Carnitine acyltransferases (CrAT) are enzymes that contribute to the reversible conversion of acetyl-CoA and carnitine into acetylcarnitine and free CoA. This enzymatic process plays a vital role in the energy metabolism of eukaryotes by promoting the β-oxidation of fatty acids. CrAT-mediated acetyl carnitine production and efflux help maintain a balance between acetyl-CoA and acetyl carnitine in the mitochondria, regenerate free CoA, and alleviate the product inhibition of pyruvate dehydrogenase (PDH), which is a key enzyme in glucose oxidation. This process promotes glucose homeostasis and helps maintain optimal cellular energy metabolism. Carnitine acetyltransferase activity also aids in the progression of the cell cycle from G1 to S phase. carnitine acetyltransferase deficiency also leads to the development of various neurological disorders including Alzheimer′s disease, ataxic encephalopathy, and several vascular diseases.Carnitine acetyltransferase maintains the cellular and mitochondrial levels of acetyl-CoA, a key cofactor required for oxidative metabolism, by catalyzing an equilibrium between acetyl-CoA and acetyl-L-carnitine, a storage form of activated acetate. Carnitine acetyltransferase also maintains the pool of acetyl-CoA required for neuronal and nonneuronal acetylcholine production.
生物活性,ActiBioPure™,天然,高性能,EnzymoPure™,来源于鸽子胸肌; ≥4 U/mg enzyme powder; ≥50 U/mg protein
生化机理
Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates.
生物活性
≥4 U/mg enzyme powder; ≥50 U/mg protein
来源
天然
CAS编号和信息
9029-90-7
酶学委员会编号
EC 2.3.1.7
分子类型
酶
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
浓度
来源于鸽子胸肌; ≥4 U/mg enzyme powder; ≥50 U/mg protein
复溶
Reconstitute in water to a concentration of 10 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
短期储存2-8℃（12个月）；长期储存-20℃（24个月）；复溶后建议分装，避免反复冻融。
单位定义
One unit will convert to 1.0 μmole of acetyl-L-carnitine and CoA from L-carnitine and acetyl-CoA per min at pH 8.0 at 25 °C.
ZJ26F0535394
危险品化学品经营许可证（带存储）