Environmental Science-Processes & Impacts
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2025
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IF 3.9
Dan Luo,Sipei Yang,Haoyang Wang,Zhibin Wu,Xiaomin Gong,Yuan Yang,Yunshan Liang,Yaoyu Zhou
The fractionation of extracellular polymeric substances (EPS) on mineral surfaces alters their composition and reactivity, thereby influencing heavy metal behavior in the environment. However, the molecular-level mechanisms governing how this process affects metal-binding properties remain unclear. Hence, this study combined multispectral techniques and chemometrics to investigate the adsorptive fractionation of EPS on mineral and its impact on heavy metal binding. Excitation–emission matrix coupled with parallel factor analysis (EEM-PARAFAC) demonstrated that aromatic and protein-like components were preferentially adsorbed on hematite (Hema) and goethite (Goet). Two-dimensional correlation spectroscopy (2D-COS) further indicated that protein-like substances were adsorbed prior to fulvic-like substances, following the sequence: tyrosine-like > tryptophan-like > fulvic-like substances. Notably, the fractionation process altered the binding affinity and order of Cu2+ to EPS components. Adsorption onto Hema reduced the copper-binding affinity of EPS, whereas adsorption onto Goet enhanced it. This difference was maybe attributed to changes in carboxyl and polysaccharide groups within the EPS. This study elucidates the influence of EPS fractionation on mineral surfaces regarding heavy metal binding at the molecular level. These findings enhance our understanding of the biogeochemical behavior of heavy metals in the presence of mineral-organic composites across aquatic and terrestrial ecosystems, providing a theoretics foundation for environmental remediation.
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Journal of Materials Research and Technology-JMR&T
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2025
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IF 6.6
Lebing Chang,Kun Li,Zeyun Cai,Peng Du,Yongxiao Wang,Chao Zhou,Enxiang Jiao,Ahsan Riaz Khan,Guoqiang Xie,Weizong Bao,Haijun Zhang
Mo alloys have emerged as a promising biodegradable metallic material due to its inherent biocompatibility and mechanical robustness. However, its clinical translation is limited by slow degradation kinetics and intrinsic brittleness. In this study, we propose a powder metallurgy-based strategy to develop immiscible Mo-Cu alloys that overcome these challenges. Cu is introduced as alloying element which due to higher corrosion potential, excellent plasticity and antimicrobial properties. The optimized Mo-Cu alloy shows a notable increase in strength by 150 MPa while maintaining ductility. Moreover, the degradation rate nearly doubles from 2.553×10 -2 to 4.765×10 -2 mm/y) due to microstructural refinement and galvanic effects. In vitro studies further confirm the biocompatibility and enhanced antibacterial performance of Mo-Cu alloys. This work provides a practical pathway for designing next-generation biodegradable implants based on immiscible alloy systems.
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WATER RESEARCH
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2025
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IF 12.4
Jiachang Shen,Maohua Yang,Zhengxin Mao,Jianmin Xing
Ultrafiltration shows promise for treating protein-rich wastewater; however, the decreased flux and increased operating costs due to protein fouling constrain its practical application. Therefore, it is crucial to investigate the fouling mechanism. Although reversible protein fouling significantly affects the ultrafiltration process, there is a relative lack of theoretical modeling studies on this subject. To solve this problem, a reversible-fouling-layer theoretical model is proposed in this study, which could help to design and optimize the ultrafiltration treatment process for wastewater containing different proteins. In this model, the reversible fouling layer has a constant specific resistance during the stable stage and its thickness increases linearly with the permeate volume per unit membrane area ( V ), and proteins in the reversible fouling layer is converted to irreversible fouling on the membrane surface. The validation of the linear relationship between reversible resistance and V in the transmembrane resistance test of three protein solutions (bovine serum albumin [BSA], ovalbumin, and γ-globulin), as well as the pressure sensitivity test, demonstrated the accuracy of the model in predicting the fouling mechanism. A complementary description of the irreversible fouling mechanism was completed by establishing an empirical formula for irreversible resistance and characterizing fouling using SEM, AFM, and particle size distribution. Finally, a coupled theoretical-empirical model that can be used for fouling and flux prediction in low irreversible fouling conversion systems was presented.
