Macropain chain Z antibody | Multicatalytic endopeptidase complex chain Z antibody | Proteasome (prosome macropain) subunit beta type 7 antibody | Proteasome beta 7 subunit antibody | Proteasome catalytic subunit 2 antibody | Proteasome subunit alpha anti
规格或纯度
ExactAb™, 已验证, 见COA
生化机理
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
宿主种属
小鼠(Mouse)
特异性
Proteasome 20S beta 7/PSMB7
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse),狗(Dog),猴(Monkey)
免疫原
Recombinant protein of human Proteasome 20S beta 7/PSMB7 (AA 58-277).
阳性对照
WB: Hep G2, HeLa, Jurkat, MCF7, A549 and NIH/3T3 cell lysates. IF/ICC: COS7 cells.
Proteasome 20S beta 7/PSMB7 Mouse mAb (Ab123389) - Western Blot All lanes: Proteasome 20S beta 7/PSMB7 Mouse mAb (Ab123389) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/20000 dilution Predicted band size: 30 kDa Observed band size: 27 kDa Exposure time: 60.0 s
Proteasome 20S beta 7/PSMB7 Mouse mAb (Ab123389) - IF/ICC Proteasome 20S beta 7/PSMB7 Mouse mAb (Ab123389) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PSMB7.
ZJ25F0117313
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