STARCH-STARKE
·
2022
·
IF 2.688
Mengyu Zhang,Wenshuai Wang,Wenxue Sun,Jianjun Zhang,Le Jia
This study investigates the efficacy of chewable tablets made from the Pleurotus djamor zinc polysaccharide (PCT-Zn) against the nonylphenol (NPs) induced male reproductive damage in mice. The trial takes the form of constructing a model by infusing NPs into mice, followed by treatment with PCT-Zn solution infusion 1 h later, for a total of 8 weeks. It is found that PCT-Zn shows potential effects on increasing the testicular coefficients, enhancing the antioxidant activities, and inhibiting the apoptotic and inflammatory responses, which indicate that PCT-Zn has the effect of alleviating the NPs-induced reproductive damage. The results of the experiment suggest that the P. djamor zinc polysaccharide can be used as a dietary supplement to develop appropriate products to alleviate reproductive damage caused by environmental pollutants.
研究领域:
环境毒理学
·
生殖生物学
·
药理学
·
营养科学
✓ 已验证
产品关联
DOI
高影响因子
STARCH-STARKE
·
2022
·
IF 2.688
Shan Gao,Junyi Wang,Yongze Zhang,Nuaner Liu,Rui Zhang,Zhongquan Sui,Hanxue Hou
Hull-less barley grass polysaccharide extracts (HBP) are prepared, and the physicochemical and antioxidant properties of agar films with different HBP contents (0, 0.5, 1, 1.5, and 2% w/w of agar mass) are investigated. Infrared spectroscopy shows that HBP interacts with the agar matrix via intermolecular hydrogen bonds. The incorporation of HBP causes rougher surface morphology with increased film thickness ( p < 0.05). The films with HBP exhibit decreased brightness with a greenish and yellowish hue. The flexibility of the films is improved gradually as HBP contents increase from 0 to 1.5% w/w ( p < 0.05), however, a slight reduction is observed with 2% w/w HBP addition ( p > 0.05). The water resistance and surface hydrophobicity of the films are enhanced by adding HBP ( p < 0.05). The antioxidant test reveals the strong antioxidant capacity of the HBP-loaded films, which is positively correlated with the HBP contents ( p < 0.05), with 2% w/w HBP leading to 59.28% DPPH radical scavenging and 69.00% ABTS radical scavenging. Results suggest that HBP is a promising functional agent for developing antioxidant biopolymer films, and the agar/HBP edible films prepared in this study have potential in food packaging fields.
研究领域:
食品科学
·
材料科学
✓ 已验证
DOI
高影响因子
STARCH-STARKE
·
2021
·
IF 2.741
Qiujie Fang,Na Chen,Shan Hu,Sheng Hu,Jianfeng Ye,Xiaozhou Ye,Yun Wang
Some special oral drugs may cause adverse reactions and degrade in the stomach; therefore, it is necessary to develop a new generation of multifunctional drug delivery carries to deal with such issues. Herein, by polyelectrolyte composite method using KGM and CS as raw material, CKGM/CS/TPP/5-ASA microcapsules are prepared using 5-ASA as model drug, and then coated with an acid-resistant polyacrylic acid polymer layer. The size of CKGM/CS/TPP/5-ASA microcapsules is relatively uniform, with average particle size 1.78 ± 0.02 mm. The inner part of microcapsules has a core-shell three-dimensional network structure, and the 5-ASA embedded in the network is in its crystal form. The microcapsules exhibited good encapsulate properties, with 495.5 µg mg −1 drug loading amount and 82.3% encapsulation efficiency under optimized conditions. The in vitro release properties of microcapsules are also studied, and results showed that the drug is released little in Simulated Gastric Fluid solution (pH 1.2) but fully released in Simulated Colonic Fluid or Phosphate Buffered Solution (pH 7.0), and the release rate is higher in SCF solution, indicating that β-mannanase could facilitate release. All these results indicated that CKGM/CS/TPP microcapsules have good pH-controlled release, enzymatic release, and sustained release properties, hence they are promising multifunctional colon-targeted release carriers.
