Small
·
2025
·
IF 12.1
Jing Yang,Ruishu Xu,Haiyan Li,Hongwen Tao,Houen Zou,Wenjun Zeng,Haowen Huang
Gold nanoclusters (AuNCs) exhibit unique physicochemical properties but their functional transitions under external stimuli remain underexplored. This study reveals that ultraviolet (UV) irradiation triggers structural evolution in AuNCs, causing fluorescence loss while activating dual enzyme-mimetic activities. UV-induced particle enlargement and surface restructuring endow AuNCs with peroxidase-like (POD-like) and laccase-like functionalities. The POD-like activity enables sensitive glucose detection in human serum, while the laccase-like capability facilitates simultaneous detection and degradation of phenolic pollutants in wastewater. These light-responsive transformations demonstrate AuNCs' dynamic adaptability, bridging their intrinsic fluorescence and catalytic properties. The findings elucidate photo-regulation mechanisms in nanomaterial functionality, proposing a novel strategy for designing multifunctional nanosystems applicable in biosensing and environmental remediation. This work advances the development of adaptive nanomaterials with programmable features for biomedical and ecological applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Zhaoyu Wu,Xiaoyu Wu,Xiangtian Meng,Jiahao Lei,Chenlin Zeng,Hongji Pu,Yijun Liu,Zhijue Xu,Xiaodong Wu,Sheng Huang,Jinbao Qin,Jianqiang Liu,Xinwu Lu,Bo Li
Abdominal aortic aneurysm (AAA) is a chronic inflammation-driven disease characterized by aortic wall destruction and expansion, leading to high morbidity and mortality. However, previous drug treatments for its common risk factors have not achieved favorable results, and the early prevention and treatment is still the main clinical dilemma. Anti-inflammation therapy is a promising therapeutical method targeting its pathogenesis mechanism, but it has not been explored in depth. Herein, interleukin-1 receptor antagonist-loaded manganese-doped mesoporous silica nanoparticles (IL-1Ra@MMSN) were designed and synthesized to target macrophage-mediated chronic aortic inflammation for AAA treatment. IL-1Ra@MMSN showed high IL-1Ra-loading efficiency, great stability and pH-responsive drug-releasing property. IL-1Ra@MMSN specially phagocytosed by macrophages can protect against oxidative stress injury and promoted the M2 polarization via transforming growth factor-β (TGF-β) signaling in vitro . Furthermore, IL-1Ra@MMSN exhibited good lesion targeting ability, hemocompatibility and biocompatibility in angiotensin II-induced murine AAA model. In vivo experiments also confirmed the excellent treatment efficacy in reducing AAA formation and progression via protecting aortic wall integrity and promoting anti-inflammatory microenvironment. Taken together, the current study demonstrated that IL-1Ra@MMSN is a promising nanoplatform for early intervention of AAA, which provides a novel treatment strategy based on anti-inflammatory immune regulation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Si Yang,Jiao Yueyue,Wang Maolin,Xiang Shengling,Diao Jiangyong,Chen Xiaowen,Chen Jiawei,Wang Yue,Xiao Dequan,Wen Xiaodong,Wang Ning,Ma Ding,Liu Hongyang
For di-nitroaromatics hydrogenation, it is a challenge to achieve the multi-step hydrogenation with high activity and selectivity due to the complexity of the process involving two nitro groups. Consequently, many precious metal catalysts suffer from low activity for this multi-step hydrogenation reaction. Herein, we employ a fully exposed Pt clusters catalyst consisting of an average of four Pt atoms on nanodiamond@graphene (Pt n /ND@G), demonstrating excellent catalytic performance for the multi-step hydrogenation of 2,4-dinitrotoluene. The TOF (40647 h −1 ) of Pt n /ND@G is significantly superior to that of single Pt atoms catalyst, Pt nanoparticles catalyst, and even all the known catalysts. Density functional theory calculations and absorption experiments reveal that the synergetic interaction between the multiple active sites of Pt n /ND@G facilitate the co-adsorption/activation of reactants and H 2 , as well as the desorption of intermediates/products, which is the key for the higher catalytic activity than single Pt atoms catalyst and Pt nanoparticles catalyst.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2024
·
IF 13
Weijin Yang,Cheng Bu,Min Zhao,Yafei Li,Shihai Cui,Jing Yang,Hongzhen Lian
