ExactAb™,已验证,无载体 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid.
ALDH1A1 is an aldehyde dehydrogenase able to oxidize a wide variety of aliphatic aldehydes (retinaldehyde, acetaldehyde, etc.) to the corresponding carboxylic acids (retinoic acid, acetic acid, etc.). ALDH1A1 (also known as RALDH1, ALDH1, or AHD2) is highly expressed in the dorsal retina, ventral midbrain (dopaminergic neurons), and hematopoietic stem cells. ALDH1A1 is involved in retinoic acid (RA) synthesis during vertebrate embryogenesis. ALDH1A1 is first detected at E9.0-E10.5 in cranial tissues (ventral mesencephalon, dorsal retina, thymic primordia, optic vesicles) and in the mesonephros. ALDH1A1 is also of interest in Parkinson's Disease (PD) being expressed in the the A9 dopaminergic (DA) neuronal group projecting to the dorsal striatum; this is the most vulnerable site in PD (Chung et al, 2005). ALDH1A1 protein is a known mesencephalic dopaminergic marker. ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid .ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea .ALDH1A1 is highly expressed in brain dopaminergic neurons, where it produces the retinoic acid required for their differentiation and development .The retinoic acid produced by ALDH1A1 is also important for the differentiation of hematopoietic stem cells.
ALDH1A1 Mouse mAb (Ab088039) - Western Blot
All lanes: ALDH1A1 Mouse mAb (Ab088039) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/10000 dilution
Predicted band size: 55 kDa
Observed band size: 52 kDa
ALDH1A1 Mouse mAb (Ab088039) - IHC
Immunohistochemical analysis of paraffin-embedded Human cerebellum tissue using ALDH1A1 Mouse mAb (Ab088039) at a dilution of 1/200 with DAB staining.
ALDH1A1 Mouse mAb (Ab088039) - IHC
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using ALDH1A1 Mouse mAb (Ab088039) at a dilution of 1/200 with DAB staining.
1/200-1/1000
1/10000
1/500-1/2000. Predicted molecular weight: 55 kDa.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ23F0700530 |
分析证书 | Ab088039 |
| ZJ23F0700531 |
分析证书 | Ab088039 |
| ZJ24F1012185 |
分析证书 | Ab088039 |
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