Energy Storage Materials
·
2024
·
IF 18.9
Yifan Zhang,Xiaoyou Wang,Shuihong Zhu,Lei Wang,Jungang Jiang,Junli Chen,XiangYang Liu
Advancements in protein structural engineering have made it possible to design protein materials that can mediate between humans and intelligent systems, manifesting a combination of characteristics such as elastic recovery, electrical conductivity, and stability. This work describes the design of a hydrogel using bovine serum albumin (BSA), based on protein-protein interactions and sulfhydryl-alkene click reactions. The multiple α-helices of BSA were intertwined together by the multi-armed olefin derivatives, acting like Lego blocks to form a gel network and locking in bound water and ions, thus imparting mechanical recovery characteristics (demonstrating 80 % recovery after the compressive strain and 638 % after tensile strain), electrical conductivity, resistance to freezing (maintaining mechanical properties after being frozen at -20 °C for 48 h), biocompatibility (the cell viability of mouse pre-osteoblast-like cells in the hydrogels was 97.5 %), antimicrobial properties, and biodegradability to the BSA hydrogels. A multi-channel wireless signal acquisition system based on BSA hydrogel devices designed for bioenergy conversion and harvesting was developed for the real-time detection of human motion along with a human-mechanics interaction system for manipulating robotic gestures with simple human finger movements. This restructuring of the BSA structure represents a significant advancement in the systematic exploration of protein structures and the development of protein materials. These applications serve as a secure bridge between humans and energy storage devices.
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Biosensors-Basel
·
2025
·Vol. 15
·期 1
·52
·
IF 5.6
Qi Yuan,Yunqing Wang
High-sensitivity and repeatable detection of hydrophobic molecules through the surface-enhanced Raman scattering (SERS) technique is a tough challenge because of their weak adsorption and non-uniform distribution on SERS substrates. In this research, we present a simple self-assembly protocol for monolayer SERS mediated by 6-deoxy-6-thio-β-cyclodextrin (β-CD-SH). This protocol allows for the rapid assembly of a compact silver nanoparticle (Ag NP) monolayer at the oil/water interface within 40 s, while entrapping analyte molecules within hotspots. The proposed method shows general applicability for detecting hydrophobic molecules, exemplified as Nile blue, Nile red, fluconazole, carbendazim, benz[a]anthracene, and bisphenol A. The detection limits range from 10−6to 10−9M, and the relative standard deviations (RSDs) of signal intensity are less than 10%. Moreover, this method was used to investigate the release behaviors of a hydrophobic pollutant (Nile blue) adsorbed on the nanoplastic surface in the water environment. The results suggest that elevated temperatures, increased salinities, and the coexistence of fulvic acid promote the release of Nile blue. This simple and fast protocol overcomes the difficulties related to hotspot accessibility and detection repeatability for hydrophobic analytes, holding out extensive application prospects in environmental monitoring and chemical analysis.
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OPTICAL MATERIALS
·
2025
·
IF 4.2
Bing Xu,Liu Yang,Yan Li,Chunyu Cao
A Spermine Oxidase (SMOX)detection local surface plasmon resonance/surface plasmon resonance (SPR/LSPR) optical fiber sensor was constructed with a three-layer structure consisting of gold film/gold nanospheres (AuNPs)/SMOX-antibody in this study. The detection of SMOX was achieved through the specific binding of immobilized antibodies to free antigens in a buffer solution. The AuNPs were immobilized on Gold Film by 1,6-Hexanedithiol (DMH) linker to enhance the sensitivity of optical fiber probe from 1821.21 to 2204.97nm/RIU. The Zeta potential and Fourier Transform Infrared Spectroscopy (FTIR) indicated that the SMOX antibody was attached to the surface of the optical fiber probe by physisorption to construct a SMOX sensor. The SMOX-detection experimental data conformed to the Langmuir model with an R 2 value of 0.92, a lower limit of detection of 0.625μg/ml and exhibited excellent selectivity, high stability, and a rapid response time of 12 min. This method provides a new concept for SMOX detection and has a broad application prospect in the field of biomedical diagnosis.
