T-cell surface glycoprotein CD3 zeta chain (CD247) is a member of the CD3Z/FCER1G family. CD247 is T-cell receptor zeta, which along with T-cell receptor alpha/beta and gamma/delta heterodimers, and also with CD3-gamma, -delta and -epsilon, creates the T-cell receptor-CD3 complex. The zeta chain has a central role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD247 antigen causes impaired immune response.
Post-translational: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
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Immobilized Recombinant Human CD3 zeta/CD247 Protein (rp188342) at 1.0 μg/mL can bind CD3 zeta Antibody (Ab094480) with the EC50 of 70.0 ng/mL.
Recombinant Human CD3 zeta/CD247 Protein (rp188342) - ELISA Immobilized Recombinant Human CD3 zeta/CD247 Protein (rp188342) at 1.0 μg/mL can bind CD3 zeta Antibody (Ab094480) with the EC50 of 70.0 ng/mL.
Recombinant Human CD3 zeta/CD247 Protein (rp188342) - SDS-PAGE 3 μg/lane of Recombinant Human CD3 zeta/CD247 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 15.2 kDa.