研究领域:
药学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
STARCH-STARKE
·
2021
·
IF 2.741
Meidong Li,Xiufang Huang,Qin Zhang,Yifeng Zhou,Kai Luo
Four new types of water-soluble polysaccharides are isolated from Cardamine hupingshanensis . Herein, this study examines C. hupingshanensis polysaccharide no. 2 (CHP-2) with a molecular weight of 21.75 kDa. Analysis revealed that CHP-2 is composed of d -glucuronic acid, d -galacturonic acid, glucose, galactose, and L-arabinose. It is speculated that the main connecting bond is →4)-α-D-Glc(p)-(1→), →t)-α-D-Glcp-(1→). Through perfusion experiments using streptozotocin-induced diabetic rats, oral CHP-2 solution is found to significantly reduce food intake, water intake, and fasting blood glucose levels, while increasing the weights of rats. In addition, CHP-2 significantly reduces the serum and liver malondialdehyde contents and increases the activity of the corresponding antioxidant enzymes. Moreover, the effect elicited by the CHP-2 solution is similar to that of phenformin hydrochloride solution. Hence, the results of this study suggest that CHP-2 exhibits blood sugar-lowering and anti-oxidation effects.
研究领域:
药理学
·
生物化学
·
糖尿病研究
✓ 已验证
DOI
高影响因子
STARCH-STARKE
·
2021
·
IF 2.741
Yawei Liu,Bing Xu,Fei An,Jie Liu
Cross-linked cassava starch-konjac glucomannan composite (CCS-KGM), native cassava starch-sodium trimetaphosphate-konjac glucomannan composite (NCS-STMP-KGM), and cross-linked cassava starch-sodium trimetaphosphate-konjac glucomannan composite (CCS-STMP-KGM) are prepared to study the effect of STMP and KGM on the native cassava starch and cross-linked cassava starch. A small amount of KGM adheres to the surface of cassava starch granules in the three composites. The results of Fourier transform infrared spectroscopy indicate that cross-links form in the cross-linked cassava starch and three composites. The X-ray diffraction analysis reveals that the crystallization type of native cassava starch modified by STMP and KGM remains unchanged (A-type). The mean particle size of cross-linked cassava starch and the three composites are larger than that of native cassava starch. STMP and KGM decrease the swelling power and water loss rate of native cassava starch. Dynamic rheological results suggest that STMP and KGM increase storage modulus and loss modulus of native cassava starch gel. It provides the possibility for both STMP and KGM to improve the gel properties of native cassava starch rather than cross-linked reaction, and also expands the application field of KGM with low cost.
研究领域:
食品科学
·
高分子化学
✓ 已验证
DOI
高影响因子
STARCH-STARKE
·
2023
·
IF 2.3
Yijuan Xu,Weifeng Hua,Haoran Xu,Harold Corke,Wuyang Huang,Zhongquan Sui
Hulless barley (HB) grass is a potential resource of functional food. In this study, the proliferation inhibitory effect against cancer cells of an alkaline extracted polysaccharide (APP) from HB grass (HBG) is analyzed. The yield of crude alkaline extracted polysaccharide (APC) reaches 15.1%. After purification, the purity and polydispersity index (PDI) of the APP are 98.3% and 1.38, respectively. The molecular weight of APP is 5.1 × 10 5 Da, whereas the number-average molecular weight of APP is 3.7 × 10 5 Da. APP is composed of arabinose (37.8%), xylose (41.3%), glucose (4.6%), and galactose (16.3%). According to the infrared spectral analysis, APP is found to contain β-glycosidic bonds. Moreover, APP possesses significant cell proliferation inhibitory effects against various cancer cell lines, such as 4T1, HT29, Caco-2, and CT26.WT in a dose-dependent manner. Notably, the IC50 value of 4T1 reaches 7.56 mg mL −1 , which indicates that APP from HBG has a potential anti-cancer effect in vitro. It may be further investigated as an ingredient or nutraceutical for development and utilization in functional foods to prevent or treat cancer and related diseases.
