CERAMICS INTERNATIONAL
·
2024
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IF 5.1
Hanjiao Yu,Ying Zhang,Syed Mesum Raza Naqvi,Chen Jiao,Jiasen Gu,Youwen Yang,Muhammad Ali Nasir,Zongjun Tian,Lida Shen,Dongsheng Wang,Huixin Liang
Barium titanate (BT) is widely studied in bone repair engineering due to its high dielectric constant, excellent ferroelectric properties, and non-toxic nature. However, one of the research focuses on the preparation of high-precision BT ceramics and enhances their limited mineralization bioactivity. BT is difficult to use for high-precision ceramic molding using Digital Light Processing (DLP) due to its high refractive index and strong ultraviolet absorption. In this manuscript, BT was doped with calcium silicate (CS) which has a refractive index close to photosensitive resin. The printing parameters of the composite ceramic scaffolds were determined to obtain a balance between printing efficiency and accuracy. Experimental results have demonstrated that within a CS doping ratio of up to 20 wt%, the scaffolds simultaneously meet the piezoelectric coefficient and mechanical properties of natural bone. Furthermore, mineralization and cell experiments have shown that the composite scaffold exhibits improved degradation rate, cell activity, and osteoinductivity. Subsequently, bone scaffolds with a doping ratio of 20 wt% were selected, which meet the requirements of natural bone and exhibit significantly enhanced biological activity. Research findings revealed that ceramic scaffolds after piezoelectric stimulation are more conducive to cell proliferation and growth compared to before stimulation.
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ACS Biomaterials Science & Engineering
·
2024
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IF 5.4
Hui Zhang,Yujun Bao,Guanghao Li,Siqi Li,Xiong Zhang,Changhong Guo,Xiaodan Wu,Yingxue Jin
Cancer metastasis and invasion are closely related to tumor cell immunosuppression and intracellular hypoxia. Activation of immunogenicity and intracellular oxygenation are effective strategies for cancer treatment. In this study, multifunctional nanomicelle hyaluronic acid and cinnamaldehyde is self-assembled into nanomicelles (HPCNPs) were constructed for immunotherapy and tumor cell oxygenation. The Schiff base was constructed of HPCNPs with pyropheophorbide a–Cu (PPa–Cu). HPCNPs are concentrated in tumor sites under the guidance of CD44 proteins, and under the stimulation of tumor environment (weakly acidic), the Schiff base is destroyed to release free PPa. HPCNPs with photodynamic therapeutic functions and chemokinetic therapeutic functions produce a large number of reactive oxygen species (1O2 and •OH) under exogenous (laser) and endogenous (H2O2) stimulations, causing cell damage, and then inducing immunogenic cell death (ICD). ICD markers (CRT and ATP) and immunoactivity markers (IL-2 and CD8) were characterized by immunofluorescence. Downregulation of Arg1 protein proved that the tumor microenvironment changed from immunosuppressive type (M2) to antitumor type (M1). The oxidation of glutathione by HPCNP cascades to amplify the concentration of reactive oxygen species. In situ oxygenation by HPCNPs based on a Fenton-like reaction improves the intracellular oxygen level. In vitro and in vivo experiments demonstrated that HPCNPs combined with an immune checkpoint blocker (α-PD-L1) effectively ablated primary tumors, effectively inhibited the growth of distal tumors, and increased the oxygen level in tumor cells.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
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IF 8.5
Yuqun Cai,Huanli Gao,Yifei Qu,Mengya Sun,Maolin Dong,Ziwei Sun,Dan Luo,Huiyang Bian,Hongqi Dai,Tingting Xu
TEMPO-CNF film modified by two-dimension transition metal MXene has certain antibacterial properties. However, the problem of long-lasting stability greatly restricts the feasibility of long-term use of the composite film. Here, we introduced polyaniline (PANI) as a modifying molecule, which was electrostatically adsorbed on the surface of the MXene nanosheets to prevent its self-stacking and delay its oxidation. The modified MXene could still maintain >85 % stability after 30 days of room temperature storage. The MXene-PANI nanocellulose (MXP/CNF) film was further prepared by combining electrostatic attraction and hydrogen bonding interactions. Thanks to the synergistic effects of the photothermal conversion and photodynamic of MXene and PANI themselves, as well as the high light-trapping properties of the heterostructures, the photothermal and photodynamic efficiencies of the MXP/CNF film were greatly improved. Under the irradiation of 808 nm near-infrared light at 1.5 W/cm 2 , the MXP/CNF film reached a temperature of 132.9 °C within 20 s. Meanwhile, reactive oxygen species are generated to degrade 55 % of crystalline violet by modified MXene composite film under light irradiation. Compared to 15 % bacterial survival on cellulose film not modified with PANI, S. aureus and E. coli were completely killed on MXP/CNF film under light conditions. The prepared thin film materials exhibit low cytotoxicity, highlighting their potential applications in biomedicine and desalination.
