N-乙酰神经氨酸(Neu5Ac)

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Moligand™ 级提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存,充氩。超低温运输。请查阅批次 COA 获取详细规格。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 50 篇同行评审文献引用。

概述

产品介绍:

N-乙酰神经氨酸，俗称唾液酸，又名燕窝酸，是一种天然存在的氨基糖，它最初由牛颌下腺粘蛋白中分离而出，也因此而得名唾液酸。唾液酸是含有氨基的九碳单糖衍生物，是所有神经氨酸或酮基-脱氧壬酮糖酸(KDN)的N-或O-衍生物的总称。唾液酸通常以低聚糖，糖脂或者糖蛋白的形式存在，主要以短链残基的形式存在于糖蛋白和糖脂的末端。N-乙酰神经氨酸有几个已知的缀和形式来源，游离N-乙酰神经氨酸，寡糖唾液酸乳糖, 含唾液酸的神经节苷脂和酪蛋白巨肽（CMP，Macropeptide，也称为糖巨肽GMP，Glycomacropeptide，和酪蛋白糖巨肽cGMP，Caseinoglycomacropeptide）。

用途：

1）细胞的营养液：

唾液酸可起到免疫辅助剂的作用，提高肠道对维生素及矿物质的吸收，增强细胞免疫力的同时提升机体抗病力，从而提高免疫力。有很好的保健作用。长期食用，可有效改善身体状态，以良好的精神状态面对繁重的生活及工作。

2）大脑的营养品：

生物医学研究中指出, 唾液酸可促进大脑神经細胞的资讯传达速度,通过与大脑細胞膜及突触的相互作用,提高大脑的反应速度。及时补充唾液酸，可有效促进大脑发育，从而提升身体能力。

3）芳华永驻佳品：

唾液酸对细胞具有保护和稳定作用，影响着新陈代谢中血球的寿命和酶蛋白的数量及活力，延缓细胞老化，唾液酸是养颜滋补的佳品，令肌肤幼滑有光泽，有效抗衰老。
应用：

1）婴儿配方食品：

N-乙酰神经氨酸是大脑神经节苷脂的重要组成部分。神经细胞膜的N-乙酰神经氨酸含量是其他细胞的20倍，由于大脑信息传递及神经冲动的传导必须通过突触来实现，而N-乙酰神经氨酸是作用于大脑细胞膜和突触的脑部营养素，所以N-乙酰神经氨酸能够促进记忆力和智力的发育。研究发现，增加哺乳期饮食中的N-乙酰神经氨酸含量，婴儿脑中的N-乙酰神经氨酸含量会增加，与学习相关的基因表达水平会增加，从而增强其学习和记忆能力。神经细胞稳定的突触链接是记忆形成的结构基础，而N-乙酰神经氨酸是神经细胞膜及突触的营养素，可促进神经细胞的分化、发育和再生。许多著名婴儿配方制造商宣称在其配方奶粉中添加唾液酸 (N-乙酰神经氨酸) 。马来西亚卫生部已在 2003年将唾液酸批准在容许使用的营养标签内。在东南亚市场上销售的美赞臣、卡洛塔妮、美素和雪印等婴儿配方奶粉，其营养成分表中明确注明唾液酸含量。随着市场的推广，唾液酸在婴幼儿乳粉和辅食中的市场容量将会有一个飞速的发展。

