family of interleukin 1-eta | FIL1 eta | FIL1 | FIL1-(ETA) | FIL1H | FILI-(ETA) | IL-1 eta | IL1-ETA | IL1F8 (Canonical product IL-1F8a) | IL-1F8 (FIL1-eta) | IL1F8 | IL-1F8 | IL1H2 | IL-1H2 | IL36 beta | IL-36 beta | IL36B | interleukin 1 family | interl
规格或纯度
无载体,His标签,SUMO标签,PBS Only,≥95%(SDS-PAGE)
生化机理
Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contain a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includes four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.
Post-translational: N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).
32.5 kDa, under reducing conditions; 32.5 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human IL36 beta/IL-1F8 Protein (rp192262) - SDS-PAGE 3 μg/lane of Recombinant Human IL36 beta/IL-1F8 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 32.5 kDa.
ZJ25F0116514
危险品化学品经营许可证（带存储）