ANALYTICA CHIMICA ACTA
·
2015
·
IF 4.513
Libo Li,Bin Yu,Xueping Zhang,Tianyan You
A novel Ru ( bpy ) 3 2 + -based electrochemiluminescence (ECL) sensing platform, using N-doped carbon nanodots (N–C dots) as co-reactant, was established for the sensitive and selective detection of bisphenol A (BPA). N–C dots not only could enhance the ECL signal, but also significantly improved the reproducibility and stability of Ru ( bpy ) 3 2 + ECL system. The developed ECL sensing system was sensitive to detect BPA based on its efficient quenching effect on Ru ( bpy ) 3 2 + / N − C dots. The N–C dots-enhanced ECL mechanism and BPA-quenched ECL mechanism were investigated. Under the optimum conditions, the inhibited ECL intensity was in good linear relationship versus the concentration of BPA in the range of 0.03–1.0 μM with the detection limit of 10 nM. The relative standard deviation (RSD) for 25 successive measurements with one sensor was 1.1% and for eight different sensors was 2.5%, respectively. The fabricated sensing platform was successfully applied for the detection of BPA in baby bottle and nipple, and relatively satisfactory recoveries were obtained.
研究领域:
分析化学
·
环境科学
·
材料科学
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Xin Zhang,Li Tian,Zhuo Sun,Qian Wu,Xiangyu Shan,Yingjie Zhao,Ruizhan Chen,Juan Lu
A molecular-imprinted electrochemiluminescence sensor for procymidone (PCM) detection was reported based on Ru(bpy) 3 2+ @ZIF-7. A novel self-accelerated Ru(bpy) 3 2+ @ZIF-7 was prepared by one-step synthesis method, which exhibited high electrochemiluminescence (ECL) emission as a coreactant in the presence of tri- n -propylamine (TPrA). Concretely, ZIF-7 was not only the carrier of Ru(bpy) 3 2+ , but also the co-reaction promoter of Ru(bpy) 3 2+ /TPrA ECL system. The introduction of molecular imprint polymer (MIP) with PCM gave new characteristics of specific recognition of analyte PCM. The change value of ECL intensity (ΔI) was proportional to the logarithm of PCM concentration, with a wide linear range and a low detection limit of 1.0 × 10 −10 to 1.0 × 10 −6 mol L −1 and 2.0 × 10 −11 mol L −1 , respectively. The presented MIP-ECL sensor had high sensitivity, selectivity and stability, and had great potential in the field of food safety detection.
研究领域:
分析化学
·
食品安全检测
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DOI
PubMed
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Jing-yi Jiang,Qingyi Li,Wen-chang Wang,Xiao-hui Chen,Zhi-dong Chen
A novel, rapid, and facile electrochemiluminescence sensor which based on carboxylated acetylene black / Ru(bpy) 3 2+ / nafion modified glass carbon electrode (CAB/Ru(bpy) 3 2+ /NAF/GCE) was developed for detecting isoniazid (INH). The CAB/Ru(bpy) 3 2+ /NAF/GCE expresses an efficient electrochemiluminescence response for INH, because of the brilliant luminous efficiency of Ru(bpy)32+ and admirable electronic transmission of acetylene black. The electrochemiluminescence intensity was quenched significantly with addition of INH. Under the optimal conditions, the sensor for the detection of isoniazid exhibits a wide linear range of 1.0 × 10 -6 ~ 1.0 × 10 -3 mol·L -1 with the detection limit of 5.0 × 10 -7 mol·L -1 . The sensor is expected to be a simple and convenient method for the determination of INH in pharmaceutical samples .
