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Information

Mycophenolic acid Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.
In vitro

Mycophenolic acid inhibits inosine-5\'-monophosphate dehydrogenase (IMPDH) by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule. Mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase, in nanomolar concentrations blocks proliferative responses of cultured human, mouse and rat T lymphocytes and B lymphocytes to mitogens or in mixed lymphocyte reactions. Mycophenolic acid (MPA) suppresses mixed lymphocyte reactions when added 3 days after their initiation. Mycophenolic acid also inhibits antibody formation by polyclonally activated human B lymphocytes. Mycophenolic acid is an immunosuppressive agent reversibly inhibiting proliferation of T and B lymphocytes and antibody formation, with a profile of activity different from that of other immunosuppressive drugs. Mycophenolic acid inhibits the formation of antibodies to sheep erythrocytes. Mycophenolic acid also suppresses, in a dose-related manner, the generation of cytotoxic T-lymphocytes against allogeneic cells in mice and prevents the elimination of allogeneic cells. Mycophenolic acid induces apoptosis and cell death in a large proportion of activated CD4+ T cells.

In vivo

Mycophenolic acid has lymphocyte-selective anti-proliferative effects in mice and can inhibit both cell-mediated and humoral immune responses without major side effects.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

规格

英文别名

Mycophenolate, RS-61443

规格或纯度

Moligand™, 10mM in DMSO

英文名称

Mycophenolic acid

生化机理

霉酚酸（Mycophenolate，RS-61443）是一种强效的 IMPDH 抑制剂，也是一种免疫抑制剂的活性代谢产物，用于预防器官移植中的排斥反应。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

抑制剂

作用机制

肌苷-5'-单磷酸脱氢酶（IMPDH）抑制剂

名称和识别符

EC号

246-119-3

分子类型

小分子

Isomeric SMILES

CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\C)/CCC(=O)O)O

分子量

320.34

Beilstein号

1295848

Reaxy-Rn

8644904

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8644904&ln=

高级数据

产品属性

ALogP	3.2

关联靶点（人）

IMPDH2 Tclin 肌苷-5'-单磷酸脱氢酶2(Inosine-5'-monophosphate dehydrogenase 2) (24 活性数据)

点击查看靶蛋白信息： IMPDH2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

IMPDH1 Tclin 肌苷-5'-单磷酸脱氢酶1(Inosine-5'-monophosphate dehydrogenase 1) (13 活性数据)

点击查看靶蛋白信息： IMPDH1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

化学和物理性质

熔点

141-145℃

安全和危险性（GHS）

信号词

警告

危险声明

H227: 可燃液体

预防措施声明

P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。

P403: 存放在通风良好的地方。

P501: 将内容物/容器送到批准的废物处理厂处理

WGK Germany

RTECS

MP8050000

Merck Index

6327

个人防护装备

Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

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