Human small nuclear ribonucleoprotein D3 polypeptide (SNRPD3; SmD3). Recombinant antigen for in vitro research and manufacturing use only.
Biochemical Test:SDS-PAGE (purity ≥85%); Western blot with anti-Sm autoantibody-positive sera.
Calculated Isoelectric Point:pH 10.33
Coating Concentration:0.4-0.8 µg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
规格
产品名称
Recombinant Human SNRPD3/SmD3 Protein
规格或纯度
无动物源, 无载体, His标签, ≥85%(SDS-PAGE), 见COA
生化机理
lays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).
Post-translational: Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.