Purity ≥ 95% SDS-PAGE. Function Interleukin-34 (IL-34) is a protein that promotes the proliferation, survival and differentiation of monocytes and macrophages. It also promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. IL-34 plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.
Recombinant Human IL-34 Protein (rp147566) - Protein Bioactivity Measured in a cell proliferation assay using human peripheral blood mononuclear cell. The ED₅₀ for this effect is 2.0 - 8.0 ng/mL.
Recombinant Human IL-34 Protein (rp147566) - SDS-PAGE 3 μg/lane of Recombinant Human IL-34 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 37.9 kDa under reducing conditions and 36.2 kDa under non-reducing conditions.