In this work, novel ternary composite ZIF-67/Ag NPs/NaYF 4 :Yb,Er is synthesized by solvothermal method. The photocatalytic activity of the composite is evaluated by sulfadiazine (SDZ) degradation under simulated sunlight. High elimination efficiency of the composite is 95.4% in 180 min with good reusability and stability. The active species (h + , ·O 2 − and ·OH) are identified. The attack sites and degradation process of SDZ are deeply investigated based on theoretical calculation and liquid chromatography-mass spectrometry analysis. The upconversion mechanism study shows that favorable photocatalytic effectiveness is attributed to the full utilization of sunlight through the energy transfer upconversion process and fluorescence resonance energy transfer. Additionally, the composite is endowed with outstanding light-absorbing qualities and effective photogenerated electron–hole pair separation thanks to the localized surface plasmon resonance effect of Ag nanoparticles. This work can motivate further design of novel photocatalysts with upconversion luminescence performance, which are applied to the removal of sulphonamide antibiotics in the environment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Zhang Li,Jie Fu
The induced-formation of natural nanoparticles by photosensitive chemicals in aquatic environment may be a ubiquitous process, however, we still know very little on this issue. Here, we reported a potential original pathway for naturally-occurring gold nanoparticles (N-AuNPs) via the reduction of Au ions by photosensitive surfactant Tween 80/85 under light irradiation in the aquatic environment. The heterolytic reaction of hydroxyl groups in Tween 80/85 with the aid of UV light yielded radical anions (Tween 80/85-O •− ) and subsequently transferred electrons to oxygen to generate superoxide radicals (O 2 •− ), which reduced Au(III) to Au(0). The negatively charged Tween 80/85-O •− could bind to the surface of Au with coordinate bonds to form the surface coating of N-AuNPs. Due to the enhanced negative charge density, the Tween 80/85-induced N-AuNPs showed a higher colloidal stability than other N-AuNPs (induced by humic acid) or engineered AuNPs (E-AuNPs). The surface coating of Tween 80/85 might hinder the attachment and internalization of N-AuNPs into bacterial cells, and bacteria could also extend the utilization range of carbon sources substrates to mitigate the adverse effects of N-AuNPs. Therefore, Tween 80/85-induced N-AuNPs exhibited relative lower ecotoxicity but could stay in water for long periods of time. This study makes us more aware of the role of anthropogenic organic pollutants in the geochemical process of metal elements.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Yangbo Song,Xiaoli Ren,Lili Zhao,Biying Zhang,Wei Chi,Yanlin Liu,Kan Shi,Shuwen Liu
Raspberries are known to contain valuable metabolites and possess a robust antioxidant capacity. However, the impact of different tablet processing stages on the nutritional content and flavor profile of raspberries remains unclear. The dynamic profile of functional and volatile metabolites was investigated through foodomics combined with UPLC-MS/MS-based widely targeted metabolomics and HS-SPME-GC–MS, and antioxidant capacities were assessed during tablet processing. 1336 functional metabolites and 645 volatile metabolites were identified. Results indicated tablets retained 34% ∼ 61% of the total volatile contents. In addition, the conversion intensity of functional metabolites was consistent with the order of “Tableting > Freeze-drying > Crushing”. Compared to raspberry, tablets showed higher antioxidant activity, which was positively correlated with vitamin contents. This study elucidated that tablet formation demonstrated advantages in antioxidation and aroma retention, which may provide insights for enhancing quality during the tableting process.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2024
·
IF 4.5
Chuanmin Zhang,Jingli Wang,Mengyue Fan,Lei Han,Bolian Xiao,Xiaoli Xie,Yao Fu,Yongqing Zhai,Chao Wang,Ning Zhang,Zhilong Xu,Lijuan Wang
Although pirarubicin (THP) was widely used for treatment of lymphoma, systemic toxicity especially cardiotoxicity, still limits its application in cancer therapy. This project designed a new folate functionalized drug delivery system (5%FA-THP-NP) containing poly (2-ethyl-2-oxazoline)-distearoyl phosphatidyl ethanolamine (PEOz 2000 -DSPE) and DOTAP for targeted delivery and controlled release of pirarubicin (THP), thus offering a strategy for overcoming the dose-limiting toxicity by facilitating the efficient accumulation of THP in cancer cells and achieving superior anti-lymphoma efficacy. The obtained 5%FA-THP-NP showed an anticipated THP drug loading (DL) reaching 27.39 %, had outstanding storage stability, excellent hemocompatibility and presented a pH-responsive drug release performance, achieving a cumulative release of 80.54 % due to their disassembly under acidic stimulation (pH 5.5). Studies on Raji lymphoma cells in vitro showed that 5%FA-THP-NP had significant advantages compared to controls, with the highest cell uptake and strongest apoptosis . More