ActiBioPure™,His标签,无动物源,无叠氮钠,无载体,生物活性 级 提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining
Description:
CRP is a member of the pentraxin family of proteins that are characterized by a cyclic pentameric structure. Human CRP gene encodes a 224 amino acids precursor. The mature human CRP protein has 206 amino acids that are non-covalently linked to form the pentameter. Human CRP shares 71% and 64% amino acid sequence homology with mouse and rat respectively. CRP, synthesized by hepatocytes, is a major acute phase serum protein in human. IL-6, IL-1 and glucocorticoids are the major inducer of the CRP gene. In response to infection, inflammation or tissue damage, the level of CRP in human serum can increase 1,000-fold within 24-48 hours. It will come back to base level of less than 1 μg/mL very fast. Human CRP is an acute-phase serum protein that plays a role in the first line in host innate host defense. Like other pentraxins, CRP exhibits Ca++‑dependent binding to ligands. Phosphocholine (PCh), a constituent of many bacterial and fungal walls, is a principal ligand of CRP. CRP also binds to the membrane of injured cells, membrane and nuclear components of necrotic and apoptotic cells. Upon binding with the ligands, CRP is recognized by C1q and initiates the activation of complement cascade. Ligand bound CRP also binds to Fc gamma RI and Fc gamma RIIa on phagocytes and activates phogocytotic responses. In addition to phogocytosis, CRP also can induce production of hydrogen peroxide and inflammatory cytokines, such as IL-1, IL-6 and TNF‑ alpha by monocytes. With these functions, human CRP is an important serum protein for anti-bacterial pathogen and clearance of damaged and apoptotic cells. However, in mouse, CRP is expressed at very low level and is not an acute phase reactant. Serum amyloid P component (SAP), another pentraxin, is the major acute phase serum protein in mice. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases.
Recombinant Human C-Reactive Protein/CRP Protein (rp169601) - ELISA
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human C-Reactive Protein/CRP (rp169601) at 1.0 μg/mL can bind Recombinant CRP Antibody (Ab007977) with the EC₅₀ of 18.28 ng/mL.
Recombinant Human C-Reactive Protein/CRP Protein (rp169601) - ELISA
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human C-Reactive Protein/CRP (rp169601) at 1.0 μg/mL can bind Recombinant CRP Antibody (Ab007978) with the EC₅₀ of 13.86 ng/mL.
Recombinant Human C-Reactive Protein/CRP Protein (rp169601) - SDS-PAGE
2 μg/lane of Recombinant Human C-Reactive Protein/CRP Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a band at 24.8 kDa under reducing conditions.
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0404517 |
分析证书 | rp169601 |
| ZJ24F0404518 |
分析证书 | rp169601 |
| ZJ24F0404519 |
分析证书 | rp169601 |
| ZJ25F0826062 |
分析证书 | rp169601 |
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