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Applied Materials Today
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2025
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IF 6.9
Jun Zeng,Tao Jia,Tong Chen,Huilin Liu,Zhaojie Sun,Xiaoyong Huang,Yunfei Shang,Shuwei Hao,Chunhui Yang
Cancer phototheranostics has emerged as a cornerstone of personalized precision medicine to achieve efficient and targeted tumor treatment. Upconversion nanoparticles (UCNPs)-mediated phototheranostics exhibited remarkable potential for imaging diagnostics and therapeutic applications. Nevertheless, integrating programmable photoactivation functions of imaging and therapy within a single UCNP with negligible phototoxicity remains a huge challenge, primarily due to the absence of precise photoswitching strategies. Herein, a pulse-responsive upconversion nanoagent (UCNA) is designed to enable imaging-guided precision phototherapy through tunable red/green emissions. The UCNA is constructed based on a UCNPs@mSiO 2 core–shell structure conjugated with photosensitizer (neutral red) and drug (curcumin), and gated by a β-cyclodextrin-adamantane (β-CD-AD) host–guest supramolecular complex. The red emission is utilized for determining the tumor area through fluorescence imaging under 980 nm laser irradiation with a long pulse width (LPW). By switching the laser duty cycle into a short pulse width (SPW) mode, the resultant green emission can active photosensitizer to produce cytotoxic singlet oxygen ( 1 O 2 ), and simultaneously trigger drug release for antitumor therapy. The results demonstrate the attractive performance of UCNP-mediated deep-tissue imaging and enhanced anti-tumor efficacy without obvious systemic toxicity. In general, this work provides a facile approach for tuning upconversion emission, thereby realizing the photoswitchable activation of imaging diagnostics and photodynamic therapeutics.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2025
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IF 5.6
Bin Zhu,Wenda Hua,Lilin Luo,Yangxiaozhi Zha,Yuqin Zhang,Zengdong Meng
Hydroxyapatite (HA) has good biocompatibility and biological activity which can be widely used in bone defect repair. Zinc oxide nanoparticles (ZnO NPs) can promote osteogenesis by enhancing angiogenesis and exhibit notable antibacterial properties. Sintering temperatures critically influence the physicochemical and biological properties of bioceramic scaffolds. In this study, porous ZnO/HA bioceramic scaffolds were fabricated at various sintering temperatures, and their structural, mechanical, and biological properties were systematically investigated. The results demonstrated that increasing sintering temperature led to reduced porosity and degradation rate, accompanied by a significant improvement in compressive strength. Biocompatibility remained consistently high across all temperatures, with all scaffolds exhibiting excellent cell compatibility and osteogenic ability. However, antibacterial efficacy declined with increasing temperature. Notably, bioceramic scaffolds sintered at 950 °C achieved an optimal balance of porosity, mechanical strength, and osteogenic potential, making them promising candidates for repairing critical-sized bone defects.
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Journal of Future Foods
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2025
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IF 7.2
Xiangqi Fan,Mohsin Rasheed,Jikai Jiang,Ming Li,Yingquan Zhang,Yutong Cui,Bo Zhang,Man Li,Boli Guo
This study investigates the effects of atmospheric steam treatment (AST) on wheat flours with varying gluten strengths (strong, medium, and weak) and their performance in frying batter applications. Wheat flours were steam-treated for 0-10 min and evaluated for gelatinization degree, water-holding capacity, microstructural changes, rheological behavior, and frying characteristics. The results indicated that the gelatinization degree and water‑holding capacity of wheat flours increased progressively with AST duration, reflecting the disruption of starch granule structure and enhancement of water absorption. These changes were further corroborated by scanning electron microscopy, which provided visual evidence of the gradual transformation of starch granules and the formation of a compact, interconnected network of gelatinized starch and denatured proteins. Rheological analysis revealed increased yield stress and apparent viscosity in AST batters, suggesting improved flow resistance and batter stability. Batters prepared with AST flours exhibited improved batter pick-up, sensory attributes, and enhanced crispness in the fried coatings. Optimal sensory performance for all three wheat flours was observed at a starch gelatinization degree of 50-55%. Within this optimal range, medium gluten flour exhibited the greatest improvements (peaking at 4-6 min) and produced fried coatings with the highest crispness, adhesion, and overall sensory acceptability. This performance may be attributed to its optimal consistency index (K) and flow index (n). These findings highlight AST as an effective clean-label method to improve wheat flour-based frying batters, offering valuable insights for selecting flour types and driving innovation in industrial frying applications.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2025
