Journal of Physical Chemistry C
·
2024
·
IF 3.3
Yanting Dou,Yu Gao,Bobo Bai,Jiqi Zheng,Shuxia Bao,Cheng Dong,Hongjiang Li,Qiuhui Bu,Dongling Ma,Fu Ding,Yaguang Sun,Zhenhe Xu
Design and conception of a competent photocatalyst for water splitting and photodegradation are critical for energy transformation and environmental remediation. Herein, for the first time, we demonstrated that mixed redox-couple-involved bornite phase Cu5FeS4 could act as an efficient and robust cocatalyst for graphitic C3N4 (g-C3N4), which enables the achievement of considerably boosted visible-light photocatalytic activities in both H2 evolution and pollutant degradation reactions. Under visible-light irradiation, the optimized g-C3N4/Cu5FeS4 heterojunction presented a remarkably increased H2 production rate of 27.92 μmol g–1 h–1 (without involving any noble metals) and methyl orange (MO) photodegradation rate of 2.18 min–1 g–1 compared with those of g-C3N4 and Cu5FeS4. To be more specific, these rates are ∼15 and 3 times higher than those of pure g-C3N4 in these two reactions, where the pure Cu5FeS4 did not show any activities. The enhanced photocatalytic performance was identified to be due to the presence of a “mixed redox-couple” of Cu(I)–S–Fe(III), which enhanced charge separation efficiency between g-C3N4 and Cu5FeS4, consequently facilitating the overall reaction kinetics. Overall, our work not only demonstrates the immense potential of using mixed redox-couple-involved bornite phase Cu5FeS4 as the cocatalyst in photocatalysis but also expedites the designing and discovering of novel photocatalytic systems based on the proposed concept of the mixed redox-couple.
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Cell Reports Medicine
·
2024
·
IF 11.7
Lihuan Shang,Xue Jiang,Xinbao Zhao,Xi Huang,Xiaojuan Wang,Xue Jiang,Xiangzhan Kong,Mingkang Yao,Shanping Jiang,Ping-Pui Wong
Low migratory dendritic cell (DC) levels pose a challenge in cancer immune surveillance, yet their impact on tumor immune status and immunotherapy responses remains unclear. We present clinical evidence linking reduced migratory DC levels to immune-cold tumor status, resulting in poor patient outcomes. To address this, we develop an autologous DC-based nanovaccination strategy using patient-derived organoid or cancer cell lysate-pulsed cationic nanoparticles (cNPs) to load immunogenic DC-derived microvesicles (cNP cancer cell @MV DC ). This approach transforms immune-cold tumors, increases migratory DCs, activates T cells and natural killer cells, reduces tumor growth, and enhances survival in orthotopic pancreatic and lung cancer models, surpassing conventional methods. In vivo imaging reveals superior cNP cancer cell @MV DC accumulation in tumors and lymph nodes, promoting immune cell infiltration. Mechanistically, cNPs enrich mitochondrial DNA, enhancing cGAS-STING-mediated DC activation and migration. Our strategy shifts cold tumors to a hot state, enhancing antitumor immunity for potential personalized cancer treatments.
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International Journal of Extreme Manufacturing
·
2025
·Vol. 7
·期 3
·035001
·
IF 21.3
Fan-Chun Bin,Xin-Yi Wu,Jie Liu,Xian-Zi Dong,Teng Li,Qi Duan,Jian-Miao Zhang,Katsumasa Fujita,Mei-Ling Zheng
Chitosan (CS)-based nanocomposites have been studied in various fields, requiring a more facile and efficient technique to fabricate nanoparticles with customized structures. In this study, Ag@methacrylamide CS/poly(ethylene glycol) diacrylate (Ag@MP) micropatterns are successfully fabricated by femtosecond laser maskless optical projection lithography (Fs-MOPL) for the first time. The formation mechanism of core-shell nanomaterial is demonstrated by the local surface plasmon resonances and the nucleation and growth theory. Amino and hydroxyl groups greatly affect the number of Ag@MP nanocomposites, which is further verified by replacing MCS with methacrylated bovine serum albumin and hyaluronic acid methacryloyl, respectively. Besides, the performance of the surface-enhanced Raman scattering, cytotoxicity, cell proliferation, and antibacterial was investigated on Ag@MP micropatterns. Therefore, the proposed protocol to prepare hydrogel core-shell micropattern by the home-built Fs-MOPL technique is prospective for potential applications in the biomedical and biotechnological fields, such as biosensors, cell imaging, and antimicrobial.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Weibing Tang,Fangjun Huo,Rongbai Ju,Xinghui Gao,Min He,Jie Long,Jingyi Zhang,Siyuan Zhang,Weidong Tian