importantly, targeted delivery and controlled release of THP with 5%FA-THP-NP exhibited higher anti-lymphoma effect and lower toxicity to normal cells than Free THP. In addition, systemic injection of 5%FA-THP-NP into tumor bearing mice not only showed excellent anti-tumor activities with the tumor inhibition ratio up to 85 % via more efficient downregulation of H3K18la and H3K9la than Free THP, but also efficiently reduced the systemic toxicity of THP by encapsulation of THP in the nanoparticles. In conclusion, the targeting nanoparticulate system developed in the current study shows potency as an alternative platform for effectively delivering chemotherapeutic agents to enhance therapeutic efficacy against lymphoma and decrease the systemic toxicity of THP.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Xiaoxiao Chen,Feng Zhang,Chenying Lu,Ronghua Wu,Baozhu Yang,Tingting Liao,Baojie Du,Fazong Wu,Jiayi Ding,Shiji Fang,Zhongwei Zhao,Minjiang Chen,Gaofeng Shu,Weiqian Chen,Jiansong Ji
Treatment for hepatocellular carcinoma (HCC) may be improved with ferroptosis, a regulated form of cell death. However, the sensitivity of HCC to ferroptosis was strongly limited by lactic acid. In this study, a platelet membrane (PM)-engineered nanoparticle loaded with erastin, superparamagnetic iron oxide nanoparticles (SPIO) and lactate oxidase (LOX) (termed PM@ESL NPs) was designed for magnetic resonance imaging (MRI)-guided enhanced ferroptosis-immunotherapy of HCC. It was found that PM@ESL NPs could actively accumulate into the tumor due to the tumor-homing ability of PM. Subsequently, PM@ESL NPs could effectively enhance the sensitivity of HCC to ferroptosis by removing the lactic acid in the tumor. The removal of lactic acid also produces hydrogen peroxide (H2O2), which therefore converted into the cytotoxic hydroxyl radicals by the reaction of H2O2 with Fe2+/Fe3+ released from SPIO. Due to the combined ferroptosis and chemodynamic therapy (CDT), PM@ESL NPS showed a strong ability to induce immunogenic cell death (ICD), which could effectively suppress the growth and metastasis of HCC when combined with αPD-L1 immunotherapy. Furthermore, the incorporation of SPIO endows PM@ESL NPs with an outstanding MRI-T2 monitoring capability for HCC treatment. In conclusion, this study introduces a pioneering MRI-guided approach that enhances ferroptosis in tumors and synergistically improves immunotherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Xingkang Diao,GuoHua Qi,Xinli Li,Yu Tian,Jing Li,Yongdong Jin
Cell cycle analysis is crucial for disease diagnosis and treatment, especially for investigating cell heterogeneity and regulating cell behaviors. Exosomes are highly appealing as noninvasive biomarkers for monitoring real-time changes in the cell cycle due to their abundant molecular information inherited from their metrocyte cells and reflecting the state of these cells to some extent. However, to our knowledge, the relationship between exosomes and the cell cycle has not been reported. Herein, we successfully monitored the variation of exosomal surface-enhanced Raman spectroscopy (SERS) spectra to discriminate different cell cycle stages (G0/G1, S, and G2/M phases) based on label-free surface-enhanced Raman spectroscopy (SERS) combined with the machine learning method of linear discriminant analysis (LDA). An average accuracy of 85% based on the trained SERS spectra of exosomes from different cell cycle stages confirmed the high reliability of the support vector machine (SVM) algorithm for analyzing dynamic changes in the cell cycle at different time points. Importantly, the related molecular mechanisms among mitotic processes (prometaphase, metaphase, and anaphase/telophase) and unique biomolecular events between cancerous (HeLa) and normal (H8) cells were also revealed by the present label-free SERS detection platform. Based on SERS analysis, the content of phenylalanine (Phe) within HeLa cells increased, and some structures of proteins containing Phe and tryptophan (Trp) residues may be transformed during the mitotic process. Notably, the α-helix and β-sheet of proteins coexisted in HeLa cells; meanwhile, the α-helix of the proteins was more dominant in H8 cells than in HeLa cells. The strategy is effective for discriminating cell cycle stages and elucidating the associated molecular events during the cell mitotic process and will provide potential application value for guiding the cell cycle treatment strategies of cancer in the future.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Jihui Yao,Lijuan Su,Lipeng Guo,Xing Wu,Haibo Zhu
