计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,干燥。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Quinotolast sodium in the concentration range of 1-100 μg/mL inhibits histamine , LTC 4 and PGD 2 release in a concentration-dependent manner.
In Vitro
Quinotolast inhibits the release of histamine and the generation of leukotriene (LT) C 4 and prostaglandin (PG) D 2 from dispersed human lung cells. Quinotolast (100 μg/mL) significantly inhibits PGD 2 and LTC 4 release. Quinotolast inhibits PGD 2 release by 100% and LTC 4 release by 54%. The inhibitory effect of Quinotolast on histamine release from dispersed lung cells is largely independent of the preincubation period, no tachyphylaxis being observed. Quinotolast shows a significant inhibition of inflammatory mediators from human dispersed lung cells. Quinotolast also shows strong inhibitory effects on histamine and peptide leukotrienes release from guinea pig lung fragments or mouse cultured mast cells. Quinotolast concentration-dependently inhibits pLTs release from cultured mast cells. The IC 50 value for Quinotolast is 0.72 μg/mL. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Quinotolast potently inhibits such type I allergic reactions as passive cutaneous anaphylaxis (PCA) and anaphylactic bronchoconstriction in rats by both intravenous and oral dosing. When Quinotolast is given i.v. to rats, Quinotolast, dose-dependently inhibits PCA. The doses of Quinotolast required to inhibit the reaction by 50% (ED 50 ) is 0.0063 mg/kg. Given p.o., Quinotolast inhibits the reaction. ED 50 value for Quinotolast is 0.0081 mg/kg. Although almost complete inhibition is observed with Quinotolast at a dose of 0.32 mg/kg, its effect is slightly attenuated at a dose of 1 mg/kg. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Assay
Mast cells are obtained after the culture of bone marrow cells from the femurs of female BDF 1 mice in the presence of conditioned medium from WEHI-3 cells containing interleukin 3. The cells are suspended with Tyrode's buffer (137 mM NaCI, 2.7 mM KC1, 1.8 mM CaCl 2 , 1 mM MgCl 2 , 0.4 mM NaH 2 PO 4 , 11.9 mM NaHCO 3 , 5.6 mM glucose) containing 0.1% gelatin and are sensitized with mouse monoclonal anti-DNP IgE (50 μg/10 6 cells). Then the cells are washed and resuspended with Tyrode's buffer containing 0.25% BSA. The cells (2×10 6 cells) are incubated for 5 min at\n37°C and challenged with TNP-BSA (2 ng BSA/mL). Quinotolast (0.1, 1, 10, 100 ug/mL) is added to the reaction tube simultaneously with the antigen. Ten minutes later, the reaction is stopped by the addition of EDTA (2.7 mM). pLTs in the cell supernatant sre quantified as immunoreactive leukotriene C 4 (iLTC 4 ) with a leukotriene C 4 /D 4 /E 4 [ 3 H] assay system. % Inhibition is calculated in each experiment from the amount of immunoreactive leukotriene C 4 (iLTC 4 ). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal administration
Rats Rats (8 week-old) are used. To study the presence of tachyphylaxis by Quinotolast, Quinotolast (0.001, 0.01, 0.1, 1,10 and 100 mg/kg) is given i.v. in a large dose 30 min before challenge, and again at a smaller dose simultaneously with the antigen challenge. aladdin has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Histamine LTC 4
规格
别名
喹诺司特钠
英文别名
UNII-G8K8E99F1S | sodium;4-oxo-1-phenoxy-N-(2H-tetrazol-5-yl)quinolizine-3-carboxamide | G8K8E99F1S | FR71021 | FR-71021 | Q27278938 | Quinotolast sodium anhydrous | Quinotolast sodium | QUINOTOLAST SODIUM [JAN] | 4H-Quinolizine-3-carboxamide, 4-oxo-1-phe
规格或纯度
≥98%
英文名称
Quinotolast sodium
生化机理
浓度为 1-100 μg/mL 的喹诺酮钠能以浓度依赖性方式抑制组胺、LTC 4 和 PGD 2 的释放。
储存条件
2-8°C储存,干燥
运输条件
低温运输
纯度
≥98%
名称和识别符
分子类型
小分子
IUPAC Name
sodium;4-oxo-1-phenoxy-N-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)quinolizine-3-carboxamide
INCHI
1S/C17H12N6O3.Na/c24-15(18-17-19-21-22-20-17)12-10-14(26-11-6-2-1-3-7-11)13-8-4-5-9-23(13)16(12)25;/h1-10H,(H2,18,19,20,21,22,24);/q;+1/p-1
InChi Key
CDPWRMHFRRXOQH-UHFFFAOYSA-M
Smiles
C1=CC=C(C=C1)OC2=C3C=CC=CN3C(=O)C(=C2)C(=O)NC4=NN=N[N-]4.[Na+]
Isomeric SMILES
C1=CC=C(C=C1)OC2=C3C=CC=CN3C(=O)C(=C2)C(=O)NC4=NN=N[N-]4.[Na+]
关联CAS
PubChem CID
MeSH Entry Terms
FR 71021;FR-71021;FR71021;quinotolast;quinotolast sodium;quinotolast sodium, monohydrate;quinotolast sodium, tetrahydrate;sodium 5-(4-oxo-1-phenoxy-4H-quinolizine-3-carboxamide)tetrazolate
分子量
371.31
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机氧化合物 |
| 类（Class) | 有机氧化合物 |
| 亚类（Subclass） | 醚 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | 二芳醚 |
| 其他上位类（Alternative Parents） | 喹嗪类 苯氧基化合物 酚醚 吡啶酮类 四唑类 杂芳族化合物 内酰胺类 炔丙基型1,3-偶极有机化合物 羧酰亚胺酸 氮杂环化合物 有机氮化合物 有机两性离子 有机钠盐 有机氧化物 碳氢化合物衍生物 |
| 分子骨架（Molecular Framework) | 芳香族杂多环化合物 |
| 取代基（Substituents） | 芳香族杂多环化合物 - 氮杂环 - 吡唑 - 苯基化合物 - 羧酰亚胺酸 - 羧酰亚胺酸衍生物 - 二芳基醚 - 杂芳香族化合物 - 烃衍生物 - 肟 - 单环苯基基团 - 有机1,3-双极性化合物 - 有机碱金属盐 - 有机硝基化合物 - 有机氧化物 - 有机盐 - 有机钠盐 - 有机双性离子 - 有机杂环化合物 - 有机氮化合物 - 苯酚醚 - 苯氧基化合物 - 丙炔型1,3-双极性有机化合物 - 吡啶 - 吡啶酮 - 喹啉嗪 - 四唑 |
| 描述（Description） | 该化合物属于称为二芳基醚的有机化合物类别。这类有机化合物含有二烷基醚官能团，其结构式为ROR'，其中R和R'均为芳基。 |
| 外部描述符（External Descriptors） | 暂无 |
三维结构
交互式化学结构模型
化学和物理性质
溶解性
DMSO : 115 mg/mL (309.71 mM; ultrasonic and warming and heat to 60°C)
安全和危险性（GHS）
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥98%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于2–8 °C、干燥条件下保存。请与干燥剂一同密封保存，本品对湿气敏感。
本产品如何运输？
本产品采用湿冰冷藏运输。收货后请立即拆包，并按上述储存条件保存。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 101193-62-8，分子式为 C17H12N6NaO3，分子量为 371.31 g/mol。InChIKey CDPWRMHFRRXOQH-UHFFFAOYSA-M。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
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