计算溶液所需的质量、体积或浓度。
结合珠蛋白 来源于食蟹猴血浆
有货
为什么选择此级别
冻干粉,天然 级 提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
结合珠蛋白是一种急性期蛋白，在人体内存在三种表型。结合珠蛋白可结合游离血红蛋白，防止铁流失以及组织氧化损伤。
蛋白生物学功能
食蟹猴结合珠蛋白是血浆糖蛋白，分子量约 86 kDa，分子结构由二硫键连接的 α 亚基与 β 亚基组成。其主要功能是结合红细胞更新过程释放的游离血红蛋白，形成稳定的 Hp‑Hb 复合物，避免血红蛋白引发组织氧化损伤，并由网状内皮系统完成安全清除。该抗氧化作用对保护组织免受氧化应激与炎症损伤至关重要。
结合珠蛋白具有基因多态性，可形成不同表型，进而影响自身结构与功能特性。结合珠蛋白功能异常或含量变化与溶血性贫血、心血管疾病、炎症性疾病相关；血红蛋白清除效率不足会加重氧化损伤与炎症反应。
在生物医学研究中，食蟹猴结合珠蛋白与人源结合珠蛋白高度同源，是免疫检测、补体依赖性细胞毒性试验的重要试剂，也可作为研究跨物种免疫应答的参考蛋白。
Haptoglobin is an acute phase protein with three phenotypes in the human population. Haptoglobin binds free hemoglobin preventing iron loss and oxidative tissue damage.
Role of protein in biology
Cynomolgus monkey haptoglobin is a plasma glycoprotein with a molecular weight around 86 kDa, structurally composed of α and β subunits linked by disulfide bonds. Its primary function is to bind free hemoglobin released during red blood cell turnover, forming a stable Hp-Hb complex that prevents hemoglobin-induced oxidative tissue damage and facilitates safe clearance by the reticuloendothelial system. This antioxidant role is crucial in protecting tissues from oxidative stress and inflammation.
Haptoglobin exhibits genetic polymorphism, resulting in different phenotypes that can influence its structural and functional properties. Altered haptoglobin function or levels are associated with diseases such as hemolytic anemia, cardiovascular disease, and inflammatory disorders, as inefficient hemoglobin clearance can exacerbate oxidative injury and inflammation.
In biomedical research, cynomolgus monkey haptoglobin is used as a critical reagent in immunoassays, complement-dependent cytotoxicity assays, and as a reference protein for studying cross-species immune responses, due to its close similarity to human haptoglobin.
规格
产品名称
结合珠蛋白 来源于食蟹猴血浆
规格或纯度
天然, 冻干粉, ≥95%(SDS-PAGE), 冻干前蛋白浓度见COA
生化机理
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
种属
食蟹猴(Cynomolgus monkey)
来源
天然
预测分子量
86000
CAS编号和信息
9087-69-8
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from deionized water.
浓度
冻干前蛋白浓度见COA
复溶
离心后，建议加入去离子水补至原体积（详见 COA 证书），随后轻柔混匀，保证充分均一。
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
长期储存-20℃（>1年）；收货后建议分装，避免反复冻融。
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
溶液计算器
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