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蛋白质和酶
靶点蛋白
重组XVII型人源化胶原蛋白

重组XVII型人源化胶原蛋白

Name: 重组XVII型人源化胶原蛋白
SKU: rp336830
Availability: InStock

CAS: 9007-34-5 货号: rp336830 EC号: 232-697-4

7篇引用文献 COA

有货

级别和纯度: 无动物源 ? 无载体 ? 重组 ? 低内毒素 ? ≥95%(SDS-PAGE)

Accession #

Q9UMD9

表达系统

Array

内毒素水平

<0.5 EU/mg

规格

库存

价格

数量

10mg

rp336830-10mg

现货

¥199.90

100mg

rp336830-100mg

现货

¥699.90

rp336830-1g

现货

¥2,999.90

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概述规格储存与运输技术文档高级数据质检证书（CoA,COO,BSE/TSE 和分析图谱) 此产品的引用文献溶液计算器

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为什么选择此级别

低内毒素,无动物源,无载体,重组级提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

2-8°C储存,避光,干燥。低温运输。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 7 篇同行评审文献引用。

概述

重组 XVII 型人源化胶原蛋白是100% 人源同源，具有生物相容性高、安全性优异（10mg/mL 浓度下细胞存活率达 99.74%）等特点。

该胶原特异性表达于毛囊隆突区基底膜，是维系毛囊干细胞功能的核心结构与信号枢纽，兼具结构支撑与信号传导双重功效：既能稳固毛囊干细胞附着、重建毛囊微环境支架，又可激活 Wnt/β-catenin 通路（WNT10B 表达提升达 278.7%）、上调 VEGF（提升至模型组 92.4%），唤醒休眠毛囊干细胞、促进血管新生、重塑毛囊生长周期，从根源改善脱发、实现毛囊再生修复。

应用上，可开发日常护理型生发液 / 凝胶、微针递送用活性涂层液、毛发移植术后修复套装等产品，适配轻中度脱发居家护理、医美协同治疗及植发术后养护等场景。

Recombinant Human Type XVII Collagen is 100% human-homologous, featuring high biocompatibility and excellent safety (cell viability reaches 99.74% at a concentration of 10 mg/mL).

Specifically expressed in the basement membrane of the hair follicle bulge region, this collagen serves as the core structural and signaling hub that maintains hair follicle stem cell function. It exerts dual effects of structural support and signal transduction: it not only stabilizes the adhesion of hair follicle stem cells and reconstructs the scaffold of the hair follicle microenvironment, but also activates the Wnt/β-catenin pathway (with WNT10B expression increased by 278.7%) and upregulates VEGF (increased to 92.4% of the model group). This awakens dormant hair follicle stem cells, promotes angiogenesis, remodels the hair follicle growth cycle, fundamentally improves hair loss, and achieves hair follicle regeneration and repair.

In terms of applications, it can be used to develop products such as daily care hair growth serums/gels, active coating solutions for microneedle delivery, and post-hair transplant repair kits, suitable for scenarios including home care for mild to moderate hair loss, combined aesthetic medical treatment, and post-transplant hair care.

规格

产品名称

重组XVII型人源化胶原蛋白

别名

重组人Pro-Collagen XVII alpha 17/COL17A1蛋白 | 重组人XVII型胶原蛋白

英文别名

ERED | JEB4 | BP180 | BPA-2 | BPAG2 | LAD-1 | BA16H23.2

规格或纯度

无动物源, 无载体, 重组, 低内毒素, ≥95%(SDS-PAGE)

生化机理

May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. Post-translational: The intracellular/endo domain is disulfide-linked. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen. The shedding is mediated by membrane-bound metalloproteases. This cleavage is inhibited by phosphorylation at Ser-544.

种属

人(Human)

无载体

Yes

无动物源

Yes

来源

重组表达

SDS-PAGE

45.0-70.0 kDa

CAS编号和信息

9007-34-5