Measured by its binding ability in a functional ELISA. When Native Human C-Reactive Protein (np008458) is immobilized at 1.0 µg/mL can bind Recombinant CRP Antibody (Ab007977) with the EC50 of 3.88 ng/mL.
CRP is an acute-phase reactive protein synthesized by the liver, which can react with the C-polysaccharide of Streptococcus pneumoniae. Its main biological function is to activate the complement system and mononuclear phagocyte system by binding to ligands (phosphorylcholine on apoptotic or necrotic cells, or invading bacteria, fungi, parasites, etc.), thereby clearing pathogens or pathological cells carrying such ligands. When the body suffers from infection, tissue damage or inflammatory diseases, the level of CRP increases rapidly, even by thousands of times; after the disease is cured, its content drops sharply. Therefore, CRP detection can provide valuable information for the diagnosis, treatment and monitoring of inflammatory processes and related diseases.
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
生物活性
Measured by its binding ability in a functional ELISA. When Native Human C-Reactive Protein (np008458) is immobilized at 1.0 µg/mL can bind Recombinant CRP Antibody (Ab007977) with the EC50 of 3.88 ng/mL.
种属
人(Human)
纯度
≥95% (SDS-PAGE)
无载体
Yes
来源
天然
预测分子量
11.8 kDa
SDS-PAGE
23.8 kDa, under reducing conditions; 22.4 kDa, under non-reducing conditions.
CAS编号和信息
9007-41-4
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20mM Tris, 150mM NaCl, 2mM CaCl2, pH 8.0.
防腐剂
No
浓度
见COA；来源于人胸膜腔积液
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at 2-8 °C short term，Store at-80°C long term(24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
图片
Native Human C-Reactive Protein (np008458) - ELISA Measured by its binding ability in a functional ELISA. When Native Human C-Reactive Protein (np008458) is immobilized at 1.0 µg/mL can bind Recombinant CRP Antibody (Ab007977) with the EC₅₀ of 3.88 ng/mL.
Native Human C-Reactive Protein (np008458) - SDS-PAGE 3 μg/lane of Native Human C-Reactive Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 23.8 kDa under reducing conditions and 22.4 kDa under non-reducing conditions.
ZJ26F0938987
危险品化学品经营许可证（带存储）