2）食品营养补充剂：

N-乙酰神经氨酸能消耗有毒过氧化氢。日本学者在有添加N-乙酰神经氨酸的培养基中观察过氧化氢对细胞的毒性，证实N-乙酰神经氨酸能够抑制由过氧化氢引起的细胞死亡。结果说明N-乙酰神经氨酸可以作为活性氧清除剂。同时N-乙酰神经氨酸的抗炎效果也非常好，还可以提高肠道对维生素及矿物质的吸收。含唾液酸的糖果在日本很受欢迎，在糖果中N-乙酰神经氨酸作为营养的补充剂。
3）抗流感和抗老年痴呆类药物：
N-乙酰神经氨酸相关医学研究很多，大量用在药物中间体领域，具有一定规模的市场。国际上药物前体市场的容量比较大的是抗流感特效药扎那米韦(Zanamivir)，是一个有效的流感病毒N-乙酰神经氨酸抑制剂，用于流感的预防和治疗，合成过程是通过对N-乙酰神经氨酸单体进行修饰而来。 N-乙酰神经氨酸对神经细胞具有保护与稳定作用。位于神经细胞膜表面的蛋白酶与N-乙酰神经氨酸结合后，能不被细胞外蛋白酶降解。一些神经性疾病，如早老年性痴呆及精神分裂等患者的血液或脑中N-乙酰神经氨酸含量会下降，经药物治疗康复后，N-乙酰神经氨酸含量又恢复正常，这表明N-乙酰神经氨酸参与了神经细胞代谢。
4）化妆品：
日本已开发含N-乙酰神经氨酸软膏和喷雾剂，保持头发健康生长。该产品被作为化妆品而不是药物出售。由于最近的研究发现的N-乙酰神经氨酸拥有的抗氧化作用，可以合理地添加到化妆品面霜或者乳霜中，给N-乙酰神经氨酸带来了巨大的潜在市场。

规格

别名

唾液酸 | 醋纽拉酸 | N-乙酰甘露糖胺丙酮酸 | 5-乙酰氨基-3,5-双脱氧-D-丙三基-D-半乳糖唾液酸 | N-(-)-乙酰甘露糖胺丙酮酸

英文别名

NAN | NANA | b-5-acetamido-3,5-dideoxy-D-glycero-D-galacto-Nonulopyranosonate | N-Acetyl-b-neuraminate | N-Acetylsialic acid | A-1600 | CHEBI:45744 | EN300-174088 | N-acetylneuramic acid | SMR000857174 | N-Acetyl-delta-neuraminic acid | 4mnp | (2S,4S,5R,6

规格或纯度

Moligand™, ≥98%

英文名称

N-Acetylneuraminic acid(Neu5Ac)

储存条件

-20°C储存,充氩

运输条件

超低温运输

作用类型

抑制剂

纯度

≥98%

名称和识别符

PubChem SID

488189832

EC号

205-023-1

分子类型

小分子

IUPAC Name

(2S,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid

INCHI

1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11-/m0/s1

InChi Key

SQVRNKJHWKZAKO-PFQGKNLYSA-N

Smiles

CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)O)O

Isomeric SMILES

CC(=O)N[C@@H]1[C@H](C[C@](O[C@H]1[C@@H]([C@@H](CO)O)O)(C(=O)O)O)O

分子量

309.27

Beilstein号

1716283

Reaxy-Rn

2339228

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2339228&ln=

技术文档

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🔬 规格说明书

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高级数据

系统学分类

分类树（Taxonomy Tree）

界（kingdom) 有机化合物
- 超类（Superclass) 有机氧化合物
  - 类（Class) 有机氧化合物
    - 亚类（Subclass）碳水化合物和碳水化合物结合物
      - 第5级 (level 5) 糖酸及其衍生物
        第6级 (level 6) 糖氨基酸及其衍生物
        第7级 (level 7) 吡喃类氨基酸及其衍生物
        第8级 (level 8) 神经氨酸及其衍生物
        第9级 (level 9) N-酰基神经氨酸及其衍生物
        第10级 (level 10) N-酰基神经氨酸

界（kingdom)	有机化合物
超类（Superclass)	有机氧化合物
类（Class)	有机氧化合物
亚类（Subclass）	碳水化合物和碳水化合物结合物
中间层级节点（Intermediate Tree Nodes）	糖酸及其衍生物 - 糖氨基酸及其衍生物 - 吡喃类氨基酸及其衍生物 - 神经氨酸及其衍生物 - N-酰基神经氨酸及其衍生物
直接上位类(Direct Parent)	N-酰基神经氨酸
其他上位类（Alternative Parents）	神经氨酸 C-葡萄糖醛酸苷 C-糖基化合物吡喃类 α-羟基酸及其衍生物氧烷乙酰胺仲羧酸酰胺仲醇半缩醛多元醇氧环化合物羧酸一元羧酸及其衍生物伯醇羰基化合物有机氮化合物碳氢化合物衍生物有机光子化合物有机氧化物
分子骨架（Molecular Framework)	脂肪族杂单环化合物
取代基（Substituents）	乙酰胺 - 羟基苯甲酸酯 - 脂肪族杂单环化合物 - α-羟基酸 - C-葡萄糖醛酸酯 - C-糖苷化合物 - 羰基 - 羧酰胺基 - 羧酰胺基 - 羧酸衍生物 - 糖基化合物 - 半缩醛 - 烃衍生物 - 羟基酸 - 单羧酸或其衍生物 - N-乙酰神经氨酸 - 神经氨酸 - 有机硝基化合物 - 有机氧化物 - 有机杂环化合物 - 有机氮化合物 - 有机氮化合物 - 氧杂环 - 氧杂环丁烷 - 多醇 - 初级醇 - 吡喃 - 醛基 - 醛基
描述（Description）	该化合物属于有机化合物类别中的正酰基神经氨酸。这类神经氨酸分子上带有N-酰基取代基。
外部描述符（External Descriptors）	N-acetylneuraminic acid