Mesenchymal stem cell (MSC)-based cell sheet engineering holds great promise for periodontal tissue engineering and restoring damaged tissues. However, achieving optimal regenerative outcomes remains a challenge. This study introduces a novel approach that integrates melatonin-coated nanofiber fragments (mNFs) into dental follicle stem cell sheets (mNF-CSs) to enhance their regenerative potential. The mNF-CSs were engineered using electrospun poly-L-lactic acid (PLLA) nanofiber sheets fragmented into mNFs and coated with melatonin, a potent antioxidant and osteogenic agent. The mNF-CSs exhibited a homogenous morphology with sustained melatonin release over 21 days, providing a prolonged antioxidative effect critical for tissue regeneration. In vitro experiments demonstrated that mNF-CSs significantly reduced intracellular reactive oxygen species (ROS) levels and upregulated antioxidative proteins such as SOD1 and SOD2, resulting in improved cell viability, maintenance of stemness, and enhanced osteogenic differentiation potential of dental follicle stem cells (DFCs). In vivo studies using both a nude mouse and a rat periodontal defect model demonstrated that mNF-CSs promoted alveolar bone repair and periodontal tissue regeneration, with enhanced retention of MSCs at the defect site and increased expression of periodontal tissue-related markers. Transcriptome analysis revealed the upregulation of genes associated with biomineralization, odontogenesis, and autophagy pathways in mNF-CSs, suggesting their ability to modulate crucial cellular processes for tissue regeneration. Overall, mNF-CSs offer a promising strategy for enhancing periodontal tissue engineering applications, providing a platform for improving bone grafts and regenerative medicine strategies in the context of periodontal diseases.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Guanhua Zhang,Shengjie Xia,Huimin Li,Hao Du,Tiantian Li,Yongyong Cao,Yue Meng,Juan Wang,Chenglin Zhong,Woon-Ming Lau
The synergistic treatment of pollutants in water by radical and non-radical pathways based on photo-like Fenton-activated peroxydisulfate (PDS) has received much attention from researchers. However, clarifying the structure–activity relationship between the photocatalyst structure and the dual-pathway degradation mechanism is difficult. Herein, the flower-like nickel–iron layered double hydroxide containing oxygen vacancy (NiFe-LDH-V O ) was constructed by dual-hydrothermal method. The NiFe-LDH-V O /PDS/light system exhibited excellent degradation performance (93.1%) for norfloxacin (NOR). Notably, the apparent rate constant exceeded pristine NiFe-LDH by 2.6 times. The results of experiments, characterization and DFT calculations indicated that the enhanced degradation activity was attributed to the dual-pathway of radical and non-radical induced by V O on the catalyst surface. V O can not only improve the migration and separation efficiency of photogenerated carriers, which ensures the energy base of PDS activation, but also act as the active site of both radical pathway and non-radical pathway. In particular, V O can change the adsorption conformation of PDS, which enhances the adsorption of PDS on the catalyst and significantly reduces the energy barriers of the two activation pathways of PDS. The reasonable pathways for NOR degradation were proposed based on HPLC-MS and DFT calculations. In addition, the toxicity analysis of intermediates indicated lower developmental toxicity and mutagenicity compared to NOR. The present work provides innovative insights into the study of photocatalysts with dual degradation pathways and their mechanistic elaboration.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
·
IF 5.3
Shuai Hou,Yao Li,Qiqi Chen,Jie Yang,Pengpeng Zhao,Yanjun Zhao
The efficient elimination of bacteria within the dentinal tubules has been hindered by the poor deposition and short residence of disinfecting agents. Meanwhile, the current irrigant ( e.g., NaClO, 5.25 %) shows severe adverse effects on the surrounding soft tissues because of its inherent high irritancy. To address this issue, this work reports an in situ generated sonosensitizer to handle the biofilm in dentinal tubules with minimal adverse effects. The production of nanoscale sonosensitizer involves the concurrent delivery of H 2 O 2 (0.01 %), ferrocene derivative (Fc), and indocyanine green (ICG). With ultrasound treatment, the reaction between H 2 O 2 and Fc liberated Fe 3+ that was further complexed with ICG to generate the nanoscale sonosensitizer in situ , followed by singlet oxygen production for potent disinfecting action. Because the above cascade reactions occur within the confined dentinal tubules, the generated ICG-Fe 3+ nanosensitizer would show prolonged retention therein. The anti-bacterial potency of nanosensitizer was demonstrated in petrodish and ex vivo biofilm models. Meanwhile, the transmission electron microscope imaging of biofilm and cytotoxicity assay in L929 fibroblast cells proved the superiority of nanosensitizer against NaClO regarding adverse effects. The current work opens new avenues of biofilm elimination in dentinal tubules, showing a high translation potential.
