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N-叔丁基-а-苯基硝酮

LPS诱导的NF-κBDNA结合活性和COX-2催化活性的抑制剂
6篇引用文献
  • ≥95%
有货

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
B100838-1g
 1g 期货 Stock Image
B100838-5g
 5g 现货 Stock Image
B100838-25g
 25g 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
COX (259) Immunology/Inflammation (1945) Metabolic Enzyme/Protease (4884) NF-κB (753) Reactive Oxygen Species (316) 氧化应激 (41) 细胞信号转导和神经科学 (85)
main product photo

基本描述

别名 N-叔丁基苯硝酮
英文别名 PBN | Phenyl-N-tert-butylnitrone | F0001-0991 | 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide, (N(Z))- | N-tert-Butyl-.alpha.-phenylnitrone | (Z)-N-Benzylidene-2-methylpropan-2-amine oxide | n-tert-butyl phenyl nitrone | (Z)-benzylidene(tert-butyl
规格或纯度 ≥95%
英文名称 N-tert-Butyl-α-phenylnitrone
生化机理 细胞可渗透\无Xa0胚根\ xa0陷阱。抑制LPS诱导的NF-κBDNA结合活性，抑制COX-2催化活性并抑制大鼠肝微粒体中的脂质过氧化。阻止活性氧指示iNOS。
应用 一种Cox-2抑制剂。
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g).一种Cox-2抑制剂。

N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g).
A Cox-2 inhibitor.

AI解读

关联靶点（人）

SH-SY5Y (11521 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Liver (3974 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RPE65 Tbio Retinoid isomerohydrolase (0 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NIH3T3 (5395 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-22 (3261 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
J774 (3120 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Syrian golden hamster (1610 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Baboon (34 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mixed cortical cells (27 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rotifers (49 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Aorta (2975 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Lipoxygenase (149 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LRAT Lecithin retinol acyltransferase (88 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504759662
EC号 222-168-6
分子类型 小分子
IUPAC Name N-tert-butyl-1-phenylmethanimine oxide
INCHI InChI=1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-
InChi Key IYSYLWYGCWTJSG-XFXZXTDPSA-N
Canonical SMILES CC(C)(C)[N+](=CC1=CC=CC=C1)[O-]
Isomeric SMILES CC(C)(C)/[N+](=C/C1=CC=CC=C1)/[O-]
WGK Germany 3
RTECS TX1760000
PubChem CID 638877
分子量 177.24
Beilstein号 2044028
Reaxy-Rn 1841513

化学和物理性质

溶解性 溶于DMSO (10 mg/ml), 氯仿 (50 mg/ml), 和水(20 mg/ml).
密度 0.99
敏感性 对空气敏感
熔点 72-75°C
分子量 177.240 g/mol
XLogP3 1.300
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 1
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 177.115 Da
单同位素质量Monoisotopic Mass 177.115 Da
拓扑极表面积Topological Polar Surface Area 28.800 Ų
重原子数Heavy Atom Count 13
形式电荷Formal Charge 0
复杂度Complexity 185.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 1
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 1
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 3
RTECS TX1760000
Reaxy-Rn 1841513
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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找到7个结果

批号(Lot Number) 证书类型 日期 货号
F2229267 分析证书 25-04-02 B100838
F2229437 分析证书 25-04-02 B100838
F2229439 分析证书 25-04-02 B100838
E2114030 分析证书 24-02-06 B100838
L2413168 分析证书 24-02-06 B100838
L2413210 分析证书 22-06-06 B100838
C2211230 分析证书 22-03-14 B100838

