JOURNAL OF CULTURAL HERITAGE
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2025
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IF 3.3
Yumei Chai,Aranzazu Sierra Fernandez,Biao Zhang,Hongjie Luo,Xichen Zhao,Mato Knez,Jianfeng Zhu
Sandstone buildings in humid environments are highly susceptible to fungal colonization, which poses a significant threat to the buildings’ preservation. Therefore, the development of coatings with antimicrobial properties is essential to protect these structures. This study demonstrates the antifungal activity and durability of amphiphobic and UV-absorbing F-ZnO/SiO 2 (FZS) coatings. We show that the coating efficiently inhibits the growth of Aspergillus niger , protecting the sandstone surface from one of the most common molds. A fungal inhibition rate of up to 94 % was achieved with FZS nanocomposite concentrations >0.30 % (g/L). To ensure consistent antifungal performance along with enhanced water repellency and durability under practical conditions, a concentration of 0.37 % was selected for the FZS coating. Accelerated aging tests revealed that the coated sandstone retained its antifungal activity for over 56 days under harsh environmental conditions, exhibiting an antifungal effect 800 % greater than that of uncoated sandstone. After 70 days, the coating still retained its water repellency. These results underscore the potential of the coating for long-term protection of sandstone relics, offering durability and ease of maintenance for real-world applications.
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ACTA BIOCHIMICA ET BIOPHYSICA SINICA
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2025
·Vol. 57
·期 10
·1589
·
IF 3.4
Jiaqi Chen,Shuting Zhang,Xiaoquan Xue,Xiaoqin Ma,Aomiao Chen,Yichuan Wu,Geningyue Wang,Qian Zhang,Yaoming Xue,Yijie Jia,Zongji Zheng
Proteinuria-induced damage to renal tubular epithelial cells is one of the main causes of diabetic kidney disease (DKD), and the clearance of overloaded albumin by lysosomes is crucial for maintaining the homeostasis of renal tubular epithelial cells. Therefore, lysosomal damage is closely related to the pathogenesis of DKD, but effective prevention and treatment measures are still lacking. Melatonin (MLT) is secreted by the pineal gland and can not only regulate circadian rhythms but also maintain lysosomal homeostasis. In this study, we demonstrate the presence of significant lysosomal damage in the renal tubules of DKD patients, which causes autophagy impairment and a concomitant oxidative stress imbalance; however, MLT can upregulate transcription factor EB (TFEB) to improve lysosomal damage and restore the biosynthesis of this organelle. Mechanistically, MLT may protect lysosomes via the upregulation of TFEB and the miR-205-5p-LRP-1 pathway in renal tubules, thus improving autophagy dysfunction and oxidative imbalance in DKD.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Siqi Liu,Jiawei Wang,Jiangwei Ren,Meng Zhang,Hui Mao
The contamination of fluoride is a concerned issue from the perspective of drinking water safety. Herein, we reported the controlled synthesis of novel chitosan aerogel functionalized by tannin-chelated Zr(IV), which was capable of accomplishing the high-performance adsorption of fluoride from water. The as-prepared functional chitosan aerogel (BTCA-Zr) featured fast adsorption kinetics and exceptional adsorption capability to fluoride. In static adsorption experiments, the superiority of the functional chitosan aerogels was demonstrated with the removal efficiency higher than 95% in the wide pH range of 3–10. The high porosity (79.08%) combined with surface decoration of amphiphilic tannin provided the functional aerogel with fast adsorption equilibrium in 40 min. Adsorption capacity of 86.0 mg g −1 for fluoride was achieved by the functional aerogel with the low fluoride concentration of 2.0 mg L −1 . The fluoride adsorption on BTCA-Zr exhibits pseudo-second-order (PSO) kinetics and fits the Langmuir isotherm, and the adsorption process is exothermic and spontaneous. The adsorption mechanism was revealed by adsorption experiments combined with the density functional theory (DFT) calculations, which confirmed the critical role to form the species of Zr-oxyfluoride with low binding energy for accomplishing the high-performance adsorption of fluoride. Notably, the functional aerogel achieved 85.59% of fluoride removal by column adsorption of the simulated underground water. The functional aerogel was recycled 5 times in column adsorption of the simulated underground water by retaining 78.38% of its initial adsorption capacity.