研究领域:
分析化学
·
药物分析
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DOI
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 15
·3130
·
IF 4.6
Jun Li,Jianlan Deng,Qian Tao,Chenyu Yan,Yuxuan Liu,Jianxiao Yang,Zhong Cao
Luminescent metal–organic frameworks (MOFs) are used for the detection of organophosphorus pesticides (OPs) due to their large surface area and pore volume as well as their special optical properties. However, most self-luminescent MOFs are not only complex to synthesize and unstable in water but also feature a “turn-off” sensing system, which has highly restricted their practical applications in OP detection. Herein, a “turn-on” fluorescence sensor based on the guest-induced luminescence MOF Ru(bpy)32+@UiO-66 was constructed, which realized the sensitive detection of OPs through a dual-enzyme system for the first time. Compared with self-luminescent MOFs, Ru(bpy)32+@UiO-66 was not only more easily synthesized but also had higher chemical and photostability in water. In this strategy, by means of the hydrolysis of AChE and ChOx, H2O2will be produced, which can oxidize Fe2+to Fe3+, thereby quenching the fluorescence of Ru(bpy)32+@UiO-66. In the presence of OPs, the activity of AChE can be inhibited, resulting in the inability to generate H2O2and Fe3+, which will turn on the fluorescence signal of Ru(bpy)32+@UiO-66. As a result, the Ru(bpy)32+@UiO-66 sensing system not only had high sensitivity for OPs detection but also possessed a satisfactory detection recovery rate for parathion-methyl in real samples, which provides a new approach for OP detection in food safety as well as environmental monitoring.
研究领域:
分析化学
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材料科学
·
环境科学
·
生物化学
·
食品科学
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 9.8
Ruidan Li,Li Tian,Yujia Song,Yanjia Guo,Guangping Ma,Pengfei Han,Hanyue Jiang,Wenzhuo Wang,Tengying Ma
In this paper, a dual-mode electrochemiluminescence-electrochemical (ECL-EC) sensor was constructed using Ru(bpy) 3 2+ @Ti 3 CN and Zn 4 Sn 3 O 5 via multi-step amplification strategy for the detection of sodium saccharin (SS). The maximum ECL/EC initial signals were obtained by the synergistic action of Ru(bpy) 3 2+ @Ti 3 CN and Zn 4 Sn 3 O 5 in the tri-n-propylamine (TPrA) solution. Given that SS reacted with Ru(bpy) 3 2+ , the ECL/EC signal values both decreased. The relevant mechanism was investigated. Under the best optimization conditions, the ECL detection exhibited a linear range of 5.0 × 10 −15 to 5.0 × 10 −10 mol·L −1 with a limit of detection (LOD) of 1.67 × 10 −15 mol·L −1 (S/N = 3), while EC detection showed a linear range of 5.0 × 10 −9 to 5.0 × 10 −4 mol·L −1 with the LOD of 1.67 × 10 −9 mol·L −1 (S/N = 3). Satisfactory results were obtained in a variety of actual samples.
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PubMed
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 8
·1-10
·
IF 5.479
Hu Yunxia,Su Luyao,Wang Sui,Guo Zhiyong,Hu Yufang,Xie Hongzhen
A method is described for combined magnetic solid phase microextraction and electrochemiluminescent (ECL) detection of the antibiotic tetracycline. A nanocomposite of type Fe 3 O 4 @SiO 2 @ZnO was used as the sorbent. Tetracycline has a strong affinity for Zn(II) ion and therefore is well extracted by this sorbent. The loaded sorbent can be magnetically removed. The extraction efficiency at a 1.0 μM tetracycline concentration is around 88%. Detection is based on the use of carbon nanodots that were prepared form urea and ethylenediaminetetraacetic acid as raw materials. The electrochemical probe Ru(bpy) 3 2+ was added to generate double ECL when scanning the potential between −3.5 and + 2 V. The two ECL signals decreased with the increase of tetracycline concentration. Under optimized experimental conditions, the ratio of the two signals is linearly related to the logarithm of the tetracycline concentration in the range from 1.0 nM to 0.1 mM, with a 0.47 nM detection limit. The method was successfully applied to the determination of tetracycline in spiked milk. It exhibited good sensitivity, selectivity and accuracy due to ratiometric read-out and prior preconcentration of analyte.
Tetracycline (TC) has a strong affinity for Zn(II) ion and is well extracted by the Fe 3 O 4 @SiO 2 @ZnO nanocomposite. Ru(bpy) 3 2+ can generate double electrochemiluminescence signals based on the use of carbon nanodots (C-dots) as coreactant. The two signals decrease with the increase of tetracycline concentration. [Ru(bpy) 3 2+ ]* stands for excited state Ru(bpy) 2 2+ .