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IF 2.8
Xi Hu,Siye Gao,Hancong Wu,Qingyun He,Jianing Liu,Danyue Zhao,Zhenqiang Wu
This study developed an environmentally friendly method for extracting polyphenols and rubusoside from Rubus suavissimus leaves. Under optimal extraction conditions, the contents of polyphenol and rubusoside reached 91.89 ± 2.39 mg/g and 47.03 ± 1.45 mg/g, respectively. The extract was purified by twelve types of macroporous resins, among which the ADS-7 resin had the highest static adsorption and desorption capacities. Optimized purification parameters for ADS-7 resin were determined by static and dynamic adsorption-desorption experiments and found to be: loading flow rate, 3 BV/h; loading concentration, 10 mg/mL; loading volume, 24 BV; elution solvent, 80 % ( v /v) ethanol; elution speed, 3 BV/h; and elution volume, 20 BV. After purification, the content of polyphenols and rubusoside increased by 2.63 and 2.32 times, respectively. Kinetic and thermodynamic analyses revealed distinct adsorption mechanisms: polyphenols followed a pseudo-second-order model, whereas rubusoside followed a pseudo-first-order model; both exhibited spontaneous (ΔG < 0) and endothermic (ΔH > 0) physisorption. Ultrafiltration-assisted centrifugal fractionation combined with UPLC-ESI-qTOF-MS/MS identified eight potential α-glucosidase inhibitors, including quercetin, apigenin, rutin, ellagic acid, kaempferol-3-O-rutinoside, kaempferol, rubusoside, and steviol. Molecular docking simulations revealed the molecular interactions between these compounds and α-glucosidase. The enriched extract demonstrated enhanced bioactivity, with a 3.35-fold higher α-glucosidase inhibition, and its IC₅₀ values for DPPH and ABTS + radical scavenging decreased from 142.03 μg/mL to 88.45 μg/mL and from 197.63 μg/mL to 107.63 μg/mL, respectively. These results substantiate the effectiveness of the extraction-purification approach for producing R. suavissimus leaf extracts and suggest their potential application as functional hypoglycemic and antioxidant food ingredients.
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Analytical Methods
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2025
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IF 2.6
Tianping Chen,Yanru Tao,Xi Cao,Shiyi He,Hua Zhao,Jiangling Hu,Hongmei Wang,Xinhui Jiang
This study developed a high-performance liquid chromatography coupled with fluorescence detection (HPLC-FLD) method for the simultaneous determination of 19 amino acids in the cortex, hippocampus, and bone marrow samples of BALB/C-nu/nu and NOD/SCID mice. We measured the changes in the levels of 19 amino substances in the cortex, hippocampus, and bone marrow samples of mice in the blank model group, acute leukemia model group, chronic leukemia model group, and treatment group. The chromatographic column used was a COSMOSIL 5 C18-MS-II analytical column (150 mm × 4.6 mm, 5 μm), with the column temperature set at 35 °C. The mobile phase was a methanol-ammonium acetate buffer solution (30 mmol L−1 ammonium acetate solution, adjusted to pH 6.40 with acetic acid), at a flow rate of 0.9 mL min−1. The single analysis time was 46 minutes. By optimizing the analysis conditions, the newly established HPLC-FLD method exhibits high sensitivity, good accuracy, and good reproducibility. This method can be successfully applied to determine 19 amino substances in the cortex, hippocampus, and bone marrow of BALB/C-nu/nu and NOD/SCID mice. The differences in amino acid content between different groups can be used to further study the development process of leukemia, disease diagnostic markers, and personalized treatment plans.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Xiaohong Shang,Qingmei Xing,Xinxin Ji,Fenghe Duan,Chuanpan Guo,Qiaojuan Jia,Shuai Zhang,Bin Hu,Zhihong Zhang
Herein, a robust photoelectrochemical (PEC) immunosensor was constructed based on an n-n heterojunction between a copper-porphyrin-based metal organic framework and Bi 2 S 3 (Bi 2 S 3 @Cu-TPyP) for efficient detection of gentamicin (GEN). The integration of Cu-TPyP features (enhanced electron transfer capability, improved photoabsorption performance, large specific surface area, and high antibody bioaffinity) with Bi 2 S 3 characteristics (narrow bandgap and visible light absorption capacity) established an efficient interfacial architecture. Enhanced separation of photogenerated electron-hole pairs and improved photoelectric conversion efficiency in the Bi 2 S 3 @Cu-TPyP heterojunction contributed to the amplified photocurrent. The immunosensor exhibited an ultralow detection limit of 0.041 fg mL −1 (1.0 fg mL −1 –1.0 ng mL −1 linear range) with high selectivity and validated applicability in analyzing GEN across diverse food matrices. This study establishes a PEC biosensing paradigm enabling ultrasensitive and rapid antibiotic monitoring in food products due to the synergistic signal amplification mechanisms without compromising specificity.
