AKT | Akt3 | AKT3 kinase | AKT3_HUMAN | DKFZp434N0250 | MPPH | PKB gamma | PKBG | PRKBG | Protein kinase Akt-3 | Protein Kinase AKT3 | Protein kinase B gamma | RAC gamma | RAC gamma serine/threonine protein kinase | RAC-gamma serine/threonine-protein kina
规格或纯度
无载体,His标签,≥80%(SDS-PAGE),见COA
生化机理
IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
Post-translational: Phosphorylation on Thr-305 and Ser-472 is required for full activity (PubMed:12162751, PubMed:9512493). Phosphorylation of the activation loop at Thr-305 by PDPK1/PDK1 is a prerequisite for full activation (PubMed:9512493). Phosphorylation at Ser-472 by mTORC2 in response to growth factors plays a key role in AKT1 activation by facilitating subsequent phosphorylation of the activation loop by PDPK1/PDK1 (By similarity). Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome. O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the interaction between AKT and PDPK1/PDK1.
Recombinant Human AKT3 Protein (rp184884) - SDS-PAGE 3 μg/lane of Recombinant Human AKT3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 68.3 kDa under reducing conditions and 69.2 kDa under non-reducing conditions.
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