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ChemSusChem
·
2024
·
IF 7.5
Borong Liao,Junhao Gao,Pei Weng,Linya He,Yusheng Zhang,Qiuhua Liu,Zaichun Zhou
Graphical A semiconductor effect from 4d x 2 − y 2 (Pd) to a 2u (π) orbitals in Pd(II) porphyrin was discovered and a domino relationship from ring distortion, core deformation, band gap variation to photocatalytic activity was established and confirmed. In this work, four saddled Pd(II) porphyrins were developed as photocatalyst for N-dealkylation of triethyl Rhodamine (TER) under visible light, and their catalytic ability was found to be negatively related to the out-of-plane of their macrocycles. Two important relationships involving the metalloporphyrins as catalyst were revealed: (1) a photoexcitative semiconductor effect between the 4d x 2 − γ 2 (Pd) and a 2u (π) orbitals of Pd(II) porphyrin on the dealkylation. (2) a domino process from strap length, ring geometry, core deformation, d-π gap variation, to photocatalytic activity. Two revelations imply a unidirectional electron transfer route from axial ligand, to central metal, to porphyrin ring based on photoexcitation and guide the design and development of complex photocatalysts, and their revelation is attributed to the acquisition of a series of Pd(II) porphyrins with continuous ring distortion. The findings help to understand the photocatalytic single electron transfer (SET)-first mechanism based on metallic complex.
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BIOMEDICINE & PHARMACOTHERAPY
·
2024
·
IF 6.9
Xianquan Feng,Lingjun Zeng,Lina Wu,Zhenzhen Chen,Wanjing Lin,Hongtao Song,Fenghua Lan
Immunotherapy has captured attention for its high clinical efficacy. However, its efficacy is limited by inadequate immune activation. Therefore, a platform to activate the immune system and amplify the host's immune response against tumors is urgently needed. Herein, a self-delivery photodynamic nanodrug (VAC@HSA) is reported as inducing immunogenic cell death (ICD), promoting the recruitment of dendritic cells (DCs), and normalizing tumor blood vessels. Firstly, verteporfin with laser assistance releases tumor-associated antigen to induce ICD, while celecoxib downregulates prostaglandin E2 and releases CCL5 to activate DC recruitment. Moreover, vasculature is normalized through axitinib, which contributes to reducing tumor hypoxia and reversing the immunosuppressive effects of vascular endothelial growth factor. This joint action promotes the infiltration of immune effector cells into the tumor. Therefore, the amplified photodynamic nanodrug with excellent biocompatibility effectively inhibits tumor growth and lung metastasis and produces a cascade of immune responses. Our study demonstrates a practically innovative strategy for activating cancer immunotherapy, which can alter the "cold" properties of tumors.
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ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Ruyi Lin,Jia Yan,Bokai Gong,Fan Tong,Yujun Song,Xue Xia,Haili Hu,Yufan Wang,Yang Zhou,Tao Gong,Maxim Shevtsov,Huile Gao
Homogeneous distribution and adequate accumulation of photosensitizer in tumor are essential for effective photodynamic therapy (PDT). However, the intricate tumor microenvironment (TME) often poses great challenges to the deep penetration and retention of therapeutic agents in tumor. Moreover, the important effect of PDT to induce specific antitumor immune response is impeded by multiple immunosuppressive mechanisms within TME. Confronting these issues, here a rationally designed nanosystem (SUN-NPA) with acid-responsive sphere-to-fiber transformation ability by leveraging the characters of drug molecules is proposed to achieve self-delivery of photosensitizer Chlorin e6 (Ce6) and two small-molecule immunomodulators, metformin (MET) and sunitinib (SUN). The spatiotemporal controlled transformation enables homogeneous distribution and high accumulation of drugs to achieve enduring PDT and complete tumor elimination. Meanwhile, the co-delivered MET and SUN alleviate tumor immunosuppression from multiple aspects, effectively synergizing with PDT to ignite potent host immune response and long-lasting immunological memory against tumor cells. The artful integration of enhanced PDT and activated antitumor immunity realized by SUN-NPA leads to the significant inhibition of tumor growth and metastasis, exhibiting great potential for oncotherapy.
