Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
Post-translational
The soluble form of isoform 1 derives from the membrane form by proteolytic processing (By similarity). The cleavage may be catalyzed by ADAM17.
Reconstitute in water to a concentration of 0.1-1.0 mg/ml
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。
图片
Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein (rp154577) - Protein Bioactivity Measured by its ability to induce TRAP activity in Raw 264.7 cells. The ED₅₀ of this effect is 7.0 ng/mL.
Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein (rp154577) - SDS-PAGE 2.5 μg/lane of Recombinant Mouse TRANCE/RANK L/TNFSF11 was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 57.4 kDa under reducing condition and 114.0 kDa under non-reducing condition.