研究领域:
分析化学
·
环境科学
·
药物分析
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Ziying Zhong,Yun Tang,Yanran Chen,Chunfang Wang,Faqiong Zhao,Baizhao Zeng
The widespread use of tetracycline unavoidably causes residue problems, hence its monitor in foods and environment is important. In this work, a simple but sensitive electrochemiluminescence (ECL) sensor is prepared for tetracycline detection. The sensor is constructed using TiO 2 nanoparticle, ZIF-5 loaded Ru(bpy) 3 2+ (Ru@ZIF-5), and molecularly imprinted poly-o-phenylenediamine. The TiO 2 NP acts as a co-reaction accelerator for tri-n-propylamine (TPrA) by producing electrons and holes at a certain potential to promote the production of TPrA . ZIF-5 has a large specific surface area and rich functional groups, thus can well immobilize a large amount of illuminant Ru(bpy) 3 2+ . The electrodeposited molecularly imprinted polymer acts as a recognition element. Due to the synergic effect of different components, the resulting ECL sensor shows a wide linear range of 10 nM–50 μM, high selectivity, low detection limit, and good stability. It can be used for the detection of tetracycline in food and environmental samples.
研究领域:
分析化学
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环境科学
·
食品科学
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DOI
高影响因子
Analytical Methods
·
2018
·Vol. 10
·期 13
·1560-1564
·
IF 2.073
Yang Li,Liu Yang,Zhewei Peng,Chengzhi Huang,Yuanfang Li
In this contribution, an ultra-sensitive electrochemiluminescence (ECL) sensor was proposed for dopamine (DA) detection based on ruthenium(II) complex (tris(2,2-bipyridyl)dichlororuthenium(II) hexahydrate, Ru(bpy)32+) functionalized Zn(II) metal–organic frameworks (Ru-MOFs). The Ru-MOFs, with large internal surface areas and abundant Ru(bpy)32+ encapsulated effectively, could act as a suitable ECL emitter in a DA detection system. The leakage of Ru molecules in the encapsulation system could be effectively prevented, which resulted in stable ECL signals and significantly improved the ECL performance. On the basis of the novel Ru-MOFs as efficient ECL tags, the as-prepared simple and label-free ECL sensor was employed to quantify dopamine, which showed an excellent linear response from 0.1 pM to 10 nM and a detection limit of 0.024 pM. The simple and sensitive strategy might be expanded to other applications in analysis and detection fields based on functional metal–organic frameworks.
研究领域:
分析化学
·
材料科学
·
电化学
·
传感器
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DOI
高影响因子
ELECTROANALYSIS
·
2023
·Vol. 35
·期 9
·e202300052
·
IF 3
Qiaoyu Ding,Xi Bai,Jiali Ju,Jiajun Shi,Guixin Li
A sensitive electrochemiluminescence (ECL) biosensor for the specific DNA sequence of hepatitis C virus (HCV) was developed based on the efficient quenching effect of the ferrocene cluster functionalized gold nanoparticles (Fc@AuNPs) on the ECL of electrodeposited silica@Ru(bpy) 3 2+ -chitosan-graphene oxide nanocomposite (SiO 2 @Ru−CS−GO). Graphene oxide (GO) can accelerate electron transfer rate, thus improving the ECL of Ru(bpy) 3 2+ on electrode surface. The molecular beacons (MB) was fixed to SiO 2 @Ru−CS−GO by glutaraldehyde (GA) using the Schiff reaction between amino groups of chitosan (CS) and MB. The ECL of SiO 2 @Ru−CS−GO was depressed greatly by the Fc@AuNPs labelled at the end of MB, then, a stronger ECL was observed when the distance between Fc@AuNPs and SiO 2 @Ru−CS−GO increased after the hybridization of target DNA with MB. Under optimum conditions, the restored ECL intensity increased linearly with the target DNA concentration in the range of 1.0×10 −16 ∼1.0×10 −10 mol ⋅ L −1 , and the limit of detection (LOD) is 1.4×10 −17 mol ⋅ L −1 . The proposed method exhibits acceptable stability and reproducibility. In general, the constructed HCV biosensor can be used for the sensitive detection of HCV in human serum, suggesting potential application prospects in bioanalysis.
