Immobilized Recombinant Mouse Alpha-synuclein Protein (rp183595) at 1.0 μg/mL can bind Alpha-synuclein Mouse mAb (Ab185363) with the EC50 of 19.8 ng/mL. Immobilized Recombinant Mouse Alpha-synuclein Protein (rp183595) at 1.0 μg/mL can bind Alpha-synuclein Mouse mAb (Ab185365) with the EC50 of 28.3 ng/mL. Immobilized Recombinant Mouse Alpha-synuclein Protein (rp183595) at 5.0 μg/mL can bind Cinpanemab (anti-Alpha-synuclein) (Ab176594) with the EC50 of 475.3 ng/mL.
Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). Besides, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease.
Post-translational: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress. Ubiquitinated. The predominant conjugate is the diubiquitinated form.
Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
生物活性
Immobilized Recombinant Mouse Alpha-synuclein Protein (rp183595) at 1.0 μg/mL can bind Alpha-synuclein Mouse mAb (Ab185363) with the EC50 of 19.8 ng/mL. Immobilized Recombinant Mouse Alpha-synuclein Protein (rp183595) at 1.0 μg/mL can bind Alpha-synuclein Mouse mAb (Ab185365) with the EC50 of 28.3 ng/mL. Immobilized Recombinant Mouse Alpha-synuclein Protein (rp183595) at 5.0 μg/mL can bind Cinpanemab (anti-Alpha-synuclein) (Ab176594) with the EC50 of 475.3 ng/mL.
17.1 kDa, under reducing conditions; 17.1 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Mouse Alpha-synuclein Protein (rp183595) - ELISA Immobilized Recombinant Mouse Alpha-synuclein Protein (rp183595) at 1.0 μg/mL can bind Alpha-synuclein Mouse mAb (Ab185363) with the EC₅₀ of 19.8 ng/mL.
Recombinant Mouse Alpha-synuclein Protein (rp183595) - SDS-PAGE 2 μg/lane of Recombinant Mouse Alpha-synuclein Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 17.1 kDa.
Recombinant Mouse Alpha-synuclein Protein (rp183595) - ELISA Immobilized Recombinant Mouse Alpha-synuclein Protein (rp183595) at 1.0 μg/mL can bind Alpha-synuclein Mouse mAb (Ab185365) with the EC₅₀ of 28.3 ng/mL.
Recombinant Mouse Alpha-synuclein Protein (rp183595) - ELISA Immobilized Recombinant Mouse Alpha-synuclein Protein (rp183595) at 5.0 μg/mL can bind Cinpanemab (anti-Alpha-synuclein) (Ab176594) with the EC₅₀ of 475.3 ng/mL.