Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells.
宿主种属
小鼠(Mouse)
特异性
SOX17
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse),狗(Dog)
免疫原
Recombinant protein of human SOX17 (AA 177-414)
阳性对照
WB: HeLa, HT-29, A549, MCF7 and Hep G2 cell lysates. IF/ICC: COS7cells transiently transfected with pCMV6-ENTRY SOX17.
Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (12 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片
SOX17 Mouse mAb (Ab128771) - Western Blot All lanes: SOX17 Mouse mAb (Ab128771) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/10000 dilution
Predicted band size: 44 kDa Observed band size: 49 kDa Exposure time: 1.9 s
SOX17 Mouse mAb (Ab128771) - IF/ICC SOX17 Mouse mAb (Ab128771) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOX17.
SOX17 Mouse mAb (Ab128771) - IF/ICC Immunofluorescent staining of HeLa cells using SOX17 Mouse mAb (Ab128771) .
ZJ25F0217738
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