研究领域:
分析化学
·
生物传感器
·
医学检测
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Ruidan Li,Li Tian,Yujia Song,Yanjia Guo,Guangping Ma,Pengfei Han,Hanyue Jiang,Wenzhuo Wang,Juan Lu
A self-supporting material of ZnNi 2 O 2 was synthesized and halloysite nanotubes (HNTs) served as carriers for Ru(bpy) 3 2+ , enhancing stability of the sensor and improving the electrochemiluminescence (ECL) value in this experiment. The ECL sensor for specific recognition of melamine (MEL) was developed based on ZnNi 2 O 2 and Ru(bpy) 3 2+ @HNTs as dual ECL reagents. The maximum initial signal was obtained in the presence of co-reactant tripropylamine (TPrA) through the synergy of ZnNi 2 O 2 and Ru(bpy) 3 2+ @HNTs. A molecularly imprinted polymer (MIP) containing specific recognition sites for MEL was to enable selective recognition, with pyrrole serving as the functional monomer and MEL as the template molecule. The quenching effect was observed as the concentration of MEL increased. Under optimal conditions, the sensor demonstrated the linear correlation between the change of ECL signal and the logarithm of MEL concentration from the range of 1.0 × 10 −12 to 1.0 × 10 −7 mol·L −1 . Satisfactory results were obtained for the detection of MEL in milk powder.
研究领域:
分析化学
·
传感器
·
纳米技术
·
食品安全
·
电化学
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 8
·1-12
·
IF 5.3
Xiao Rui,Wu Di,Liu Chun,Wu Tong,Ma Lingyan,Tan Long,Qi Wenjing
A novel electrochemiluminescence (ECL) enhanced method for sensitive, selective and accurate ECL detection of ascorbic acid (AA) is developed using tris (2,2′-bipyridine) ruthenium (II) (Ru(bpy) 3 2+ ) embedded into zirconium-based metal-organic frameworks (Ru(bpy) 3 2+ @UiO-67 MOFs). AA is oxidized by cerium ion (Ce 4+ ) into dehydroascorbic acid (DHA) and hydrolyzed into 2,3-diketogulonic acid (DKG). The oxidation product DKG has α-keto acid structure and can form acyl radical, which enhances the ECL of Ru(bpy) 3 2+ @UiO-67 MOFs nearly 220 times. Therefore, AA is used as an efficient ECL co-reactant of Ru(bpy) 3 2+ @UiO-67 MOFs and applied in highly sensitive ECL enhanced detection of AA from 0.1 μM to 100 μM with a limit of detection of 29 nM. More importantly, this method also has high selectivity in AA detection toward other common ions, substances with similar structure to AA and some reducing substances owing to specific α-keto acid structure of the oxidation product DKG of AA. It achieves ECL enhanced detection of AA in tablets, chewable tablets and beverages. Graphical
研究领域:
分析化学
·
生物传感器
·
药物分析
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产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2026
·
IF 5.8
Weiwei Zhang,Dongqin Ye,Jingcheng Zheng,Yuwu Chi
Determination of the solvent polarity is important across various scientific and industrial fields. Classic empirical parameters for evaluating solvent polarity, such as Rohrschneider–Snyder parameters (P′), Reichardt’s ET(30), Kamlet–Taft parameters, dielectric constant (ε) measurement, and Hansen solubility parameters (HSPs) often suffer from complicated instrumentation and measurement operation, which seriously limits their applications in real-time and fast determination and selection of unknown solvent polarity. In this work, we utilize recently emerging perovskite quantum dots (PQDs) with extremely high fluorescence quantum yield, high sensitivity to solvent polarity, and facile preparation and surface engineering to to develop a visualized and disposable solvent polarity sensor based on dual-fluorescent PQDs@SiO2/Ru(bpy)32+@SiO2 (PQDs@SiO2/Ru(II)@SiO2) nanocomposites. Among the nanocomposites, the components of PQDs@SiO2 are stable in nonpolar solvents but not stable in polar solvents due to degradation. Meanwhile, the component Ru(bpy)32+ is stable in both polar and nonpolar solvents, giving a constant red background fluorescence. Therefore, when inserting the glass slide loaded with PQDs@SiO2/Ru(II)@SiO2 nanocomposites into a nonpolar solvent, it retainss green light emission since the fluorescence quantum yield of PQDs is much larger than that of Ru(bpy)32+. In contrast, when the glass slide contacts with polar solvents, its fluorescence color will change from green to yellow, then orange, and finally to red due to the instability of PQDs in this case. The complete color change time from initial green to final red (tccc) was proposed as a new type of solvent polarity parameter. This work not only provides an empirical parameter for evaluating solvent polarity but also opens up an avenue for detecting solvent polarity using functional nanomaterial.
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高影响因子
危险品化学品经营许可证（带存储）