Immobilized Recombinant Human Growth Hormone Protein (rp181573) at 2.0 μg/mL can bind Recombinant Human Growth Hormone R (GHR) Protein (rp183621) with the EC50 of 55.1 ng/mL.
Growth hormone (GH), also known as somatotropin, is a member of a family of growth factors that includes prolactin, placental lactogens, proliferins, and somatolactin. It is synthesized primarily by somatotropes in the anterior pituitary and is stored in secretary granules. The pulsatile release of GH into circulation is regulated by the concerted actions of the hypothalamic hormones - GH-releasing hormone (GHRH) and somatostatin (SST) - as well as by signals from the periphery - ghrelin and leptin. The human GH cDNA encodes a 217 amino acid (aa) residue precursor protein with a 26 aa putative signal peptide. By alternative splicing, at least four isoforms of GH have been identified.Human GH is a pleiotropic cytokine that exerts its biological actions by binding to the transmembrane GH receptor, which is present in many cell types. GH stimulates the liver and other tissues to produce IGF-1, which regulates growth and metabolism. GH has also been shown to have direct effects on growth that is independent of IGF-1. GH, directly or indirectly via IGF-1, can act on B cells, T cells, NK cells, macrophages and neutrophils to exert immunomodulatory activities. In addition, GH can act directly on various cell types to induce lipolysis, lactation, amino acid uptake and protein synthesis.
生物活性
Immobilized Recombinant Human Growth Hormone Protein (rp181573) at 2.0 μg/mL can bind Recombinant Human Growth Hormone R (GHR) Protein (rp183621) with the EC50 of 55.1 ng/mL.
19.6 kDa, under reducing conditions; 17.0 & 20.4 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human Growth Hormone Protein (rp181573) - ELISA Immobilized Recombinant Human Growth Hormone Protein (rp181573) at 5.0 μg/mL can bind Growth Hormone Mouse mAb (Ab175997) with the EC₅₀ of 43.3 ng/mL.
Recombinant Human Growth Hormone Protein (rp181573) - SDS-PAGE 3 μg/lane of Recombinant Human Growth Hormone Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 19.6 kDa under reducing conditions and 17.0 & 20.4 kDa under non-reducing conditions.
Recombinant Human Growth Hormone Protein (rp181573) - Binding Activity
Immobilized Recombinant Human Growth Hormone Protein (rp181573) at 2.0 μg/mL can bind Recombinant Human Growth Hormone R (GHR) Protein (rp183621) with the EC50 of 55.1 ng/mL.
ZJ24F1215373
危险品化学品经营许可证（带存储）