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JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Yiying Sun,Huaimin Wang,Meng Shuang,Chenying Zhou,Yiming Sun,Heng Zhang,Yang Liu,Peng Zhou,Bo Lai
Coupling extra electron supply with iron-mediated advanced oxidation processes (AOPs) is an efficient strategy for long-lasting oxidation of organic contaminants in environmental remediation. Many subsequent attempts have been made, such as homogeneous catalysts and metal catalysts, of which secondary organic pollution and surface passivation layers limit their application. In this work, metal borides as co-catalysts can efficiently accelerate the Fenton reaction by firmly sacrificing electrons to Fe(III) reduction. Among multiple metallic borides, vanadium boride (VB 2 ) performs superiorly as dual active sites to solve the Fe(III) cycle dilemma and quickly generate hydroxyl radicals via Fenton reaction for almost completely eliminating almost carbamazepine (CBZ) in VB 2 /Fe(III)/H 2 O 2 . Characterization analysis and the density functional theory (DFT) calculation unveil that the synergistic effect of V and B on the surface of VB 2 makes Fe-O bonds of FeOH 2+ weaker (from 173.8 pm to 178.4 pm) to produce more active Fe(III) species. And meanwhile, active Fe(III) can be rapidly reduced into Fe(II) on the surface of VB 2 and then be completely released into solution for subsequent Fenton reaction and hydroxyl radical generation. More importantly, VB 2 performs steadily and efficiently for 7th consecutive test in VB 2 /Fe(III)/H 2 O 2 to degrade more than 95% CBZ, resulting from the self-cleaning surface of VB 2 to expose reactive regions for persistent electron sacrifice and sustainably stimulative Fenton oxidation. Therefore, this research offers the detailed fundamental perception into the genesis of VB 2 as well as a novel electron donor for boosting Fenton oxidation towards water remediation.
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ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Lihua Li,Qianru Su,Ke Xu,Li Ren,Qiuhan Zhao,Qiushuang Wu,Junfang Xia,Xin Lü,Li Wang
Surfactants are extensively utilized in food, pharmaceutical, and industrial fields owing to their distinct interfacial properties. Nonetheless, their defects of poor biocompatibility and biodegradability impose a significant burden on the natural environment and on human health. Herein, we design cinnamic acid-functionalized chitosan (CC) as a biobased surfactant by substituting certain hydrophilic amino groups in chitosan molecular chains with the hydrophobic benzene rings of cinnamic acid. CC, exhibiting a surface contact angle close to 90°, demonstrates exceptional emulsification capabilities. Molecular simulations suggest that there is substantial interaction energy between CC and water, oil, and CC molecules. CC can be self-assembled into a gel network or stably distributed at the oil–water interface based on the interaction of polar groups with water and between hydrophobic groups with oil. Leveraging these interfacial characteristics, CC can be employed in the preparation of high internal phase emulsions (HIPEs), cell scaffolds with adjustable pore sizes, and aerogels for oil–water separation and dye adsorption. Notably, HIPEs loaded with curcumin and quercetin exhibit robust stability in gastric juice, intestinal targeted release, noncytotoxicity, and resistance to bacterial and mold growth even after 90 days. This work provides some references for the development of new biobased surfactants.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yi-Fei Xue,Xiaojie Song,Xiao-Qing Ling,Qi-Yan Lv,Yu Xia,Hui-Fang Cui
Nanoassemblies based on drug conjugates with high drug loading efficiency and stability have been regarded as promising candidates for the next generation of drug formulations. However, they are mostly amphiphilic. Here, a dual-hydrophobic drug conjugate-based nanoassembly has been created for enhanced synergistic antiproliferation against colorectal cancer cells. Camptothecin (CPT) and doxorubicin (DOX) were chosen as the hydrophobic drugs and covalently linked with a disulfide bond (-ss-). The synthesized CPT-ss-DOX can self-assemble into nanocubes (NCs) in an aqueous solution with the assistance of a small amount of polyethylene glycol (PEG), named PEGylated CPT-ss-DOX NCs. The PEGylated CPT-ss-DOX NCs were approximately 111.8 nm, possessing a crystal structure and a very low critical aggregation concentration (8.36 μg·mL–1). The self-assembly mechanism was studied using molecular docking and molecular dynamic simulation methods. The NCs demonstrated excellent storage stability and improved water solubility of CPT and DOX. These NCs could be taken up by cancer cells and gradually release the drugs. In addition, they had higher toxicity to cancer cells than a mixture of CPT and DOX, while they displayed reduced toxicity to normal cells. Due to assembly and PEG modification, the NCs improved drug retention time and enhanced accumulation at the tumor site. More importantly, they significantly inhibited colorectal tumor growth (58.37%) in vivo, superior to the CPT+DOX mix (42.63%). Moreover, the NCs reduced the cardiac toxicity of free drugs. Therefore, the prepared PEGylated CPT-ss-DOX NCs hold great potential for clinical transformation and provide a novel method for the self-delivery of hydrophobic molecules in cancer therapy.