三维结构

交互式化学结构模型

球棍
棍棒
线框模型
空间填充
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关联靶点（人）

NEU2 Tbio Sialidase 2 (382 活性数据)

点击查看靶蛋白信息： NEU2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

NEU3 Tchem Sialidase 3 (398 活性数据)

点击查看靶蛋白信息： NEU3

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

NEU4 Tchem Sialidase 4 (267 活性数据)

点击查看靶蛋白信息： NEU4

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

NEU1 Tchem Sialidase 1 (236 活性数据)

点击查看靶蛋白信息： NEU1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 活性数据)

点击查看靶蛋白信息： CBX1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KPNB1 Tbio Importin subunit beta-1/Snurportin-1 (25097 活性数据)

点击查看靶蛋白信息： KPNB1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

NA Neuraminidase (1107 活性数据)

点击查看靶蛋白信息： NA

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 活性数据)

点击查看靶蛋白信息： Hdac6

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

化学和物理性质

溶解性

Soluble in water (50 mg/ml).

敏感性

对湿度&空气& 热敏感

比旋光度

-32 ° (C=1, H2O)

熔点

192-194°C

分子量

309.270 g/mol

XLogP3

-3.500

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

309.106 Da

单同位素质量Monoisotopic Mass

309.106 Da

拓扑极表面积Topological Polar Surface Area

177.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

403.000

同位素原子数Isotope Atom Count

定义的原子立体中心计数Defined Atom Stereocenter Count

未定义的原子立体中心计数Undefined Atom Stereocenter Count

定义的键立体中心计数Defined Bond Stereocenter Count

未定义的键立体中心计数Undefined Bond Stereocenter Count

所有立体化学键的总数The total count of all stereochemical bonds

共价键合单元计数Covalently-Bonded Unit Count

安全和危险性（GHS）

象形图

GHS07

信号词

警告

危险声明

H319: 引起严重眼睛刺激

预防措施声明

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

WGK Germany

Merck Index

8484

个人防护装备

Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到48个结果

批号(Lot Number)	证书类型	货号
I2608230	分析证书	A100555
I2608246	分析证书	A100555
I2608247	分析证书	A100555
I2608290	分析证书	A100555
J2210125	分析证书	A100555
B2219235	分析证书	A100555
K2506226	分析证书	A100555
K2506221	分析证书	A100555
K2506217	分析证书	A100555
K2506214	分析证书	A100555
G2609132	分析证书	A100555
G2106246	分析证书	A100555
C2517298	分析证书	A100555
C2524555	分析证书	A100555
C2517302	分析证书	A100555
C2517301	分析证书	A100555
C2517300	分析证书	A100555
C2517299	分析证书	A100555
C2517297	分析证书	A100555
K2428218	分析证书	A100555
K2428219	分析证书	A100555
K2428221	分析证书	A100555
K2428222	分析证书	A100555
L2407020	分析证书	A100555
I2022150	分析证书	A100555
G2402068	分析证书	A100555
B2321083	分析证书	A100555
B2420042	分析证书	A100555
B2506023	分析证书	A100555
J2422022	分析证书	A100555
J2313100	分析证书	A100555
J2210133	分析证书	A100555
J2210132	分析证书	A100555
J2210131	分析证书	A100555
J2210107	分析证书	A100555
J2210105	分析证书	A100555
F2314414	分析证书	A100555
I2406032	分析证书	A100555
B2520032	分析证书	A100555
J2326136	分析证书	A100555
D2310234	分析证书	A100555
G2306099	分析证书	A100555
B2321105	分析证书	A100555
B2321084	分析证书	A100555
B2321068	分析证书	A100555
B2219241	分析证书	A100555
B2219240	分析证书	A100555
B2219238	分析证书	A100555

