计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
HIF3 alpha/IPAS Mouse mAb
有货
概述
Mouse anti Human HIF3 alpha/IPAS Antibody, Monoclonal (OTI2F7), could be used for WB and so on.
规格
产品名称
HIF3 alpha/IPAS Mouse mAb
别名
缺氧诱导因子3α/HIF-3α抗体|HIF3 alpha/IPAS抗体|HIF3 alpha/IPAS单克隆抗体
英文别名
HIF3A|IPAS|MOP7|PASD7|HIF-3A|HIF3-alpha-1|Basic-helix-loop-helix-PAS protein MOP7 antibody|bHLHe17 antibody|Class E basic helix-loop-helix protein 17 antibody|HIF 3A antibody|HIF 3A4 antibody|HIF-3-alpha antibody|HIF3 alpha antibody|HIF3-alpha antibody|HIF3-alpha-1 antibody|HIF3A antibody|Hypoxia Inducible Factor 3 alpha antibody|Hypoxia inducible factor 3 alpha subunit antibody|Hypoxia inducible factor three alpha antibody|Hypoxia-inducible factor 3-alpha antibody|Inhibitory PAS domain protein antibody|IPAS antibody|Member of PAS protein 7 antibody|MOP7 antibody|PAS domain-containing protein 7 antibody|PASD7 antibody
规格或纯度
见COA
生化机理
Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea.
宿主种属
小鼠(Mouse)
特异性
HIF3 alpha/IPAS
种属反应性
人(Human)
免疫原
Recombinant protein fragment of human HIF3A produced in E.coli (AA 355-669)
阳性对照
WB: HEK293T transfected with the pCMV6-ENTRY HIF3A cDNA for 48 hrs, HepG2, HeLa, Jurkat and MCF7 lysates.
偶联
Unconjugated
克隆类型
单克隆抗体
Format
Whole IgG
纯化方法
Protein G purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
物理外观
Liquid
储存缓冲液
10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3
防腐剂
0.02% Sodium azide
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
短期储存4℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。
应用
应用名称
稀释比例
WB
1/500-1/1000
高级数据
关联靶点（人）
HIF3A
Tbio
缺氧诱导因子3-α(Hypoxia-inducible factor 3-alpha)
(0 活性数据)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品应如何储存？
请于?20 °C条件下保存。避免反复冻融。建议按单次用量分装保存。
本产品如何运输？
本产品采用保温箱配冰袋运输。收货后请立即拆包，并按上述储存条件保存。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
该抗体已验证对哪些物种有反应性？
已验证的反应性列在PDP和每批次的数据表上。我们针对靶标（HIF3 alpha/IPAS Mouse mAb）最常测试的物种进行验证；未经测试的物种可能存在交叉反应性，但不能保证。如有特定物种咨询，请联系技术支持。
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