly imprinted polymer exhibited good repeatability and stability, and can be successfully used to determine phoxim in cucumber samples.
研究领域:
分析化学
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环境科学
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农业科学
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高影响因子
Analytical Methods
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2015
·Vol. 7
·期 23
·10018-10025
·
IF 1.821
Junxia Guo,Yuzhi Wang,Yanjin Liu,Yigang Zhou
A surface molecularly imprinted polymer (MIP-Fe3O4@AA) was prepared on a magnetic material (Fe3O4@AA) surface for the selective recognition and adsorption of bovine hemoglobin (BHb). The acrylic acid (AA) monomer was directly grafted to the surface of Fe3O4 through a simple coordination reaction between the carboxyl group of AA and unsaturated iron ions (Fe3O4@AA). Then the composite of MIP-Fe3O4@AA based on BHb was successfully synthesized by the surface grafting copolymerization method. The amounts of raw materials were optimized. The characteristics of the obtained MIP-Fe3O4@AA were determined by Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), vibrating sample magnetometry (VSM) and thermogravimetric analysis (TGA). The adsorption capacity of MIP-Fe3O4@AA was evaluated and well fitted by the Langmuir model. The maximum theoretical adsorption capacity (Qmax) was calculated to be 117.27 mg g−1 for MIP-Fe3O4@AA. The selectivity experiment showed that the MIP-Fe3O4@AA had an outstanding selectivity toward the template protein (BHb) with an imprinting factor of 4.43. The MIP-Fe3O4@AA was also used to capture BHb from the protein mixture and real sample with satisfactory results, which demonstrated its potential practical analytical performance.
研究领域:
材料科学
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生物技术
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分析化学
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高影响因子
CHIRALITY
·
2017
·Vol. 29
·期 7
·340-347
·
IF 1.956
Hongxing Dong,Danxia Zhang,Hailong Lin,Yudan Wang,Lijia Liu,Meixia Zheng,Xiaobo Li,Chunhong Zhang,Junqing Li,Peng Zhang,Juhyok So
Acrylamide (AM) was copolymerized with ethylene glycol dimethacrylate (EGDMA) in the presence of ( R )-1,1′-binaphthalene-2-naphthol (BINOL) as the template molecules on the surface of silica gel by a free radical polymerization to produce a chiral stationary phase based on the surface molecularly imprinted polymer (SMIP-CSP). The SMIP-CSP showed a much better separation factor ( α = 4.28) than the CSP based on the molecularly imprinted polymer (MIP-CSP) without coating on the silica gel ( α = 1.96) during the chiral separation of BINOL enantiomers by high-performance liquid chromatography. The influence of the pretreatment temperature and the content of the template molecule (( R )-BINOL) of the SMIP-CSP, and the mobile phase composition on the separation of the racemic BINOL were systematically investigated.
研究领域:
分析化学
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材料科学
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PubMed
高影响因子
FOOD CHEMISTRY
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2017
·
IF 4.529
Hongwu Wang,Yanqing Liu,Su Yao,Peijie Zhu
In this work, a highly selective molecular imprinted polymer (SBA-15@MIP) was prepared using dicyandiamide (DCD) as the template molecule and mesoporous silica SBA-15 as the carrier. The resulting polymers were characterized by scanning electron microscopy and FT-IR spectra. A highly ordered mesoporous nanostructure was observed for the fabricated polymer. The performance tests showed that the adsorption capacity of SBA-15@MIP for DCD was higher than those of non-imprinted mesoporous silica polymer (SBA-15@NIP) and SBA-15. SBA-15@MIP was successfully used as the solid-phase extraction (SPE) sorbent coupled with HPLC for trace DCD determination in bovine milk and milk powder. Under selected conditions, a favorable linearity between 1 μg/mL and 100 μg/mL was obtained and the detection limit was estimated to be 0.08 μg/mL (bovine milk) and 0.10 μg/mL (milk powder). These results indicated that SBA-15@MIP could be used as an efficient SPE adsorbent for enrichment of DCD in bovine milk and milk powder.