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1. Jiahao Hu, Yuchan You, Luwen Zhu, Jucong Zhang, Yanling Song, Jingyi Lu, Xinyi Xu, Xiaochuan Wu, Xiajie Huang, Xiaoling Xu, Yongzhong Du. (2023) Sialic Acid-Functionalized Pyroptosis Nanotuner for Epigenetic Regulation and Enhanced Cancer Immunotherapy. Small, [PMID:37880861] [10.1002/smll.202306905]
2. Guan Hanxiao, Xie Chen, Cao Yuqi, Huang Pingjie, Hou Dibo, Zhang Guangxin. (2023) Qualitative Identification of Sialic Acid Content Based on Terahertz Time-Domain Spectroscopy. Journal of Infrared Millimeter and Terahertz Waves, 44 (9): (780-794). [10.1007/s10762-023-00939-w]
3. Li Huixin, Xu Yanpeng, Wang Yang, Cui Yihao, Lin Jiake, Zhou Yuemin, Tang Shuling, Zhang Ying, Hao Haibin, Nie Zihao, Wang Xiaoyu, Tang Ruikang. (2023) Material-engineered bioartificial microorganisms enabling efficient scavenging of waterborne viruses. Nature Communications, 14 (1): (1-13). [PMID:37537158] [10.1038/s41467-023-40397-5]
4. Shiwei Liu, Shuang Han, Yuzhuo Song, Ruonan Sun, Le Zhao, Chen Yan. (2023) Disulfide-Bridged Dendritic Organosilicas-Based Biodegradable Molecularly Imprinted Polymers for Multiple Targeting and pH/Redox-Responsive Drug Release toward Chemical/Photodynamic Synergistic Tumor Therapy. Advanced Healthcare Materials, 12 (20): (2300184). [PMID:36943098] [10.1002/adhm.202300184]
5. Liu Quanzhen, Wei Guoguang, Yang Pengfan, Wang Chengyong, Chen Kequan, Ouyang Pingkai, Zhang Alei. (2023) One-pot biosynthesis of N-acetylneuraminic acid from chitin via combination of chitin-degrading enzymes, N-acetylglucosamine-2-epimerase, and N-neuraminic acid aldolase. Frontiers in Microbiology, [PMID:37025634] [10.3389/fmicb.2023.1156924]
6. Huihui Yang, Xiaosen Bai, Baolong Feng, Qinghua Wang, Li Meng, Fengzhong Wang, Yutang Wang. (2022) Application of Molecular Transformer approach for predicting the potential reactions to generate advanced glycation end products in infant formula. FOOD CHEMISTRY, [PMID:36516683] [10.1016/j.foodchem.2022.135143]
7. Rufeng Zhu, Yuedan Wang, Yang Tao, Yao Wang, Yuanli Chen, Mufang Li, Qiongzhen Liu, Liyan Yang, Dong Wang. (2022) Layer-by-layer assembly of composite conductive fiber-based organic electrochemical transistor for highly sensitive detection of sialic acid. ELECTROCHIMICA ACTA, [10.1016/j.electacta.2022.140716]
8. Qiang Chen, Chunjing Guo, Xiudi Zhou, Yanguo Su, Huimin Guo, Min Cao, Jing Li, Yue Zhang, Weiyi Zhao, Xin Gao, Shuqi Mi, Daquan Chen. (2022) N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:35513096] [10.1016/j.ijbiomac.2022.04.180]
9. Shuang Han, Yuzhuo Song, Shiwei Liu, Le Zhao, Ruonan Sun. (2022) Dual responsive molecularly imprinted polymers based on UiO-66-DOX for selective targeting tumor cells and controlled drug release. EUROPEAN POLYMER JOURNAL, [10.1016/j.eurpolymj.2022.111219]
10. Zeng Jiaxin, Meng Yuan, Chen Shi-Yi, Zhao Gaofeng, Wang Lianchun, Zhang En-Xin, Qiu Hong. (2021) Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin. GLYCOCONJUGATE JOURNAL, 39 (3): (315-325). [PMID:34699015] [10.1007/s10719-021-10018-8]
