穿心莲内酯, TAS2R46 的激动剂;TAS2R50 的激动剂;TAS2R8 的激动剂

NF-κB Inhibitors
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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
A407762-1ml
1ml 现货 Stock Image
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Compound libraries (12332)

基本描述

英文别名 2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3E,4S)-
规格或纯度 Moligand™, 10mM in DMSO
英文名称 Andrographolide
生化机理 穿心莲内酯是一种唇形二萜类化合物,是药用植物穿心莲的主要生物活性成分。
储存温度 -80℃储存
运输条件 超低温冰袋运输
作用类型 激动剂
作用机制 TAS2R46 的激动剂;TAS2R50 的激动剂;TAS2R8 的激动剂
产品介绍

Andrographolide, a bioactive diterpene lactone, is the main constituent of Andrographis paniculata, a plant used in traditional medicines. It is known to have different biological activities such as anti-inflammatory, anti-malarial, anti-cancer and hepatoprotective activity. It also shows potent anti-viral effect against dengue virus植物抗菌制剂。具有抗炎特性的二萜内酯。它阻止T细胞对异体刺激带来的增殖和巨噬细胞趋化补体迁移。阻止几种癌症细胞在体外的增殖。异体刺激

Information

Andrographolide Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.
In vitro


In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

关联靶点(人)

TAS2R8 Tchem 2 型味觉受体成员 8(Taste receptor type 2 member 8) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
TAS2R46 Tchem 2 型味觉受体成员 46(Taste receptor type 2 member 46) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
TAS2R50 Tchem 2 型味觉受体成员 50(Taste receptor type 2 member 50) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

名称和识别符

Canonical SMILES CC1(CO)C(O)CCC2(C)C(C\C=C\3C(O)COC3=O)C(=C)CCC12
分子量 350.45

安全和危险性(GHS)

技术规格说明书

Concentration(Compounding value) 9-11(mmol/L)
Appearance(A407762) Colorless Transparent Liquid
Record the entire process by video Conform

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

此产品的引用文献

1. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang.  (2021)  Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1178  (122767).  [PMID:34224966] [10.1016/j.jchromb.2021.122767]

参考文献

1. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang.  (2021)  Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1178  (122767).  [PMID:34224966] [10.1016/j.jchromb.2021.122767]

溶液计算器

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