重组人源铜锌超氧化物歧化酶 (rh-Cu/Zn-SOD)

CAS: 9054-89-1 货号: R1523652 EC号: 232-943-0
有货
级别和纯度: 生物活性 ? 生物活性级(Bioactive)—— 经验证在功能检测中保持生物活性。当分子须具有功能活性而不仅是纯度时使用。 重组 ? 重组(Recombinant)—— 通过重组表达生产,序列确定、批次稳定。适用于来源明确、无动物源的可重现蛋白。 ActiBioPure™ ? ActiBioPure™ —— 阿拉丁面向生物活性和重组产品的优质系列。当同时需要高纯度和保持生物活性时使用。 EnzymoPure™ ? EnzymoPure™ —— 阿拉丁的高质量酶解决方案系列。当酶纯度和明确活性决定检测或工艺性能时使用。 ≥95%(SDS-PAGE) ≥1000 U/mg enzyme powder; 金属辅基:铜/锌
Accession #
P00441
表达系统
毕赤酵母
内毒素水平
<0.2 EU/μg
生物活性
≥1000 U/mg enzyme powder
★
规格
库存
价格
数量
1000KU
R1523652-1000KU
现货 Stock Image
¥999.90
请输入您要添加的产品数量
🧪
为什么选择此级别

ActiBioPure™,EnzymoPure™,生物活性,重组 级 提供 ≥95%(SDS-PAGE) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。

🌡

储存与运输

避光,-20°C储存,干燥,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。

📋

质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

📚

文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 13 篇同行评审文献引用。

概述

超氧化物岐化酶(Superoxide Dismutase,SOD),别名肝蛋白、奥古蛋白,是一种源于生命体的活性物质,能消除生物体在新陈代谢过程中产生的有害物质。SOD 具有自由基清除能力,是具有抗衰老,免疫调节、调节血脂,调节血糖,抗辐射、美容功能的活性物质。

本品是重组人源铜锌超氧化物岐化酶(rhSOD),是通过重组毕赤酵母发酵培养,经分离纯化、冷冻干燥得到的冻干粉。

产品优势

无动物源性:无动物病毒、无致病物质、无外源因子污染,安全性高。

纯度高:比活高;宿主蛋白残留小于生物制品限度要求。

符合中国药典2020版和USP43的标准。

合规性:生产设备和生产环境符合相关法规要求,符合GMP指导原则。

质量文件完整:按客户需求,可提供相关法规支持文件。 

推荐使用方法

化妆品用途:直接添加于低于40°C的化妆品配方的水相中,于配方最后阶段加入。1g化妆品基质中,建议添加100U-1000U。

其他用途:酌情添加。

产品用途

化妆品领域——吸收紫外线,具有明显的防晒效果。有效清除体内自由基,防止皮肤老化。减少黑色素的积累,淡化色斑。限制油性皮脂分泌,减少粉刺。

保健品领域——通过清除自由基,清除有害物质,增强人体免疫力。

食品领域——具有抗炎作用,可作为食品防腐剂,水果、蔬菜的保鲜剂。

运输和储存稳定性

运输稳定性:冰袋保温运输,活性稳定。

储存稳定性:于-15~-20°C储存,24个月内稳定;当以pH6.0至pH8.0的Tris-HCl缓冲液配制成酶浓度大于1mg/ml的溶液时,于4°C能至少稳定存放48h。

注意事项与免责声明

本品具有吸潮性,应室温平衡后再取用。

本品仅供研究使用,不得用于动物或人类的诊断或治疗仅供科研生产使用,不能用于人体。

Superoxide Dismutase (SOD), also known as orgotein, is a bio-derived active substance that eliminates harmful substances produced during metabolic processes in organisms. With free-radical-scavenging activity, SOD exerts anti-aging, immunomodulatory, lipid-regulating, blood-glucose-regulating, anti-radiation and skin-beautifying effects.