11. Zhang Xin, Wang Chen, Han Qing, Chen Xuan, Li Guoyun, Yu Guangli. (2021) Highly sialylated mucin-type glycopeptide from porcine intestinal mucosa after heparin extraction: O-glycan profiling and immunological activity evaluation. GLYCOCONJUGATE JOURNAL, 38 (5): (527-537). [PMID:34480673] [10.1007/s10719-021-10014-y]
12. Xi Lin, Chunsheng Xiao, Ling Ling, Liming Guo, Xinhua Guo. (2021) A dual-mode reactive matrix for sensitive and quantitative analysis of carbohydrates by MALDI-TOF MS. TALANTA, [PMID:34517650] [10.1016/j.talanta.2021.122792]
13. Junyang Chen, Shan Jiang, Mengke Wang, Xiaolei Xie, Xingguang Su. (2021) Self-assembled dual-emissive nanoprobe with metal−organic frameworks as scaffolds for enhanced ascorbic acid and ascorbate oxidase sensing. SENSORS AND ACTUATORS B-CHEMICAL, [10.1016/j.snb.2021.129910]
14. Fan Kai, Lu Chengying, Shu Gaofeng, Lv Xiu-Ling, Qiao Enqi, Zhang Nannan, Chen Minjiang, Song Jingjing, Wu Fazong, Zhao Zhongwei, Xu Xiaoling, Xu Min, Chen Chunmiao, Yang Weibin, Sun Jihong, Du Yongzhong, Ji Jiansong. (2021) Sialic acid-engineered mesoporous polydopamine dual loaded with ferritin gene and SPIO for achieving endogenous and exogenous synergistic T2-weighted magnetic resonance imaging of HCC. JOURNAL OF NANOBIOTECHNOLOGY, 19 (1): (1-17). [PMID:33731140] [10.1186/s12951-021-00821-8]
15. Feiyang Jin, Jing Qi, Minxia Zhu, Di Liu, Yuchan You, Gaofeng Shu, Yan Du, Jun Wang, Hui Yu, Mingchen Sun, Xiaoling Xu, Qiying Shen, Xiaoying Ying, Jiansong Ji, Yongzhong Du. (2020) NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity. ACS Applied Materials & Interfaces, [PMID:32597641] [10.1021/acsami.0c07503]
16. Nian Cao, Faqiong Zhao, Baizhao Zeng. (2020) A novel ratiometric molecularly imprinted electrochemiluminescence sensor for sensitive and selective detection of sialic acid based on PEI-CdS quantum dots as anodic coreactant and cathodic luminophore. SENSORS AND ACTUATORS B-CHEMICAL, [10.1016/j.snb.2020.128042]
17. Jinmin Wang, Limin Zhao, Bing Yan. (2020) Indicator Displacement Assay Inside Dye-Functionalized Covalent Organic Frameworks for Ultrasensitive Monitoring of Sialic Acid, an Ovarian Cancer Biomarker. ACS Applied Materials & Interfaces, [PMID:32106673] [10.1021/acsami.0c00101]
18. Xiang-Nan He, Ya-Ning Wang, Yue Wang, Zhang-Run Xu. (2019) Accurate quantitative detection of cell surface sialic acids with a background-free SERS probe. TALANTA, [PMID:31892066] [10.1016/j.talanta.2019.120579]
19. Xiao-Juan Wang, Gao-Feng Shu, Xiao-Ling Xu, Chen-Han Peng, Chen-Ying Lu, Xing-Yao Cheng, Xiang-Chao Luo, Jie Li, Jing Qi, Xu-Qi Kang, Fei-Yang Jin, Min-Jiang Chen, Xiao-Ying Ying, Jian You, Yong-Zhong Du, Jian-Song Ji. (2019) Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles. BIOMATERIALS, [PMID:31288173] [10.1016/j.biomaterials.2019.119326]
