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药物发现
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Recombinant Mouse MAdCAM-1 Protein
- 种属: 小鼠(Mouse)
- Accession #: G5E838
- 表达系统: HEK293
- 蛋白标签: C-His
- 内毒素水平: <0.1 EU/μg
- 生物活性: Measured by the ability of the immobilized protein to support the adhesion of HuT 78 human cutaneous T cell lymphoma cells. When 5 x 104 cells/well are added to mouse MAdCAM-1/Fc Chimera coated plates (10 µg/mL with 100 µL/well), approximately 80-90% will adhere after MnCl2 stimulation for 1 hour incubation at room temperature.
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Recombinant Mouse HGF Protein
- 种属: 小鼠(Mouse)
- Accession #: Q08048
- 表达系统: HEK293
- 蛋白标签: C-His
- 内毒素水平: <0.1 EU/μg
- 生物活性: Measured in a cell proliferation assay using mIMCD‑3 mouse epithelial cells. The ED50 for this effect is 10-30 ng/mL. Measured by its ability to bind Recombinant Mouse HGF R/c-MET Fc Chimera in a functional ELISA with an estimated KD <0.2 nM.
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Recombinant Mouse Cathepsin B Protein
- 种属: 小鼠(Mouse)
- Accession #: P10605
- 表达系统: HEK293
- 蛋白标签: C-10His
- 内毒素水平: <0.1 EU/μg
- 生物活性: Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC. The specific activity is >2,000 pmol/min/µg, as measured under the described conditions.
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Recombinant Mouse IL-12/IL-23 p40 Monomer Protein
- 种属: 小鼠(Mouse)
- Accession #: P43432
- 表达系统: HEK293
- 蛋白标签: C-His
- 内毒素水平: <0.1 EU/μg
- 生物活性: Measured by its ability to inhibit IL-23 induced IL-17 secretion by mouse splenocytes. The ED50 for this effect is 3-18 ng/mL.
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Recombinant Mouse ErbB3/Her3 Protein
- 种属: 小鼠(Mouse)
- Accession #: Q61526
- 表达系统: HEK293
- 蛋白标签: C-hFc & His
- 内毒素水平: <0.1 EU/μg
- 生物活性: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse ErbB3/Her3 Protein (rp166491) at 2 μg/mL can bind Recombinant Human NRG1-beta1Protein, the ED50 for this effect is 60.44 ng/mL.
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Recombinant Mouse ICAM-1/CD54 Protein
- 种属: 小鼠(Mouse)
- Accession #: P13597
- 表达系统: HEK293
- 蛋白标签: C-His
- 内毒素水平: <0.1 EU/μg
- 生物活性: Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated Jurkat cells. When 5 x 104 cells/well are added to Recombinant Mouse ICAM-1/CD54 Protein (rp154082) coated plates (10 µg/mL with 100 µL/well), approximately 65 - 95% will adhere after 1 hour incubation at 37℃.
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Recombinant Mouse TNF RII/TNFRSF1B Protein
- 种属: 小鼠(Mouse)
- Accession #: P25119
- 表达系统: HEK293
- 蛋白标签: C-hFc & His
- 内毒素水平: <0.1 EU/μg
- 生物活性: Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D (A113142). The ED50 for this effect is typically 0.95 ng/mL in the presence of 0.5 ng/mL of Recombinant Mouse TNF-alpha Protein (rp154759).
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Recombinant Mouse OX40 Ligand/TNFSF4 Protein
- 种属: 小鼠(Mouse)
- Accession #: P43488
- 表达系统: HEK293
- 蛋白标签: N-10His
- 内毒素水平: <0.1 EU/μg
- 生物活性: Measured by its ability to co-stimulate IL-2 secretion by mouse T cells in the presence of anti-CD3. The ED50 for this effect is 10-30 ng/mL in the presence of a cross-linking antibody, Mouse Anti-polyHistidine Monoclonal Antibody.
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Recombinant Mouse HGFR/c-MET Protein
- 种属: 小鼠(Mouse)
- Accession #: P16056
- 表达系统: HEK293
- 蛋白标签: C-hFc & His
- 内毒素水平: <0.1 EU/μg
- 生物活性: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse HGF Protein at 2 μg/mL can bind Recombinant Mouse HGFR/c-MET Protein (rp167874), the ED50 for this effect is 25.05 ng/mL.
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Recombinant Mouse CD40/TNFRSF5 Protein
- 种属: 小鼠(Mouse)
- Accession #: P27512
- 表达系统: HEK293
- 蛋白标签: C-His
- 内毒素水平: <0.1 EU/μg
- 生物活性: Measured by its binding ability in a functional ELISA. When Recombinant Mouse CD40/TNFRSF5 is immobilized at 1 µg/mL (100 µL/well), the concentration of Recombinant Mouse CD40 Ligand/TNFSF5 that produces 50% optimal binding is found to be 100-600 ng/mL.
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Recombinant Mouse Activin RIIB Protein
- 种属: 小鼠(Mouse)
- Accession #: P27040
- 表达系统: HEK293
- 蛋白标签: C-hFc & His
- 内毒素水平: <0.1 EU/μg
- 生物活性: Measured by its ability to inhibit Activin A-induced hemoglobin expression in K562 human chronic myelogenous leukemia cells. The ED50 for this effect is 5-30 ng/mL in the presence of 3 ng/mL of recombinant human Activin A.
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Recombinant Mouse CD47 Protein
- 种属: 小鼠(Mouse)
- Accession #: NP_034711
- 表达系统: HEK293
- 蛋白标签: C-His
- 内毒素水平: <0.1 EU/μg
- 生物活性: Measured by its binding ability in a functional ELISA. When Recombinant Mouse SIRP alpha /CD172a Fc Chimera is coated at 2 μg/mL, Recombinant Mouse CD47 binds with an apparent Kd <0.6 nM. Also measured by its ability to antagonize mouse red blood cell adhesion to immobilized Recombinant Mouse SIRP alpha /CD172a Fc Chimera. The ED50 for this effect is 2.0-8.0 μg/mL. Optimal dilutions should be determined by each laboratory for each application.
