Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
宿主种属
小鼠(Mouse)
特异性
Survivin
种属反应性
人(Human)
免疫原
Recombinant Survivin expressed in E.coli (AA 1-142)
阳性对照
WB: HEK293, A549 and Jurkat cell lysates. IHC: Human ovary, small intestine, lymph node, spleen and stomach tissues.
偶联
Unconjugated
克隆类型
单克隆抗体
克隆号
C3
Format
Whole IgG
亚型
Mouse IgG1
轻链亚型
kappa
纯化方法
Protein A + Protein G purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
物理外观
Liquid
储存缓冲液
10mM PBS, 50% Glycerol, 0.05% Proclin 300, pH7.4
防腐剂
0.05% Proclin 300
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
4℃ 短期储存（1-2 周）。-20℃长期保存（24 个月）。收货后建议分装。避免冷冻/解冻循环。
图片
Survivin Mouse mAb (Ab129838) - Western Blot All lanes: Survivin Mouse mAb (Ab129838) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/30000 dilution
Predicted band size: 18 kDa Observed band size: 17 kDa Exposure time: 3.9 s
Survivin Mouse mAb (Ab129838) - IHC DAB staining on IHC Sample: Human Uterus Tissue Primary Ab: 30 μg/mL Survivin Mouse mAb (Ab129838) Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody.
Survivin Mouse mAb (Ab129838) - IHC DAB staining on IHC Sample: Human Ovary Tissue Primary Ab: 30 μg/mL Survivin Mouse mAb (Ab129838) Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
Survivin Mouse mAb (Ab129838) - IHC DAB staining on IHC Sample: Human Small intestine Tissue Primary Ab: 30 μg/mL Survivin Mouse mAb (Ab129838) Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
Survivin Mouse mAb (Ab129838) - IHC DAB staining on IHC Sample: Human Lymph node Tissue Primary Ab: 30 μg/mL Survivin Mouse mAb (Ab129838) Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
Survivin Mouse mAb (Ab129838) - IHC DAB staining on IHC Sample: Human Spleen Tissue Primary Ab: 30 μg/mL Survivin Mouse mAb (Ab129838) Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
Survivin Mouse mAb (Ab129838) - IHC DAB staining on IHC Sample: Human Stomach Tissue Primary Ab: 30 μg/mL Survivin Mouse mAb (Ab129838) Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
ZJ24F1011788
危险品化学品经营许可证（带存储）