ActiBioPure™,Fc标签,His标签,无动物源,无叠氮钠,无载体,生物活性 级 提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Purity
>95% SDS-PAGE.
Function
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.
Post-translational
The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17. On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2. On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization.
Recombinant Human Growth Hormone R Protein (rp146679) - Protein Bioactivity
Immobilized Human GH at 2.0 μg/mL can bind Recombinant Human Growth Hormone R Protein (rp146679) with a linear range of 0.10 - 8.58 ng/mL. The EC₅₀ is 2.4 ng/mL.
Recombinant Human Growth Hormone R Protein (rp146679) - SDS-PAGE
3 μg/lane of Recombinant Human Growth Hormone R Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 71.4 kDa under reducing conditions and 156.2 kDa under non-reducing conditions.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0505412 |
分析证书 | rp146679 |
| ZJ24F0505413 |
分析证书 | rp146679 |
| ZJ24F0505414 |
分析证书 | rp146679 |
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