20. Shaomei Xu, Songtian Che, Pinyi Ma, Fangmei Zhang, Longbin Xu, Xin Liu, Xinghua Wang, Daqian Song, Ying Sun. (2019) One-step fabrication of boronic-acid-functionalized carbon dots for the detection of sialic acid. TALANTA, [PMID:30771974] [10.1016/j.talanta.2019.01.074]
21. Feiyang Jin, Di Liu, Hui Yu, Jing Qi, Yuchan You, Xiaoling Xu, Xuqi Kang, Xiaojuan Wang, Kongjun Lu, Xiaoying Ying, Jian You, Yongzhong Du, Jiansong Ji. (2018) Sialic Acid-Functionalized PEG–PLGA Microspheres Loading Mitochondrial-Targeting-Modified Curcumin for Acute Lung Injury Therapy. MOLECULAR PHARMACEUTICS, [PMID:30431285] [10.1021/acs.molpharmaceut.8b00861]
22. Jing-Bo Hu, Di Liu, Jing Qi, Kong-jun Lu, Fei-yang Jin, Xiao-Ying Ying, Jian You, Yong-Zhong Du. (2018) An E-selectin targeting and MMP-2-responsive dextran–curcumin polymeric prodrug for targeted therapy of acute kidney injury. Biomaterials Science, 6 (12): (3397-3409). [PMID:30371703] [10.1039/C8BM00813B]
23. Jianping Li, Xionghui Ma, Mengxi Li, Yun Zhang. (2017) Does polysaccharide is an idea template selection for glycosyl imprinting?. BIOSENSORS & BIOELECTRONICS, [PMID:28818784] [10.1016/j.bios.2017.08.004]
24. Lingbo Sun, Hongxia Fu, Yanru Li, Xinrui Duan, Zhengping Li. (2016) Rapid Recognition and Isolation of Live Colon Cancer Stem Cells by Using Metabolic Labeling of Azido Sugar and Magnetic Beads. ANALYTICAL CHEMISTRY, [PMID:26937691] [10.1021/acs.analchem.6b00154]
25. Tiantian Yin, Licong Yang, Yanan Liu, Xianbo Zhou, Jing Sun, Jie Liu. (2015) Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease. Acta Biomaterialia, [PMID:26143603] [10.1016/j.actbio.2015.06.035]
26. Xinlv Peng, Caixia Pei, Eika W. Qian, Yuguang Du, Jian-Jun Li. (2024) Co-immobilization of a bi-enzymatic cascade into hierarchically porous MIL-53 for efficient 6′-sialyllactose production. Nanoscale, [PMID:39046038] [10.1039/D4NR01775G]
27. Juncheng Liu, Xingyu Lu, Fang Fang, Kaizhang Wu, Jihong Wu, Jie Gao. (2024) Comparison of the in-vitro effect of five prebiotics with different structure on gut microbiome and metabolome. Food Bioscience, [10.1016/j.fbio.2024.103810]
28. Sun Yunze, Mi Zhuang, Chen Xiaoyu, Li Jian-Jun, Lu Jun, Shan Xinyan, Lu Xinghua, Du Yuguang. (2024) Identification of nine mammal monosaccharides by solid-state nanopores. Scientific Reports, 14 (1): (1-9). [PMID:39738399] [10.1038/s41598-024-83690-z]
29. Liang Shuyu, Tang Qi, Guo Xunzi, Li Zi’an, Guo Yilan, Chang Jinghan, Cheng Bo, Song Qitao, Sun Jiayu, Dai Peng, Chen Xing. (2025) Mutant glycosidases for labeling sialoglycans with high specificity and affinity. Nature Communications, 16 (1): (1-14). [PMID:39915445] [10.1038/s41467-025-56629-9]
30. Liu Zhaohong, Xiang Peng, Zeng Shengmei, Weng Ping, Wen Yilin, Zhang Wanping, Hu Hui, Zhao Dezhang, Ma Limei, Yu Chao. (2024) N-Acetylneuraminic acid triggers endothelial pyroptosis and promotes atherosclerosis progression via GLS2-mediated glutaminolysis pathway. Cell Death Discovery, 10 (1): (1-16). [PMID:39537619] [10.1038/s41420-024-02233-7]