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Advanced Composites and Hybrid Materials
·
2024
·Vol. 7
·期 6
·1-18
·
IF 23.2
Zhao Kui,Qi Luming,Li Qi,Wang Yin,Qian Cheng,Shi Zhengjun
Biocompatible and mechanically stable porous hydrogels are promising materials for artificial skin in wound healing. The rigid PVA phase was selected to make the scaffold, and a dense and uniform porous phase was formed in both transverse and longitudinal phases by freezing casting technology. The names PVA and PVA + PNS2A were used in in vitro activity tests using polymer solutions that had not been molded before. The crosslinked materials were named Base, CP1 (0.1% PNS2A), and CP2 (0.5% PNS2A). HUVEC and HaCat cell proliferation experiments proved to be safe and non-toxic and significantly promoted proliferation activity after 48 h. The cell model with Raw 264.7 proved anti-inflammatory effect by mixed polymer solution. The scratch test showed that the CP2 promotes the migration of HaCat cells more effectively at 48 h. The cell adhesion experiment showed that the skin-like composite material grew rapidly along the void direction. Animal experiments showed that the multi-layer skin-like CP2 increased the mechanical properties, gelation, and hemostasis (58.8% reduction) and inhibits inflammation through active polysaccharide in the early stage of wound healing. It promoted collagen formation in the late stages of the healing process. Upon contact with the wound, the material undergoes gelation to isolate the wound and completely healed the hurt after 12 days. Stent disintegration and 48-h absorption time provide support for implant material development. Graphical
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Advanced Science
·
2024
·
IF 14.3
Yanchao Liu,Weijiong Dai,Jiajun Zheng,Yanze Du,Quanhua Wang,Niklas Hedin,Bo Qin,Ruifeng Li
Waste plastics bring about increasingly serious environmental challenges, which can be partly addressed by their interconversion into valuable compounds. It is hypothesized that the porosity and acidity of a zeolite-based catalyst will affect the selectivity and effectiveness, enabling a controllable and selective conversion of polyethylene (PE) into gas-diesel or lubricating base oil. A series of embryonic, partial- and well-crystalline zeolites beta with adjustable porosity and acidity are prepared from mesoporous SBA-15. The catalysts and catalytic systems are studied with nuclear magnetic resonance (NMR), X-ray diffraction (XRD), and adsorption kinetics and catalytic reactions. The adjustable porosity and acidity of zeolite-beta-based catalysts achieve a controllable selectivity toward gas-diesel or lubricating base oil for PE cracking. With a catalyst with mesopores and appropriate acid sites, a fast escape and reduced production of cracking of intermediates are observed, leading to a significant fraction (88.7%) of lubricating base oil. With more micropores, a high acid density, and strong acid strength, PE is multiply cracked into low carbon number hydrocarbons. The strong acid center of the zeolite is confirmed to facilitate significantly the activation of hydrogen (H 2 ), and, an in situ ammonia poisoning strategy can significantly inhibit hydrogen transfer and effectively regulate the product distribution.
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FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Xinyi Zha,Jianzhong Jiang
Inorganic salts frequently influence the stability of nanoemulsions, thereby restricting their potential applications. Herein, calcium salt-tolerant nanoemulsions were prepared using a complex of starch sodium octenyl succinate (SSOS) and tannic acid (S-TA). The nanoemulsions stabilized by the S-TA complex demonstrated significant advantages when compared to those stabilized solely by SSOS or by other SSOS complexes. Specifically, the nanoemulsions stabilized by the S-TA complex preserved a slight change in the droplet size 346.24 ± 7.65 nm for over 4 weeks at 2.0 wt% calcium chloride. Furthermore, they exhibited exceptional centrifugal stability at 5000 rpm for 10 min over 5 cycles, as well as notable antioxidant properties. The primary and secondary oxidation products of the nanoemulsions stabilized by the S-TA complex after 14 days were 131.69 μg/mL and 19.34 μg/mL, respectively. Analyses including FT-IR, XRD, and hydrophobicity fluorescence confirmed that non-covalent interactions (such as hydrogen bonding and hydrophobic interactions) endowed the S-TA complex with enhanced interfacial activity and salt resistance. The research improves the salt resistance of starch emulsifiers, offering a strategy for nanoemulsions to maintain stability in environments with inorganic salts, especially calcium salts, thereby broadening their potential applications.
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