H2419371计算溶液所需的质量、体积或浓度。
N1-Me-Pseudo UTP 三钠盐 溶液
有货
为什么选择此级别
PharmPure™,医药级 提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存,避免反复冻融。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
N1-Me-Pseudo UTP即N1-Methyl-Pseudo-UTP，中文名为N1-甲基-假尿苷三磷酸，是最常用的修饰核苷三磷酸之一，可用于分子生物学中多种相关应用，如体外转录、siRNA合成等。研究发现，使用假尿苷三磷酸或N1-甲基-假尿苷三磷酸合成的mRNA具有更好的稳定性和翻译效率，并且降低了mRNA自身免疫原性，使其在疾病预防和治疗领域得到了广泛应用。本产品为纯度≥ 99% (HPLC) 的N1-Me-Pseudo UTP钠盐水溶液，浓度为100mM±5mM，且没有核酸内切酶、核酸外切酶和核糖核酸酶污染。
本制品采用药用规格原辅料生产，并严格控制生产过程中各类污染等，符合GMP规范的产品生产与质量管理规程保障生产过程及所有原辅料可追溯。
遵循以下规范生产
1. ISO 9001:2015, certified facility。
2. 《GMP附录-细胞治疗产品》国家药品监督管理局。
3. 《人用基因治疗总论-中国药典2020》国家药典委。
4. USP Chapter <1043>, Ancillary Materials for Cell, Gene, and Tissue-Engineered Products用于细胞治疗，基因治疗和组织工程产品中的辅料。
5. USP Chapter <92>, Growth Factors and Cytokines Used in Cell Therapy Manufacturing 细胞治疗产品生产过程中细胞因子和生长因子。
6. Ph. Eur. General Chapter 5.2.12, Raw Materials of Biological Origin for the Production of Cell-based and Gene Therapy Medicinal Products用于生产细胞或基因治疗药物的生物来源原料。
保存温度
产品可以在-20±5℃短期保存或运输，长期保存于-70±5℃，产品有效期1年；
避免多次冻融循环和频繁的温度变化；
产品冷冻后可能会形成浓度梯度，使用前需充分混合均匀。
N1 me pseudoudo UTP is N1 methyl pseudoudo UTP, which is called N1 methyl pseudouridine triphosphate in Chinese. It is one of the most commonly used modified nucleoside triphosphates and can be used in a variety of related applications in molecular biology, such as in vitro transcription, siRNA synthesis and so on. It is found that the mRNA synthesized by pseudouridine triphosphate or N1 methyl pseudouridine triphosphate has better stability and translation efficiency, and reduces the autoimmunity of mRNA, which makes it widely used in the field of disease prevention and treatment. This product is N1 me pseudoutp sodium saline solution with purity ≥ 99% (HPLC), the concentration is 100mm ± 5mm, and there is no pollution of endonuclease, exonuclease and ribonuclease.
This product is produced with medicinal raw and auxiliary materials, and all kinds of pollution in the production process are strictly controlled. It complies with the product production and quality management procedures of GMP, so as to ensure the traceability of the production process and all raw and auxiliary materials.
Follow the following specifications
1. ISO 9001:2015, certified facility
2. GMP appendix - cell therapy products State Drug Administration.
3. General introduction to human gene therapy - Chinese Pharmacopoeia 2020, national pharmacopoeia commission.
4. USP chapter < 1043 >, ancillary materials for cell, gene, and tissue engineered products are used as excipients in cell therapy, gene therapy and tissue engineering products.
5. USP chapter < 92 >, growth factors and cytokines used in cell therapy manufacturing.
6. Ph. Eur. General chapter 5.2.12, raw materials of biological origin for the production of cell-based and gene therapy medical products.
Storage temperature
The product can be stored or transported at - 20 ± 5 ℃ for a short time, and stored at - 70 ± 5 ℃ for a long time. The product is valid for 1 years;
Avoid multiple freeze-thaw cycles and frequent temperature changes;
The product may form a concentration gradient after freezing. It needs to be fully mixed before use.
规格
别名
N¹-甲基假尿苷 5'-三磷酸钠 | [(2R,3S,4R,5S)-3,4-二羟基-5-(1-甲基-2,4-二氧代-1,2,3,4-四氢嘧啶-5-基)四氢呋喃-2-基]甲基四氢三磷酸钠
英文别名
n1-methylpseudouridine-5'-triphosphate | N1-Methylpseudouridine-5-triphosphate | SCHEMBL16094950 | ((2R,3S,4R,5S)-3,4-Dihydroxy-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate | 1-Methylpseudou
规格或纯度
医药级, PharmPure™, ≥99%, 100mM
英文名称
N1-Me-Pseudo UTP Trisodium solution
储存条件
-80℃储存,避免反复冻融
运输条件
特低温运输
纯度
≥99%
名称和识别符
PubChem SID
分子类型
寡核苷酸
IUPAC Name
[[(2R,3S,4R,5S)-3,4-dihydroxy-5-(1-methyl-2,4-dioxopyrimidin-5-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
INCHI
1S/C10H17N2O15P3/c1-12-2-4(9(15)11-10(12)16)8-7(14)6(13)5(25-8)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5-8,13-14H,3H2,1H3,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t5-,6-,7-,8+/m1/s1
InChi Key
OLRONOIBERDKRE-XUTVFYLZSA-N
Smiles
CN1C=C(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
Isomeric SMILES
CN1C=C(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
PubChem CID
分子量
564.11
技术文档
高级数据
三维结构
交互式化学结构模型
化学和物理性质
敏感性
对热敏感
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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