HIF3A | IPAS | MOP7 | PASD7 | HIF-3A | bHLHe17 | HIF3-alpha-1 | Basic-helix-loop-helix-PAS protein MOP7 antibody | bHLHe17 antibody | Class E basic helix-loop-helix protein 17 antibody | HIF 3A antibody | HIF 3A4 antibody | HIF-3-alpha antibody | HIF3 alp
规格或纯度
见COA
生化机理
Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea.
宿主种属
小鼠(Mouse)
特异性
HIF3 alpha/IPAS
种属反应性
人(Human)
免疫原
Recombinant protein fragment of human HIF3A produced in E.coli (AA 355-669)
阳性对照
WB: HEK293T transfected with the pCMV6-ENTRY HIF3A cDNA for 48 hrs, HepG2, HeLa, Jurkat and MCF7 lysates.