31. Yuzhen Zhao, Mingge Li, Yue Guo, Jian Jin, Fei Pei, Wenya Wang, Changhua Liu, Wenyan Yu, Jinjin Shi, Na Yin. (2024) Neutrophil hitchhiking nanoparticles enhance bacteria-mediated cancer therapy via NETosis reprogramming. JOURNAL OF CONTROLLED RELEASE, [PMID:38301928] [10.1016/j.jconrel.2024.01.068]
32. Xiangyu Meng, Chen Xv, Jiaping Lv, Shuwen Zhang, Changlu Ma, Xiaoyang Pang. (2024) Optimizing Akkermansia muciniphila Isolation and Cultivation: Insights into Gut Microbiota Composition and Potential Growth Promoters in a Chinese Cohort. Microorganisms, 12 (5): (881). [PMID:38792711] [10.3390/microorganisms12050881]
33. Su Fang, Jianrong Wu, Wenxuan Niu, Tiantian Zhang, Tiantian Hong, Hongtao Zhang, Xiaobei Zhan. (2024) Sialylation of dietary mucin modulate its digestibility and the gut microbiota of elderly individuals. FOOD RESEARCH INTERNATIONAL, [PMID:38609225] [10.1016/j.foodres.2024.114246]
34. Zhenjun Wang, Zongtao Xie, Chuanxin Liu, Xiaojun Zhang. (2024) Synergistic chemotherapy and photothermal therapy of lung cancer using MoS2 nanosheets co-loaded with silybin and doxorubicin. Alexandria Engineering Journal, [10.1016/j.aej.2024.09.033]
35. SunHongzheng , HanLongsen , GuoYueshuai , AnHuiqing , WangBing , ZhangXiangzheng , LiJiashuo , JiangYingtong , WangYue , SunGuangyi , ZhuShuai , TangShoubin , GeJuan , ChenMinjian , GuoXuejiang , WangQiang. (2024) The global phosphorylation landscape of mouse oocytes during meiotic maturation. EMBO JOURNAL, [PMID:39256562] [10.1038/s44318-024-00222-1]
36. Zihan Zhu, Yan Zhang, Cui He, Yimin Jin, Wei Bian, Xinjing Tang, Jing Wang. (2025) Tumor microenvironment-responsive multinucleated nanocomplexes loaded with carbon dots for combined photothermal/chemodynamic therapy of breast cancer. ChemMedChem, [PMID:39821494] [10.1002/cmdc.202400983]
37. Yuanyuan Lu, Yueying Dai, Yushi Qin, Xiaoru Jia, Xiaoya Li, Shuang Lu, Xinrong Liu, Yanzhi Song, Yihui Deng. (2025) An in vivo combined induction strategy of whole cancer cell vaccines triggers systemic immunity to eradicate triple-negative breast cancer. JOURNAL OF CONTROLLED RELEASE, [PMID:40681021] [10.1016/j.jconrel.2025.114045]
38. Guozhen Ma, Xiaolong Jiang, Bin Yang, Linxing Li, Ruiying Liu, Qing Meng, Jiawei Li, Lijie Xie, Han Guo, Sijia Liu, Yuxuan Wang, Yibo Wang, Xiaojing Zhao, Ziyu Li, Yujie Wang, Menglei Xia, Di Huang. (2025) Development of a high-efficiency N-acetylneuraminic acid production platform through multi-pathway synergistic engineering. TRENDS IN BIOTECHNOLOGY, [PMID:40885671] [10.1016/j.tibtech.2025.07.016]
39. Yuanyuan Li, Haifu Jia, Yaping Zheng, Xiaoxia Sun, Yaqian Zhang, Wei Liu, Wei Zhang, Yujun Jiang, Qianyu Zhao, Ling Guo. (2025) The Nutritional Composition and Multi-Omics Analysis of Raw Milk From Normande and Holstein Cows. Food Frontiers, [10.1002/fft2.70115]
40. Qianyun Fu, Guoyun Li, Chen Wang, Ya Wang, Qinying Li, Jiejie Hao, Guangli Yu. (2019) Profiling and Structural Characterization of High Neu5Gc or Sulfate-Containing O-glycans from Hyla Rabbit Intestinal Mucin. MOLECULES, 24 (7): (1365). [PMID:30959980] [10.3390/molecules24071365]
