Interdisciplinary Medicine
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2025
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IF 13.6
Bo Li,Yaqi Zhang,Xuerui Zhou,Weiguo Wang,Fan Yang,Qiushi Wei,Leilei Chen,Ziqi Li,Mincong He,Xiaoming He,Shengting Chai,Xiuhong Cao,Rui Wang,Tongmeng Jiang,Chen Wang,Wei He
The microstructure of scaffolds is essential for enhancing cell-extracellular matrix interactions, which are critical for osteochondral regeneration. This study investigates the innovative use of 3D printing to mimic DOUGONG brackets to achieve this goal. Composite scaffolds of β-tricalcium phosphate, akermanite (AKer), and strontium silicate (SrSiO 3 ) at 1%, 5%, and 10% concentrations were fabricated via 3D printing. The osteogenic differentiation effects on bone marrow mesenchymal stromal cells and chondrogenic promotion effects on chondrocytes of different scaffolds were analyzed in vitro. An osteochondral defect model was created in SD rat knee joints, and various scaffold materials were implanted to evaluate their repair and anti-inflammatory effects. Characterization showed that SrSiO 3 composite scaffolds had uniform pore structures and high porosity with improved mechanical properties and sustained strontium ion release capacities. The Aker/Sr5% scaffold significantly enhanced cell viability and proliferation, inhibited apoptosis, and upregulated osteogenic markers (RUNX2, COL1A1, OCN, OPN) while downregulating inflammatory factors (IL-6 and TNF-α). This scaffold also improved the chondrocyte phenotype as indicated by increased chondrogenic markers (COL2A1 and SOX9). Additionally, it excelled in bone volume, bone mineral density, and tissue repair scores. The DOUGONG-inspired AKer/SrSiO 3 composite scaffold promotes osteochondral regeneration by enhancing osteogenesis via the PI3K/Akt signaling pathway and cytokine-cytokine receptor interaction, while simultaneously facilitating cartilage repair by promoting chondral phenotypes. This work provides a theoretical basis and new strategies for the clinical transformation of osteochondral repair.
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FOOD CHEMISTRY
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2025
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IF 9.8
Guoli Chang,Fei Zhang,Zihan Qin,Wenyan Hong,Degui He,Haixia Lu,Junli Zhu
Zhejiang rosy vinegar (ZRV), a popular condiment in southeastern China, has a flavor profile and bioactivity that are not yet fully understood. This study aimed to determine the flavor characteristics and functional properties of ZRV from different regions. Sensory evaluation and electronic nose analysis revealed regional flavor variations. GC–MS identified 80 volatile compounds, while GC-IMS detected 22 volatile compounds. OPLS-DA models identified 17 GC–MS and 8 GC-IMS biomarkers, predominantly including 9 esters, 4 alcohols, and 4 aldehydes. Based on the analysis of odor activity values, five characteristic flavors in ZRV were identified, including acetic acid, benzaldehyde, 3-methylbutyl acetate, phenethyl acetate, and 2,4,5-trimethyl-1,3-dioxolane. Non-volatile compounds such as polyphenols, flavonoids, tartaric acid, and amino acids (isoleucine, valine, and proline) significantly enhanced antioxidant activity. The research establishes a theoretical framework for improving ZRV quality control and brand identity by mapping regional flavor signatures and bioactive components.
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Soft Matter
·
2025
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IF 2.8
Caiyan Wang,Yiyao Zhu,Runhua Wang,Pufan Wang,Jincheng Wang,Liya Jia,Hua Zhang
This work explores the creation of a novel self-healing material based on methyl vinyl silicone rubber (MVQ), which was functionalized with COO− groups through a thiol–ene click reaction and crosslinked with tannic acid (TA) and ZnCl2 to form a composite characterized by ionic and coordination bonds, thereby enabling self-healing. The carboxylated carbon nanotubes modified with KH550 (KH550-CNTs) were uniformly dispersed in the elastomer matrix, successfully fabricating a sensing material that combines flexibility with skin-like sensing capabilities. The results showed that the self-healing silicone elastomers had a tensile strength of approximately 0.41 MPa and an elongation at break of 868.97%. The material also demonstrated excellent self-healing capabilities (96.09% healing efficiency at 80 °C/6 h). Due to its complex porous structure, the sensor exhibited very high sensitivity, with a maximum gauge factor (GFmax) of 230. The material exhibited no significant mass loss or compositional degradation over the temperature range of 0–400 °C, as determined by TG analysis. Notably, this self-healing MVQ can be manufactured on a large scale with cost-effectiveness, thereby promoting its widespread adoption and further application across diverse industries and fields.