研究领域:
食品科学
·
癌症研究
·
药理学
·
植物化学
✓ 已验证
产品关联
DOI
高影响因子
STARCH-STARKE
·
2023
·
IF 2.3
Yao Wen,Caimei Su
A Box–Behnken design (BBD) of response surface methodology (RSM) is employed to further optimize ultrasonic-assisted extraction conditions for Ophiopogon japonicus polysaccharides. The results show that optimized extraction conditions are liquid–solid ratio of 22:1 mL g −1 , ultrasonic time of 27 min, and ultrasonic power of 200 W. Under these conditions, the mean experimental value of extraction yield (39.49%) is achieved, which is 1.33 times that of distilled water leaching extraction (29.68%). In addition, one of the eluting fractions, SPs-1 , has high α -glucosidase and α -amylase inhibitory activities as well as 1,1-Diphenyl-2-picrylhdrazyl radical and α-glucosidase, 2,2’-Azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) cation scavenging activities with an IC 50 value of 0.060, 0.021, 0.50, and 0.10 mg mL −1 . Therefore, SPs-1 from O. japonicus can be considered as multifunctional biological ingredients to be used in anti-hyperglycemic pharmaceutical formulation and antioxidant in functional foods.
研究领域:
药学
·
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
STARCH-STARKE
·
2023
·
IF 2.3
Yunchun Wang,Zeyu Wu,Yanting Lin,Ailing Hui,Han Tao,Alia Shah,Qingsong Liu,Jianwen Li,Shengnan Li,Hao Liu,Wencheng Zhang
In this study, the effects of chain length distribution and drying methods on the structural properties and in vitro digestibility of resistant starch (RS) are investigated. Rice starch is debranched at 10% w/w solid concentrations, incubated at 60 °C, and further subjected to freeze drying and oven drying treatment to obtain debranched starch (DBS). The chain length distribution shows that DBS (the degree of polymerization [DP] = 19.52 ± 0.13) has a high proportion of B1 and B2 chains (DP13-36) and a narrow chain length distribution. In addition, the results of scanning electron microscopy (SEM) show that the oven-dried samples have denser structures and larger particle morphology compared to samples prepared by freeze-drying. In FTIR, LCM-Raman and X-ray diffraction patterns, debranched starch supernatant fraction 1 (DBSS1) exhibit higher short-range molecular order and crystallinity than other samples. Digestibility analysis shows that DBSS1 with narrow chain length distribution (DP13-36) promotes the high content of RS formation and oven drying is more favorable for RS formation than freeze drying (RS DBSFS1 = 79.69 ± 5.09% and RS DBSOS1 = 84.17 ± 0.17%). This suggests that the proper narrow chain length distribution is conducive to the formation of ordered structure and an increase in resistance. Oven drying provides a larger starch particle size, which facilitates resistance to digestion.
研究领域:
食品科学
·
淀粉化学
·
营养学
✓ 已验证
产品关联
DOI
高影响因子
STARCH-STARKE
·
2023
·
IF 2.3
Min Zhu,Jieyi Xiong,Shanshan Li,Qifeng Chen
Carbon quantum dots (CQDs) are one of the most promising luminescent nanomaterials for anti-counterfeiting due to their excellent optical properties, low toxicity, and environmental friendliness. With the development of green chemistry, biomass carbon sources have attracted attention. Herein, nitrogen-doped carbon quantum dots (N-CQDs) are synthesized using waste corn bract nanocellulose as the carbon source and L-histidine as the nitrogen source in a simple and quick one-step microwave method. It is found that a raw material mass ratio of 1:4, a temperature of 100 °C, and a preparation time of 5 min are the optimum preparation conditions. The fluorescence quantum yield of N-CQDs obtained under these conditions is 32.64%. Under the excitation of light at a wavelength of 365 nm, the emission peak of N-CQDs is located at 430 nm and emits blue light. This study also provides a method to prepare fluorescent anti-counterfeiting films with excellent performance and fluorescent detection probes solely from waste biomass corn bract leaves and L-histidine.