41. Yao Zimin, Zheng Guoliang, Zheng Yonggui, Wen Xiaokun, Hong Xia, Yan Jiayi, Liu Wen, Wang Jiwei, Wang Kexin, Cao Shuo. (2025) Ratiometric fluorescence sensing of sialic acid based on dual-emission carbon dots. MICROCHIMICA ACTA, 192 (7): (1-9). [PMID:40473999] [10.1007/s00604-025-07237-3]
42. Yuyao Jiang, Yanru Guan, Ruidong Chen, Jason T. Magnuson, Wen Zexin, Zijie Ding, Leyi Zhang, Wumuerzati Maermaer, Yuanyuan Liu, Shuying Li, Wenjun Gui, Daniel Schlenk. (2025) Chlorpyrifos cardiotoxic responses may be mediated by phagocytic activation in larval zebrafish. Environmental Chemistry and Ecotoxicology, [10.1016/j.enceco.2025.12.001]
43. Lemei Li, Jinyang Wu, Huilei Hao, Ying Wang, Shaoying Hou. (2025) Sialic Acid Supplementation in Perinatal Mice Attenuates Gestational Diabetes Mellitus-induced Liver Injury in Offspring at Early Adulthood. JOURNAL OF NUTRITION, [PMID:41478595] [10.1016/j.tjnut.2025.101292]
44. Guimeng Xiao, Xiaonan Zhao, Shaoyun Shi, Jianxing Lu, Guiling Li, Fengying Gong, Xinming Feng, Juanjuan Liu, Dongdong Meng. (2025) Thermostable Whole-Cell Biocatalysts Enable Sustainable and Practical Synthesis of N-Acetylneuraminic Acid. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:41456346] [10.1021/acs.jafc.5c10911]
45. Cheng Fu, Tianyi Hu, Xiangli Zhao, Man Zhang, Tianhui Pan, Yahui Huang, Jiang Zhang, Lan Zhu, Gang Chen. (2026) Kidney Targeting Liposomes Loaded with the Antioxidant Pinocembrin for Treatment of Acute Kidney Injury. ACS Applied Materials & Interfaces, [PMID:41510988] [10.1021/acsami.5c18109]
46. Daying Xia, Qunyan Fan, Ling Chen, Feifei Xu, Fei Liu, Maoshen Chen, Fang Zhong. (2026) Edible bird's nest attenuates menopausal syndromes by stimulating extragonadal estrogen biosynthesis in ovariectomized rats. Food Bioscience, [10.1016/j.fbio.2026.108497]
47. Sun Xiaoyan, Qin Yaxin, Ben Zhiqing, Zhang Zhicheng, Bao Xiaoyan, Yang Yufan, Shui Yongjie, Chen Haiyan, Wu Dang, Wei Qichun, Han Min. (2026) Spatial Targeting of Sialic Acid Receptors for MRI/BNCT-Integrated Boron Drug-Based Antitumor Therapy. PHARMACEUTICAL RESEARCH, [PMID:41760875] [10.1007/s11095-026-04015-5]
48. Xue Yu, Zihan Zhai, Qiangcheng Zeng, Jiajia Chen, Jiayi Wang, Wei Zhao, Jinling Liang, Guoxiu Han. (2026) Integrated High-Purity Sialic Acid Production Process Using Multi-Stage Membrane Filtration Coupled with Resin Adsorption. Separations, 13 (4): (108). [10.3390/separations13040108]
49. Xinchen Zhao, Liyan Qiu. (2026) Composite nanovesicles for enhanced chemodynamic cancer therapy via decitabine-mediated epigenetic reactivation. JOURNAL OF CONTROLLED RELEASE, [PMID:41871782] [10.1016/j.jconrel.2026.114849]
50. Yang Chen, Ranjie Lei, Qi Guo, Kehao Liu, Huaiyi Cheng, Sanyang Yu, Yuzhou Li, Ping He, Sheng Yang. (2026) Charge-Adaptive Nanoparticle Attenuates Inflammation via Targeting Neutrophil Extracellular Traps (NETs) and Breaking NETs–Macrophage Crosstalk. ACS Nano, [10.1021/acsnano.6c02254]