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TRIBOLOGY INTERNATIONAL
·
2025
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IF 6.9
Hongyu Liang,Qilin Yang,Shijing Zou,Cheng Yang,Jiahui Li,Xu Fang,Hanlin Zheng,Yongfeng Bu
Deep eutectic solvents (DES) based on hydrogen bonding are a key class of liquid superlubricious materials, with the typical binary DES composed of choline chloride and ethylene glycol. However, the limitations of conventional binary designs and their hydrogen bond acceptors/donors have hindered the development of advanced and sustainable superlubricious materials. This study introduces a novel ternary DES comprising the organic ligands 2-pyrrolidinone (PD) and succinonitrile (SN) combined with lithium bis(trifluoromethanesulfonyl)imide (LiTFSI). Compared to the base lubricant (LP 1:3 ) with a single ligand (PD), the optimized system with two ligands (LPS 1:3:3 ) demonstrates superlubricity, achieving an ultralow coefficient of friction (∼0.007) and high load-bearing capacity (469 MPa). Competitive coordination between PD, SN, and Li + reduces viscosity and enhances the asymmetric contact probability of size-expanded liquid clusters, forming ultra-low shear sliding interfaces. Additionally, replacing water molecules with organic molecules in the Li + solvation shell improves resistance to various humidity levels. This study highlights the role of size-distribution-expanded clusters and adsorbed films in intensifying the ligand competition-induced asymmetric contact effect, providing fresh insights into the design of next-generation multivariate DES superlubricious materials.
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POLYMER
·
2025
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IF 4.5
Chenyu Zhao,PengFei Chen,Rongjie Yang,Wenchao Zhang,Jinxian Zhai
Research concerning polymer shear viscosity and the glass transition temperature has traditionally concentrated on parameters such as segmental structure and molecular weight, with comparatively limited attention devoted to the influence of end-group configurations. In this investigation, hydroxyl-terminated ethylene oxide-tetrahydrofuran copolyether (PET-OH) served as the precursor material to synthesize three copolyethers, namely, propargyl ester-terminated (PET-O 2 CC≡CH), propargyl ether-terminated (PET-OCH 2 C≡CH), and azide-terminated (PET-N 3 ), which possess nearly identical main chain architectures, molecular weights, and molecular weight distributions, differing solely in their end-group configurations. Differential scanning calorimetry (DSC) analysis reveals that the glass transition temperatures ( T g ) of these four copolymer ethers decrease progressively in the order: PET-O 2 CC≡CH > PET-OH > PET-OCH 2 C≡CH > PET-N 3 . Correspondingly, the crystallization enthalpy of the tetrahydrofuran microblocks increases gradually at low temperatures. Viscosity measurements and low-field nuclear magnetic resonance investigations demonstrate a consistent correlation between segmental mobility and viscosity, with the zero-shear flow activation energy decreasing accordingly. Variable-temperature infrared spectroscopy indicates the presence of hydrogen bonding among end groups in PET-O 2 CC≡CH, PET-OH, and PET-OCH 2 C≡CH, thus restricting segmental motion; conversely, PET-N 3 displays lower viscosity, enhanced segmental mobility, reduced T g , and increased crystallinity owing to the absence of intermolecular end-group interactions. Density functional theory (DFT) calculations further corroborate that the hydrogen bonding strength at the terminal groups of these three modified copolyethers diminishes in the sequence: PET-CO 2 C≡CH > PET-OH > PET-OCH 2 C≡CH. Moreover, the extent of association exhibits a positive correlation with both segmental mobility and T g . These findings offer new theoretical insights and practical approaches for modulating thermodynamic properties, rheological behavior, and aggregation structures in polymeric materials.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Bingxian Niu,Yuxia Wang,Yu Han,Pan Zhang,Yonghong Cai,Yufeng Wu,Linlin Zhao,Ying Xu
This paper presents the synthesis of a novel polyaspartate derivative (PASP-BBA) with both corrosion inhibition and antibacterial properties. The compound is synthesised using polysuccinimide (PSI), 1,4-bis(3-aminopropyl)piperazine (BAPP) and bromoacetic acid (BA) as raw materials. By controlling the degree of polymerisation, a BAPP grafting rate of 55 % is achieved. The corrosion inhibition performance of PASP-BBA was evaluated using electrochemical methods and weight loss method. The potentiodynamic polarization results indicated that at a concentration of 70 mg/L, the corrosion inhibition efficiency of PASP-BBA was 54.28 %, which was 33.53 % higher than that of PASP. The study on the corrosion inhibition mechanism of PASP-BBA through quantum chemical calculations showed that PASP-BBA achieved this effect through physical and chemical adsorption, adhering to the surface of carbon steel and reducing the contact with corrosive media. The antibacterial performance was evaluated using filter paper method and dilution plating method. The research results indicated that PASP-BBA has selective antibacterial effects and can effectively inhibit Escherichia coli . When the concentration of PASP-BBA was 100 mg/mL, the survival rate of Escherichia coli dropped to 21 %. Meanwhile, Bacillus cereus could survive, thereby enhancing the dual functions of polyaspartic acid derivatives in corrosion inhibition and antibacterial applications. This study provides certain theoretical references for the design of green multifunctional water treatment agents.