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Journal of Advanced Research
·
2025
·
IF 13
Mengjiao Wu,Chengpu Lv,Yuling Xiong,Wenglong Li,Yuangui Lin,Jing Li,Fei Yu,Huan Yuan,Biao You,Qiuping Zhang,Ming Xu
Introduction Heterostructured photocatalysts have shown an enormous potential in photocatalytic degradation of organic pollutants in wastewater. However, the efficacy of such heterojunction on the photocatalytic degradation behaviors has not yet been fully revealed. Objectives This work aims to demonstrate a specific photocatalytic degradation behavior of ZnO-based heterostructured nanocomposites toward methyl orange (MO) and methylene blue (MB) dyes based on a systematically comparative investigation for their physical and chemical properties. Methods A series of low-cost and efficient ZnO-based heterostructured nanocomposite photocatalysts including ZnO/CuO, ZnO/TiO 2 and ZnO/SnO 2 with 3 and 10 mol% of CuO/TiO 2 /SnO 2 were synthesized by a simple strategy to combine the modified polymer-network gel and traditional sol–gel methods. The physical and chemical properties were analyzed using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscope (TEM), X-ray photoelectron spectra (XPS), ultraviolet–visible (UV–Vis) absorption spectra, photoluminescence (PL), surface photovoltage (SPV), electrochemical impedance spectroscopy (EIS) and zeta potential. Results Owing to the fast interfacial charge transfer at the heterojunction, all the three ZnO-based nanocomposite catalysts exhibited higher efficient separation of photogenerated electrons and holes, delivering an enhanced photocatalytic activity for the degradation of organic dyes compared with pure ZnO. Three photocatalysts of ZnO/3 %-CuO, ZnO/3 %-TiO 2 and ZnO/10 %-SnO 2 (marking as ZC3, ZT3 and ZS10, respectively) were capable of achieving the complete degradation of 4 mg/L concentration of MB dye within 50 min, and the first two could degrade MO within 80 min. However, the degradation rate of MO by ZS10 became significantly slower. For MO and MB degradation, the active species of photogenerated holes ( h h ν + ) and superoxide radicals ( · O 2 - ) play the predominant roles, respectively, followed by hydroxyl radicals ( · OH ). The differences in heterojunction configuration and dominant active species result in a specific photocatalytic degradation behavior of ZnO-based composite nanostructures. Conclusion The generation of the active species are influenced by the heterojunction configurations, of which the essence is that the different band alignments can results in the differences of interfacial charge transfer behaviors, and thus selective generation of the active species such as h h ν + , · O 2 - and · OH . Importantly, this work offers a fundamental understanding for specific photocatalytic degradation of the different heterojunction nanostructures towards the different organic dyes.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
·
IF 6.3
Junfeng Sun,Yanyan Jiang,Xin Li,Jiaxian Li,Chao Liu,Na Li,Guoying Wang,Gaofeng Shi
High-performance gas sensors can be used to detect low-concentration volatile organic compounds (VOCs), toxic and explosive gases in the atmospheric environment, which is of great significance to environmental protection and human health. In this paper, In 2 O 3 @HCNFs gas sensing material with core-shell structure was successfully synthesized by coaxial electrospinning method , and a new room temperature O 3 sensor was developed with potassium ferrite superionic conductor (K 2 Fe 4 O 7 ) as solid electrolyte. The response test shows that the K 2 Fe 4 O 7 -In 2 O 3 @HCNFs sensor has the highest response value and the shortest response/recovery time for 180–420 ppb O 3 . The logarithmic fitting of the response value and the O 3 concentration shows that the sensor has a stronger sensitivity to O 3 . In addition, the K 2 Fe 4 O 7 -In 2 O 3 @HCNFs sensor has good repeatability and stability for O 3 . In the high humidity environment (90 %RH), the sensor still has a certain response value to O 3 , which proves the feasibility of the sensor under high humidity conditions. Additionally, the sensor has good selectivity for O 3 in the presence of other interfering substances. The excellent performance of K 2 Fe 4 O 7 -In 2 O 3 @HCNFs sensor was verified by analyzing the structural composition of gas sensing materials and the detection mechanism of the sensor. Therefore, compared with the traditional uniaxial electrospinning, the In 2 O 3 @HCNFs composite synthesized by coaxial electrospinning has excellent gas sensing properties, and the solid electrolyte gas sensor prepared by it has a good application prospect in the detection of ppb-level O 3 .