研究领域:
材料科学
·
绿色化学
·
光学材料
✓ 已验证
产品关联
DOI
高影响因子
STARCH-STARKE
·
2023
·
IF 2.3
Yongjie Lin,Yan Lin,Zhiyun Wang,Yanbo Wang,Yi Zhang,Baodong Zheng,Hongliang Zeng
The objectives of this study are to investigate the structural and physicochemical properties of a novel acetylated lotus seed starch (LSA). LSA is successfully prepared using an aqueous phase method. Fourier transform infrared spectroscopy (FTIR) proves that a carbonyl C=O vibration at 1737 cm −1 are due to the introduced acetyl groups. X-ray diffraction (XRD) indicates that the acetylation treatment does not change the crystal structure, but reduces the relative crystallinity of starch. Scanning electron microscopy (SEM) shows that the surface of LSA with 12% of acetic anhydride (LS-12A) becomes the roughest. Moreover, compared with lotus seed starch (LS), the particle size, transparency, swelling power, and solubility of LSA are increased to 18.01 ± 0.66 µm, 15.30% ± 0.30%, 9.59 ± 1.78 g g −1 , and 6.06% ± 0.99% at 55 °C with the additional content of acetic anhydride. However, differential scanning calorimetry (DSC) shows that the melting enthalpy of LSA decreases compared with LS. This work provides some theoretical basis for the study and development of acetylated starch.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2019
·Vol. 9
·期 4
·547
·
IF 4.034
Meng Li,Jian-Wei Guo,Wei-Qiu Wen,Jem-Kun Chen
A typical amphiphilic star polymer adamantane-[poly(lactic-co-glycolic acid)-bis(2-carboxyethyl) sulfide-poly(ethylene glycol) monomethyl ether)]4with a specific hydrophilic/redox-sensitive/hydrophobic structure was designed and synthesized through ring opening and esterification reactions. The self-assembled nanomicelles were used as doxorubicin (DOX) delivery vehicles with suitable critical micelle concentrations (5.0 mg/L). After the drug being loaded, drug-loaded micelles showed good drug-loading efficiency (10.39%), encapsulation efficiency (58.1%), and drug release (up to 60%) under simulated biological environment conditions. In addition, the backbone structure of the biodegradable polymer was easily hydrolyzed by the action of biological enzymes. As expected, cell-based studies showed that the designed polymer micelles possessed good biocompatibility (a survival rate of 85% for NH-3T3 cells). Moreover, the drug (DOX) still maintained good anti-cancer effects after being loaded, which caused 40% of MCF-7 cells to survive. These redox-sensitive micelles showed anti-tumor therapeutic potential.
研究领域:
药剂学
·
肿瘤学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
·
2011
·
IF 3.044
Jundong Zhu,Zhichao Zhou,Cuihong Yang,Deling Kong,Ying Wan,Zheng Wang
Folate (FA)-conjugated star-shaped copolymer was prepared as a targeted carrier for anticancer drug delivery by ring-opening polymerization of L -lactide using pentaerythritol (PTL) as an initiator, followed by conjugation with methoxy poly(ethylene glycol) (MPEG) and FA-poly(ethylene glycol) (FA-PEG). The resulting amphiphilic star-shaped copolymer was shaped into drug-loaded micelles, and the achieved micelles had an average size of around 146 nm in diameter. It was found that the sustained release time of model drug (indomethacin, IMC) from some selected micelles could reach around 40 h. In comparison with linear poly( L -lactic acid)-block-methoxy poly(ethylene glycol) copolymer (PLA-MPEG), the stability of the star-shaped pentaerythritol- co -poly( L -lactic acid)-block-[methoxy poly(ethylene glycol) and FA-poly(ethylene glycol)] (PTL-PLA-MPEG/PEG-FA) micelle was significantly improved because of the lower critical micelle concentration (CMC). The specificity of PTL-PLA-MPEG/PEG-FA targeting cancer cells was demonstrated by intracellular uptake of PTL-PLA-MPEG/PEG-FA and PTL-PLA-MPEG using HeLa human cervical cancer cells. After 2 h in vitro incubation, a significant intracellular uptake for PTL-PLA-MPEG/PEG-FA over PTL-PLA-MPEG was observed by using inverted fluorescence microscope and flow cytometry. These results suggested that PTL-PLA-MPEG/PEG-FA polymeric micelle could be a potentially useful carrier for delivering selected drugs to FA-receptor positive cancer cells. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
研究领域:
生物材料
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）