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ANALYTICA CHIMICA ACTA
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2025
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IF 6
Yao Chu,Yangyang Chen,Zhen Gu,Xinyi Liu,Tao Cheng,Yichuan Shen,Jian Lv,Yiping Wu,Nan Chen,Haifeng Yang,Wanxin Tang
As an electrochemical cell and sweat reservoir, hydrogel plays a significant role in wearable sweat glucose sensing. However, the uncontrolled and randomly distributed network in the hydrogel, the aggregation of enzyme and leaching from the sensing surface often cause a concentration gradient of sweat glucose, which could lead to the distorted signal. In this study, a magnetic porous hydrogel is designed with uniformly embedded GOx. Such hydrogel is integrated with MWCNTs, CaCO 3 , and glutaraldehyde-coated magnetic nanoparticles (G-Fe 3 O 4 NPs). Acid etching of CaCO 3 forms the porous structure of hydrogel with high water absorbency. G-Fe 3 O 4 NPs provide controllable cross-linkers between GOx and hydrogel. Guided by an external magnet, GOx distribution in the hydrogel is oriented in a constant and uniform order, thus can avoid non-quasi-equilibrium and distorted glucose sensing that caused by GOx aggregation and leakage. Importantly, MG-MFPH-GOx hydrogel show enhanced sensitivity when tested for both on-body and finger sweat glucose sensing and the detection limit reaches 0.25 μmol/L. Moreover, sweat glucose sensors based on MG-MFPH-GOx hydrogel show stable performance for 30 days. Therefore, the regulated enzymatic hydrogel prepared with the facility of an external magnetic field provides a new strategy for constructing wearable sensors.
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FOOD HYDROCOLLOIDS
·
2025
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IF 12.4
Zongyu Wu,Xiao Dong Chen,Peng Wu
Optimizing nutritional strategies for the elderly requires a deep understanding of how food structure influences digestive behavior. This study explored the effects of dietary fiber fortification on milk digestion under simulated elderly gastrointestinal conditions (characterized by reduced gastric acidity, lower digestive enzyme activity, and slower motility), with a particular focus on the formation and properties of gastric clots and their impact on protein hydrolysis kinetics. Milk was fortified with polydextrose (PD), sodium alginate (SA), hydroxypropyl trimethyl ammonium chloride chitosan (HACC), or wheat bran (WB) at 10 mg/mL, and subjected to in vitro digestion modeling. The results demonstrated that dietary fibers significantly altered clot characteristics, such as mass, rigidity, and viscosity, thereby modulating enzymatic accessibility and digestion efficiency. HACC-Milk and WB-Milk formed larger, denser clots with increased mechanical strength and viscosity, resulting in reduced degrees of hydrolysis (26.15 ± 1.23% and 24.55 ± 1.05%, respectively) compared to control milk (30.31 ± 1.90%) by the end of intestinal digestion. In contrast, SA-Milk and PD-Milk generated softer, more fragmented clots, enhancing enzyme diffusion and yielding significantly higher hydrolysis levels (35.33 ± 1.43% and 32.60 ± 1.06%, respectively). Rheological and textural analyses confirmed that WB and HACC reinforced clot structure and hindered proteolysis, while SA and PD attenuated clot formation, promoting protein breakdown. These findings highlight the pivotal role of gastric clots in modulating protein digestion kinetics and provide insights for designing fiber-enriched dairy formulations tailored to the elderly.
