Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
宿主种属
兔(Rabbit)
特异性
TAK1
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human TAK1 (AA 550-606).
阳性对照
WB: HeLa, Jurkat, Hep G2, MCF7, SH-SY5Y, NIH/3T3 and C6 cell lysates. IF/ICC: A431 cells.
Recombinant TAK1 Antibody (Ab130191) - Western Blot All lanes: Recombinant TAK1 Antibody (Ab130191) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 67 kDa Observed band size: 71 kDa Exposure time: 34.5 s