24p3 antibody | 25 kDa alpha 2 microglobulin related subunit of MMP9 antibody | 25 kDa alpha-2-microglobulin-related subunit of MMP-9 antibody | Alpha 2 microglobulin related protein antibody | HGNC:6526 antibody | HNL antibody | Lcn 2 antibody | Lcn2 ant
规格或纯度
≥90%(SDS-PAGE), 见COA
生化机理
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
宿主种属
小鼠(Mouse)
特异性
LCN2
种属反应性
人(Human)
免疫原
Recombinant NGAL protein.
偶联
Unconjugated
克隆类型
单克隆抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Antigen affinity chromatography
配对抗体
[Ab113226] NGAL Mouse mAb as Capture antibody in LF, ELISA
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