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 5.9
Lidong Gong,Zichao Liang,Xianling Ning,Jianan He,Junjie Huang,Runtao Li,Yuxin Yin,Ridong Li,Zhiqiang Lin
A series of novel 2,4-diarylaminopyrimidine derivatives incorporating a 3-sulfamoylbenzamide moiety were designed and synthesized as potent focal adhesion kinase (FAK) inhibitors. Three compounds ( 5f, 10b , and 10c ) demonstrated FAK inhibitory activities comparable to the reference inhibitor TAE226 . In cellular assays, most analogues exhibited significant antiproliferative effects against four FAK-overexpressing tumor cell lines (HCT116, HeLa, MDA-MB-231, and A375), with IC 50 values below 1 μM. Notably, compound 10c displayed superior potency, showing IC 50 values ranging from 0.08 to 0.31 μM across the tested cell lines, and exhibited approximately 2-fold enhanced activity over TAE226 in inhibiting HCT116, MDA-MB-231, and A375 cell proliferation. Further mechanistic studies revealed that 10c effectively suppressed colony formation, migration, and adhesion of HCT116 cells, while inducing apoptosis via ROS elevation. Molecular docking analysis suggested that the enhanced activity of 10c may arise from an additional hydrogen bond interaction with the Arg426 residue of FAK, leading to stronger binding affinity compared to TAE226 . In vivo , 10c showed good oral bioavailability and significantly inhibited HCT116 xenograft tumor growth (TGI = 62.22 % at 50 mg/kg), outperforming TAE226 (50.98 %) without inducing weight loss or hepatorenal toxicity. These results highlight 10c as a promising FAK-targeted candidate worthy of further preclinical investigation.
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FOOD CHEMISTRY
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2025
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IF 9.8
Zhiling Tang,Yiyuan Zou,Haoran Luo,Zehua Zhang,Fayin Ye,Guohua Zhao
Buckwheat noodles (WB) are always superior in health effects but inferior in textural quality to wheat noodles (W). Artemisia sphaerocephala Krasch gum (AsKg) has been proven to be an improver for the latter. To elaborate on this, the effects of physical state (dry or pre-hydrated) and addition mode (pre-addition or delayed addition) of AsKg on the quality of buckwheat noodles (buckwheat:wheat = 3:7, w/w) were investigated in this work as four procedures, namely, dry/pre-addition (DP), dry/delayed addition (DD), pre-hydrated/pre-addition (HP), and pre-hydrated/delayed addition (HD). The dough mixing property, water distribution, rheological behavior, the structure of the gluten network, and noodle quality were determined. The results indicated that on most occasions, the improvements were in a procedure order of HP > DD > HD > DP, corresponding to the same order in their levels of gluten hydration. These findings are of practical significance for producing high-quality buckwheat noodles.