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Zening Zhang, Peng Deng, Yang Chen, Zhiyong He, Fang Qin, Qiuming Chen, Zhaojun Wang, Jie Chen, Maomao Zeng, Hongyang Pan.  (2024)  Exploration of the synergistic inhibition of 4-methylimidazole and 5-hydroxymethylfurfural in caramel colors by amino acid combinations and potential mechanisms.  Food Bioscience,  57  (103471).  [10.1016/j.fbio.2023.103471]
2. Ming Yuan, Dayun Huang, Zefeng Wang, Xin Chen, Minghua Yang.  (2022)  Synthesis of ultra-high molecular weight poly(methyl methacrylate) with hydrosilane as initiator.  Materials Today Communications,  33  (104927).  [10.1016/j.mtcomm.2022.104927]
3. Hao-Xiang Gao, Nan Chen, Qiang He, Bi Shi, Zhi-Long Yu, Wei-Cai Zeng.  (2022)  Effects of Ligustrum robustum (Rxob.) Blume extract on the quality of peanut and palm oils during storage and frying process.  JOURNAL OF FOOD SCIENCE,  87  (10): (4504-4521).  [PMID:36124403] [10.1111/1750-3841.16311]
4. Yingjie Ma, Hairong Huang, Yan Zhang, Feng Li, Bei Gan, Qiang Yu, Jianhua Xie, Yi Chen.  (2022)  Soluble dietary fiber from tea residues with inhibitory effects against acrylamide and 5-hydroxymethylfurfural formation in biscuits: The role of bound polyphenols.  FOOD RESEARCH INTERNATIONAL,  159  (111595).  [PMID:35940761] [10.1016/j.foodres.2022.111595]
5. Zhou Yulan, Liao Wanfeng, Ni Xiuyuan.  (2021)  Cationic Photopolymerization Initiated by a Photocatalytic Complex Sensitive to Visible Light at 520 nm.  CATALYSIS LETTERS,  151  (6): (1766-1775).  [10.1007/s10562-020-03437-z]
6. Wanfeng Liao, Xiuyuan Ni, Yulan Zhou.  (2018)  Cationic and free radical polymerization initiated by a visible-light sensitive complex based on the photocatalytic decarboxylation of carboxylic acid.  JOURNAL OF CATALYSIS,  361  (423).  [10.1016/j.jcat.2018.03.005]

参考文献

1. Zening Zhang, Peng Deng, Yang Chen, Zhiyong He, Fang Qin, Qiuming Chen, Zhaojun Wang, Jie Chen, Maomao Zeng, Hongyang Pan.  (2024)  Exploration of the synergistic inhibition of 4-methylimidazole and 5-hydroxymethylfurfural in caramel colors by amino acid combinations and potential mechanisms.  Food Bioscience,  57  (103471).  [10.1016/j.fbio.2023.103471]
2. Ming Yuan, Dayun Huang, Zefeng Wang, Xin Chen, Minghua Yang.  (2022)  Synthesis of ultra-high molecular weight poly(methyl methacrylate) with hydrosilane as initiator.  Materials Today Communications,  33  (104927).  [10.1016/j.mtcomm.2022.104927]
3. Hao-Xiang Gao, Nan Chen, Qiang He, Bi Shi, Zhi-Long Yu, Wei-Cai Zeng.  (2022)  Effects of Ligustrum robustum (Rxob.) Blume extract on the quality of peanut and palm oils during storage and frying process.  JOURNAL OF FOOD SCIENCE,  87  (10): (4504-4521).  [PMID:36124403] [10.1111/1750-3841.16311]
4. Yingjie Ma, Hairong Huang, Yan Zhang, Feng Li, Bei Gan, Qiang Yu, Jianhua Xie, Yi Chen.  (2022)  Soluble dietary fiber from tea residues with inhibitory effects against acrylamide and 5-hydroxymethylfurfural formation in biscuits: The role of bound polyphenols.  FOOD RESEARCH INTERNATIONAL,  159  (111595).  [PMID:35940761] [10.1016/j.foodres.2022.111595]
5. Zhou Yulan, Liao Wanfeng, Ni Xiuyuan.  (2021)  Cationic Photopolymerization Initiated by a Photocatalytic Complex Sensitive to Visible Light at 520 nm.  CATALYSIS LETTERS,  151  (6): (1766-1775).  [10.1007/s10562-020-03437-z]
6. Wanfeng Liao, Xiuyuan Ni, Yulan Zhou.  (2018)  Cationic and free radical polymerization initiated by a visible-light sensitive complex based on the photocatalytic decarboxylation of carboxylic acid.  JOURNAL OF CATALYSIS,  361  (423).  [10.1016/j.jcat.2018.03.005]

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