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Journal of Cleaner Production
·
2024
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IF 9.7
Zhonghua Niu,Taoshan Xu,Licheng Zhang,Lianmin Ji,Lijuan Li
With the increasing demand for lithium resources, recovery of lithium from solution with high Na/Li ratio is an effective way to meet the growing demand. Salicylate extraction system has been found to be an effective system for Li/Na separation. In this work, the studies of equilibrium, process and mechanism were carried out for the 2-ethylhexyl salicylate (ES) and trialkyl phosphine oxide (TRPO) co-extraction system. The factors affecting lithium extraction such as composition of the organic phase, the conditions of aqueous phase, extraction time and acid-alkali tolerance of the ES extraction system were systematically investigated; According to the equilibrium study, a series of process studies were carried out for lithium recovery from mother solution of lithium carbonate, and the whole process including extraction, elution, stripping and regeneration was designed, and through the process, 99% of lithium was recovered and lithium-rich solution containing 25.85 g/L Li and 0.08 g/L Na was obtained. In the mechanism study, the extraction process was proved as a thermodynamic spontaneous entropy increase process; At the molecular level, the coordination mechanism was first expounded by ultraviolet–visible (UV–Vis) and fluorescence spectrum (Fl), which was further confirmed by 1 H NMR and Fourier transform infrared (FT-IR). The current study points a way to separation of lithium from alkaline solutions, which will support the future supply of lithium in a more economical and sustainable manner.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Zijian Li,Wenpei Dong,Jing Ren,Wenli Gao,Leitao Cao,Yan Gu,Shengjie Ling
Abdominal wall defects, often caused by trauma, infection, or tumor resection, pose significant clinical challenges, typically leading to organ protrusion and chronic pain. Current repair materials like polypropylene (PP) and expanded polytetrafluoroethylene (ePTFE) meshes offer mechanical stability but can trigger foreign body reaction, leading to visceral adhesions and inflammation. While calcium alginate ionic hydrogels (CAIHs) present a biocompatible alternative, but lack the mechanical strength needed for abdominal wall defects repair. This work develops a two perpendicular directions mechanically trained CAIH (PDMT-CAIH) by cyclic stretching, enhancing its mechanical properties and stability without introducing any additional chemical elements. In vitro and in vivo assessments show that PDMT-CAIH supports cell proliferation, promotes tissue regeneration, and significantly reduces visceral adhesion formation compared to PP meshes. Additionally, PDMT-CAIH demonstrates superior resistance to degradation, maintaining structural integrity over time. These findings highlight PDMT-CAIH as a promising, safer alternative for abdominal wall repair, reducing complications and improving clinical outcomes without the need for chemical additives.
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Acta Biomaterialia
·
2024
·
IF 9.4
Shue Jin,Jing Wen,Yao Zhang,Ping Mou,Zeyu Luo,Yongrui Cai,Anjin Chen,Xiaoxue Fu,Weikun Meng,Zongke Zhou,Jidong Li,Weinan Zeng
Designing scaffolds that can regulate the innate immune response and promote vascularized bone regeneration holds promise for bone tissue engineering. Herein, electrospun scaffolds that combined physical and biological cues were fabricated by anchoring reparative M2 macrophage–derived exosomes onto topological pore structured nanofibrous scaffolds. The topological pore structure of the fiber and the immobilization of exosomes increased the nanoscale roughness and hydrophilicity of the fibrous scaffold. In vitro cell experiments showed that exosomes could be internalized by target cells to promote cell migration, tube formation, osteogenic differentiation, and anti-inflammatory macrophage polarization. The activation of fibrosis, angiogenesis, and macrophage was elucidated during the exosome-functionalized fibrous scaffold–mediated foreign body response (FBR) in subcutaneous implantation in mice. The exosome-functionalized nanofibrous scaffolds also enhanced vascularized bone formation in a critical-sized rat cranial bone defect model. Importantly, histological analysis revealed that the biofunctional scaffolds regulated the coupling effect of angiogenesis, osteoclastogenesis, and osteogenesis by stimulating type H vessel formation. This study elaborated on the complex processes within the cell microenvironment niche during fibrous scaffold–mediated FBR and vascularized bone regeneration to guide the design of implants or devices used in orthopedics and maxillofacial surgery. Statement of significance How to design scaffold materials that can regulate the local immune niche and truly achieve functional vascularized bone regeneration still remain an open question. Here, combining physical and biological cues, we proposed new insight to cell-free and growth factor-free therapy, anchoring reparative M2 macrophage–derived exosomes onto topological pore structured nanofibrous scaffolds. The exosomes functionalized-scaffold system mitigated foreign body response, including excessive fibrosis, tumor-like vascularization, and macrophage activation. Importantly, the biofunctional scaffolds regulated the coupling effect of angiogenesis, osteoclastogenesis, and osteogenesis by stimulating type H vessel formation.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Jiahong Chen,Yunzhu Qian,Heng Li,Wei Zuo,Wentao Sun,Danlei Xing,Xuefeng Zhou