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Molecular Catalysis
·
2024
·
IF 3.9
Yu Chen,Ming-Yu Qi,Zi-Rong Tang
Integrating selective organic transformation and hydrogen (H 2 ) evolution in one photoredox reaction system is one of the most sustainable and promising approaches to efficiently produce solar fuels and chemicals by simultaneously utilizing photogenerated electrons and holes. Herein, through the cation-exchange engineering method, the nanoleaf-like Pd/CdS composites are gingerly fabricated for visible-light-driven receptor-free dehydrogenation of 1,2,3,4-tetrahydroisoquinoline (THIQ) to 3,4-dihydroisoquinoline (DHIQ) and H 2 under ambient conditions. The optimized electronic structure endows Pd/CdS with a narrow band gap and suitable energy band positions, thus facilitating the light harvesting as well as the separation and transfer of photoexcited charge carriers. Consequently, the Pd/CdS exhibits significantly improved photoredox activity compared to bare CdS . In-situ Fourier-transform infrared spectroscopy and electron paramagnetic resonance spectroscopy track the progression of reaction intermediates during such a dual-functional photoredox-catalyzed system, revealing that the carbon-centered radical is the key reaction intermediate in this reaction process. It is anticipated that this work would guide the rational utilization of CdS-based materials to enable simultaneous photochemical coupling of organic transformation and H 2 evolution.
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Inorganic Chemistry Frontiers
·
2025
·
IF 6.4
Wenjun Gong,Yating Pang,Chenyu Wang,Wenming Wang,Hong-Fei Wang
The dinitrosyl iron complex (DNIC) is a ubiquitous functional brick often used as a vehicle for the NO radical and chelatable iron pool, with a key role in chemical and biomedical applications. In this work, four DNICs modified with different thiolate bridging ligands (–SL) were synthesized. These complexes were characterized by 1H-NMR, electrospray ionization mass spectrometry, and X-ray crystal diffraction. Photoinduced NO release from the complexes in solution was further explored by time-resolved infrared and time-resolved electron paramagnetic resonance (EPR) spectra. The cluster complexes showed relatively lower cytotoxicity against the normal human liver cell line HL-7702 and higher cytotoxicity against human cervical cancer cells, with a selectivity index of 2.4–4.8. The cluster complexes with different L groups had different rates of NO release and protein binding constants. Moreover, NO released upon photoirradiation entered living cells, which were successfully imaged using an NO-selective fluorescent probe. The ferritin complex adducts further enhanced the cytotoxicity and cellular fluorescent intensity of NO, and the crystal structure revealed the coordination of the Fe(SL)2 unit with Cys102 of ferritin. This study provides insight into the photodynamic mechanism of nitrosyl iron−sulfur clusters to understand their physiological activity.
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Journal of Environmental Chemical Engineering
·
2024
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IF 7.4
Pengshan Guo,Dongmei Yu,Chuntao Zhao,Jianping Wang,Ji Cheng,Wenxuan Fan,Tongtong Ma,Tian Gao,Jinghua Li
The increasing demand for potash has led to the increased use of 4-dodecyl morpholine (DMP), an important froth flotation agent for the extraction for potash extraction by “reverse flotation-cold crystallization”. As it is not easy to be stable and decompose in its natural state, it has seriously endangered the environment of salt lakes and the development of salt lake resources. The development of a safe and harmless catalytic system to accomplish the degradation and removal of DMP is urgent. Herein, A Cu 2 O/SnO 2 /PDA (CSP) nanoparticle with a synergistic effect of photocatalysis and Fenton-like catalysis was developed, and the CSP had a good photothermal conversion efficiency. Under 808 nm NIR irradiation, not only the catalyst activity was enhanced, but also the complexation rate of electron-hole pairs was reduced, which effectively increased the degradation efficiency of DMP (an increase of about 31.56 %). In addition, by analyzing the degradation products of DMP, the possible pathways of the DMP degradation process were proposed and, at the same time, the degradation catalytic system we used was proved to be safe and harmless. A new pathway is provided for the degradation and removal of DMP in the salt lake environment.