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Materials Today Advances
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2025
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IF 8
Chenyue Qiu,Jinfa Ye,Lang Ke,Xingyuan Wei,Peiyu Wang,Yun Han,Xiaofei Wen,Gang Liu,Chengchao Chu
We developed a kind of virus-mimetic nanovesicle (Mel-VSVG-NA), which could react with tumor cells in a membrane fusion procedure (named as First Fusion ), result by the function of Vesicular Stomatitis Virus Glycoprotein (VSVG) in acid microenvironment. Meanwhile, the melittin on Mel-VSVG-NA was transfer on the surface of targeted tumor cell, and thus execute hole-digging process on the tumor cell membrane, causing severe cell content loss and suppression of tumor growth. After the first-round treatment, a harmless ultrasound exposure was carried out, the further engineered vesicles were generated from the damaged cells. Afterwards, the produced vesicles were also confirmed to engineered with VSVG and melittin, which could further fuse with other tumor cells and induced another cell death (named as Second Fusion ). These results indicated that Mel-VSVG-NA is a reliable advance of nano-treatment in ocular tumor therapy, and we bring in this concept of Hijacking- Integration-Vesicular amplification-Exocytosis mode as HIVE therapy.
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REACTIVE & FUNCTIONAL POLYMERS
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2025
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IF 5.1
Birui Yang,Gong Li,Zhimeng Deng,Fangnan He,Yuxiang Wang,Jie Liang,Yong Sun,Yujiang Fan,Xingdong Zhang
Fiber-reinforced hydrogels are widely utilized in biomedical field; however, their mechanical strength and biological functionality are constrained by the poor integration between the fibrous components and the hydrogel matrix. Herein, we developed a biomimetic composite hydrogel (H-P-MA) with effective molecular integration through covalently photopolymerization between a GelMA/HAMA/DopaMA hydrogel network and reactive surface-functionalized PCLMA short fibers created by plasma technology. The H-P-MA composite hydrogel presented a micro-nano topological structure similar to that of the extracellular matrix (ECM) and exhibited superior mechanical properties as well as adhesion capabilities through strong covalent bonding between fibers and matrix, thereby facilitating better cell proliferation. This strategy provides a reliable pathway for developing composite hydrogel materials with ECM biomimicry.
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ULTRASONICS SONOCHEMISTRY
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2025
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IF 9.7
Yiting Xue,Jun Zhang,Ji Yan,Junhao Qiu,Jiaxin Zeng,Yixin Li,Xiaoren Huang,Xinjue Li,Lingyuan Guo,Lingtian Wu,Qian Wang
Scorias spongiosa , a highly nutritious edible fungus native to bamboo forests, is colloquially known as “Bamboo bird’s nest”. Polysaccharides are its primary bioactive ingredients, but comparative studies on their structural characteristics, in vitro antioxidant activities and anti-aging effects across different extraction methods remain scarce. In this study, Scorias spongiosa polysaccharides (SSPs) were extracted using five distinct techniques, including room-temperature water extraction (RWE, 37°C), hot water extraction (HWE), ultrasound-assisted water extraction (UAE), ultrasound-assisted acid extraction (UAE-H), and ultrasound-assisted alkali extraction (UAE-OH). Among these techniques, UAE-OH was identified as the most efficient approach for SSPs preparation, mainly owing to its higher polysaccharide yield (25.4 ± 3.77 %), improved purity (85.25 ± 4.13 %), and enhanced antioxidant activity. In addition, SSPs-UAE-OH possessed the robust anti-senescence effect by mitigating H 2 O 2 -induced oxidative damage, reactive oxygen species (ROS) accumulation, malondialdehyde (MDA) production and SA-β-gal expression in H9C2 cells. Structural analysis revealed that SSPs-UAE-OH primarily consists of glucose, with a molecular weight of 490 KDa, and FT-IR spectroscopy suggested its potential classification as an α/β-dextran. Furthermore, ultrasonic power was optimized to 500 W through a yield- and activity-guided approach, achieving an enhanced SSPs-UAE-OH yield (32.57 ± 1.57 %) and significantly improved the viability of H9C2 cells (82.33 ± 3.74 %). This study not only established an efficient extraction protocol for SSPs but also elucidated the structural basis of their antioxidant and anti-aging properties in vitro . These findings provide critical insights for developing SSPs-based functional foods.
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