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Materials Today Bio
·
2025
·
IF 10.2
Li Chen,Mengyi Zhan,Li Zhang,Zhuohang Xiong,Chi Zhang,Xuanxuan Zhang,Zhengyang Yang,Lixin Ma,Yibin Cheng,Huanhuan Chen
Diabetic foot ulcers (DFU) are a refractory form of chronic wound characterized by persistent infection and impaired healing. Distinct from other hard-to-treat infections, DFU are aggravated by neuropathy, vasculopathy, and immune dysfunction, which hinder microbial clearance and tissue repair. Their management is further challenged by antibiotic overuse, rising resistance, and the limited efficacy of current therapies. To address these issues, we developed the dual-layer microneedles (IGR MNs) platform that integrated a nitroreductase (NTR)-responsive fluorescent probe for real-time infection monitoring with near-infrared (NIR)-triggered photothermal therapy. The microneedle tips were loaded with liposome-encapsulated antibacterial and immunomodulatory agents for controlled, on-demand release, while the base layer incorporated the infection-responsive probe for spatially precise detection. The IGR MNs overcame the limitations of conventional single-layer microneedles by simultaneously enabling diagnosis and therapy. In vivo evaluations in diabetic wound models demonstrated efficient infection detection, reduced local inflammation, enhanced collagen deposition and neovascularization, and significantly accelerated wound closure. This antibiotic-free strategy enables targeted biofilm disruption and immunomodulation, providing a clinically translatable approach for managing refractory, infected diabetic wounds.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Zhu Zhijie,Qian Shuairen,Dong Xudong,Liu Shuang,Zhou Yuxuan,Nie Kaiqi,An Xingda,Li Chaoran,Cheng Yi,Yan Binhang,Feng Kai,Zhang Xiaohong,He Le
Plasmonic photocatalysis offers a promising route to harvest solar energy and drive chemical reactions by the generated heat and energetic charge carriers towards a low-carbon economy. Understanding the mechanisms of plasmonic photocatalysis is vital for the rational design of efficient catalysts but remains a great challenge. Here we report the discovery of an overlooked photocatalytic mechanism based on the enhanced coverage of CO on an Au-Ni heterostructure under light. Detailed studies reveal that hot carrier transfer from Au to Ni via plasmonic excitation increases the electron density of Ni, thereby boosting the population of Ni sites capable of CO adsorption. This increase in active CO-binding sites, rather than local heating or altered adsorption properties of individual Ni sites, is found to be the major contributor to the light-promoted CH 4 production in the Au-Ni-catalyzed CO hydrogenation reaction. This mechanism is further validated by the observation of higher CH 4 selectivity in photocatalytic CO 2 hydrogenation. Our study deepens the mechanistic understanding of plasmonic photocatalysis and offers new ideas for the design of advanced catalytic structures.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2025
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IF 6.3
Liang Zhang,Xuefeng Shao,Yuxiang Zhang,Zhiqiang Tang,Yanping Yuan
The typical inorganic hydrated salt phase change material SAT is recommended as a potential medium ideal for long-term thermal energy storage due to its stable supercooling. The crystallization-triggering approach to activate the release of latent heat requires further investigation. The present work mainly deals with the bubbling-triggered crystallization of SAT. The experimental results showed that bubbling can trigger the crystallization of SAT in the cooling temperature range of 10–25 °C. Unfortunately, it has the issue of poor repeatability during crystallization. Furthermore, it was found that a coupled technology of bubbling with seeding can further shorten the crystallization duration, thus accelerating the crystallization process. Under constant cooling, the degree of subcooling is reduced to as low as 2.2 °C, and the crystallization time is shortened by 4 min at a typical cooling temperature of 25 °C. The crystal structure of bubbling-triggered crystallization was also involved, and the experiments show that there is no significant change in the crystal structure with bubbling, indicated by the lattice constant of the SAT crystal. Therefore, such a coupled technology is recommended for SAT crystallization in long-term latent heat storage scenarios. The obtained results are helpful for crystallization triggering and supercooling reduction in the field of long-term latent heat storage.
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DALTON TRANSACTIONS
·
2025
·
IF 3.3
An-Ran Xue,Yang Hao,Cun-Wei Kang,Qing Cai,Jia-Shen Li,Kun Dong,Songdong Ding,Yuan-Ru Guo,Qing-Jiang Pan
A synthetic strategy was developed to fabricate large surface-area, hierarchical structured and anti-photocorrosion CdS composite starting from CdCO3 with the assistance of nitrogen-doped carbon dots (NCDs). Initially, NCDs were coated over the CdCO3 surface. Once triggering the reaction, NCDs electrostatically enriched S2– ions and meticulously regulated the interface of the newly-formed CdS with CdCO3 to facilitate mass transfer. This led to entire conversion to the composite NCDs/CdS, where CdS exhibited a hierarchical nanoflake-layer-particle architecture. Various characterizations indicate that NCDs loaded on CdCO3 dynamically promoted the formation of cubic-phase CdS. The unique morphology enlarged the specific surface area to 62.1 m2 g–1. Of the synthesized samples, NCDs/CdS-60 achieved a hydrogen production rate as large as 2.27 mmol g–1 h–1, which is almost 11-fold higher than CdS prepared without adding NCDs. Notably, the component of NCDs suppressed the hole-induced photocorrosion of CdS during the photocatalytic reaction and extended the catalyst’s service life.
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