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Molecular Catalysis
·
2024
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IF 3.9
Xiao-Juan Li,Hai-Tao Wan,Ming-Yu Qi,Chang-Long Tan,Zi-Rong Tang
Photocatalytic selective organic transformations coupled with hydrogen (H 2 ) generation under anaerobic conditions is a promising alternative to tackle the challenges of global energy scarcity and green synthesis. In this work, we report the synthesis and application of Ni doped Mn 0.25 Cd 0.75 S (MCS-Ni) composites for efficient selective dehydrocoupling of amines into imines and H 2 . The optimal MCS-Ni composite displays markedly enhanced activities for imines and H 2 generation, which are 7.9 and 11.5 times as high as those of pristine MCS, respectively. The Ni doping modulates the electronic structure of MCS, which improves the light-harvesting abilities and inhibits the recombination of photo-generated electron-hole pairs, thereby remarkably improving the photocatalytic performance of the MCS-Ni composite. Furthermore, the electron paramagnetic resonance (EPR) technique reveals that carbon centered radicals are the critical intermediates in the amine oxidation reaction. This work is promising to provide inspiration towards the rational construction of metal doped semiconductor composite photocatalysts with effective utilization of photo-generated electrons and holes for the coproduction of clean H 2 fuel and high-value added chemicals in a collaborative photoredox reaction.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
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IF 19
Zidan Zou,Yue Shen,Chun Chen,Wenchao Li,Yunxia Zhang,Haimin Zhang,Zhixin Yu,Huijun Zhao,Guozhong Wang
For size-sensitive catalytic reaction systems, precise control of geometric size of heterogeneous transition metal catalysts, especially for non-noble metals, is in desperate need and also a great challenge. Here, highly dispersed Ni nanoparticles (NPs) anchored within mesoporous silica (MS) is fabricated through a hybrid strategy of amino-modification and vacuum-impregnation. The Ni NPs in Ni/MS catalyst can be precisely regulated from 2.2 to 12.6 nm, causing a variation in the proportion of low and high coordination sites of Ni atoms. The Ni/MS catalysts show a volcanic trend between 2-methoxy-4-methylphenol (MMP) yield and Ni geometry size in hydrodeoxygenation (HDO) of bio-derived vanillin, and the Ni/MS-4.8 catalyst with middle size (4.8 nm) shows optimal HDO performance with the highest MMP productivity of 19.5 g MMP g Ni −1 h −1 . DFT calculation demonstrates that the medium-sized Ni/MS-4.8 catalyst possesses abundant low/high coordinated Ni atoms, wherein the low coordinated Ni atoms facilitate the adsorption of H 2 and vanillin, and the high coordinated Ni atoms promote the dissociation of H 2 and activating of C═O and C─O bonds, thus displays superior performance in HDO reaction. This work paves a way in precise control of geometric size of heterogeneous catalysts applicating in size-sensitive catalysis.
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MOLECULES
·
2025
·Vol. 30
·期 4
·852
·
IF 4.6
Qiqi Jin,Qianwen Xu,Zhiyong Zhao,Wenshuai Si,Bing Bai,Lei Chen,Changyan Zhou
This study presents a method for the simultaneous determination of six acidic herbicides and their metabolites in various matrices, including fruits, vegetables, grains, and edible oils. The method employs acidified acetonitrile extraction combined with dispersive solid-phase extraction cleanup (dSPE) using MgSO4, Florisil, and Graphitized carbon black (GCB). The analysis was performed by ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) with electrospray ionization (ESI) in both positive and negative modes using multiple reaction monitoring (MRM). The mass concentrations of six herbicide pesticides and their metabolites were predominantly within the range of 0.0005~0.050 mg/L and exhibited strong linear relationships with the corresponding peak area, with the coefficient of determination (R2) exceeding 0.993. The limits of detection (LOD) for the method ranged from 0.0001 to 0.008 mg/kg. The recovery rates of adding recovery experiments to cabbage, chives, pear, wheat flour, and soybean oil were 69.8~120%, and the relative standard deviation (RSD) was 0.6~19.5%. The results indicate that this method is efficient and fast, and can be used for the detection of compounds in various actual matrices.