研究领域:
分析化学
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食品科学
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PubMed
高影响因子
Journal of Environmental Chemical Engineering
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2016
·
IF 0
Yanzhuo Zhu,Dayu Jiang,Dongshu Sun,Yongsheng Yan,Chunxiang Li
In this work, erythromycin-based (EM-based) magnetic molecularly imprinted polymers (MMIPs) were prepared by magnetic eggshells-stabilized Pickering emulsion imprinting polymerization. The feature of easy separation caused by good magnetism made the product separation and adsorption process more time-saving and convenient. More importantly and interestingly, the magnetic eggshell particles were not prepared beforehand, but were found to form instantly and spontaneously in water phase. The magnetic eggshell particles created in this way were used as stabilizers of emulsion polymerization for the first time, which may be benefit for the preservation of magnetism of MMIPs. The imprinting process was conducted by radical polymerization and the MMIPs was characterize by various characterization methods such as Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and vibrating sample magnetometer (VSM). The results sufficiently demonstrated the formation of the approximately spherical and wrinkled magnetic imprinted polymers. A series of adsorption experiments showed that the as-prepared MMIPs exhibited not only outstanding adsorption capacities, but also excellent selective adsorption effect toward EM molecules, and the adsorption mechanism were also discussed in detail with different adsorption models.
研究领域:
环境科学
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材料科学
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药物化学
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DOI
JOURNAL OF CHROMATOGRAPHY A
·
2014
·
IF 4.258
Guifu Ma,Ligang Chen
The sensitive and efficient magnetic molecularly imprinted polymers (MMIPs) were successfully synthesized using carbon nanotubes as matrix and Fe 3 O 4 particles as magnetic ingredient. Tetraethyl orthosilicate was used as modification material of the carbon nanotubes. Cyhalothrin, methacrylic acid and ethylene glycol dimethacrylate were used as template molecule, functional monomer and cross-linker, respectively. Azo-isobutyronitrile and polyvinylpyrrolidone were used as initiator and dispersant, respectively. The MMIPs were used for the separation of pyrethroids including beta-cyfluthrin, cyhalothrin, cyphenothrin and permethrin in fruit samples followed by high performance liquid chromatography analysis. The polymers were characterized with Fourier transform infrared spectrometry, Brunauer–Emmett–Teller method, transmission electron microscopy and a physical property measurement system. The isothermal absorption experiment, kinetics absorption experiment and selectivity of MMIPs were studied in detail. Scatchard analysis revealed that two kinds of different binding sites existed in MMIPs. The maximum adsorption capacities of two binding sites were 65.21 and 189.83 mg g −1 , and dissociation constants were 7.11 and 30.40 μg mL −1 , respectively. The kinetic property of MMIPs was well fitted to the second-order equation. The selectivity experiment indicated that MMIPs had higher selectivity toward cyhalothrin and its structural analogs than reference compound. The feasibility of detecting pyrethroids from real samples was testified in spiked fruit samples with different concentrations (0.025, 0.25 and 2.5 mg kg −1 ). The LODs of beta-cyfluthrin, cyhalothrin, cyphenothrin and permethrin were 0.0072, 0.0035, 0.0062 and 0.0068 mg kg −1 , respectively. Precisions of intra-day and inter-day ranging from 2.6% to 4.3% and 4.2% to 5.6% were obtained, respectively. This method was applied to determine pyrethroids in different fruit samples including apple, pear, orange, grape and peach, and satisfied recoveries (82.4–101.7%) were obtained.
研究领域:
分析化学
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环境科学
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PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Shuang Han,Yuzhuo Song,Shiwei Liu,Le Zhao,Ruonan Sun
The preparation of synthetic drug delivery systems free of antibody modifications that can effectively recognize tumor sites and control drug delivery is essential for cancer therapy. In this study, UiO-66 metal–organic framework (MOF) modified with amino and phenylboronic acid groups was used as substrate to load the anti-cancer drug doxorubicin (DOX). Then a molecularly imprinted polymer (UiO-66-DOX@MIP) with sialic acid (SA) as the template molecule was further prepared on the surface of the synthesized nanoparticles using surface molecular imprinting technique (MIT). This polymer combines the excellent properties of UiO-66 and molecularly imprinted polymer (MIP). It was simple to prepare, economical and easy to obtain, and had a regular morphology. UiO-66-DOX@MIP containing molecularly imprinted binding sites that match the template molecule SA, could specifically recognize target tumor cells. The imprinted layer prevented drug leakage in normal body fluids while degrading and drug release under tumor microenvironment, with pH and glutathione (GSH) dual-responsive drug release properties. The UiO-66-DOX@MIP showed excellent biocompatibility and great cellular uptake efficiency to cancer cells without influence of interfering substances.
研究领域:
生物材料学
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药物递送系统
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癌症治疗
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DOI
高影响因子
危险品化学品经营许可证（带存储）