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CARBOHYDRATE POLYMERS
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2025
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IF 12.5
Lina Pei,Xi Feng,Lijia Zhang,Wen Huang,Zhinan Mei,Ying Liu
In this study, carboxymethyl pachymaran (CMP) with three different degrees of substitution were prepared and their hypolipidemic activities were investigated. CMP2 with a substitution degree of 0.791 had different molecular weight and surface smoothness textural profile than CMP1 (0.756) and CMP2 (0.871). All CMPs could reduce 0.5 mM oleic acid-induced lipid accumulation in HepG2 cells, however, CMP2 exhibited a stronger activity than that of CMP1 and CMP3 in lowering lipid and oxidative stress levels. The results demonstrated that CMP2 can reduce lipid levels , serum inflammatory factors and improve liver enzymes in mice. Moreover, the gut microbiota composition was balance and the levels of healthy beneficial short-chain fatty acids were increased treated by CMP2. RT-qPCR analysis demonstrated that CMP2 regulated hepatic and biliary cholesterol efflux by up-regulating the expression levels of LDLR, PPARα, and ABCA1 , while down-regulating the expression levels of SREBP-2. CMP2 effectively inhibited lipid accumulation in hepatocytes and attenuates inflammatory injury by a dual regulatory mechanism. Our results revealed potential to develop hypolipidemic functional foods with CMP2.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2025
·
IF 6.1
Xin-Yu Wang,Zi-Peng Li,Bi-Yun Feng,Jie Cheng,Ji-Xiao Zhu,Guang-Hui Xu,Wei-Feng Huang,Li-Tao Yi
Chlorantraniliprole, a widely used anthranilic diamide insecticide, has been linked to adverse effects on mammalian health, yet the precise toxicological mechanisms affecting intestine and brain remain unclear. In this study, mice were exposed to chlorantraniliprole at doses of 80, 160, and 320 mg/kg over a 28-day period. Significant damage to the intestinal barrier was observed, evidenced by decreased expression of tight junction protein ZO-1 and increased levels of inflammatory markers. Cognitive impairments, including decreased locomotor activity, impaired reward response, and increased anhedonia, were observed in behavioral tests. Oxidative stress was overactivated in both colonic and hippocampal tissues. Chlorantraniliprole exposure caused gut dysbiosis, characterized by an increase in Lactobacillus and Allobaculum and a reduction in Parabacteroides . In addition, short-chain fatty acid (SCFA) production decreased following chlorantraniliprole exposure. Metabolomic profiling revealed an increase in lipid-related metabolites and peptides, but a decrease in organic acids and nucleic acids, indicating metabolic dysregulation. Furthermore, iron accumulation and mitochondrial damage were observed in colonic tissue. These findings suggest that chronic chlorantraniliprole exposure disrupts intestinal and neural homeostasis through interconnected pathways involving inflammation, oxidative stress, gut microbiota alterations, and metabolic dysfunction.
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Journal of Advanced Research
·
2025
·
IF 13
Jing Huang,Yue Qin,Haiyu Chen,Fangkun Liu
Introduction Snakebites, one of the world’s deadliest neglected tropical diseases, predominantly affect impoverished rural communities in tropical and subtropical regions. The clinical management of snakebite envenomation currently relies heavily on antivenom serum, which is often inaccessible and expensive in these areas. Thus, effective and cost-efficient therapies for treating snakebite envenomation are urgently needed. Pimpinella diversifolia DC, a herb widely distributed across Asia, has long been used in traditional medicine for the treatment of snake venom poisoning. Objectives To investigate the efficacy of P. diversifolia in counteracting venom-induced lethality caused by various neurotoxic venoms in mouse models and in vitro experiments. Methods The protective effects of P. diversifolia against various neurotoxic venoms were evaluated in C57BL/6 mice by intraperitoneal administration of the aqueous extract immediately after injection of snake venom. The primary components of P. diversifolia were identified using liquid chromatography-mass spectrometry, and the compounds were subsequently assessed for their ability to protect against neurotoxicity. Additionally, the neurotoxic effects of Bungarus multicinctus venom and efficacy of the drug against venom-induced neurotoxicity were examined in chick biventer cervicis (BC) and mouse phrenic nerve-diaphragm (PND) preparations. Results P. diversifolia partially prevented lethality in some of the mice injected with various snake venoms. Adenosine, one of the most abundant compounds in the extract, significantly prevented lethality in mice caused by B. multicinctus venom, with 100% survival observed within 48 h. Adenosine markedly attenuated the neurotoxic effects of B. multicinctus venom in BC and PND preparations, and prevented the inhibition of muscular contractions induced by exogenous acetylcholine and carbamylcholine. Conclusion Adenosine may have a protective role against B. multicinctus venom-induced neurotoxicity in preclinical models, warranting further investigation into its mechanisms and clinical applicability.
