无气味。味初苦后微甜，遇日光渐变深。能溶于丙酮、甘油、盐酸、沸水和苛性碱溶液，微溶于水，几乎不溶于氯仿、乙醚、石油醚和苯。对石蕊呈中性反应。0.5%水溶液pH为5.8-6.1。最大吸收波长257、313nm。半数致死量(狗，经口)2000mg/kg。有刺激性。用于亚硝酸盐的测定，生化研究，有机合成。

Information

Sulfanilamide Sulfanilamide (Sulphanilamide) is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
In vitro

Sulfanilamide containing the sulfonamide functional group displays inhibitory activity for dihydropteroate synthetase partially purified from Escherichia coli which normally uses para-aminobenzoic acid (PABA) for synthesizing the necessary folic acid acting as a coenzyme in the synthesis of purine, pyrimidine and other amino acids, exhibiting an IC 50 of 320 μM for dihydropteroate synthetasea and Km of 2.5 uM for PABA. Sulfanilamide shows IC50 of 286.8 μg/mL for recombinant S. cerevisiae strains with wild-type FOL1 genes, but the single mutation ⁵⁵Trp to ⁵⁵Ala or ⁵⁷Pro to ⁵⁷Ser within the putative active site of the fungal DHPS confers resistance to Sulfanilamide with IC50 of >800 μg/mL. Sulfanilamide moderately inhibits the growth of bacterial cells harboring plasmodium falciparum pKOS-pfPPPK-DHPS (His) with IC50 of 380 uM.

In vivo

Administration of Sulfanilamide with the dosage of 100 mg/kg/day is effective in the prevention of P. carinii infection in the immunosuppressed rat model. When the dosage of sulfaguanidine and Sulfanilamide reduced to 10 mg/kg/day, breakthrough P. carinii infection occurs in the rats.
Cell Data

cell lines：Primary HCC cell lines including 2-1318, 4-1318 and 26-1004 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

规格

英文别名

4-amino-benzenesulfonamide

规格或纯度

Moligand™, 10mM in DMSO

英文名称

Sulfanilamide

生化机理

磺胺（Sulphanilamide）是细菌二氢蝶酸合成酶的竞争性抑制剂，其 IC50 值为 320 μM。

储存条件

-80℃储存

运输条件

特低温运输

名称和识别符

EC号

200-563-4

分子类型

小分子

Isomeric SMILES

C1=CC(=CC=C1N)S(=O)(=O)N

PubChem CID

5333

UN Number

1759

Packing Group

分子量

172.21

Beilstein号

511852

技术文档

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全面的危险、操作、储存及法规合规文件。

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✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

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📊 产品数据表

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🔬 规格说明书

该级别的完整质量属性和验收标准。

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高级数据

产品属性

ALogP	-0.6

化学和物理性质

溶解性

Solubility (25°C) In vitro DMSO: 100 mg/mL (133.16 mM);

熔点

164-166°C

安全和危险性（GHS）

信号词

警告

危险声明

H303: 要是吞了可能有害

预防措施声明

P312: 打电话给毒物中心或医生。。。如果你觉得不舒服

WGK Germany

RTECS

WO8400000

Class

Merck Index

8925

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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