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ACS Omega
·
2024
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IF 3.7
Pengyin Li,Shaoqing Chen,Yanyan Meng,Cheli Wang,Xinye Ni
Hydrogels have broad application prospects in bone repair. Pure poly(vinyl alcohol) (PVA) hydrogels have limited applications because of their low hardness and poor mechanical properties. This study found that resveratrol (Res) and PVA self-assembled and cross-linked through the formation of strong hydrogen bonds after freeze–thawing, forming an easily available PVA–Res supramolecular hydrogel through a green process. PVA–Res hydrogels with different Res wt %:10 wt % PVA ratios were prepared through freeze–thawing and designated as 0.4, 1.2, and 2.0 wt % PVA–Res hydrogels. Rheological studies demonstrated that the viscoelastic modulus of the PVA–Res hydrogels was significantly improved compared to pure PVA hydrogels. The viscoelastic modulus G′ of 1.2% PVA–Res hydrogel was 2299 Pa, which was 8.5-fold that of the pure PVA hydrogel. We conducted a study on cell proliferation and osteogenic differentiation using MC3T3-E1 (preosteoblasts from newborn mouse calvaria). The results showed that the 0.4% PVA-Res hydrogel promotes alkaline phosphatase activity and mineral deposition. Real-time quantitative PCR (RT-qPCR) analysis demonstrated that the 0.4% PVA–Res hydrogel upregulated the expression of osteogenic differentiation-related genes (BMP-9, OCN, and ALP). Furthermore, RT-qPCR and flow cytometry demonstrated that the 0.4% PVA–Res hydrogel could effectively promote the M2 transformation and polarization of mouse mononuclear macrophage leukemia cells (Raw 264.7). The expression of related genes, such as Arg-1 and CD206, significantly increased, whereas that of M1 polarization-related genes, such as iNOS and TNF-α, significantly decreased. In summary, PVA–Res supramolecular hydrogels are potential materials for use in bone repair.
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EUROPEAN POLYMER JOURNAL
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2024
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IF 5.8
Pan Gu,Ying Mao,Wangyang Lu,Wenxing Chen
Poly (lactide-co-glycolide) (PLGA) has been extensively utilized to fabricate electrospun fibers for tissue engineering scaffolds due to its good biocompatibility and biodegradability. However, such scaffolds in biological media shrink and distort severely, which is undesired for practical application. In this study, a silk fibroin incorporated electrospun aliphatic polyester nanofiber scaffold (PLGA/PCL/SF) was developed via facile one-step electrospinning, with PLGA as the substrate and incorporating polycaprolactone (PCL) and silk fibroin (SF). The resulting scaffold exhibited fine fibers and water absorbency. Particularly, the addition of SF into scaffolds improved the water adsorption ability, and that of PCL effectively prevented scaffold shrinkage behaviors. In vitro degradation analyses showed that it was accelerating for the obtained scaffolds with SF added, without any undesirable acidic environment induced. Additionally, the PLGA/PCL/SF scaffold exhibited the most promising result in cell proliferation, presenting a valuable insight into the design of tissue engineering scaffolds.
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International Journal of Nanomedicine
·
2024
·
IF 6.6
Gang Deng,Yuanyuan Yang,Song Lu,Lin Ma,Guohua Wu
Introduction With the development of technology, personal heat management has become a focus of attention. Phase change fabrics, as intelligent materials, are expected to be widely used in multiple fields, bringing comfortable, intelligent and convenient living experience.Methods In this study, miniature phase change microcapsules (MPCM) with n-octadecane as core and poly(methyl methacrylate) as shell were successfully prepared. Using the in-situ reduction property of polydopamine, gold nanoparticles were deposited on the surface of the microcapsules, which retained the heat storage function and imparted photothermal and antibacterial properties. The MPCM with photothermal conversion function was modified on the surface of silk fabric using aqueous polyurethane after verified by comprehensive material characterisation techniques.Results Under the near infrared light of 808 nm wavelength and 0.134 W/cm² irradiation intensity, the MPCM@PDA@Au modified silk fabrics showed excellent photothermal conversion performance, which could be increased from 25°C to 60°C in 50s. After the light source was cut off, the fabrics showed good heat release ability, with melting enthalpy and crystallisation enthalpy reaching 41.58 J/g and 43.3 J/g, respectively, which were not changed after repeated cycles. After the light source is cut off, the fabric has good heat release ability, and the enthalpy of melting and crystallisation reaches 41.58 J/g and 43.3 J/g, respectively, and the photothermal efficiency remains unchanged after many cycles of use, which proves that it has excellent durability and stability. The antimicrobial test shows that the fabric has significant antibacterial effect on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).Discussion MPCM@PDA@Au silk fabrics bring new possibilities for the future of personal thermal management and antimicrobial protection in the field of medical health, outdoor sports and other areas of broad application prospects, heralding the birth of a series of innovative applications and solutions.
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