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IMMUNITY
·
2025
·Vol. 58
·期 7
·1811-1829
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IF 26.3
Ding Qiu,Shuishen Zhang,Chanyan Huang,Xinying Wang,Jianping Deng,Haiyang Sun,Bingbing Feng,Ying Tan,Kaile Ji,Shaoting Xu,Xiaoqi Ye,Chao Cheng,Shigeru Kakuta,Yoshiyuki Adachi,Yoichiro Iwakura,Shuai Wang,Shaowei Dong,Ce Tang
Dectin-1 ( Clec7a ), a C-type lectin receptor for β-glucans, is critical in host defense against fungal infections and has been implicated in allergic responses, yet its role in pulmonary fibrosis remains unclear. In this study, we reveal that bleomycin-induced pulmonary fibrosis was suppressed in Dectin-1-deficient mice, mediated by interactions with the commensal lung fungus Engyodontium . Dectin-1 was predominantly expressed on alveolar macrophages (AMs), correlating with fibrosis severity in both humans and mice. Dectin-1 deficiency reduced Arginase-1 and TGF-β-producing AMs and profibrotic factor expression. Mechanistically, Dectin-1 signaling promoted quiescent AM differentiation into profibrotic AMs via the Raf1-dependent pathway, bypassing CARD9 signaling and mono-macrophage chemotactic recruitment. Therapeutic targeting of Dectin-1 with laminarin or Raf1 inhibitors attenuated fibrosis in mice and reduced profibrotic factors in human AMs and fibroblasts. These findings highlight the Dectin-1-Raf1 axis as a key regulator of pulmonary fibrosis and a promising therapeutic target for fibrotic diseases.
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Tingting Yang,Xinming Zhang,Chenhan Huang,Guanghua Xia,Haohao Shi,Xueying Zhang,Fan Wang,Liming Zhang,Jiamei Wang
With the increasing demand of consumers for food preservation materials, the development of high-performance active packaging films has become a research hotspot. This study constructed a novel chondroitin sulfate-zein nanoparticles system co-encapsulating curcumin and resveratrol (ZCRC NPs) for gelatin-based active packaging, modified by atmospheric cold plasma (ACP) to achieve multifunctional enhancement. The ACP-treated composite film exhibited significantly improved in physical properties, with opacity increasing to 1.15 ± 0.16, while mechanical strength and elongation at break improved by 168 % (from 0.025 ± 0.001 MPa to 0.067 ± 0.003 MPa, P < 0.05) and 105 % (from 25.76 ± 2.46 % to 52.81 ± 3.54 %), respectively. Barrier properties were simultaneously enhanced, with oxygen permeability reduced by 50 % (from 3.61 ± 0.05 to 1.82 ± 0.03 g/m·d) and water vapor permeability decreasing from (7.45 ± 0.76) × 10 −7 to (2.63 ± 0.86) × 10 −7 g/m·d·Pa. The scanning electron microscopy (SEM) exhibited that ZCRC NPs were uniformly dispersed in the gelatin-based film and exhibited good compatibility with the matrix. Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) analyses confirmed that ACP treatment enhanced NPs cross-linking in gelatin-based films by driving hydrogen bonding, hydrophobic interactions, and electrostatic forces, while also enhancing crystallinity. Moreover, differential scanning calorimetry (DSC) and thermogravimetry (TG) analysis demonstrated that the thermal stability of the composite film was significantly improved ( P < 0.05). Antioxidant capacity significantly increased ( P < 0.05), with DPPH inhibition (29.11 ± 1.34 % to 60.63 ± 1.05 %) and ABTS scavenging (45.25 ± 1.67 % to 76.80 ± 1.94 %), effectively delaying fish fillet deterioration. In summary, this study provides new insights into the application and preservation potential of ACP-modified NPs in active food packaging films.
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