Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).
生物活性
Fully biologically active determined by the dose dependent increase in proliferation of TF-1 cells. ED50 for this effect is 39.0 ng/mL.
32.7 kDa, under reducing conditions; 32.7 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
PBS, 10% Glycerol, pH 7.4
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20℃ for 6 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片
Protein Bioactivity: Recombinant Rat IL-1 beta/IL-1F2 Protein (rp192260) Fully biologically active determined by the dose dependent increase in proliferation of TF-1 cells. ED₅₀ for this effect is 39.0 ng/mL.
Recombinant Rat IL-1 beta/IL-1F2 Protein (rp192260) - SDS-PAGE 3 μg/lane of Recombinant Rat IL-1 beta/IL-1F2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 32.7 kDa under reducing conditions and 32.7 kDa under non-reducing conditions.