1. Immobilized Recombinant Human S100A8 Protein (rp183594) at 2.0 μg/mL can bind Recombinant Human S100A9 Protein (rp183637) with the EC50 of 135.5 ng/mL. 2. Immobilized Recombinant Human S100A9 Protein (rp183637) at 2.0 μg/mL can bind Recombinant Human S100A8 Protein (rp183594) with the EC50 of 194.6 ng/mL.
Protein Function: Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS) (By similarity). Promotes tubulin polymerization when unphosphorylated. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions.
规格
产品名称
Recombinant Human S100A9 Protein
别名
重组人S100A9蛋白 | 重组人S100A9蛋白
英文别名
60B8AG | CAGB | Calgranulin B | Calgranulin-B | Calprotectin L1H subunit | CFAG | CGLB | Cystic fibrosis antigen B | L1AG | Leukocyte L1 complex heavy chain | LIAG | MAC387 | MIF | Migration inhibitory factor related protein 14 | Migration inhibitory fact
规格或纯度
无载体,生物活性,ActiBioPure™,His标签,≥95%(SDS-PAGE)
生物活性
1. Immobilized Recombinant Human S100A8 Protein (rp183594) at 2.0 μg/mL can bind Recombinant Human S100A9 Protein (rp183637) with the EC50 of 135.5 ng/mL. 2. Immobilized Recombinant Human S100A9 Protein (rp183637) at 2.0 μg/mL can bind Recombinant Human S100A8 Protein (rp183594) with the EC50 of 194.6 ng/mL.
12.7 & 28.7 kDa, under reducing conditions; 12.7 & 28.7 kDa, under non-reducing conditions
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, 1mM DTT, pH 7.4
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Human S100A9 Protein (rp183637) - Binding Activity Immobilized Recombinant Human S100A8 Protein (rp183594) at 2.0 μg/mL can bind Recombinant Human S100A9 Protein (rp183637) with the EC50 of 135.5 ng/mL.
Recombinant Human S100A9 Protein (rp183637) - Binding Activity Immobilized Recombinant Human S100A9 Protein (rp183637) at 2.0 μg/mL can bind Recombinant Human S100A8 Protein (rp183594) with the EC50 of 194.6 ng/mL.
Recombinant Human S100A9 Protein (rp183637) - SDS-PAGE 3 μg/lane of Recombinant Human S100A9 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 12.7 & 28.7 kDa.