N -ethylcarbazole, as a liquid organic hydrogen carrier, has shown great promise in the field of hydrogen storage technology. The development of efficient and stable catalyst for producing H 2 through N -ethylcarbazole dehydrogenation is crucial for its practical application. In this study, a series of mesoporous Al 2 O 3 -supported Pt catalysts with K modification were developed for N -ethylcarbazole dehydrogenation. These catalysts were characterization using various techniques including XRD, N 2 adsorption–desorption, TEM, 27 Al MAS NMR, XPS, NH 3 -TPD, H 2 -TPR, CO-FTIR, and Py-IR, providing detailed structural information to elucidate the structure–activity relationship. Mesoporous Al 2 O 3 was found to possess significant amounts of coordinatively unsaturated pentacoordinate Al 3+ , which greatly promotes the dispersion of Pt species for the formation of small Pt particles. The addition of K was observed to modulate the electronic structure of Pt, reduce the acidity of the catalysts, and inhibit the sintering of Pt. These synergetic effects led to Pt 3.0 /K 3.0 -Al 2 O 3 -m achieving remarkable performance in dodecahydro- N -ethylcarbazole dehydrogenation at 180 °C and 101 kPa, delivering a dodecahydro- N -ethylcarbazole conversion of 100 %, H 2 release amount of 5.63 wt% and dehydrogenation efficiency of 97.10 %. Additionally, this catalyst demonstrated high efficiency in the dehydrogenation of dodecahydro- N -propylcarbazole, octahydro-2-methylindole, and octahydro-1,2-dimethylindole, achieving dehydrogenation efficiencies of 99.60 %, 100 % and 100 %, respectively. These findings provide valuable knowledge for the rational design of efficient metal-based catalysts for liquid organic hydrogen carriers in hydrogen storage systems.
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2024
·
IF 4.2
Han Sun,Xu Pang,Jian-Rui Li,Hu Li,Mei Tang,Tao Zhang,Li-Yan Yu,Zong-Gen Peng
Abnormal cell adhesion between leukocytes and endothelial cells is closely associated with the development of numerous inflammation-related diseases, with adhesion molecules playing a crucial role. The disruption of cell adhesion directly or indirectly inhibits excessive cell adhesion and thus produces a therapeutic effect. However, there are only a few clinically available antagonists of cell adhesion. One of the biggest challenges is the development of novel and efficient cell adhesion inhibitors. Recently, the anti-inflammatory pharmacological activity of natural products of microbial origin has also received increasing attention. Here, we obtained a potential cell adhesion inhibitor isoechinulin B, an indole diketopiperazine derivative, from the Antarctic fungus Aspergillus sp. CPCC 401072, which is active against cell adhesion. Isoechinulin B decreased the expression of vascular endothelial adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) by inhibiting the activation of the NF-κB signaling pathway, thereby inhibiting cell adhesion between leukocytes and endothelial cells to reduce macrophage infiltration in the liver and significantly attenuate lipopolysaccharide-induced acute liver injury in mice. Conclusion Isoechinulin B is a novel cell adhesion inhibitor derived from fungi found in extreme environments.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Ning Liu,Jie Wang,Huiyu Yang,Fan Cheng,Shuguang Bi,Guoliang Liu,Ying Ou,Hai Liu,Chunli Gong
In order to improve the proton conductivity, CH 3 OH barrier performance and long-term durability of proton exchange membranes in direct methanol fuel cells (DMFCs), herein, a novel functional nanofiber substrate (IL-ZIF-8@PVDF) was prepared by in situ growing metal-organic framework (ZIF-8) on poly(vinylidene fluoride) (PVDF) nanofibers, followed by modification with ionic liquid (IL) containing sulfonic acid groups. PVDF nanofibers can provide flexible mechanical support for ZIF-8, thereby effectively solving the processing difficulties of ZIF-8 caused by its brittleness. Further IL modification of ZIF-8 can not only increase the compatibility between ZIF-8@PVDF and the filling polymer, but also utilize the continuous PVDF nanofiber network to establish long-distance continuous H + transport pathways within the membrane. The as-prepared sulfonated poly (ether ether ketone) impregnated IL-ZIF-8@PVDF composite membrane showed a very high proton conductivity of 161.92 mS cm −1 (80 °C). Meanwhile, the presence of nanofiber backbone and ZIF-8 inside the membrane effectively limited the swelling and methanol permeation. The peak power density (PPD) of the DMFC output equipped with the membrane is up to 114.86 mW cm −2 (2 M methanol, 80 °C), 1.28 times that of the commercial Nafion 211. The durability test suggested that the composite membrane assembled DMFC possessed excellent open circuit voltage stability (only 6.3 % attenuation after 320 h of continuous testing). This work provides a new design idea for PEMs for DMFCs.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）