This product is recombinant human copper-zinc superoxide dismutase (rh-Cu/Zn-SOD). It is produced by fermentation of engineered Komagataella phaffii (formerly Pichia pastoris), followed by separation, purification and lyophilization to obtain lyophilized powder.

Product Advantages

Animal-origin free: Free of animal viruses, pathogenic substances and exogenous factor contamination, featuring high safety.
High purity: Elevated specific activity; residual host protein content complies with the limits specified for biological products.
Complies with the standards of Chinese Pharmacopoeia 2020 Edition and USP 43.
Compliance: Production facilities and environment meet relevant regulatory requirements and GMP guidelines.
Complete quality documentation: Relevant regulatory supporting documents are available upon customer request.

Recommended Application Methods

Cosmetics: Add directly to the aqueous phase of cosmetic formulations at a temperature below 40 °C in the final preparation stage. The recommended dosage is 100 U–1000 U per gram of cosmetic base.Other applications: Dosage can be adjusted as appropriate.

Product Applications

Cosmetics: Absorbs ultraviolet rays to deliver prominent sun protection. Effectively scavenges free radicals to prevent skin aging, reduces melanin accumulation and fades pigmentation spots. It also inhibits sebum secretion and relieves acne.
Health supplements: Eliminates free radicals and harmful substances to boost human immunity.
Food: Possesses anti-inflammatory properties, and can be used as a food preservative as well as a fresh-keeping agent for fruits and vegetables.

Transportation & Storage Stability

Transportation: Shipped with ice packs to maintain constant activity during transit.
Storage: Store at −15 ~ −20 °C; stable for up to 24 months. When formulated into solutions with enzyme concentration above 1 mg/mL using Tris-HCl buffer (pH 6.0–8.0), the product remains stable for at least 48 hours at 4 °C.

Precautions & Disclaimer

This product is hygroscopic. Please let it equilibrate to room temperature before use.
This product is for research and production use only. It shall not be used for the diagnosis or treatment of humans and animals, and is prohibited from direct application to human bodies.

规格

产品名称
重组人源铜锌超氧化物歧化酶 (rh-Cu/Zn-SOD)
别名
重组人 SOD | 重组人铜锌超氧化物歧化酶
英文别名
rh-SOD | SOD1 | Recombinant Human Superoxide Dismutase [Cu-Zn]
规格或纯度
生物活性, 重组, ActiBioPure™, EnzymoPure™, ≥95%(SDS-PAGE), ≥1000 U/mg enzyme powder; 金属辅基:铜/锌
生化机理
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying H2S and limiting the accumulation of reactive sulfur species (RSS) such as persulfides and polysulfidesuniprot function. Post-translational: Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation. The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.The ditryptophan cross-link at Trp-33 is responsible for the non-disulfide-linked homodimerization. Such modification might only occur in extreme conditions and additional experimental evidence is required.Palmitoylation helps nuclear targeting and decreases catalytic activity.Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.
生物活性
≥1000 U/mg enzyme powder
表达系统
毕赤酵母
种属
人(Human)
来源
重组表达
SDS-PAGE
14.3-17.5 kDa
CAS编号和信息
9054-89-1
酶学委员会编号
EC: 1.15.1.1
分子类型
酶
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from ddH₂O with mannitol as a protective agent.
浓度
≥1000 U/mg enzyme powder; 金属辅基:铜/锌
复溶
Reconstitute in sterile water or physiological saline to a concentration of 100U-1000 U/ml.
储存条件
避光,-20°C储存,干燥,避免反复冻融
运输条件
超低温运输
稳定性与储存
长期储存-20℃(24个月);复溶后建议分装,避免反复冻融;避光;密封。
单位定义
25℃时抑制邻苯三酚自氧化速率50%时所需的SOD 酶量为1U

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到1个结果

批号(Lot Number) 证书类型 货号
ZJ26F0737794 分析证书 R1523652
技术文档和文章
此产品的引用文献
溶液计算器