Guided bone regeneration (GBR) technology has been widely used for the regeneration of periodontal bone defects. However, the limited mechanical properties and bone regeneration potential of the currently available GBR membranes often limit their repair effectiveness. In this paper, serum-derived growth factor lysophosphatidic acid (LPA) nanoparticles and dopamine-decorative nanohydroxyapatite (pDA/nHA) particles were double-loaded into polylactic-glycolic acid/polycaprolactone (PLGA/PCL) scaffolds as an organic/inorganic biphase delivery system, namely, PP-pDA/nHA-LPA scaffolds. Physicochemical properties and osteogenic ability in vitro and in vivo were performed. Scanning electron microscopy and mechanical tests showed that the PP-pDA/nHA-LPA scaffolds had a 3D bionic scaffold structure with improved mechanical properties. In vitro cell experiments demonstrated that the PP-pDA/nHA-LPA scaffolds could significantly enhance the attachment, proliferation, osteogenic differentiation, and mineralization of MC3T3-E1 cells. In vivo, the PP-pDA/nHA-LPA scaffolds exhibited great cytocompatibility and cell recruitment ability in 2- and 4-week subcutaneous implantation experiments and significantly promoted bone regeneration in the periodontal defect scaffold implantation experiment. Moreover, LPA-loaded scaffolds were confirmed to enhance osteogenic activities by upregulating the expression of β-catenin and further activating the Wnt/β-catenin pathway. These results demonstrate that the biphase PP-pDA/nHA-LPA delivery system is a promising material for the GBR.
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RSC Advances
·
2024
·Vol. 14
·期 50
·37104-37113
·
IF 3.9
Yuefang Hu,Yuxin Chen,Wenwang Wei,Hanfu Liu
Effective real-time cell tracking and tumor growth monitoring are important for precise diagnosis and therapy of tumors and can also be used to monitor biological processes. In this study, a facile, green microwave method was developed to synthesize biomass-derived red emission carbon dots (RCDs) using the ethanolic extract of holly leaves. Owing to the advantages of the prepared RCDs, such as near infrared emission, stability, strong fluorescence intensity, excellent biocompatibility, penetration of thick tissues, avoiding background fluorescence interference, and improvement of the signal-to-noise ratio of biological imaging, they were applied to cell imaging, real-time cell tracking and tumor growth monitoring. Experimental results revealed that the RCDs could present strong red fluorescence emission when they entered the cells. The labeled cells still emitted red fluorescence after 13 generations of passage and could monitor tumor growth in real-time for more than 18 days. These results indicated that RCDs could be used as effective long-term near-infrared fluorescent imaging probes for cells and tumors, presenting broad application prospects in image-guided therapy.
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PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Xi Yu,Yansong Liu,Lixiao Gao,Li Wang,Xizhi Chen,Yuanlin Ren,Xiaohui Liu
To endow silk with multifunctionality and expand its application fields, the silk fabric was treated with protocatechualdehyde to prepare a novel silk fabric with Schiff base structure (CAT@Silk). Then, CAT@Silk was immersed in iron (III) solution to chelate Fe 3+ to obtain flame retardant , antibacterial and UV-resistant silk fabric (CAT@Fe@Silk). Compared with the limiting oxygen index (LOI) value of the original silk, the CAT@Fe@Silk increased from 23.3 % to 35.1 %, and remained 32.4 % even after 20 laundering cycles (LCs), indicating excellent flame retardant durability. The UV protection coefficient of CAT@Fe@Silk was 67.74, which was higher than that of the original sample (21.02). In addition, CAT@Fe@Silk had good antibacterial effects against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). This work constructed a dynamic cross-linking network that mimicked the adhesion of mussels generating from the complexation of catechol groups and Fe 3+ ions (catechol-Fe 3+ ), which not only endowed silk fabric with good flame retardancy, but also with UV resistance and antibacterial properties, demonstrating good potential application.
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