PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.
规格
产品名称
Recombinant Human PDGF R alpha Protein
别名
重组人PDGF R alpha蛋白 | 重组人 PDGF R alpha 蛋白
英文别名
CD140 antigen-like family member A | CD140a antigen | CD140a | EC 2.7.10 | EC 2.7.10.1 | MGC74795 | PDGF R alpha | PDGFR alpha | PDGFR2 | PDGFRA | PDGFRA/BCR fusion | PDGF-R-alpha | platelet-derived growth factor receptor, alpha polypeptide | alpha-type p
68.0-98.0 kDa, under reducing conditions; 60.0-88.0 kDa, under non-reducing conditions
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Human PDGF R alpha Protein (rp181613) - ELISA Immobilized Recombinant Human PDGF R alpha Protein (rp181613) at 1.0 μg/mL can bind Olaratumab (anti-PDGFRA) (Ab176458) with the EC50 of 17.27 ng/mL.
Recombinant Human PDGF R alpha Protein (rp181613) - SDS-PAGE 3 μg/lane of Recombinant Human PDGF R alpha Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 68.0-98.0 kDa under reducing conditions and 60.0-88.0 kDa under non-reducing conditions.